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Department of Physiology and Biophysics

University of Colorado Department of Physiology and Biophysics
 

Kelsey Anbuhl

Neurosciende Graduate Student in Dan Tollin's Lab


Spring Hill College- B.S. in Cell and Molecular Biology, 2011
Our lab focuses on understanding the neural mechanisms of auditory perception with particular emphasis on how sound sources are localized. My main interests lie within the realm of auditory development, and in particular, the role of altered acoustic experience in the developing system. It is known that chronic ear infections resulting in a conductive hearing loss (CHL) during development can produce long-term deficits in auditory functions, including those involved with binaural hearing. These include impairment in locating sounds in space, detecting sounds in noisy environments, as well as acquisition of speech and language- all tasks that require the proper integration of information from both ears. In particular, the cues to sound location, which include interaural time (ITD) and level (ILD) difference cues, rely heavily on the proper input of sound information from both ears. Since CHL can attenuate and delay incoming sounds, the cues to sound location can thus be effectively altered. The presence of a CHL during developmental sensitive periods early in life may result in the binaural auditory system adapting to altered binaural cues to location instead of the normal cues, thus providing a possible basis for the persistent spatial hearing problems observed clinically in children. The exact mechanism underlying these persistent effects, however, is not entirely known.

My current project addresses this issue in the developing guinea pig using novel behavioral and information-theoretic techniques to understand the effects of early CHL on  (1) behavioral spatial hearing ability and (2) information processing by neurons in the inferior colliculus sensitive to sound location.

Recent Publications:

Greene NT*, Anbuhl KL*, Tollin DJ (2014) The acoustical cues to sound location in the guinea pig (Cavia porcellus). Hearing Research 316:1-15.  *Co-first authors

Thornton JL, Anbuhl KL, Tollin DJ (2013) “Unilateral conductive hearing loss causes impaired auditory information processing in neurons in the central auditory system.” In: T Dau, S Santurette, Dalsgaard JC, Tranebjærg L, Anderson T, Poulsen T (Eds.), Auditory Plasticity-Listening with the Brain, pp. 171-178 (CFC & Co. A/S).

Conference Abstracts:

Anbuhl KL, Greene N, Ferber A, Tollin DJ (2014) The role of external ear acoustics of the adult guinea pig in a spatial acuity behavioral task. Abstract for poster, Gordon Research Seminar and Conference- Auditory System, Lewiston, MA.

Anbuhl KL, Greene N, Ferber A, Tollin DJ (2014) The role of external ear acoustics of the adult guinea pig in a spatial hearing behavioral task. Abstract for poster, Otolaryngology Research Day, Aurora, CO.

Anbuhl KL, Greene N, Ferber A, Tollin DJ (2014) The role of external ear acoustics of the adult guinea pig in a spatial hearing behavioral task. Abstract for poster, Annual Meeting for Rocky Mountain Regional Neuroscience Group, Aurora, Colorado.

Anbuhl KL, Greene N, Ferber A, Tollin DJ (2014) The role of external ear acoustics of the adult guinea pig in a spatial hearing behavioral task. Abstract for poster, Association for Research in Otolaryngology (ARO), San Diego, CA.

Anbuhl KL, Ferber A, Koka K, Williams W, Thornton J, Tollin DJ (2013) The acoustical cues to sound location in the adult Guinea pig: measurements of Directional Transfer Functions (DTFs). Abstract for poster, 11th Annual Meeting of the Front Range Neuroscience Group, Fort Collins, Colorado.

Greene NT, Ferber AT, Anbuhl KL, Allen PD, Tollin DJ (2013) Spatial hearing capabilities of the adult guinea pig (Cavia porcellus). Society for Neuroscience (SFN). Abstract 353.06/QQ25.

Thornton J, Anbuhl KL, Tollin DJ (2013) Unilateral conductive hearing loss causes impaired auditory information processing in neurons in the central auditory system. International Symposium on Auditory and Audiological Research (ISAAR), Nyborg, Denmark.

Anbuhl KL, Ferber A, Koka K, Williams W, Thornton J, Tollin DJ (2013) The acoustical cues to sound location in the adult Guinea pig: measurements of Directional Transfer Functions (DTFs). Abstract for poster, Annual Meeting for Rocky Mountain Regional Neuroscience Group, Aurora, Colorado.

Anbuhl KL, Ferber A, Koka K, Williams W, Thornton J, Tollin DJ (2013) The acoustical cues to sound location in the adult Guinea pig: measurements of Directional Transfer Functions (DTFs). Abstract for poster, Association for Research in Otolaryngology (ARO), Baltimore, Maryland.

Anbuhl KL, Tollin DJ (2012) Applying mutual information theory to the auditory system. Abstract for poster, 10th Annual Meeting of the Front Range Neuroscience Group, Fort Collins, Colorado.

Anbuhl KL, Phillips J, Westerfield M (2010) Investigating the role of gpr98 (ush2c) in zebrafish sensory cell development and function. Abstract for oral presentation, Annual Biomedical Research Conference for Minority Students (ABRCMS), 2010, Charlotte, North Carolina.

Anbuhl KL, Hale M, Lowry C (2009) The effects of subcutaneous and intratracheal administration of mycobacterium vaccae on catecholaminergic systems in mice. Abstract for poster, National Student Leadership Alliance Symposium, 2009, Chantilly, Virginia.

Honors and awards:

​2007-2011 Gulf Coast Scholars, Spring Hill College​
​2007-2011 ​Honors Program, Spring Hill College
​2008-2011 ​Dean's List, Spring Hill College
​2009 ​Summer Multicultural Access to Research Training (SMART Program), University of Colorado at Boulder
​2010 ​Summer Program for Undergraduate Research (SPUR Program), University of Oregon
​2010 ​Annual Biomedical Research Conference for Minority Students (ABRCMS) Student Travel Award
​2010 Annual Biomedical Research Conference for Minority Students (ABRCMS) Oral Presentation Award
​2011 ​B.S. Magna Cum Laude, with Honors, Spring Hill College
​2011-2012 ​NIH Neuroscience Training Grant (T32) Trainee
​2012 ​Recipient for AAAS/Science Program for Excellence in Science Award
​2012 ​NIDCD Supplemental Grant Award (Project period: 12/09/2011-11/30/2016)
​2013 ​Best Poster Award. 2nd Place, Neuroscience Program Annual Conference
​2014 ​NIH NIDCD Predoctoral Fellow (F31; Project period: 9/10/2014-2017)