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Publications and Presentations


​Green Lab Selected Publications and Presentations

 
Green AL, Kieran MW. “Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors.” Curr Onc Rep 17(3):436-446, March 2015.
 
Green AL, Ramkissoon SH, McCauley D, Jones K, Perry JA, Hsu JH, Ramkissoon LA, Maire CL, Hubbell-Engler B, Knoff DS, Shacham S, Ligon KL, Kung AL. “Preclinical anti-tumor efficacy of selective Exportin 1 inhibitors in glioblastoma.” Neuro-Oncology 17(5):697-707, May 2015.
 
DeSisto J, Flannery P, Kashyap T, Venkataraman S, Kung A, Vibhakar R, Landesman Y, Green A. “Effects of the XPO1 inhibitor selinexor on the NGFR/NF-kB pathway in pediatric high-grade glioma and diffuse intrinsic pontine glioma.” International Symposium on Pediatric Neuro-Oncology, Liverpool, June 2016 (poster, Commendation award).
 
Green AL, Flannery P, DeSisto J, Lemieux M, Ramkissoon S, Jones K, Perry J, DeRyckere D, Venkataraman S, Foreman N, Orkin S, Ligon K, Jones K, Graham D, Kung AL, Vibhakar R. “An epigenomic screen reveals the chromatin remodeling protein BPTF as a driver of high-grade glioma in vitro and in vivo.” International Symposium on Pediatric Neuro-Oncology, Liverpool, June 2016 (oral presentation).
 
Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, Handler MH, Green AL, Vibhakar R, Foreman NK, Thorburn A. “Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors.” eLife 319671, January 2017.
 
Green A, DeSisto J, Flannery P, Lemma R, Kashyap T, Kung A, Landesman Y, Vibhakar R. “Mechanism of action and combination therapy studies on the XPO1 inhibitor selinexor in pediatric high-grade glioma and diffuse intrinsic pontine glioma.” American Society of Pediatric Hematology-Oncology Annual Meeting, Montreal, April 2017 (oral presentation, Young Investigator award).
 
Marini B, Benitez L, Zureick A, Salloum R, Gauthier A, Brown J, Wu Y, Robinson D, Kumar C, Lonigro R, Vats P, Cao X, Kasaian K, Anderson B, Mullan B, Chandler B, Linzey J, Camelo-Piragua S, Venneti S; Mc Keever P, McFadden K, Lieberman A, Brown N, Shao L, Leonard M; Junck L, McKean E, Maher C, Garton H, Muraszko K, Hervey-Jumper S, Mulcahy-Levy J, Green A, Hoffman L, Dorris K, Vitanza N, Wang J, Schwartz J, Lulla R, Pillay Smiley N, Bornhorst M, Haas-Kogan D, Robertson P, Chinnaiyan A, Mody R, Koschmann C (2017). “Blood brain barrier-adapted precision medicine therapy for pediatric brain tumors.” Transl Res 188(27):e1-27, Aug 2017.
 
DeSisto J, Donson A, Flannery P, Lemma R, Sanford B, Foreman N, Vibhakar R, Jones K, Green A. “Pediatric radiation-induced glioblastoma: transcriptomic and drug screening analysis of primary patient samples.” Annual Meeting of the Society of Neuro-Oncology, San Francisco, CA, November 2017 (oral presentation).
 
Flannery PC,* DeSisto JA,* Amani V, Venkataraman S, Lemma RT, Prince EW, Donson A, Moroze EE, Hoffman L, Mulcahy Levy JM, Foreman N, Vibhakar R, Green AL. “Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma.” Oncol Rep, epub Nov 2017.
 
DeSisto J, Lucas J, Donson A, Sanford B, Wu G, Armstrong G, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Hoffman L, Dorris K, Liu A, Foreman N, Vibhakar R, Jones K, Allen S, Baker S, Merchant T, Orr B, Green A. “Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: germline DNA repair defects as a potential etiology.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018 (oral presentation).
 
Flannery P, DeSisto J, Donson A, Lemma R, vibhakar R, Jones K, Green A. “Transcriptional analysis of ATRT samples from long-term survivors and matched primary/recurrent pairs.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018 (poster).
Green A, Flannery P, Hankinson T, O’Neill B, DeSisto J, Lemma R, Hoffman L, Mulcahy Levy J, Raybin J, Hemenway M, Koschmann C, Handler M, Foreman N, Vibhakar R, Wempe M, Dorris K. “Intratumoral pharmacokinetics of chemotherapy in DIPG: xenograft and initial phase 0 clinical trial results.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018 (poster).
 
Griesinger A, Pierce A, Witt D, Flannery P, Donson A, Gowan K, Hankinson T, Handler M, Jones K, Green A, Vibhakar R, Foreman N. “Patient-derived PFA ependymoma xenograft model.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018 (poster).
 
Lemma R, DeSisto J, Flannery P, Sanford B, Balakrishnan I, Madhavan K, Veo B, Mulcahy Levy J, Foreman N, Vibhakar R, Jones K, Venkataraman S, Green A. “The H3K27M mutation causes wide-ranging changes mediating DIPG tumorigenesis.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018 (poster).
 
Mulcahy Levy J, Sanford B, Morin A, Green A, Flannery P, Jones K, Banerjee A, Nazemi K, Samuel D, Kilburn L, Solomon D, Nicolaides T. “Analysis of paired BRAFV600E mutant glioma patient samples identifies novel resistance mechanisms to targeted BRAF inhibition.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018 (oral presentation).