Dr. Natarajavelalar Balasubramaniyan’s major scientific interest include MicroRNAs, which are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. We would like to see miRNA function in nuclear receptors such as FXR and its co-factors during developmental stages and in Cholastasis. We also wanted to see the miRNA role in FXR target gene such as BSEP, MRP2, OSTαβ and NTCP. The verification of the existence some of these miRNAs and their interaction with target genes will be the key to find the function of all individual miRNAs during development, Cholastasis and other cellular processes in liver.
Dr. David Brumbaugh’s major scientific interest is the identification of prenatal and postnatal factors that influence the risk of development of obesity and metabolic disease in children. Specifically, Dr. Brumbaugh is examining the impact of maternal obesity on the development of offspring adipose stores.
Dr. Edwin de Zoeten’s major scientific interests include understanding how the immune system functions in the intestines; egigenetic regulation of immune cells; and defining novel treatments for inflammatory bowel diseases. Dr. de Zoeten also focuses on immunodeficiencies that affect the function of the intestines.
Dr. Sophie Fillon’s research seeks to understand the relationship between the microbiome and gastrointestinal eosinophils.
Dr. Glenn Furuta's research interests focus on determining the impact of eosinophils during gastrointestinal inflammatory disease including eosinophilic gastrointestinal diseases (EGIDs) and inflammatory bowel diseases (IBD). The laboratory component determines eosinophils' impact on intestinal barrier function and remodeling. The translational component is identifying novel diagnostic modalities.