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Clinical Genetics and Metabolism - Research Funding


 

(listed alphabetically by Principal Investigator or by Section faculty member involved)

Cooking Tutorial for Families with Inherited Metabolic Disorders on Special Diets
Project Leader: Laurie E. Bernstein, MS, RD, FADA
Source: Family Donation
Amount: $5,000/yr
Term: 2007

Development of an Inherited Metabolic Disorder Visual Aid
Project Leader: Laurie E. Bernstein, MS, RD, FADA
Source: Vitaflo
Amount: $15,000/yr
Term: 2007 - 2008

Education Grant - Satellite Symposium on the Use of Chaperone Therapy
Principal Investigator: Laurie E. Bernstein, MS, RD, FADA
Source: BioMarin Pharmaceutical
Amount: $3,000/yr
Term: 2008

Maternal PKU Resource Packet
Principal Investigator: Laurie E. Bernstein, MS, RD, FADA
Co-Investigator: Cynthia L. Freehauf, RN, MS, CGC
Source: March of Dimes Birth Defects Foundation
Amount: $2,250
Term: 2008

Metabolic University: An International Week-Long Program for Metabolic Nutritionists, Nurses, and Genetic Counselors
Principal Investigator: Laurie E. Bernstein, MS, RD, FADA
Co-Investigator: Cynthia L. Freehauf, RN, MS, CGC
Source: Nutricia North America - PN200705-077
Amount: $66,500
Term: 2007 - 2009

Mile High Low Protein Cookbook
Project Leader: Laurie E. Bernstein, MS, RD, FADA
Source: Family Donation
Amount: $5,000/yr
Term: 2007

Neonatal Implants of Neural Progenitor Cells as a Life-Long Treatment for Down Syndrome
Principal Investigator: Kimberly B. Bjudstad, PhD
Source: National Down Syndrome Society: Charles J. Epstein Research Award
Amount: $34,559/yr
Term: 2008 - 2011

Neural Stem Cells as Potential Treatment for Down Syndrome Using Young and Aged Trisomic Mice
Principal Investigator: Kimberly B. Bjudstad, PhD
Co-Principal Investigator: Kenneth Maclean, PhD
Source: Anna and John J. Sie Foundation
Amount: $50,000/yr
Term: 2006 - 2008

Reconstruction of the Nigrostriatal Pathway by Photopolymerized Neurotrophin Containing Hydrogels
Principal Investigator: Kimberly B. Bjudstad, PhD
Source: NINDS, NIH - R01 NS052597
Amount: $993,272
Term: 2006 - 2009

Tau Deposition in Aged Ts65Dn Mice
Principal Investigator: Drew Kern
Mentor: Kimberly B. Bjudstad, PhD
Source: American Foundation for Aging Research
Amount: $1,000/yr
Term: 2008

The Use of Degradable Photopolymerized Implants to Attenuate L-Dopa Induced Dyskinesias in the Parkinsonian Rat
Principal Investigator: Kimberly B. Bjudstad, PhD
Source: The McKnight Endowment Fund for Neuroscience
Amount: $100,000/yr
Term: 2008 - 2010

Effects of Neural Progenitor Cell Transplantation in Neonatal Ts65Dn Mice
Principal Investigator: Angela Rachubinski, BS
Mentor: Kimberly B. Bjudstad, PhD
Source: NINDS, NIH - F31 NS060517
Amount: $27,792/yr
Term: 2008 - 2012

Vitamin-Dependent Electron Transfer Flavoprotein Ubiquinone Oxidoreductase; a Novel Potential Site for Production of Reactive Oxygen Species in Mitochondria Consultant: Frank E. Frerman, PhD
Source: Danish Medical Research Council
Amount: International funding
Term: 2008

Rare Diseases Consortium on Urea Cycle Disorders
Principal Investigator: Renata C. Gallagher, MD, PhD
Source: TCH Research Institute
Amount: $108,334/yr
Term: 2008 - 2009

The Biology of Chromosome 21 Genes: Expert Workshop
Principal Investigator: Katheleen Gardiner, PhD
Source: NICHD, NIH - 7 R13 HD055810-02
Amount: $14,999
Term: 2007 - 2008

Comparative and Functional Genomics Conference
Principal Investigator: Katheleen Gardiner, PhD
Source: U.S. Department of Energy
Amount: $7,831
Term: 2006 - 2007

Data Mining for Down Syndrome Gene-Phenotype and Drug Response Correlations
Principal Investigator: Katheleen Gardiner, PhD
Source: Fondation Jérôme Lejeune
Amount: $18,000/yr
Term: 2007 - 2009

Disregulation of Calcineurin in Mouse Models of Down Syndrome
Principal Investigator: Katheleen Gardiner, PhD
Source: NICHD, NIH - R03 HD49460-01
Amount: $50,000/yr
Term: 2005 - 2008

Expert Workshop on the Biology of Chromosome 21 Genes
Principal Investigator: Katheleen Gardiner, PhD
Source: Fondation Jérôme Lejeune
Amount: $25,000/yr
Term: 2007 - 2008

Perturbation of Signaling Pathways in Mouse Models of Down Syndrome
Principal Investigator: Katheleen Gardiner, PhD
Source: Fondation Jérôme Lejeune
Amount: $28,000/yr
Term: 2007 - 2009

Systems Biology for Studies of Cognition in Down Syndrome
Principal Investigator: Katheleen Gardiner, PhD
Source: NICHD, NIH - R01HD056235
Amount: $499,742/yr
Term: 2008 - 2013

Crystallization and Structure Determination of Human Propionyl CoA Carboxylase
Principal Investigator: Jan P. Kraus, PhD
Source: Propionic Acidemia Foundation
Amount: $30,000/yr
Term: 2008 - 2011

Cystathionine Beta Synthase (CBS): A Key Enzyme in Homocysteine and Hydrogen Sulfide Metabolism
Principal Investigator: Jan P. Kraus, PhD
Source: Fondation Jérôme Lejeune - PN200707-071
Amount: $35,706
Term: 2007 - 2009

Genotype-Phenotype Correlations in Propionic Acidemia
Principal Investigator: Jan P. Kraus, PhD
Source: Propionic Acidemia Foundation
Amount: $40,000/yr
Term: 2008 - 2011

Homocysteine and Heme: A Role in Thrombosis?
Principal Investigator: Jan P. Kraus, PhD
Source: NHLBI, NIH - R01 HL065217
Amount: $384,079
Term: 2008 - 2012

Homocysteine and Thrombosis
Principal Investigator: Jan P. Kraus, PhD
Source: AHA - 0655670Z
Amount: $198,000
Term: 2006 - 2009

Mouse Models of Cystathionine Beta Synthase (CBS) Deficient Homocystinuria
Principal Investigator: Jan P. Kraus, PhD
Source: Fondation Jérôme Lejeune - PN0503-102
Amount: $49,845
Term: 2005 - 2008

Therapeutic Approaches to Propionic Acidemia
Principal Investigator: Jan P. Kraus, PhD
Source: Propionic Acidemia Foundation - PN 200509-235
Amount: $55,000
Term: 2006 - 2008

Attentional Dysfunction in Fragile X Syndrome
Principal Investigator: Kenneth Maclean, PhD
Source: NICHD, NIH - R01 HD047029
Amount: $1,032,986
Term: 2003 - 2008

Genetics, Neurobiology, and Cognition in Down Syndrome
Principal Investigator: Kenneth Maclean, PhD
Source: NICHD, NIH - R01 HD045224
Amount: $1,240,522
Term: 2003 - 2008

Taurine as an Adjuvant Therapy for Cystathionine Beta Synthase Deficient Homocystinuria
Principal Investigator: Kenneth Maclean, PhD
Source: Special Products (UK pharmaceutical company)
Amount: $50,000/yr
Term: 2008

Ts65Dn Mice as a Preclinical Model for Investigating Cognitive Enhancement by the Acetylcholinesterase Inhibitor Donepezil in Down Syndrome
Principal Investigator: Kenneth Maclean, PhD
Source: The Anna and John J. Sie Foundation
Amount: $50,000
Term: 2006 2007

Lipid Aldehyde and Ethanol-Induced Liver Damage
Principal Investigator: Dennis R. Petersen, PhD
Co-Principal Investigator: Kenneth Maclean, PhD
Source: National Institute on Alcohol Abuse and Alcoholism, NIH - R01 AA009300
Amount: $2,207,544
Term: 2008 - 2013

Proteomic Profiling of NASH (non-alcoholic steatohepatitis): Disease Mechanisms and Novel Treatment
Principal Investigator: Dennis R. Petersen, PhD
Co-Principal Investigator: Kenneth Maclean, PhD
Source: NIDDK, NIH - R01 DK074487
Amount: $1,566,508
Term: 2007 - 2012

Colorado Intellectual and Developmental Disabilities Research Center
Principal Investigator: Karl H. Pfenninger, MD
Source: NICHD, NIH - P30 HD004024
Amount: $4,845,762
Term: 2003 - 2008

  • Center Director: Karl H. Pfenninger, MD
  • Core Director of Translational Nexus Core: Cordelia Robinson, PhD, RN; Co-Director: Gunter Scharer, MD, PhD
  • Core Director of Animal Models: Kenneth N. Maclean, PhD; Co-Directors: Timothy Benke, MD, PhD, Michael Mesches, PhD, and Natalie Serkova, PhD
  • Core Directors of Cellular Systems and Analysis: Karl H. Pfenninger, MD
  • Core Director of Molecular Discovery: Frank E. Frerman, PhD; Co-Director: Elaine B. Spector, PhD
  • Core Director of Administrative Core: Karl H. Pfenninger, MD

Novel Directions in Cystathionine Beta Synthase (CBS) Deficiency
Principal Investigator: Karl H. Pfenninger, MD
Source: TCH Research Institute
Amount: $40,000/yr
Term: 2008 - 2009

Research on Growth Cone Adhesion and Motility
Principal Investigator: Karl H. Pfenninger, MD
Source: Dean's Bridge Funding, UCD
Amount: $50,000/yr
Term: 2007 - 2008

Role of Down Syndrome Cell Adhesion Molecule in Cognitive Disability
Principal Investigator: Karl H. Pfenninger, MD
Source: Anna and John J. Sie Foundation
Amount: $25,000/yr
Term: 2006 - 2008

Improving Neural Graft Function in Parkinsonian Monkeys
Principal Investigator: John R. Sladek, Jr., PhD
Source: NINDS, NIH - PO1 NS 044281
Amount: $179,222/yr
Term: 2007 - 2008

Clinical Testing for Multiple Acyl-CoA Dehydrogenase
Principal Investigator: Elaine B. Spector, PhD
Co-Principal Investigators: Frank E. Frerman, PhD, Gunter Scharer, MD, PhD, and Johan L. Van Hove, MD, PhD
Source: Collaboration, Education, and Test Translation (CETT) Program, Office of Rare Diseases, NIH
Amount: $48,100/yr
Term: 2008 - 2009

Consultant to Kingdom of Jordan for the Establishment of the Forensic and Molecular Diagnostics Laboratory (FAMDL)
Consultant: Elaine B. Spector, PhD
Source: Science Application International Corporation
Amount: $55,000/yr
Term: 2006 - 2007

Gene Discovery for Craniofacial Disorders
Principal Investigator: Richard A. Spritz, MD
Source: National Institute of Dental and Craniofacial Research, NIH - DE015191
Amount: $375,154/yr
Term: 2003 - 2007

Genetic Studies of Human Pigmentation Disorders
Principal Investigator: Richard A. Spritz, MD
Source: National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH - AR039892
Amount: $465,433/yr
Term: 2001 - 2006

Mapping of Vitiligo Susceptibility Genes
Principal Investigator: Richard A. Spritz, MD
Co-Investigator: Pamela R. Fain, PhD
Source: National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH - R01 AR045584
Amount: $2,603,647
Term: 2004 - 2009

Missing Mutations in Oculocutaneous and Ocular Albinism
Principal Investigator: Richard A. Spritz, MD
Source: National Eye Institute, NIH - EY015626
Amount: $285,409/yr
Term: 2004 - 2007

VitGene International Consortium to Identify Susceptibility Genes for Generalized Vitiligo
Principal Investigator: Richard A. Spritz, MD
Source: NIH - R01 AR056292
Amount: $1,281,422/yr
Term: 2008-2012

Development and Ongoing Functioning of the Colorado Lysosomal Storage Disorders Program
Project Leader: Janet A. Thomas, MD
Source: Genzyme Corporation
Amount: $68,000/yr
Term: 2007 - 2009

Development of Center of Excellence for Lysosomal Storage Disease
Principal Investigators: Matthew R. G. Taylor, MD, and Janet A. Thomas, MD
Source: Genzyme Therapeutics
Amount: $68,000/yr
Term: 2003 - 2006

Iduronate-2-Sulfatase Enzyme Replacement Therapy in Mucopolysaccharidosis II (MPSII)
Principal Investigator: Janet A. Thomas, MD
Source: Transkaryotic Therapies, Inc. - Clinical Protocol No. TKT024Ext
Amount: $51,762
Term: 2005 - 2007

The Long-Term Tracking of Patients Diagnosed via Expanded Newborn Screening
Project Leader: Janet A. Thomas, MD
Source: Mountain States Regional Genetic Collaborative Center
Amount: $28,000/yr
Term: 2007 - 2008

The Long-Term Tracking of Patients Diagnosed via Expanded Newborn Screening
Project Leader: Janet A. Thomas, MD
Source: Mountain States Regional Genetic Collaborative Center
Amount: $90,000/yr
Term: 2006 - 2007

Autism Network for Best Care of Patients
Consultant: Chun-Hui (Anne) Tsai, MD, MSc
Source: Colorado Health Foundation
Amount: $250,000
Term: 2007 - 2009

Dysmorphology Exam in Classification of Autism
Consultant: Chun-Hui (Anne) Tsai, MD, MSc
Source: National Center on Birth Defects and Developmental Disabilities, CDC
Amount: $16,000/yr
Term: 2007 - 2009

Natural History of Recombinant 8 Syndrome
Principal Investigator: Chun-Hui (Anne) Tsai, MD, MSc
Source: Mountain States Genetic Network
Amount: $30,000
Term: 2005 - 2006

Rare Liver Disease Network
Principal Investigator: Ronald J. Sokol, MD
Co-Investigator: Johan L. Van Hove, MD, PhD
Source: NIDDK, NIH - U54 DK078377
Amount: $3,750,000
Term: 2004 - 2009

Center for Research in Mental Retardation (supports tissue culture, molecular biology, enzyme and molecular diagnostic, mass spectrometry, animal behavior, human subjects recruitment and evaluation and developmental neuropsychology core facilities)
Program Director: Stephen I. Goodman, MD
Core Director of Tissue Culture: Stephen I. Goodman, MD
Core Director of Molecular Biology: Jan P. Kraus, PhD
Core Directors of Enzyme and Molecular Diagnosis: Frank E. Frerman, PhD, and Elaine B. Spector, PhD
Core Director of Chemistry/Mass Spectrometry: Paul V. Fennessey, PhD
Core Director of Animal Housing and Assessment: Kenneth N. Maclean, PhD
Core Director of Human Subjects Recruitment and Evaluation: Randal Ross, MD
Source: National Institutes of Health, National Institute of Child Health and Human Development - HD04024
Amount: $4,976,931
Term: 2003-2008

Genetic Biochemical Disorders in Mental Retardation
Program Director and Principal Investigator: Stephen I. Goodman, MD
Source: National Institutes of Health, National Institute of Child Health and Human Development - HD08315
Amount: $6,113,976
Term: 2000-2005

  • The Biochemical and Molecular Basis of ETF-QO Deficiency
    Principal Investigator: Frank E. Frerman, PhD
  • The Biochemical and Molecular Bases of Glutaric and D-2-Hydroxyglutaric Acidemia
    Principal Investigator: Stephen I. Goodman, MD
  • The Molecular Biology of ATMI, a Putative Mitochondrial Iron Transporter
    Principal Investigator: David M. Koeller, MD
  • The Molecular Basis of CBC Disorders in Human Disease
    Principal Investigator: Jan P. Kraus, PhD
  • The Molecular Basis of Propionic Acidemia
    Principal Investigator: Jan P. Kraus, PhD

Denver Autoimmunity Center of Excellence
Principal Investigator: Michael Holers, MD
Basic Project III: Genetic Analysis of Autoimmune Polyendocrine Syndrome-II
Principal Investigator: Richard A. Spritz, MD
Co-Investigator: Pamela R. Fain, PhD
Source: National Institutes of Health, National Institute of Allergy and Infectious Diseases - U19-AI46374
Amount: $150,000/yr
Term: 2003-2008

Homocysteine and Thrombosis
Principal Investigator: Jan P. Kraus, PhD
Source: National Heart, Lung and Blood Institute - HL65217
Amount: $566,250
Term: 2000-2005

Mouse Models of CBS Deficient Homocystinuria
Principal Investigator: Jan P. Kraus, PhD
Source: Jerome LeJeune Foundation
Amount: $50,000
Term: 2005-2007

Genetics, Neurobiology and Cognition in Down Syndrome
Principal Investigator: Kenneth N. Maclean, PhD
Source: National Institutes of Health, National Institute of Child Health and Human Development - HD45224
Amount: $1,260,305
Term: 2003-2007

Attentional Dysfunction in Fragile X Syndrome
Principal Investigator: Kenneth N. Maclean, PhD
Source: National Institutes of Health, National Institute of Child Health and Human Development - HD047029
Amount: $1,049,609
Term: 2003-2008

Rare Liver Disease Network
Principal Investigator: Ronald J. Sokol, MD
Co-Investigator: Johan Van Hove, MD, PhD
Source: National Institutes of Health - U54 RR019455
Amount: $4,700,000
Term: 2004-2009

Genetic Studies of Human Pigmentation Disorders
Principal Investigator: Richard A. Spritz, MD
Source: National Institutes of Health, National Institute of Arthritis, Musculoskeletal and Skin Diseases - AR039892
Amount: $465,433/yr
Term: 2001-2006

Mapping of Vitiligo Susceptibility Genes
Principal Investigator: Richard A. Spritz, MD
Co-Investigator: Pamela R. Fain, PhD
Source: National Institutes of Health, National Institute of Arthritis, Musculoskeletal and Skin Diseases - 5R01AR045584-06
Amount: $547,668/yr
Term: 2004-2009

Gene Discovery for Craniofacial Disorders
Principal Investigator: Richard A. Spritz, MD
Source: National Institutes of Health, National Institute of Dental and Craniofacial Research - DE015191
Amount: $375,154/yr
Term: 2003-2007

Missing Mutations in Oculocutaneous and Ocular Albinism
Principal Investigator: Richard A. Spritz, MD
Source: National Institutes of Health, National Eye Institute - EY015626
Amount: $285,409/yr
Term: 2004-2007

Development of Center of Excellence for Lysosomal Storage Disease
Principal Investigators: Matthew R. G. Taylor, MD, and Janet A. Thomas, MD
Source: Genzyme Therapeutics
Amount: $68,000/yr
Term: 2003-2006

Iduronate-2-Sulfatase Enzyme Replacement Therapy in Mucopolysaccharidosis II (MPSII): TKT - Clinical Protocol No. TKT024Ext
Principal Investigator: Janet A. Thomas, MD
Source: Transkaryotic Therapies, Inc.
Amount: $51,7620
Term: 2005-2007

Natural History of Recombinant 8 Syndrome
Principal Investigator: Chun-Hui (Anne) Tsai, MD, MSc
Source: Mountain States Genetic Network
Amount: $30,000
Term: 2005-2006

Aged Forebrain Cholinergic Neurons: Estrogen and NGF
Co-Investigator: Linda S. Crnic, PhD
Source: National Institutes of Health, National Institute of Aging - AG12122
Amount: $1,213,670/yr
Term: 2000-2003

Program Project Grant - Somatic Cell Genetic Studies of Down Syndrome
Principal Investigator: David Patterson, PhD
Source: National Institutes of Health, National Institute of Child Health and Human Development - HD17449
Term: 1997-2003

  • Behavioral Assessment Core
    Principal Investigator: Linda S. Crnic, PhD
    Amount: $552,750
  • Project 7: Behavioral Analysis of a Mouse Model of Down Syndrome
    Principal Investigator: Linda S. Crnic, PhD
    Amount: $700,827

Video Analysis System for Home Cage Behavior
Co-Investigator: Linda S. Crnic, PhD
Source: National Institutes of Health, National Institute of Mental Health - MH58964
Amount: $53,448
Term: 2000-2003

Treatment of a Mouse Model of Fragile X Syndrome with MPEP
Principal Investigator: Linda S. Crnic, PhD
Source: Fragile X Association
Amount: $49,000
Term: 2003-2004

Glutaryl-CoA Dehydrogenase and Neurologic Disease
Principal Investigator: Frank E. Frerman, PhD
Source: National Institute of Neurological Disorders and Stroke - NS39339
Amount: $1,064,286
Term: 1999-2003

Genetic Biochemical Disorders in Mental Retardation
Program Director and Principal Investigator: Stephen I. Goodman, MD
Source: National Institutes of Health, National Institute of Child Health and Human Development - HD08315
Amount: $6,113,976
Term: 2000-2005

  • The Biochemical and Molecular Basis of ETF-QO Deficiency
    Principal Investigator: Frank E. Frerman, PhD
  • The Biochemical and Molecular Bases of Glutaric and D-2-Hydroxyglutaric Acidemia
    Principal Investigator: Stephen I. Goodman, MD
  • The Molecular Biology of ATMI, a Putative Mitochondrial Iron Transporter
    Principal Investigator: David M. Koeller, MD
  • The Molecular Basis of CBC Disorders in Human Disease
    Principal Investigator: Jan P. Kraus, PhD
  • The Molecular Basis of Propionic Acidemia
    Principal Investigator: Jan P. Kraus, PhD

Center for Research in Mental Retardation (supports tissue culture, molecular biology, enzyme and molecular diagnostic, mass spectrometry, animal behavior, human subjects recruitment and evaluation and developmental neuropsychology core facilities)
Program Director: Stephen I. Goodman, MD
Core Director of Tissue Culture: Stephen I. Goodman, MD
Core Director of Molecular Biology: Jan P. Kraus, PhD
Core Directors of Enzyme and Molecular Diagnosis: Frank E. Frerman, PhD, and Elaine B. Spector, PhD
Core Director of Chemistry/Mass Spectrometry: Paul V. Fennessey, PhD
Core Director of Animal Housing and Assessment: Stephen I. Goodman, MD
Core Director of Human Subjects Recruitment and Evaluation: Randal Ross, MD
Source: National Institutes of Health, National Institute of Child Health and Human Development - HD04024
Amount: $4,976,931
Term: 2003-2008

Homocysteine and Thrombosis
Principal Investigator: Jan P. Kraus, PhD
Source: National Heart, Lung and Blood Institute - HL65217
Amount: $566,250
Term: 2000-2005

Genetics, Neurobiology and Cognition in Down Syndrome
Principal Investigator: Kenneth N. Maclean, PhD
Source: National Institutes of Health, National Institute of Child Health and Human Development - HD45224
Amount: $1,260,305
Term: 2003-2007

Attentional Dysfunction in Fragile X Syndrome
Principal Investigator: Kenneth N. Maclean, PhD
Source: National Institutes of Health, National Institute of Child Health and Human Development - HD047029
Amount: $1,049,609
Term: 2003-2008

Treatment of Cystathionine Beta Synthase Knockout Mice with Cystatyionine: A New Essential Amino Acid?
Principal Investigator: Kenneth N. Maclean, PhD
Source: The Children's Hospital Research Institute #6703
Amount: $30,000
Term: 2002-2004

Mapping of Vitiligo Susceptibility Genes
Principal Investigator: Richard A. Spritz, MD
Co-Investigator: Pamela R. Fain, PhD
Source: National Institutes of Health, National Institute of Arthritis, Musculoskeletal and Skin Diseases - AR045584
Amount: $544,954/yr
Term: 2004-2009

Genetic Studies of Human Pigmentation Disorders
Principal Investigator: Richard A. Spritz, MD
Source: National Institutes of Health, National Institute of Arthritis, Musculoskeletal and Skin Diseases - AR039892
Amount: $465,433/yr
Term: 2001-2006

Gene Discovery for Craniofacial Disorders
Principal Investigator: Richard A. Spritz, MD
Source: National Institutes of Health, National Institute of Dental and Craniofacial Research - DE015191
Amount: $375,154/yr
Term: 2003-2007

Missing Mutations in Oculocutaneous and Ocular Albinism
Principal Investigator: Richard A. Spritz, MD
Source: National Institutes of Health, National Eye Institute - EY015626
Amount: $285,409/yr
Term: 2004-2007

Denver Autoimmunity Center of Excellence
Principal Investigator: Michael Holers, MD
Basic Project III: Genetic Analysis of Autoimmune Polyendocrine Syndrome-II
Principal Investigator: Richard A. Spritz, MD
Co-Investigator: Pamela R. Fain, PhD
Source: National Institutes of Health, National Institute of Allergy and Infectious Diseases - U19-AI46374
Amount: $150,000/yr
Term: 2003-2008

Development of Center of Excellence for Lysosomal Storage Disease
Principal Investigators: Matthew R. G. Taylor, MD, and Janet A. Thomas, MD
Source: Genzyme Therapeutics
Amount: $68,000/yr
Term: 2003-2006

Clinical Experience with 3360 C-3360 in the Dietary Management of Amino Acid Inborn Errors of Metabolism
Principal Investigator: Janet A. Thomas, MD
Source: Mead Johnson and Company
Amount: $2,850 per patient plus $2,000
Term: 2002-2003

The Use of the MiniMed Continuous Glucose Monitoring System in the Management of Glycogen Storage Disease, Type IA
Principal Investigator: Janet A. Thomas, MD
Source: MiniMed, Inc.
Amount: Supplying CGMS, sensors and software
Term: 2001-2003

Coenzyme A Metabolism in the Pathophysiology of Fatty Acid Oxidation Disorders
Principle Investigator: Johan L. Van Hove, MD, PhD
Co-Investigators: Jaak Jaeken, MD, PhD, and Hubert Carchon, PhD
Source: Onderzoekstoelage KULeuven (University Research Grant), Belgium
Amount: $182,000
Term: 2000-2003

Head CT in the Evaluation of 1st Afebrile Seizures
Principal Investigator: Lalit Bajaj, MD, MPH
Co-Investigators: Mark G. Roback, MD, Louis C. Hampers, MD, MBA, Carol Okada, MD, and Rebecca Fastle, MD
Term: 2000-2004

Postreduction Management of Intussusception
Principal Investigator: Lalit Bajaj, MD, MPH
Co-Investigators: Mark G. Roback, MD, and Shayne Bland, MSc
Term: 2000-2002

Emergency Medical Services for Children Partnership Grant
Principal Investigator: F. Keith Battan, MD
Source: US Department of Health and Human Services, Maternal and Child Health Bureau -
FLAEMS01-00250
Amount: $122,000
Term: 2000-2001

L.O.C.O. (Latinos Overcoming Cultural Obstacles) "Needs Assessment for The Children's Hospital"
Principal Investigator: Sonja Burbano-O'Leary, MD
Co-Investigator: Louis C. Hampers, MD, MBA
Source: Colorado Chapter of the American Academy of Pediatrics
Amount: $3,000
Term: 2001

The Truth about Language Barriers
Principal Investigator: Sonja Burbano-O'Leary, MD
Co-Investigators: Louis C. Hampers, MD, MBA, and Stephen Federico, MD
Source: Colorado Chapter of the American Academy of Pediatrics
Amount: $3,000
Term: 2001-ongoing

Jungle Mobile: A Mobile Injury Prevention Project for Children
Principal Investigator: Kathryn D. Emery, MD
Co-Investigators: Allison Hawkes, MD, MS, Theresa Rapstine, RN, and Victoria Cassenbaugh, RN
Term: 1998-ongoing

A Screening Tool for the Detection of Child Abuse in the Emergency Department Setting
Joint Project with the Child Advocacy Protection Team

Principal Investigator: Kathryn D. Emery, MD
Term: 2001

Seat Belt and Car Safety Seat Use in SUVs
Primary Investigator: Kathryn D. Emery, MD
Co-Investigators: Lisa Hardin Van Bramer, MD, and Kevin Raines, MD
Source: National Highway Traffic Safety Administration - STNH22-01-H-05-257
Amount: $350,000
Term: 2001-2003

Childhood Injury Prevention Concerns of Migrant and Seasonal Farm Workers in Weld County
Principle Investigator: Kathryn D. Emery, MD
Co-Investigator: S. Glenn Faries, MD
Source: Colorado Injury Control Research Center
Amount: $15,000
Term: 2002-2003

Domestic Violence Policies in Pediatric Emergency Departments
Principle Investigator: Kathryn D. Emery, MD
Co-Investigators: Sheila Sullivan, MD, Andrew P. Sirotnak, MD, and Stephanie Stronks-Knapp, MD
Term: 2002-ongoing

Development of an Injury-Free Coalition for Kids
Principal Investigator: S. Glenn Faries, MD
Co-Investigator: Kathryn D. Emery, MD
Term: 2001-ongoing

Resident Education in the Emergency Department
Principal Investigator: S. Glenn Faries, MD
Term: 2002-ongoing

Need for Atropine for Emergent Pediatric Intubations
Principal Investigator: Rebecca Fastle, MD
Co-Investigator: Mark G. Roback, MD
Term: 1999-ongoing

Resuscitation Teaching at Primary Care Centers
Principal Investigator: Margaret Ferguson, MD
Co-Investigator: Mark G. Roback, MD
Term: 1998-ongoing

Utility of Anaerobic Blood Cultures in a Pediatric Emergency Department
Principal Investigator: Stephen Freedman, MD
Co-Investigator: Genie E. Roosevelt, MD, MPH
Term: 2001-2003

PEM Collaborative Research Committee, Cerebral Edema and DKA
Principal Investigator: Nicole Glaser, MD
Co-Investigator: Mark G. Roback, MD
Term: 1998-2001

Comparison of Oral Prednisone vs. Dexamethasone in Pediatric Asthma
Principal Investigator: Richard A. Greenberg, MD
Co-Investigators: Genie E. Roosevelt, MD, MPH, and Gwendolyn S. Kerby, MD
Term: 2002-ongoing

Peak Flow vs. Spirometry in Acute Asthma
Principal Investigator: David Gutglass, MD
Co-Investigator: Louis C. Hampers, MD, MBA
Term: 1997-ongoing

A.C.C.E.S.S. for Latinos: After-Hours Call Center and Extended Spanish Service
Principal Investigator: Louis C. Hampers, MD, MBA
Co-Investigators: Lauren Clark, PhD, RN, and Stephen Berman, MD
Term: 2001-2002

The Impact of Interpreters on Resource Utilization in a Pediatric Emergency Department
Principal Investigator: Louis C. Hampers, MD, MBA
Co-Investigator: Jennifer McNulty, MD
Term: 1999-2002

Physician-Based Practice Pattern Variations in the Management of AGE
Principal Investigator: Louis C. Hampers, MD, MBA
Co-Investigator: Elizabeth Powell, MD, MPH
Term: 2001-ongoing

Practice Variation in the Management of Croup
Principal Investigator: Louis C. Hampers, MD, MBA
Co-Investigators: S. Glenn Faries, MD, and Steven R. Poole, MD
Term: 1999-2002

Regional After-Hours Urgent Care Provided by a Tertiary Children's Hospital
Principal Investigator: Louis C. Hampers, MD, MBA
Co-Investigators: S. Glenn Faries, MD, and Steven R. Poole, MD
Term: 2001-2002

Booster Seat Project
Principal Investigator: Lisa Hardin Van Bramer, MD
Co-Investigator: Kathryn D. Emery, MD
Source: Emergency Medical Services and Kiwanis Pediatric Trauma Institute
Amount: $18,000
Term: 2001-2002

Association of Influenza with Bacterial Tracheitis
Principal Investigator: Ron L. Kaplan, MD
Co-Investigators: Mark G. Roback, MD, and Peggy Kelly, MD
Term: 2002-ongoing

Safety, Tolerability and Efficacy Study of Levalbuterol and Racemic Albuterol in Pediatric Patients Birth to 48 Months Old with Reactive Airways Disease in an Acute Setting
Principal Investigator: Gwendolyn S. Kerby, MD
Co-Investigator: S. Glenn Faries, MD
Term: 2001-2002

Effect of Ondansetron on Ketamine Sedation-Associated Vomiting
Principal Investigator: William T. Langston, MD
Co-Investigators: Joseph E. Wathen, MD, and Mark G. Roback, MD
Source: The Children's Hospital Research Institute
Amount: $5,000
Term: 2002-ongoing

Effect of Medical Spanish Classes on Satisfaction of Hispanic Patients in Pediatric Emergency Department
Principal Investigator: Suzanne Mazor, MD
Co-Investigators: Vidya Chande, MD, Louis C. Hampers, MD, MBA, and Steven Krug, MD
Term: 2000-2002

Interpretation of Traumatic Lumbar Punctures: Who Can Go Home?
Principal Investigator: Suzan Mazor, MD
Co-Investigators: Jennifer McNulty, MD, and Genie E. Roosevelt, MD, MPH
Term: 2001-ongoing

How Is Emergency Department Decision-Making Affected by the Existence of Reliable Follow-Up?
Principal Investigator: Jennifer McNulty, MD
Co-Investigators: Louis C. Hampers, MD, MBA, and Steven Krug, MD
Term: 1999-2001

Decision Rules for Obtaining Radiographs in Pediatric Knee Injuries
Principal Investigator: Brian Moore, MD
Co-Investigators: Louis C. Hampers, MD, MBA, and Kathryn Emery, MD
Term: 1998-ongoing

Indications for Knee Radiographs in Pediatric Patients with Acute Knee Injuries/Validation of a Clinical Decision Rule
Principal Investigator: Brian Moore, MD
Co-Investigators: Carol Turner, MD, and Kathryn D. Emery, MD
Term: 2000-ongoing

Correlation of Hemolysis with Facticous Hyperkalemia
Principal Investigator: Heather Owens, MD
Co-Investigator: Louis C. Hampers, MD, MBA
Term: 2002-ongoing

Acute Complication of Type 1 Diabetes in Children
Primary Investigator: Arleta B. Rewers, MD, PhD
Co-Investigators: Mark G. Roback, MD, and Joan P. Bothner, MD
Term: 2001-ongoing

Childhood Pedestrian Injuries
Primary Investigator: Arleta B. Rewers, MD, PhD
Term: 2002-ongoing

Femur Fractures and Associated Injuries
Principal Investigator: Arleta B. Rewers, MD, PhD
Co-Investigators: Kathryn D. Emery, MD, and F. Keith Battan, MD
Term: 2000-ongoing

Are Chest X-Rays Required for all First-Time Wheezers?
Principal Investigator: Mark G. Roback, MD
Co-Investigators: Mark E. Anderson, MD, and John D. Strain, MD
Term: 1998-ongoing

Comparison of the Efficacy and Safety of Sedation Drugs Used in a Pediatric Emergency Department
Principal Investigator: Mark G. Roback, MD
Co-Investigators: Joseph E. Wathen, MD, and Joan P. Bothner, MD
Term: 1999-ongoing

IV vs. IM Ketamine Sedation in the Pediatric Emergency Department
Principal Investigator: Mark G. Roback, MD
Co-Investigator: Joseph E. Wathen, MD
Source: The Children's Hospital Research Institute
Amount: $35,000
Term: 2000-ongoing

Pediatric Resuscitation Practice and Success Rate
Principal Investigator: Mark G. Roback, MD
Co-Investigator: Rebecca Fastle, MD
Term: 2000-ongoing

Predictors of Which Patients will Benefit from Observations vs. Hospital Admission
Principal Investigator: Genie E. Roosevelt, MD, MPH
Co-Investigator: S. Glenn Faries, MD
Term: 2002-ongoing

Randomized, Double-Blind Study of Intravenous Fluids With and Without Dextrose in the Treatment of Dehydration in Pediatric Patients with Vomiting and Ketosis
Principal Investigator: Genie E. Roosevelt, MD, MPH
Term: 2002-ongoing

The Effect of Dehydration on the QT Interval of Healthy Children
Principal Investigator: Carl Shaw, MD
Co-Investigators: Joseph E. Wathen, MD, and Michael S. Schaffer, MD
Term: 2001

The Prevalence of Urinary Tract Infections in Febrile Children with AGE
Principal Investigator: Carl Shaw, MD
Co-Investigator: Louis C. Hampers, MD, MBA
Term: 2002-ongoing

Use of Complementary Medicine in Pediatric Patients with Asthma
Principal Investigator: Alison Siegel Tothy, MD
Co-Investigator: Genie E. Roosevelt, MD, MPH
Term: 2001-2002

Associations between Insurance Type and Pediatric Admission Rate in Colorado, 1993-1999: Is Managed Care Fulfilling Its Promise?
Principal Investigator: Marion R. Sills, MD, MPH
Co-Investigators: Jill Joseph, MD, PhD, and James K. Todd, MD
Term: 2000-ongoing

Associations of Parental Depression and Child Health Outcomes
Principal Investigator: Marion R. Sills, MD, MPH
Co-Investigators: Allison Kempe, MD, John Steiner, MD, David Price, MD, and David Magid, MD
Term: 2002-ongoing

Comparison of the Longitudinal Marginal Cost, Morbidity and Mortality of Inflicted and Unintentional Head Injuries in Young Children in a Nationwide Sample of Children's Hospitals
Principal Investigator: Marion R. Sills, MD, MPH
Co-Investigator: Anne Libby, PhD
Term: 2001-ongoing

Costs of Childhood Physical Abuse: Comparing Inflicted and Unintentional Head Injuries in Colorado Inpatients Under Three Years Old
Principal Investigator: Marion R. Sills, MD, MPH
Co-Investigator: Anne Libby, PhD
Term: 2001-ongoing

Epidemiology of Pediatric Psychiatric Visits to US Emergency Departments, Based on the National Hospital Ambulatory Medical Care Survey 1995-1999
Principal Investigator: Marion R. Sills, MD, MPH
Co-Investigator: Shayne Bland, MSc
Term: 2001-ongoing

Hospital-Level Predictors of Inefficiency Amongst Hospitalized Patients in New York State
Principal Investigator: Marion R. Sills, MD, MPH
Co-Investigators: Jill Joseph, MD, PhD, and Andrew Racine, MD, PhD
Term: 2000-ongoing

Management of Acute Gastroenteritis Visits to Emergency Departments Based on the National Hospital Ambulatory Medical Care Survey, 1995-1999
Principal Investigator: Marion R. Sills, MD, MPH
Co-Investigator: Shayne Bland, MSc
Term: 2001-ongoing

Management of Bronchiolitis Visits to Emergency Departments Based on the National Hospital Ambulatory Medical Care Survey, 1993-1999
Principal Investigator: Marion R. Sills, MD, MPH
Co-Investigator: Shayne Bland, MSc
Term: 2001-ongoing

Comparison of Fascia Iliaca Compartment Nerve Block to Traditional Systemic Analgesics for Femur Fractures in a Pediatric Emergency Department
Principal Investigator: Joseph E. Wathen, MD
Co-Investigators: Glen Merritt, MD, Gaia Georgopoulos, MD, and F. Keith Battan, MD
Source: The Children's Hospital Research Institute
Amount: $17,594
Term: 2001-2004

Pediatric EKG Interpretation Accuracy by Pediatric Emergency Medicine Physicians
Principal Investigator: Joseph E. Wathen, MD
Co-Investigators: Arleta Rewers, MD, PhD, Angela Yetman MD, and Michael Schaffer MD
Term: 2001-ongoing

A Randomized Trial of Telephonic vs. On-Site Language Interpretation in a Pediatric ED
Principal Investigator: Ethan S. Wiener, MD
Co-Investigator: Louis C. Hampers, MD, MBA
Term: 2002-ongoing