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Endocrinology - Research Publications & Grant Funding


 

2014

Kelsey MM, Zaepfel A, Bjornstad P, Nadeau KJ. Age-Related Consequences of ChildhoodObesity. Gerontology. 2014 Jan 9. [PMID: 24434909]

Kappy MS, Allen DB and Geffner ME: Pediatric Practice: Endocrinology- 2nd edition. McGraw-Hill Co, Publishers, New York City 2014

Srivasta A, Mazjoub J, Kappy MS: Posterior Pituitary Disorders; in: Kappy et al: Pediatric Practice- Endocrinology, 2nd Edition; McGraw-Hill Publishers, New York 2014

Lindquist KA, Chow K, West A, Pyle L, Isbell TS, Cree-Green M, Nadeau KJ. The StatStrip Glucose Monitor Is Suitable for Use During Hyperinsulinemic Euglycemic Clamps in a Pediatric Population. Diabetes Technol Ther. 2014 Jan 28. [PMID: 24471560]

Jaacks LM, Bell RA, Dabelea D, D'Agostino RB Jr, Dolan LM, Imperatore G, Klingensmith G, Lawrence JM, Saydah S, Yi-Frazier J, Mayer-Davis EJ, SEARCH for Diabetes in Youth Study Group. Diabetes Self-Management Education Patterns in a US Population-Based Cohort of Youth With Type 1 Diabetes. Diabetes Educ. 2014 Jan-Feb;40(1):29-39. PubMed [PMID: 24248833]

Bjornstad P, Paul Wadwa R, Sirota JC, Snell-Bergeon JK, McFann K, Rewers M, Rivard CJ, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Serum uric Acid and hypertension in adults: a paradoxical relationship in type 1 diabetes. J Clin Hypertens (Greenwich). 2014 Apr;16(4):283-8. doi: 10.1111/jch.12305. Epub 2014 Mar 26. [PMID: 24667019]

Lamb MM, Miller M, Seifert JA, Frederiksen B, Kroehl M, Rewers M, Norris JM. The effect of childhood cow's milk intake and HLA-DR genotype on risk of islet autoimmunity and type 1 diabetes: The Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2014 Jan 20. doi: 10.1111/pedi.12115.] PMID: 24444005

Alonso GT. Continuous Glucose Monitoring in Pediatric Patients. Diabetes Technol Ther. 2014 Apr 3 PMID: 24697901

Tamborlane WV, Renard E, Wadwa RP, Blevins T, Jacober SJ, Liu R, D'Souza DN, Rees TM. Glycemic Control after 6 Days of Insulin Pump Reservoir Use in Type 1 Diabetes: Results of Double-Blind and Open-Label Cross-Over Trials of Insulin Lispro and Insulin Aspart J Diabetes. 2014 Apr 15. doi: 10.1111/1753-0407.12162. PMID: 24734891

Shah AS, Dabelea D, Talton JW, Urbina EM, D Agostino RB Jr, Wadwa RP, Marcovina S, Hamman RF, Daniels SR, Dolan LM. Smoking and Arterial Stiffness in Youth with Type 1 Diabetes: The SEARCH Cardiovascular Disease Study. J Pediatr. 2014 Mar 27. pii: S0022-3476(14)00144-9. doi: 10.1016/j.jpeds.2014.02.024.  PMID: 24681182

Garg SK, Brazg RL, Bailey TS, Buckingham BA, Slover RH, Klonoff DC, Shin J, Welsh JB, Kaufman FR. Hypoglycemia begets hypoglycemia: The order effect in the ASPIRE in-clinic study. Diabetes Technol Ther. 2014 Mar;16(3):125-30. doi: 10.1089/dia.2013.0219. Epub 2014 Jan 9.  PMID: 24405492


2013

Ruth S. Weinstock, Sonia Caprio, Kenneth C. Copeland, Samuel S. Gidding, Kathryn Hirst, Lorraine L. Katz, Santica Marcovina, Kristen J. Nadeau, David M. Nathan for the TODAY Study Group. Lipid and Inflammatory Cardiovascular Risk Worsens Over 3 Years in Youth With Type 2 Diabetes: The TODAY clinical trial. Diabetes Care June 2013 36:1758-1764; doi:10.2337/dc12-2388.

Kathy Love-Osborne, Jeanelle Sheeder, Phil Zeitler and Kristen Nadeau. “Follow-Up of Dysglycemia in Obese Adolescents", abstract #751155, to the 2013 Pediatric Academic Societies’ Annual Meeting, May 4-7, in Washington, DC

Kathy Love-Osborne, Jeanelle Sheeder, Phil Zeitler and Kristen Nadeau. Can Patient Notification of Borderline Diabetes Testing Results Improve Outcomes? (Abstract #: 751907) to the 2013 Pediatric Academic Societies’ Annual Meeting, May 4-7, in Washington, DC

Melanie Cree-Green, Martina King, Annie Ferland, Gregory L Kinney, David M. Maahs, Hong Wang, Uyen Truong, John Hokanson, Robert H Eckel, Kristen Nadeau. Lipoprotein subfraction distributions in adolescents with PCOS show an atherogenic pattern which is distinct from distributions in adolescents with type 2 diabetes. (Abstract #76) 11th Annual World Congress on Insulin Resistance, Diabetes & Cardiovascular Disease. Endocrine Practice 2013

Specht BJ, Wadwa RP, Snell-Bergeon JK, Nadeau KJ, Bishop FK, Maahs DM. Estimated insulin sensitivity and cardiovascular disease risk factors in adolescents with and without type 1 diabetes. J Pediatr. 2013 Feb;162(2):297-301. PubMed PMID: 22921593

Zeitler PS, Barker J, Travers SH, Moriarty-Kelsey M, Nadeau K, Kappy MS. Endocrine Disorders. In Current Diagnosis and Treatment in Pediatrics, 21st edition. Hay, Levin, Sondheimer, and Deterding ( Eds). McGraw-Hill, 2013

Clements S, Travers SH, Disorders of Puberty. In Endocrine Secrets, 6th edition. McDermott MT (Ed). Hanley & Belfus Inc, Philadelphia PA, 2013

Frederiksen BN, Steck AK, Kroehl M, Lamb MM, Wong R, Rewers M, Norris JM. Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young. Clin Dev Immunol. 2013;2013:417657. doi: 10.1155/2013/417657 PMID: 24367383

Miao D, Guyer KM, Dong F, Jiang L, Steck AK, Rewers M, Eisenbarth GS, Yu L. GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes. Diabetes. 2013 Dec;62(12):4174-8. doi: 10.2337/db13-0534. PMID: 23974918

Weinstock RS, Xing D, Maahs DM, Michels A, Rickels MR, Peters AL, Bergenstal RM, Harris B, Dubose SN, Miller KM, Beck RW. Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry. J Clin Endocrinol Metab. 2013 Aug;98(8):3411-9. doi: 10.1210/jc.2013-1589. PMID: 23760624

Gerard-Gonzalez A, Gitelman SE, Cheng P, Dubose SN, Miller KM, Olson BA, Redondo MJ, Steck AK, Beck RW. 11. Comparison of autoantibody-positive and autoantibody-negative pediatric participants enrolled in the T1D Exchange clinic registry. J Diabetes. 2013 Jun;5(2):216-23. doi: 10.1111/1753-0407.12031. PMID: 23368514


2012

Bacha F, Pyle L, Nadeau K, Cuttler L, Goland R, Haymond M, Levitsky L, Lynch J, Weinstock RS, White NH, Caprio S, Arslanian S, TODAY Study Group (Kelsey M, Zeitler P). Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study. Pediatr Diabetes. 2012 Aug;13(5):376-83. [PMID: 22332798]

Baker PR, Nanduri P, Gottlieb PA, Yu L, Klingensmith GJ, Eisenbarth GS, Barker JM. Predicting the onset of Addison's disease: ACTH, renin, cortisol and 21-hydroxylase autoantibodies. Clin Endocrinol (Oxf). 2012 May;76(5):617-24. [PMID: 22066755]

Barker JM. Compounding risk for hypoglycemia: type 1 diabetes and Addison's disease. Diabetes Technol Ther. 2012 May;14(5):383-5. [PMID: 22506859]

Beck RW, Tamborlane WV, Bergenstal RM, Miller KM, DuBose SN, Hall CA, T1D Exchange Clinic Network (Nadeau K). The T1D Exchange clinic registry. J Clin Endocrinol Metab. 2012 Dec;97(12):4383-9. [PMID: 22996145]

Brumbaugh DE, Crume TL, Nadeau K, Scherzinger A, Dabelea D. Intramyocellular lipid is associated with visceral adiposity, markers of insulin resistance, and cardiovascular risk in prepubertal children: the EPOCH study. J Clin Endocrinol Metab. 2012 Jul;97(7):E1099-105. [PMID: 22508709]

Kapadia C, Zeitler P. Hemoglobin A1c measurement for the diagnosis of Type 2 diabetes in children. Int J Pediatr Endocrinol. 2012;2012(1):31. [PMID: 23256825]

Kappy MS, editor. Advances in pediatrics. Vol. 59. St. Louis, MO: Mosby; 2012.

Laffel L, Chang N, Grey M, Hale D, Higgins L, Hirst K, Izquierdo R, Larkin M, Macha C, Pham T, Wauters A, Weinstock RS, TODAY Study Group (Kelsey M, Nadeau K, Zeitler P). Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study. Pediatr Diabetes. 2012 Aug;13(5):369-75. [PMID: 22369102]

Larson A, Nokoff NJ, Travers S. Disorders of sex development: clinically relevant genes involved in gonadal differentiation. Discov Med. 2012 Nov;14(78):301-9. [PMID: 23200061]

Lawrence JM, Yi-Frazier JP, Black MH, Anderson A, Hood K, Imperatore G, Klingensmith GJ, Naughton M, Mayer-Davis EJ, Seid M, SEARCH for Diabetes in Youth Study (Nadeau K). Demographic and clinical correlates of diabetes-related quality of life among youth with type 1 diabetes. J Pediatr. 2012 Aug;161(2):201-7.e2. [PMID: 22361221]

Mizokami-Stout K, Cree-Green M, Nadeau KJ. Insulin resistance in type 2 diabetic youth. Curr Opin Endocrinol Diabetes Obes. 2012 Aug;19(4):255-62. [PMID: 22732484]

Popler J, Alimohammadi M, Kampe O, Dalin F, Dishop MK, Barker JM, Moriarty-Kelsey M, Soep JB, Deterding RR. Autoimmune polyendocrine syndrome type 1: Utility of KCNRG autoantibodies as a marker of active pulmonary disease and successful treatment with rituximab. Pediatr Pulmonol. 2012 Jan;47(1):84-7. [PMID: 21901851]

Snell-Bergeon JK, Nadeau K. Cardiovascular disease risk in young people with type 1 diabetes. J Cardiovasc Transl Res. 2012 Aug;5(4):446-62. [PMID: 22528676]

Sundaram SS, Alonso EM, Zeitler P, Yin W, Anand R. Obesity after pediatric liver transplantation: prevalence and risk factors. J Pediatr Gastroenterol Nutr. 2012 Dec;55(6):657-62. [PMID: 22744193]

Zeitler PS, Barker JM, Travers SH, Moriarty Kelsey M, Nadeau K, Kappy MS. Endocrine disorders. In: Hay Jr. WW, Levin MJ, Deterding RR, Abzug MJ, Sondheimer JM, editors. Current diagnosis and treatment pediatrics. 21st ed. New York: McGraw Hill; 2012.

Zeitler P, Hirst K, Pyle L, Linder B, Copeland K, Arslanian S, Cuttler L, Nathan DM, Tollefsen S, Wilfley D, Kaufman F. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med. 2012 Jun 14;366(24):2247-56. [PMID: 22540912]


2011

Baker PR, Baschal EE, Fain PR, Nanduri P, Triolo TM, Siebert JC, Armstrong TK, Babu SR, Rewers MJ, Gottlieb PA, Barker JM, Eisenbarth GS. Dominant suppression of Addison's disease associated with HLA-B15. J Clin Endocrinol Metab. 2011 Jul ;96(7):2154-62. [PMID: 21565792]

Barker JM, Kappy MS. Precocious puberty in boys. In: Bajaj L, Hambidge S, Nyquist A-C, Kerby G, editors. Berman's pediatric decision making. 5th ed. Philadelphia: Elsevier Mosby; 2011.

Barker JM, Kappy MS. Precocious puberty in girls. In: Bajaj L, Hambidge S, Nyquist A-C, Kerby G, editors. Berman's pediatric decision making. 5th ed. Philadelphia: Elsevier Mosby; 2011.

Clements SA, Travers SH. Supraclavicular swelling in hypothyroidism. Curr Opin Pediatr. 2011 Aug;23(4):482-5. [PMID: 21602679]

Copeland KC, Zeitler P, Geffner M, Guandalini C, Higgins J, Hirst K, Kaufman FR, Linder B, Marcovina S, McGuigan P, Pyle L, Tamborlane W, Willi S, TODAY study group (Nadeau K). Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab. 2011 Jan;96(1):159-67. [PMID: 20962021]

Dabelea D, D'Agostino RB Jr, Mason CC, West N, Hamman RF, Mayer-Davis EJ, Maahs D, Klingensmith G, Knowler WC, Nadeau K. Development, validation and use of an insulin sensitivity score in youths with diabetes: the SEARCH for Diabetes in Youth study. Diabetologia. 2011 Jan;54(1):78-86. [PMID: 20886205]

Hobernicht SL, Schweiger B, Zeitler P, Wang M, Hunger SP. Acquired growth hormone deficiency in a girl with chronic myelogenous leukemia treated with tyrosine kinase inhibitor therapy. Pediatr Blood Cancer. 2011 Apr;56(4):671-3. [PMID: 21298759]

Kappy MS, editor. Advances in pediatrics. Vol. 58. London: Elsevier Mosby; 2011.

McKittrick IB, Bogaert Y, Nadeau K, Snell-Bergeon J, Hull A, Jiang T, Wang X, Levi M, Moulton KS. Urinary matrix metalloproteinase activities: biomarkers for plaque angiogenesis and nephropathy in diabetes. Am J Physiol Renal Physiol. 2011 Dec;301(6):F1326-33. [PMID: 21921021]

Nadeau K. Pediatric Endocrinology. In: Draznin B, Epstein S, Turner HE, Wass JAH, editors. Oxford American handbook of endocrinology and diabetes. New York: Oxford University Press; 2011.

Nadeau K, Kolotkin RL, Boex R, Witten T, McFann KK, Zeitler P, Walders-Abramson N. Health-related quality of life in adolescents with comorbidities related to obesity. J Adolesc Health. 2011 Jul;49(1):90-2. [PMID: 21700164]

Nadeau KJ, Maahs DM, Daniels SR, Eckel RH. Childhood obesity and cardiovascular disease: links and prevention strategies. Nat Rev Cardiol. 2011 Sep;8(9):513-25. [PMID: 21670745]

Nadeau KJ, Reusch JE. Cardiovascular function/dysfunction in adolescents with type 1 diabetes. Curr Diab Rep. 2011 Jun;11(3):185-92. [PMID: 21336845]

Tartaglia N, Ayari N, Howell S, D'Epagnier C, Zeitler P. 48,XXYY, 48,XXXY and 49,XXXXY syndromes: not just variants of Klinefelter syndrome. Acta Paediatr. 2011 Jun;100(6):851-60. [PMID: 21342258]

Triolo TM, Armstrong TK, McFann K, Yu L, Rewers MJ, Klingensmith GJ, Eisenbarth GS, Barker JM. Additional autoimmune disease found in 33% of patients at type 1 diabetes onset. Diabetes Care. 2011 May;34(5):1211-3. [PMID: 21430083]

Wadwa RP, Kappy MS. Delayed puberty. In: Bajaj L, Hambidge S, Nyquist A-C, Kerby G, editors. Berman's pediatric decision making. 5th ed. Philadelphia: Elsevier Mosby; 2011.

Wadwa RP, Kappy MS. Short stature. In: Bajaj L, Hambidge S, Nyquist A-C, Kerby G, editors. Berman's pediatric decision making. 5th ed. Philadelphia: Elsevier Mosby; 2011.

Wilfley D, Berkowitz R, Goebel-Fabbri A, Hirst K, Ievers-Landis C, Lipman TH, Marcus M, Ng D, Pham T, Saletsky R, Schanuel J, Van Buren D, TODAY Study Group (Zeitler P). Binge eating, mood, and quality of life in youth with type 2 diabetes: baseline data from the today study. Diabetes Care. 2011 Apr;34(4):858-60. [PMID: 21357794]

Wood JH, Partrick DA, Barham HP, Bensard DD, Travers SH, Bruny JL, McIntyre RC Jr. Pediatric thyroidectomy: a collaborative surgical approach. J Pediatr Surg. 2011 May;46(5):823-8. [PMID: 21616234]

Zeitler P, Haqq A, Rosenbloom A, Glaser N. Hyperglycemic hyperosmolar syndrome in children: pathophysiological considerations and suggested guidelines for treatment. J Pediatr. 2011 Jan;158(1):9-14, 14.e1-2. [PMID: 21035820]

2010

Moriarty-Kelsey M, Harwood JE, Travers SH, Zeitler PS, Nadeau KJ. Testosterone, obesity and insulin resistance in young males: evidence for an association between gonadal dysfunction and insulin resistance during puberty. J Pediatr Endocrinol Metab. 2010 Dec;23(12):1281-7. [PMID: 21714462]

Zeitler PS, Travers SH, Nadeau K, Barker J, Kelsey MM, Kappy MS. Endocrine Disorders. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 20th ed. New York: McGraw-Hill; 2010.


2009

Kappy MS, Allen DB, Geffner ME. Pediatric practice endocrinology. New York: McGraw-Hill; 2009. 432 p.

Moriarty M, Travers S, Nadeau K. Sex differences in pubertal onset and progression in obese children. Presented at: Organization for the Study of Sex Differences Annual Meeting. 2010 June 4-6; Toronto, Canada.

Schweiger B, Moriarty MW, Cadnapaphornchai MA. Severe neonatal hyperkalemia due to pseudohypoaldosteronism type I. Current Opinion in Pediatrics. 2009 Apr;21(2):269-271.

Zeitler PS, Travers SH, Hoe F, Nadeau K, Kappy MS. Endocrine disorders. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 19th ed. New York: McGraw Hill; 2009.


2008

Bailey HK, Kappy MS, Giller RH, Gralla J. Time-course and risk factors of hypothyroidism following allogeneic hematopoietic stem cell transplantation (HSCT) in children conditioned with fractionated total body irradiation. Pediatr Blood Cancer. 2008 Sep;51(3):405-9. [PMID: 18523993]

Chiang PW, Aliaga S, Travers S, Spector E, Tsai AC. Case report: WT1 exon 6 truncation mutation and ambiguous genitalia in a patient with Denys-Drash syndrome. Curr Opin Pediatr. 2008 Feb;20(1):103-6. [PMID: 18197048]

Collett-Solberg PF, Misra M, Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. The role of recombinant human insulin-like growth factor-I in treating children with short stature. J Clin Endocrinol Metab 2008 Jan;93(1):10-8. [PMID: 18165284]

Dabelea D, Mayer-Davis EJ, Lamichhane AP, D'Agostino RB Jr, Liese AD, Vehik KS, Narayan KM, Zeitler P, Hamman RF. Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study. Diabetes Care. 2008 Jul;31(7):1422-6. [PMID: 18375420]

Kappy MS, Accurso FJ, Barness LA, Barton L, Gilbert-Barness E, Kaback MM, editors. Advances in pediatrics. Vol 55. New York: Elsevier; 2008.

Kim TJ, Travers S. Case report: thyroid hormone resistance and its therapeutic challenges. Curr Opin Pediatr. 2008 Aug;20(4):490-3. [PMID: 18622209]

Love-Osborne K, Sheeder J, Zeitler P. Addition of metformin to a lifestyle modification program in adolescents with insulin resistance. J Pediatr. 2008 Jun;152(6):817-22. [PMID: 18492523]

Love-Osborne KA, Nadeau KJ, Sheeder J, Fenton LZ, Zeitler P. Presence of the metabolic syndrome in obese adolescents predicts impaired glucose tolerance and nonalcoholic fatty liver disease. J Adolesc Health. 2008 Jun;42 (6):543-8. [PMID: 18486862]

Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008 Aug;122(2):398-417. [PMID: 18676559]

Nadeau K, Dabelea D. Epidemiology of Type 2 diabetes in children and adolescents. Endocr Res. 2008;33(1-2):35-58. [PMID: 19156573]

Nadeau K, Zeitler PS. A boost to the study of insulin secretion in children and adolescents. J Pediatr. 2008 May;152(5):603-4. [PMID: 18410758]

Nadeau KJ, Ehlers LB, Zeitler PS, Love-Osborne K. Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents. Pediatr Diabetes. 2008 Aug 20. [PMID: 18721166]

Pinhas-Hamiel O, Zeitler P. Screening and prevention of type 2 diabetes in youth. In: Dabelea D, Klingensmith GJ, editors. Epidemiology of diabetes in youth. New York: Informa HealthCare, 2008.

Rosenbloom AL, Silverstein JH, Amemiya S, Zeitler P, Klingensmith GJ. ISPAD Clinical Practice Consensus Guideline 2006-2007.Type 2 diabetes mellitus in the child and adolescent. Pediatr Diabetes. 2008 Oct;9(5):512-26. [PMID: 18694453]

Zeitler PS, Nadeau K editors. Insulin resistance and metabolic syndrome: childhood precursors and adult disease. 1st ed. New York: Humana Press; 2008.

2007

Davenport ML, Crowe BJ, Travers SH, Rubin K, Ross JL, Fechner PY, Gunther DF, Liu C, Geffner ME, Thrailkill K, Huseman C, Zagar AJ, Quigley CA. Growth hormone treatment of early growth failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial. J Clin Endocrinol Metab. 2007 Sep;92(9):3406-16. [PMID: 17595258]

Kappy MS, Accurso FJ, Barness LA, Barton L, Gilbert-Barness E, Kaback MM, editors. Advances in pediatrics. Vol 54. New York: Elsevier; 2007.

Maahs DM, Wadwa RP, McFann K, Nadeau K, Williams MR, Eckel RH, Klingensmith GJ. Longitudinal lipid screening and use of lipid-lowering medications in pediatric type 1 diabetes. J Pediatr. 2007 Feb;150(2):146-50, 150.e1-2. [PMID: 17236891]

Nadeau KJ, Ehlers LB, Aguirre LE, Reusch JE, Draznin B. Discordance between intramuscular triglyceride and insulin sensitivity in skeletal muscle of Zucker diabetic rats after treatment with fenofibrate and rosiglitazone. Diabetes Obes Metab. 2007 Sep;9(5):714-23. [PMID: 17697064]

Pinhas-Hamiel O, Zeitler P. Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. Lancet. 2007 May;369(9575):1823-31. [PMID: 17531891]

Pinhas-Hamiel O, Zeitler P. Clinical presentation and treatment of type 2 diabetes in children. Pediatr Diabetes. 2007 Dec;8 Suppl 9:16-27. [PMID: 17991129]

Pinhas-Hamiel O, Zeitler P. Type 2 diabetes in children and adolescents. Pediatr Med. 2007;3:24-6.

Simmons J, Steelman J, Zeitler P. Advances in the diagnosis and treatment of osteoporosis. Advances in pediatrics. Vol 54. Kappy MS, Accurso FJ, Barness LA, Barton L, Gilbert-Barness E, Kaback MM, editors. New York: Elsevier; 2007.

Simmons J, Zeitler P, Steelman J. Advances in the diagnosis and treatment of osteoporosis. Adv Pediatr. 2007;54:85-114. [PMID: 17918468]

The TODAY study group, Zeitler P, Epstein L, Grey M, Hirst K, Kaufman F, Tamborlane W, Wilfley D. Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes. Pediatr Diabetes. 2007 Apr;8(2):74-87. [PMID: 17448130]

Wolf NI, Harting I, Innes AM, Patzer S, Zeitler P, Schneider A, Wolff A, Baier K, Zschocke J, Ebinger F, Boltshauser E, Rating D. Ataxia, delayed dentition and hypomyelination: a novel leukoencephalopathy. Neuropediatrics. 2007 Apr;38(2):64-70. [PMID: 17712733]

Zeitler P. Editorial: School based intervention to reduce obesity and diabetes risks: small steps for a big problem. J Clin Endocrinol Metab. 2007 Feb;92:422-424. [PMID: 17284645]

Zeitler P, Epstein L, Grey M, Hirst K, Kaufman F, Tamborlane W, Wilfley D. Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes. Pediatr Diabetes. 2007 Apr;8(2):74-87. [PMID: 17448130]

Zeitler PS, Travers SH, Hoe F, Nadeau K, Kappy MS. Endocrine disorders. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 18th ed. New York: McGraw Hill; 2007.


2006

Brant WO, Rajimwale A, Lovell MA, Travers SH, Furness PD 3rd, Sorensen M, Oottamasathien S, Koyle MA. Gonadoblastoma and Turner syndrome. J Urol. 2006 May;175(5):1858-60. [PMID: 16600779]

Cohen AC, Nadeau KC, Tu W, Hwa V, Dionis K, Bezrodnik L, Teper A, Gaillard M, Heinrich J, Krensky AM, Rosenfeld RG, Lewis DB. Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency. J Immunol. 2006 Sep;177(5):2770-4. [PMID: 16920911]

Kappy MS, Drake A, Gao D, Ratliff R. Assessing adrenal function in primary care settings with a single sample subcutaneous glucagon test. J Pediatr. 2006 Nov; 149(5):682-6. [PMID: 17095343]

Love-Osborne K, Butler N, Gao D, Zeitler P. Elevated fasting triglycerides predict impaired glucose tolerance in adolescents at risk for type 2 diabetes. Pediatr Diabetes. 2006 Aug;7(4):205-10. [PMID: 16911007]

Maniatis AK, Taylor L, Letson GW, Bloch CA, Kappy MS, Zeitler P. Congenital hypothyroidism and the second newborn metabolic screening in Colorado, USA. J Pediatr Endocrinol Metab. 2006 Jan;19(1):31-8. [PMID: 16509526]

Nadeau KJ, Ehlers LB, Aguirre LE, Moore RL, Jew KN, Ortmeyer HK, Hansen BC, Reusch JE, Draznin B. Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E90-8. [PMID: 16449296]

Pinhas-Hamiel O, Chernausek SD, Zeitler P. Acute necrotizing pancreatitis in an adolescent with type 2 diabetes. Curr Opin Pediatr. 2006 Apr;18(2):206-8. [PMID: 16601505]

Siriwardana G, Bradford A, Coy D, Zeitler P. Autocrine/paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen-activated protein kinase. Mol Endocrinol. 2006 Sep;20(9):2010-9. [PMID: 16613992]


2005

Czernichow P, Friedman AL, Kappy MS. Disorders of water metabolism. In: Kappy MS, Allen DB, Geffner ME, editors. Principles and practice of pediatric endocrinology. Springfield, Illinois: Charles C Thomas Publisher Ltd; 2005.

Hoe, FM, Jackson MB, Grimberg A. Endocrinology. In: Frank G, Catallozzi M, Shah SS, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Malden, Massachusetts: Blackwell Publishing; 2005.

Kappy MS, Allen DB, Geffner ME, editors. Principles and practice of pediatric endocrinology. Springfield, Illinois: Charles C Thomas Publisher Ltd; 2005.

Levine MA, Zapalowski C, Kappy, MS. Disorders of Calcium, Phosphage, PTH and Vitamin D. In: Kappy MS, Allen DB, Geffner ME, editors. Principles and practice of pediatric endocrinology. Springfield, Illinois: Charles C Thomas Publisher Ltd; 2005.

Maahs DM, Maniatis AK, Nadeau K, Wadwa RP, McFann K, Klingensmith GJ. Total cholesterol and high-density lipoprotein levels in pediatric subjects with type 1 diabetes mellitus. J Pediatr. 2005 Oct;147(4):544-6. [PMID: 16227045]

Maniatis AK, Simmons JH, Zeitler PS. Hypothalamic obesity in a patient with craniopharyngioma: dysregulation of neurohormonal control of energy balance. Curr Opin Pediatr. 2005 Apr;17(2):275-9. [PMID: 15800425]

Nadeau KJ, Klingensmith G, Zeitler P. Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):94-8. [PMID: 15990637]

Pinhas-Hamiel O, Zeitler P. Advances in epidemiology and treatment of type 2 diabetes in children. Adv Pediatr. 2005;52:223-59. [PMID: 16124343]

Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr. 2005 May;146(5):693-700. [PMID: 15870677]

Simmons JH, Miller E, Travers S. Hyponatremia in a neonate: a case report. Curr Opin Pediatr. 2005 Aug;17(4):525-7. [PMID: 16012267]

Simmons JH, Zeitler PS, Fenton LZ, Abzug MJ, Fiallo-Scharer RV, Klingensmith GJ. Rhinocerebral mucormycosis complicated by internal carotid artery thrombosis in a pediatric patient with type 1 diabetes mellitus: a case report and review of the literature. Pediatr Diabetes. 2005 Dec;6(4):234-8. [PMID: 16390393]

Walsh MD Jr., Chan K, Travers S, McIntyre RC Jr. Destructive maxillomandibular brown tumor in severe hyperparathyroidism. J Am Coll Surg. 2005 Aug;201(2):315. [PMID: 16038830]

Zeitler PS, Travers SH, Barker J, Nadeau K, Kappy MS. Endocrine disorders. In: Hay WW Jr., Hayward AR, Levin ML, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 17th ed. New York: McGraw Hill; 2005.

Impact of Obesity and Androgens on Cardiovascular Function and Organ Specific Insulin Sensitivity in Youth with PCOS
Principal Investigator: Melanie Cree Green, MD, PhD
Source: American Heart Association
Term: 01/01/2013-12/31/2014


Clinical Research Fellowship in Women’s Health Role of Obesity and Androgens on Insulin Sensitivity and Cardiovascular function in PCOS
Principal Investigator:  Melanie Cree Green, MD, PhD
Source: The Endocrine Society
Term: 6/1/2013-5/31/2014


Dysglycemia in Cystic Fibrosis
Principal Investigator:  Christine L. Chan, MD
Source: National Institute of Diabetes and Digestive and Kidney Diseases
Term: 7/1/2013-6/30/2016


Metformin Therapy for Overweight Adolescents with Type 1 Diabetes
Co-Investigator:  Kristen J. Nadeau, MD
Source: Juvenile Diabetes Research Foundation
Term: 8/1/2013-7/31/2015


Fellowship Training Grant in Pediatric Diabetes 
Principal Investigator: Georgeanna Klingensmith, MD
Source: National Institutes of Health NIDDK (T32 DK063687) National Institute of Diabetes and Digestive and Kidney Diseases Training Programs in Diabetes Research for Pediatric Endocrinologists
Term: 7/01/14-6/30/19

1995-2012 Grant Funding

Star 3: Sensor-Augmented Pump Therapy for A1C Reduction
Principal Investigator: Robert Slover, MD
Source: Minimed Medtronic
Term: 2006-Present


Genetic and Environmental Causes of Celiac Disease
Principal Investigator: Marian Rewers, MD
Source: NIH, NIDDK, R01 DK50979
Amount: $3,624,258 total funding $315,700 annually
Term: 10/1995-3/2015


Natural History of Pre-diabetic Autoimmunity (DAISY)
Principal Investigator: Marian Rewers, MD
Source: NIH, NIDDK/NIAID R37 DK32493
Amount: 12,393,512 total funding $846,586 annually
Term: 7/97-6/2016


Prevention and Treatment of Type 2 Diabetes in Children and Adolescents- T2P2
Co-Investigator: Kristen J. Nadeau, MD
Source: NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Term: 3/1/2002-02/28/2015


Fellowship Training Grant in Pediatric Diabetes
Principal Investigator: Georgeanna Klingensmith, MD
Source: National Institutes of Health NIDDK (T32 DK063687), National Institute of Diabetes and Digestive and Kidney Diseases, Training Programs in Diabetes Research for Pediatric Endocrinologists
Term: 9/30/02-6/30/12


Periodontal Disease Prevention and Control in American Indian Adolescents and Young Adults
Principal Investigator:  Kristen J. Nadeau, MD
Source: NIH/National Institute of Dental and Craniofacial Research
Term: 1/11/2011-12/30/2013


Treatment Alternatives in Pediatric Type 2 Diabetes (TODAY2)
Principal Investigator: Philip S. Zeitler, M.D., Ph.D.
Co-Investigator: Georgeanna J. Klingensmith, M.D.
Source: National Institutes of Health NIDDK (U01 DK061242)
Amount: $508,000 annual direct costs
Term: 03/01/2011-02/29/2013


Impact of Metformin on Organ-Specific Insulin Sensitivity and Cardiovascular Function in Youth with Type 1 Diabetes
Principal Investigator: Kristen J. Nadeau, MD
Source: American Diabetes Association
Term: 7/1/11-06/30/16


Beta-cell rescue in youth with new-onset T2DM
Principal Investigator: Kristen Nadeau, MD
Co-Investigator: Philip S. Zeitler, MD. Ph.D
Source: NIH/NIDDK U01 DK094467
Amount: Annual direct Costs $981,663
Term: 2011-2016


Beta-cell Rescue in Youth with New Onset T2DM
Principal Investigator: Kristen Nadeau, MDSource: NIH/NIDDK 1U01DK094467-01S1
Amount: Direct $315,881 Indirect $19,867
Term: 10/01/11-09/30/16


RISE: Resorting Insulin Sensitivity
Principal Investigator: Kristen Nadeau, MD
Source: NIH/NIDDK 1U01DK94467-1
Amount: $665,782
Term: 09/24/11-06/30/16


RISE: Resorting Insulin Sensitivity Supplement
Principal Investigator: Kristen Nadeau, MD
Source: NIH/NIDDK 1U01DK094467-01S1
Amount: $315,881
Term: 09/30/11-06/30/16


Treat-to-Range Closed-Loop Therapy for Type 1 Diabetes
Principal Investigators: Buckingham, Tamborlane, Slover
Co-Investigator: David Maahs, MD
Source: NIDDK, # 22-2011-639
Amount: $119,965
Term: 7/1/12-present


In Home Closed Loop Reduction of Nocturnal Hypoglycemic and Daytime Hyperglycemic
Principal Investigator: David Maahs, MD
Source: R01 DK085591-01
Term: 7/1/12-present


Periodontal Microorganisms and Markers of Cardiovascular Disease in Youth
Principal Investigators: Anwar Merchant, U South Carolina; Colorado PI: Elaine Morrato
Co-Investigator: David Maahs, MD and R Paul Wadwa
Source: American Diabetes Association
Amount: $108,769
Term: 7/11-12/13


T1DM Grows Up:  Novel Intervention for Transitioning Patients from Pediatric to Adult Care.
Principal Investigator: Jennifer Raymond, MD
Source: American Diabetes Association 1-12-JF-46
Amount: $130,000 per year for three years
Term: 1/1/12-12/31/14


Role of vascular function: oxygen delivery vs. oxygen utilization in the exercise impairment in type 2 diabetes
Co-Investigator:  Kristen J. Nadeau, MD
Source: American Diabetes Association
Term: 1/1/2012-12/31/2015


Health Influences of Puberty (HIP) Study
Principal Investigator: Megan Kelsey, MD
Source: American Diabetes Association Junior Faculty Award, 1-11-JF-23
Term: 01/2011-12/2013


Impact of Obesity and Androgens on CV Function and Organ Specific IR in Youth with PCOS
Co-Principal Investigator:  Melanie Cree Green, MD, PhD
Source: University of Colorado Denver Internal Award
Term: 10/1/2012-9/30/2014


MRI and Vascular Dysfunction
Principal Investigator: Kristen J. Nadeau, MD
Source: University of Colorado Denver Internal Award
Term:11/1/2012-10/31/2013


2010-2009 Grant Funding

SEARCH for Diabetes in Youth 3: Colorado Center
Principal Investigator: Dana Dabelea, M.D.
Co-Investigator: Georgeanna J. Klingensmith, M.D.
Source: Center for Disease Control (U01 DP003246)
Amount: $518,301 annual direct costs
Term: 9/30/10- 9/29/15


Genetic and Environmental Causes of Celiac Disease (CEDAR)
Principal Investigator: Marian Rewers, MD, PhD, MPH
Co-Investigator: Georgeanna Klingensmith, MD
Source: National Institutes of Health NIDDK (R01 DK50979)
Term: 09/30/1995-03/31/2016


Genetic determinants of multi-organ autoimmunity in type 1 diabetes
Principal Investigator: Jennifer Barker, MD
Source: Juvenile Diabetes Research Foundation Early Career Patient Oriented Diabetes Research Award 11-2005-15
Amount: $750,000/5 years
Term: 2005-2010


Treatment Options for Type 2 Diabetes in Adolescents and Youth 2, Phase 1
Principal Investigator: Phil Zeitler, MD, PhD
Behavioral Consultant: Natalie Walders-Abramson, PhD
Source: TODAY2
Term: 2001-2013


Insulin Resistance: The New Frontier for Cardiovascular Disease Prevention
Principal Investigator: Kristen Nadeau, MD
Source: Juvenile Diabetes Research Foundation JDRF 11-2010-343
Amount: Direct $136,364 Indirect $13,636
Term: 05/1/10-04/30/15


Determinants of macrovascular disease in adolescents with type 1 diabetes
Principal Investigator: Paul Wadwa, MD
Source: Juvenile Diabetes Research Foundation 11-2007-694
Term: 9/01/07-8/31/12


SEARCH for Diabetes in Youth 3: Colorado Center
Principal Investigator: Dabelea
Co-Investigator: Paul Wadwa, MD
Source: Centers for Disease Control This is one of five centers designated by CDC to set-up a national registry of childhood diabetes. Researchers will ascertain, register, characterize, and conduct follow-up of diabetes and complications of diabetes in youth aged 0-19 with an emphasis on Type 1a (autoimmune), Type 2 and other forms of diabetes in Colorado and American Indian communities
Term: 09/30/10 - 09/29/15


The Environmental Determinants of Diabetes in the Young (TEDDY)
Principal Investigator: Marian Rewers, MD
Source: NIH, NIDDK U01 DK63821
Amount: $5,101,027 total funding, $2,080,000 annually
Term: 10/1/02-4/30/13