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Critical Care Medicine - Publications


Bagdure DN, Bhoite GR, Reiter PD, Dobyns EL. Dexmedetomidine in a child with methylphenidate intoxication. Indian J Pediatr. 2013 Apr;80(4):343-4. [PMID: 22562228]

Brown RD, Ambler SK, Li M, Sullivan TM, Henry LN, Crossno JT Jr, Long CS, Garrington TP, Stenmark KR. MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H269-81. [PMID: 23125215]

Goldenberg NA, Jenkins S, Jack J, Armstrong-Wells J, Fenton LZ, Stence NV, Oleszek J, Boada R, Wilkening GN, Wilkinson C, Soep JB, Miyamoto SD, Bajaj L, Mourani PM, Manco-Johnson MJ, Bernard TJ. Arteriopathy, D-dimer, and risk of poor neurologic outcome in childhood-onset arterial ischemic stroke. J Pediatr. 2013 May;162(5):1041-6.e1. [PMID: 23260102]

Hancock HS, Wang M, Gist KM, Gibson E, Miyamoto SD, Mourani PM, Manco-Johnson MJ, Goldenberg NA. Cardiac findings and long-term thromboembolic outcomes following pulmonary embolism in children: a combined retrospective-prospective inception cohort study. Cardiol Young. 2013 Jun;23(3):344-52. [PMID: 23088931]

Nagel MA, Traktinskiy I, Stenmark KR, Frid MG, Choe A, Gilden D. Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries. Neurology. 2013 Jan 1;80(1):62-8. [PMID: 23243076]

Scott D, Tan Y, Shandas R, Stenmark KR, Tan W. High pulsatility flow stimulates smooth muscle cell hypertrophy and contractile protein expression. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1;304(1):L70-81. [PMID: 23087017]

Stenmark KR, Yeager ME, El Kasmi KC, Nozik-Grayck E, Gerasimovskaya EV, Li M, Riddle SR, Frid MG. The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol. 2013;75:23-47. [PMID: 23216413]

Umapathy SN, Kaczmarek E, Fatteh N, Burns N, Lucas R, Stenmark KR, Verin AD, Gerasimovskaya EV. Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling. PLoS One. 2013;8(4):e59733. [PMID: 23613714]

Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E. Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome. Antioxid Redox Signal. 2013 May 10;18(14):1753-64. [PMID: 23240585]


Albietz JA, Carpenter TC, Czaja AS, Dobyns EL, Exo J, Grayck EN, Mourani PM, Ventre K. Critical Care. In: Hay WW, Levin MJ, Deterding RR, Abzug MJ, Sondheimer JM, editors. Current diagnosis and treatment pediatrics. 21st ed. New York: McGraw-Hill, Lange; 2012.

Anwar A, Li M, Frid MG, Kumar B, Gerasimovskaya EV, Riddle SR, McKeon BA, Thukaram R, Meyrick BO, Fini MA, Stenmark KR. Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 Jul;303(1):L1-L11. [PMID: 22582113]

Baker CD, Balasubramaniam V, Mourani PM, Sontag MK, Black CP, Ryan B SL, Abman SH. Cord blood angiogenic progenitor cells are decreased in bronchopulmonary dysplasia. Eur Respir J. 2012 Apr 10. [PMID: 22496315]

Barberio M, Reiter PD, Kaufman J, Knupp K, Dobyns EL. Continuous infusion pentobarbital for refractory status epilepticus in children. J Child Neurol. 2012 Jun ;27(6):721-6. [PMID: 22156786]

Branchford BR, Mourani P, Bajaj L, Manco-Johnson M, Wang M, Goldenberg NA. Risk factors for in-hospital venous thromboembolism in children: a case-control study employing diagnostic validation. Haematologica. 2012 Apr;97(4):509-15. [PMID: 22133768]

Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC. Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L312-26. [PMID: 22728465]

Carpenter TC, Schroeder W, Stenmark KR, Schmidt EP. Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury. Am J Respir Cell Mol Biol. 2012 Jan;46(1):40-7. [PMID: 21799118]

Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res. 2012 Mar 2;110(5):739-48. [PMID: 22282194]

Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2784-93. [PMID: 22988108]

Cooper L, Moore C, Branchford B, Greffe B, Capocelli K, Kuder A, Mehta I, Mourani PM. Successful pulmonary artery embolectomy in a patient with a saddle Wilms tumor embolus. Pediatr Blood Cancer. 2012 May;58(5):806-9. [PMID: 21681933]

Coulthard MG, Morgan M, Woodruff TM, Arumugam TV, Taylor SM, Carpenter TC, Lackmann M, Boyd AW. Eph/Ephrin signaling in injury and inflammation. Am J Pathol. 2012 Nov;181(5):1493-503. [PMID: 23021982]

Czaja AS, Moss M, Mealer M. Symptoms of posttraumatic stress disorder among pediatric acute care nurses. J Pediatr Nurs. 2012 Aug;27(4):357-65. [PMID: 22703683]

Czaja AS, Valuck R. Off-label antidepressant use in children and adolescents compared with young adults: extent and level of evidence. Pharmacoepidemiol Drug Saf. 2012 Sep;21(9):997-1004. [PMID: 22760843]

Davidson J, Tong S, Hancock H, Hauck A, da Cruz E, Kaufman J. Prospective validation of the vasoactive-inotropic score and correlation to short-term outcomes in neonates and infants after cardiothoracic surgery. Intensive Care Med. 2012 Jul;38(7):1184-90. [PMID: 22527067]

Gerasimovskaya E, Kratzer A, Sidiakova A, Salys J, Zamora M, Taraseviciene-Stewart L. Interplay of macrophages and T cells in the lung vasculature. Am J Physiol Lung Cell Mol Physiol. 2012 May;302(10):L1014-22. [PMID: 22387295]

Hayes LW, Dobyns EL, DiGiovine B, Brown AM, Jacobson S, Randall KH, Wathen B, Schwab C, Duncan KD, Thrasher J, Logsdon TR, Hall M, Markovitz B. A multicenter collaborative approach to reducing pediatric codes outside the ICU. Pediatrics. 2012 Mar;129(3):e785-91. [PMID: 22351886]

Hemerka JN, Wu X, Dixon CE, Garman RH, Exo JL, Shellington DK, Blasiole B, Vagni VA, Janesko-Feldman K, Xu M, Wisniewski SR, Bayir H, Jenkins LW, Clark RS, Tisherman SA, Kochanek PM. Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in mice. J Neurotrauma. 2012 Aug 10;29(12):2192-208. [PMID: 22738159]

Kaufman J, Rannie M, Kahn MG, Vitaska M, Wathen B, Peyton C, Judd J, Quinby Z, da Cruz EM, Dobyns E. An interdisciplinary initiative to reduce unplanned extubations in pediatric critical care units. Pediatrics. 2012 Jun;129(6):e1594-600. [PMID: 22585764]

Lammers S, Scott D, Hunter K, Tan W, Shandas R, Stenmark KR. Mechanics and Function of the Pulmonary Vasculature: Implications for Pulmonary Vascular Disease and Right Ventricular Function. Compr Physiol. 2012 Jan 1;2(1):295-319. [PMID: 23487595]

Manco-Johnson MJ, Wang M, Goldenberg NA, Soep J, Gibson E, Knoll CM, Mourani PM. Treatment, Survival, and Thromboembolic Outcomes of Thrombotic Storm in Children. J Pediatr. 2012 May 11. [PMID: 22578585]

Panzhinskiy E, Zawada WM, Stenmark KR, Das M. Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFbeta receptor-JNK1 signalling. Cardiovasc Res. 2012 Aug 1;95(3):356-65. [PMID: 22735370]

Reiter PD, Ng J, Dobyns EL. Continuous hydromorphone for pain and sedation in mechanically ventilated infants and children. J Opioid Manag. 2012 Mar-2012 Apr 30 ;8(2):99-104. [PMID: 22616315]

Reiter PD, Wathen B, Valuck RJ, Dobyns EL. Thrombosis risk factor assessment and implications for prevention in critically ill children*. Pediatr Crit Care Med. 2012 Jul;13(4):381-6. [PMID: 22198812]

Reusser M, Hunter KS, Lammers SR, Stenmark KR. Validation of a pressure diameter method for determining modulus and strain of collagen engagement for long branches of bovine pulmonary arteries. J Biomech Eng. 2012 May;134(5):054501. [PMID: 22757496]

Shein SL, Bell MJ, Su E, Kochanek PM, Exo J. Intracranial monitoring and continuous data collection. Crit Care Med. 2012 Nov;40(11):3115-6; author reply 3116. [PMID: 23080469]

Stenmark KR, Frid MG, Yeager M, Li M, Riddle S, McKinsey T, El Kasmi KC. Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change. Pulm Circ. 2012 Jan-2012 Mar 31 ;2(1):3-14. [PMID: 22558514]

Stenmark KR, Yeager ME, El Kasmi KC, Nozik-Grayck E, Gerasimovskaya EV, Li M, Riddle SR, Frid MG. The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol. 2013;75:23-47. [PMID: 23216413]

Tian L, Lammers SR, Kao PH, Albietz JA, Stenmark KR, Qi HJ, Shandas R, Hunter KS. Impact of residual stretch and remodeling on collagen engagement in healthy and pulmonary hypertensive calf pulmonary arteries at physiological pressures. Ann Biomed Eng. 2012 Jul;40(7):1419-33. [PMID: 22237861]

Ventre K. Pediatric advanced life support case 10-a fussy baby. MedEdPORTAL; 2012. Available from:

Ventre KM, Zebuhr CA. Updates to the Pediatric Advanced Life Support course: are we running just to stand still? Pediatr Crit Care Med. 2012 Sep;13(5):605-7. [PMID: 22955465]

Yeager ME, Belchenko DD, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR. Endothelin-1, the unfolded protein response, and persistent inflammation: role of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 2012 Jan;46(1):14-22. [PMID: 21778413]

Yeager ME, Colvin KL, Everett AD, Stenmark KR, Ivy DD. Plasma proteomics of differential outcome to long-term therapy in children with idiopathic pulmonary arterial hypertension. Proteomics Clin Appl . 2012 Jun;6(5-6):257-67. [PMID: 22653875]

Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD, Stenmark KR. Circulating fibrocytes are increased in children and young adults with pulmonary hypertension. Eur Respir J. 2012 Jan;39(1):104-11. [PMID: 21700605]

Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD, Stenmark KR. Circulating myeloid-derived suppressor cells are increased and activated in pulmonary hypertension. Chest. 2012 Apr;141(4):944-52. [PMID: 21940769]

Yeager ME, Reddy MB, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR. Activation of the unfolded protein response is associated with pulmonary hypertension. Pulm Circ. 2012 Apr-2012 Jun 30;2(2):229-40. [PMID: 22837864]

Yeager ML, Frid MG, Nozik-Grayck E, Stenmark KR. Smooth muscle in the normal and diseased pulmonary circulation. In: Hill JA, Olson EN, editors. Muscle: fundamental biology and mechanisms of disease. London: Academic Press/Elsevier; 2012.

Zebuhr C, Sutton RM, Morrison W, Niles D, Boyle L, Nishisaki A, Meaney P, Leffelman J, Berg RA, Nadkarni VM. Evaluation of quantitative debriefing after pediatric cardiac arrest. Resuscitation. 2012 Feb 3. [PMID: 22306665]

Zhao L, Chen CN, Hajji N, Oliver E, Cotroneo E, Wharton J, Wang D, Li M, McKinsey TA, Stenmark KR, Wilkins MR. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation. 2012 Jul 24;126(4):455-67. [PMID: 22711276]


Bagdure DN, Reiter PD, Bhoite GR, Dobyns EL, Laoprasert P. Persistent hiccups associated with epidural ropivacaine in a newborn. Ann Pharmacother. 2011 Jun;45(6):e35. [PMID: 21652787]

Cerro MJ, Abman S, Diaz G, Freudenthal AH, Freudenthal F, Harikrishnan S, Haworth SG, Ivy D, Lopes AA, Raj JU, Sandoval J, Stenmark K, Adatia I. A consensus approach to the classification of pediatric pulmonary hypertensive vascular disease: Report from the PVRI Pediatric Taskforce, Panama 2011. Pulm Circ. 2011;1(2):286-98. [PMID: 21874158]

Czaja AS, Scanlon MC, Kuhn EM, Jeffries HE . Performance of the Pediatric Index of Mortality 2 for pediatric cardiac surgery patients. Pediatr Crit Care Med. 2011 Mar;12(2):184-9. [PMID: 20581732]

Dobyns EL. Assessment and monitoring of respiratory function. In: Fuhrman BP, Zimmerman JJ, editors. Pediatric critical care. 4th ed. Philadelphia: Elsevier; 2011.

Donoghue A, Ventre K, Boulet J, Brett-Fleegler M, Nishisaki A, Overly F, Cheng A. Design, implementation, and psychometric analysis of a scoring instrument for simulated pediatric resuscitation: a report from the EXPRESS pediatric investigators. Simul Healthc. 2011 Apr;6(2):71-7. [PMID: 21358564]

Exo J, Kochanek PM, Adelson PD, Greene S, Clark RS, Bayir H, Wisniewski SR, Bell MJ. Intracranial pressure-monitoring systems in children with traumatic brain injury: combining therapeutic and diagnostic tools. Pediatr Crit Care Med. 2011 Sep ;12(5):560-5. [PMID: 20625341]

Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ. The Accreditation Council for Graduate Medical Education proposed work hour regulations. Pediatr Crit Care Med. 2011 Jan;12(1):120-1. [PMID: 21209582]

Hartney T, Birari R, Venkataraman S, Villegas L, Martinez M, Black SM, Stenmark KR, Nozik-Grayck E. Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia. PLoS One. 2011;6(11):e27531. [PMID: 22140445]

Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, Meyrick B, Klemm D, Rojas M, Wagner DH Jr, Majka SM. The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells. 2011 Apr;29(4):725-35. [PMID: 21312316]

Kao PH, Lammers SR, Tian L, Hunter K, Stenmark KR, Shandas R, Qi HJ. A microstructurally driven model for pulmonary artery tissue. J Biomech Eng. 2011 May;133(5):051002. [PMID: 21599093]

Lammers AE, Adatia I, Cerro MJ, Diaz G, Freudenthal AH, Freudenthal F, Harikrishnan S, Ivy D, Lopes AA, Raj JU, Sandoval J, Stenmark K, Haworth SG. Functional classification of pulmonary hypertension in children: Report from the PVRI pediatric taskforce, Panama 2011. Pulm Circ. 2011 Aug 2;1(2):280-5. [PMID: 21874157]

Li M, Riddle SR, Frid MG, El Kasmi KC, McKinsey TA, Sokol RJ, Strassheim D, Meyrick B, Yeager ME, Flockton AR, McKeon BA, Lemon DD, Horn TR, Anwar A, Barajas C, Stenmark KR. Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J Immunol. 2011 Sep 1;187(5):2711-22. [PMID: 21813768]

Lyubchenko T, Woodward H, Veo KD, Burns N, Nijmeh H, Liubchenko GA, Stenmark KR, Gerasimovskaya EV. P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells. Am J Physiol Cell Physiol. 2011 Feb;300(2):C266-75. [PMID: 20962269]

Majka S, Burnham E, Stenmark KR. Cell-based therapies in pulmonary hypertension: who, what, and when? Am J Physiol Lung Cell Mol Physiol. 2011 Jul;301(1):L9-L11. [PMID: 21515661]

Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir Res. 2011;12:84. [PMID: 21696628]

Mourani PM, Harris JK, Sontag MK, Robertson CE, Abman SH. Molecular identification of bacteria in tracheal aspirate fluid from mechanically ventilated preterm infants. PLoS One. 2011;6(10):e25959. [PMID: 22016793]

Nagel MA, Traktinskiy I, Azarkh Y, Kleinschmidt-DeMasters B, Hedley-Whyte T, Russman A, VanEgmond EM, Stenmark K, Frid M, Mahalingam R, Wellish M, Choe A, Cordery-Cotter R, Cohrs RJ, Gilden D. Varicella zoster virus vasculopathy: analysis of virus-infected arteries. Neurology. 2011 Jul 26;77(4):364-70. [PMID: 21753174]

Nakagawa TA, Rigby MR, Bratton S, Shemie S, Ajizian SJ, Berkowitz I, Bowens CD, Cosio CC, Curley MA, Dhanani S, Dobyns E, Easterling L, Fortenberry JD, Helfaer MA, Kolovos NS, Koogler T, Lebovitz DJ, Michelson K, Morrison W, Naim MY, Needle J, Nelson B, Rotta AT, Rowin ME, Serrao K, Shore PM, Smith S, Thompson AE, Vohra A, Weise K. A call for full public disclosure for donation after circulatory determination of death in children. Pediatr Crit Care Med. 2011 May;12(3):375-7; author reply 377-8. [PMID: 21637157]

Pihl, S. Genetic and metabolic disorders: physiology and diagnostics. In: Bolick, B, Reuter-Rice, K, editors. Pediatric acute care: a guide to interprofessional practice. 11th ed. Burlington: Jones and Bartlett; 2011.

Pihl, S. Genetic and metabolic disorders: overview of selected genetic disorders. In: Bolick, B, Reuter-Rice, K, editors. Pediatric acute care: a guide to interprofessional practice. 11th ed. Burlington: Jones and Bartlett; 2011.

Randolph AG, Vaughn F, Sullivan R, Rubinson L, Thompson BT, Yoon G, Smoot E, Rice TW, Loftis LL, Helfaer M, Doctor A, Paden M, Flori H, Babbitt C, Graciano AL, Gedeit R, Sanders RC, Giuliano JS, Zimmerman J, Uyeki TM, Pediatric Acute Lung Injury and Sepsis Investigator's Network and the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network: Sanders RC, Hefley G, Tellez DW, Woodward V, Babbitt C, Gurrola R, Markovitz B, Terry J, Waters K, Graciano AL, Baldwin M, Ayala A, Flori H, Simon J, Anas N, Osborne S, Sapru A, Convery M, Giuliano JS Jr, Martino K, Czaja A, Mourani P, Burr S, Carroll CL, Sadhu I, McLaughlin G, Mijares Y, Paden M, Toney R, Cheng R, Tanaka L, Murakami S, Montgomery V, Randolph A, Richardson K, Yoon G, Sullivan R, Agan A, Bembea M, White B, Doctor A, Hicks B, Wincek J, Yu R, Surender R, Zink M, Turner DA, Tate S, Truemper E, Levin DL, Dean Jarvis J, Ackerman K, Cholette J, Tallie E, Hall MW, Greathouse K, Philip Barton R, Brown K, Dallis C, Kirby A, Thomas N, Raymond J, Spear D, Helfaer M, Diliberto MA, Clair A, Barr R, Berry P, Higgerson R, Ann Christie L, Rhodes T, Darnell C, Long J, Loftis LL, Kay Henry Y, Jaimon N, Kyle U, Willson DF, Traul C, Zimmerman J, Barker R, Gedeit R, Murkowski K, Luther K.. Critically ill children during the 2009-2010 influenza pandemic in the United States. Pediatrics. 2011 Dec;128(6):e1450-8. [PMID: 22065262]

Roedersheimer M, Nijmeh H, Burns N, Sidiakova AA, Stenmark KR, Gerasimovskaya EV. Complementary effects of extracellular nucleotides and platelet-derived extracts on angiogenesis of vasa vasorum endothelial cells in vitro and subcutaneous Matrigel plugs in vivo. Vasc Cell. 2011;3(1):4. [PMID: 21349161]

Shellington DK, Du L, Wu X, Exo J, Vagni V, Ma L, Janesko-Feldman K, Clark RS, Bayir H, Dixon CE, Jenkins LW, Hsia CJ, Kochanek PM. Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice. Crit Care Med. 2011 Mar;39(3):494-505. [PMID: 21169820]

Stenmark KR, Frid MG. Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms. In: Yuan JX-J, Garcia JGN, Hales CA, Rich S, Archer SL, West, JB, editors. Textbook of Pulmonary Vascular Diseases. 1st ed. New York: Springer; 2011.

Stenmark KR, Majka S, Frid MG. Pulmonary Vascular Remodeling: Role of Progenitor Cells in Pulmonary Vascular Remodeling. In: Yuan JX-J, Garcia JGN, Hales CA, Rich S, Archer SL, West, JB, editors. Textbook of Pulmonary Vascular Diseases. 1st ed. New York: Springer; 2011.

Stenmark KR, Nozik-Grayck E, Gerasimovskaya E, Anwar A, Min L, Riddle S, Frid M. The Adventitia: Essential Role in Pulmonary Vascular Remodeling. Compr Physiol 2011, 1: 141-161.

Stidham T, Reiter PD, Ford DM, Lum GM, Albietz J. Successful utilization of high-flux hemodialysis for treatment of vancomycin toxicity in a child. Case Rep Pediatr. 2011;2011:678724. [PMID: 22606521]

Teng SN, Kaufman J, Czaja AS, Friesen RH, da Cruz EM. Propofol as a bridge to extubation for high-risk children with congenital cardiac disease. Cardiol Young. 2011 Feb;21(1):46-51. [PMID: 20955640]

Teng S, Kaufman J, Pan Z, Czaja A, Shockley H, da Cruz E. Continuous arterial pressure waveform monitoring in pediatric cardiac transplant, cardiomyopathy and pulmonary hypertension patients. Intensive Care Med. 2011 Aug;37(8):1297-301. [PMID: 21626432]

Tian L, Lammers SR, Kao PH, Reusser M, Stenmark KR, Hunter KS, Qi HJ, Shandas R. Linked opening angle and histological and mechanical aspects of the proximal pulmonary arteries of healthy and pulmonary hypertensive rats and calves. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1810-8. [PMID: 21856906]

Van Rheen Z, Fattman C, Domarski S, Majka S, Klemm D, Stenmark KR, Nozik-Grayck E. Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling. Am J Respir Cell Mol Biol. 2011 Apr;44(4):500-8. [PMID: 20539010]

Ventre KM, Arnold JH. Acute parenchymal disease in pediatrics. In: Vincent J-L, Abraham E, Moore FA, Kochanek PM, Fink, MP, editors. Textbook of critical care. 6th ed. Philadelphia: Elsevier; 2011.

Ventre KM, Brenneman A. Strategic approaches to improving arrest management: the promise of technology and the limits of advance training. Pediatr Crit Care Med. 2011 May;12(3):366-8. [PMID: 21637152]

Ventre KM, Collingridge DS, DeCarlo D. End-user evaluations of a personal computer-based pediatric advanced life support simulator. Simul Healthc. 2011 Jun;6(3 ):134-42. [PMID: 21646982]

Ventre KM, Wolf GK, Arnold JH. Pediatric respiratory diseases: 2011 update for the Rogers' Textbook of Pediatric Intensive Care. Pediatr Crit Care Med. 2011 May;12(3):325-38. [PMID: 21378592]

Verrier JD, Exo JL, Jackson TC, Ren J, Gillespie DG, Dubey RK, Kochanek PM, Jackson EK. Expression of the 2',3'-cAMP-adenosine pathway in astrocytes and microglia . J Neurochem. 2011 Sep;118(6):979-87. [PMID: 21777245]

Walker LA, Walker JS, Glazier A, Brown DR, Stenmark KR, Buttrick PM. Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H832-40. [PMID: 21622821]

Wang GS, Erwin N, Zuk J, Henry DB, Dobyns EL. Retrospective review of emergency response activations during a 13-year period at a tertiary care children's hospital. J Hosp Med. 2011 Mar;6(3):131-5 . [PMID: 21387548]

Yeager ME, Frid MG, Stenmark KR. Progenitor cells in pulmonary vascular remodeling. Pulm Circ. 2011 Jan;1(1):3-16. [PMID: 22034593]

Yegutkin GG, Helenius M, Kaczmarek E, Burns N, Jalkanen S, Stenmark K, Gerasimovskaya EV. Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells. Angiogenesis. 2011 Dec;14(4):503-13. [PMID: 21922294]


Albietz JA, Czaja AS, Dobyns EL, Grayck EN, Mourani PM. Critical Care. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 20th ed. New York: McGraw-Hill; 2010.

Bagdure D, Curtis DJ, Dobyns E, Glode MP, Dominguez SR. Hospitalized children with 2009 pandemic influenza A (H1N1): comparison to seasonal influenza and risk factors for admission to the ICU. PLoS One . 2010;5(12):e15173. [PMID: 21179517]

Baker CD, Mourani PM, Sontag MK, Balasubramaniam V, Roth EM, Ryan SL, Ingram DA, Abman SH. Early decreased peripheral blood progenitor cell levels in preterm newborns are associated with moderate-to-severe BPD. Am J Respir Crit Care Med. 2010 May; 181:A4129.

Belchenko DD, Colvin KM, Nguyen CM, Ivy D, Stenmark KR, Yeager ME. High levels of endothelin-1 induce the unfolded protein response in pulmonary artery and microvascular endothelium. Poster presented at: 2010 American Thoracic Society International Conference; 2010 May 14-19; New Orleans, LA.

Brown RD, Ambler SK, Garrington TP, Long CS, Stenmark KR. MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of right ventricle in hypoxia-induced pulmonary hypertension. Presented at: American Thoracic Society International Conference. 2010 May 14-19; New Orleans, LA.

Cercone MA, Ferguson CA, Miyamota SD, Mourani PM. Resolution of severe catecholamine-induced cardiomyopathy secondary to pheochromocytoma. Am J Respir Crit Care Med. 2010 May; 181:A6069.

Colvin KM, Nguyen CM, Ivy D, Stenmark KR, Yeager ME. The unfolded protein response is activated in severe pulmonary artery hypertension. Poster presented at: 2010 American Thoracic Society International Conference; 2010 May 14-19; New Orleans, LA.

Gunville CF, Sontag MK, Stratton KA, Ranade DJ, Abman SH, Mourani PM. Scope and impact of early and late preterm infants admitted to the PICU with respiratory illness. J Pediatr. 2010 Aug;157(2):209-14.e1. [PMID: 20338574]

Hunter KS, Albietz JA, Lee PF, Lanning CJ, Lammers SR, Hofmeister SH, Kao PH, Qi HJ, Stenmark KR, Shandas R. In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation. J Appl Physiol. 2010 Apr;108(4):968-75. [PMID: 20093662]

Mourani PM,Sontag MK, Kerby GS, Fashaw L, Abman SH. Persistent impairment of lung function during infancy correlates with severity of bronchopulmonary dysplasia at diagnosis. Am J Respir Crit Care Med. 2010 May; 181:A3931.

Wang GS, Erwin N, Zuk J, Henry DB, Dobyns EL. Retrospective review of emergency response activations during a 13-year period at a tertiary care children's hospital. J Hosp Med. 2010 Nov 24. [PMID: 21108250]

Yeager ME, Nguyen CM, Colvin KM, Ivy D, Stenmark KR. Evidence of neo-lymphangiogenesis in severe pulmonary artery hypertension. Poster presented at: 2010 American Thoracic Society International Conference; 2010 May 14-19; New Orleans, LA.


Ambler SK, Brown RD, Long CS. Activation of cardiac fibroblast phenotypes following myocardial ischemia-reperfusion injury in transgenic mouse models. FASEB J. 2009 Apr 22; 23: 1002.1.

Brown RD, Ambler SK, Stenmark KS. Coordinate activation of cardiac and pulmonary fibroblasts by hypoxia-induced pulmonary hypertension in a transgenic mouse model. FASEB J. 2009 Apr 22; 23:928.2.

Brown RD, Ambler SK, Long CS, Stenmark KR. Hypoxia-induced pulmonary hypertension coordinately activates cardiac and pulmonary fibroblasts. Am J Respir Crit Care Med. 2009 Apr; 179:A1845.

Cercone M, Schroeder W, Carpenter T. EphA2 contributes to pulmonary vascular leak in young rats exposed to viral infection and hypoxia. Presented at: 2009 American Thoracic Society International Conference. 2009 May 15-20; San Diego, CA.

Czaja AS, Rivara FP, Wang J, Koepsell T, Nathens AB, Jurkovich GJ, Mackenzie E. Late outcomes of trauma patients with infections during index hospitalization. J Trauma. 2009 Oct;67(4):805-14. [PMID: 19820589]

Czaja AS, Zimmerman JJ. The use of dexmedetomidine in critically ill children. Pediatr Crit Care Med. 2009 May;10(3):381-6. [PMID: 19325505]

Czaja AS, Zimmerman JJ, Nathens AB. Readmission and late mortality after pediatric severe sepsis. Pediatrics. 2009 Mar;123(3):849-57. [PMID: 19255013]

Mourani PM, Sontag MK, Ivy DD, Abman SH. Effects of long-term sildenafil treatment for pulmonary hypertension in infants with chronic lung disease. J Pediatr. 2009 Mar;154(3):379-84, 384.e1-2. [PMID: 18950791]


Abman SH, Mourani PM, Sontag M. Bronchopulmonary dysplasia: a genetic disease. Pediatrics. 2008 Sep;122(3):658-9. [PMID: 18762536]

Ahmadi FA, Grammatopoulos TN, Poczobutt AM, Jones SM, Snell LD, Das M, Zawada WM. Dopamine selectively sensitizes dopaminergic neurons to rotenone-induced apoptosis. Neurochem Res. 2008 May;33(5):886-901. [PMID: 17992568]

Carpenter TC, Dobyns EL, Grayck EN, Mourani PM, Stenmark, KR. Critical care. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 19th ed. New York: McGraw-Hill; 2009.

Carpenter TC, Easley BL, Stenmark KR. The molecular biology of acute lung injury. In: Nichols D, editor. Rogers textbook of pediatric intensive care. 4th ed. Philadelphia: Lippincott Williams Wilkins; 2008.

Das M, Burns N, Wilson SJ, Zawada WM, Stenmark KR. Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia. Cardiovasc Res. 2008 Jun 1;78(3):440-8. [PMID: 18218684]

Gerasimovskaya EV, Woodward HN, Tucker DA, Stenmark KR. Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells. Angiogenesis. 2008;11(2):169-82. [PMID: 18071915]

Lammers SR, Kao P, Qi HJ, Hunter K, Lanning C, Albietz J, Hofmeister S, Mecham RP, Stenmark KR, Shandas R. Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1451-9. [PMID: 18660454]

Larson J, Schomberg S, Schroeder W, Carpenter TC. Endothelial EphA receptor stimulation increases lung vascular permeability. Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L431-9. [PMID: 18599503]

Lu BR, Gralla J, Liu E, Dobyns EL, Narkewicz MR, Sokol RJ. Evaluation of a scoring system for assessing prognosis in pediatric acute liver failure. Clin Gastroenterol Hepatol. 2008 Oct;6(10):1140-5. [PMID: 18928939]

Majka SM, Skokan M, Wheeler L, Harral J, Gladson S, Burnham E, Loyd JE, Stenmark KR, Varella-Garcia M, West J. Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L1028-39. [PMID: 18931051]

Mourani PM, Ivy DD, Rosenberg AA, Fagan TE, Abman SH. Left ventricular diastolic dysfunction in bronchopulmonary dysplasia. J Pediatr. 2008 Feb;152(2):291-3. [PMID: 18206706]

Mourani PM, Sontag MK, Younoszai A, Ivy DD, Abman SH. Clinical utility of echocardiography for the diagnosis and management of pulmonary vascular disease in young children with chronic lung disease. Pediatrics. 2008 Feb;121(2):317-25. [PMID: 18245423]

Nozik-Grayck E, Suliman HB, Majka S, Albietz J, Van Rheen Z, Roush K, Stenmark KR. Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L422-30. [PMID: 18599502]

Stenmark KR, Gerasimovskaya E, Davie NJ, Frid, MG. Mesenchymal-endothelial interactions in the control of angiogenic, inflammatory and fibrotic responses in the pulmonary circulation. In: Voelkel NF, Rounds S, editors. The pulmonary endothelium. London: John Wiley & Sons; 2008.

Stevens T, Phan S, Frid MG, Alvarez D, Herzog E, Stenmark KR. Lung vascular cell heterogeneity: endothelium, smooth muscle and fibroblasts. Proc A. Thorac Soc. 2008 Sep 15;5(7):783-91. [PMID: 18757318]


Arciniegas E, Frid MG, Douglas IS, Stenmark KR. Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L1-8. [PMID: 17384082]

Carpenter TC, Dobyns EL, Grayck EN, Mourani PM, Ferguson, M, Stenmark, KR. Critical care. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 18th ed. New York: McGraw Hill; 2007.

Crossno JT Jr, Garat CV, Reusch JE, Morris KG, Dempsey EC, McMurtry IF, Stenmark KR, Klemm DJ. Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L885-97. [PMID: 17189321]

Czaja AS. A critical appraisal of a randomized controlled trial: Willson et al: Effect of exogenous surfactant (calfactant) in pediatric acute lung injury. Pediatr Crit Care Med. 2007 Jan;8(1):50-3. [PMID: 17251882]

Lizotte PP, Hanford LE, Enghild JJ, Nozik-Grayck E, Giles BL, Oury TD. Developmental expression of the receptor for advanced glycation end-products (RAGE) and its response to hyperoxia in the neonatal rat lung. BMC Dev Biol. 2007 Mar;7:15. [PMID: 17343756]

Nozik-Grayck E, Stenmark KR. Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling. Adv Exp Med Biol. 2007;618:101-12. [PMID: 18269191]


Davie NJ, Gerasimovskaya EV, Hofmeister SE, Richman AP, Jones PL, Reeves JT, Stenmark KR. Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and endothelin-1. Am J Pathol. 2006 Jun;168(6):1793-807. [PMID: 16723696]

Frid MG, Brunetti JA, Burke DL, Carpenter TC, Davie NJ, Reeves JT, Roedersheimer MT, van Rooijen N, Stenmark KR. Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am J Pathol. 2006 Feb;168(2):659-69. [PMID: 16436679]

Liu E, MacKenzie T, Dobyns EL, Parikh CR, Karrer FM, Narkewicz MR, Sokol RJ. Characterization of acute liver failure and development of a continuous risk of death staging system in children. J Hepatol. 2006 Jan;44(1):134-41. [PMID: 16169116]

Short MD, Fox SM, Lam CF, Stenmark KR, Das M. Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression. Mol Biol Cell. 2006 Apr;17(4):1995-2008. [PMID: 16467381]

Stenmark KR, Davie N, Frid M, Gerasimovskaya E, Das M. Role of the adventitia in pulmonary vascular remodeling. Physiology. 2006 Apr;21:134-45. [PMID: 16565479]

Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res. 2006 Sep;99(7):675-91. [PMID: 17008597]

Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MC. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Circ Res. 2006 Mar;98(6):846-55. [PMID: 16484612]

Zee E, Schomberg S, Carpenter TC. Hypoxia upregulates lung microvascular neurokinin-1 receptor expression. Am J Physiol Lung Cell Mol Physiol. 2006;291(1):L102-10. [PMID: 16461432]


Banks MF, Gerasimovskaya EV, Tucker DA, Frid MG, Carpenter TC, Stenmark KR. Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts. J Appl Physiol. 2005 Feb;98(2):732-8. [PMID: 15475598]

Carpenter TC, Dobyns EL, Mateev SN, Mourani PM, Ferguson MA, Stenmark KR. Critical care. In: Hay WW Jr., Hayward AR, Levin ML, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 17th ed. New York: McGraw Hill; 2005.

Carpenter TC, Schomberg S, Stenmark KR. Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia. Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L1075-82. [PMID: 16040626]

Frid MG, Brunetti JA, Burke DL, Carpenter TC, Davie NJ, Stenmark KR. Circulating mononuclear cells with a dual, macrophage-fibroblast phenotype contribute robustly to hypoxia-induced pulmonary adventitial remodeling. Chest. 2005 Dec;128(6 Suppl):583S-584S. [PMID: 16373848]

Gerasimovskaya EV, Davie NJ, Ahmad S, Tucker DA, White CW, Stenmark KR. Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodeling. Chest. 2005 Dec;128(6 Suppl):608S-610S. [PMID: 16373860]

Gerasimovskaya EV, Tucker DA, Stenmark KR. Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation. J Appl Physiol. 2005 Feb;98(2):722-31. [PMID: 15501927]

Gerasimovskaya EV, Tucker DA, Weiser-Evans M, Wenzlau JM, Klemm DJ, Banks M, Stenmark KR. Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathways. J Biol Chem. 2005 Jan 21;280(3):1838-48. [PMID: 15522879]

Narkewicz MR, Kasaragod A, Lucia MS, Pflummer S, Sokol RJ, Stenmark KR. Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia. J Pediatr Surg. 2005 Nov;40(11):1721-5. [PMID: 16291159]

Reeves JT, Linehan JH, Stenmark KR. Distensibility of the normal human lung circulation during exercise. Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L419-25. [PMID: 15695542]

Short M, Fox S, Stenmark KR, Das M. Hypoxia-induced alterations in protein kinase C zeta signaling result in augmented fibroblast proliferation. Chest. 2005 Dec;128(6 Suppl):582S. [PMID: 16373847]

Stenmark KR, Abman SH. Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia. Annu Rev Physiol. 2005;67:623-61. [PMID: 15709973]

Stenmark KR, Balasubramaniam V. Angiogenic therapy for bronchopulmonary dysplasia: rationale and promise. Circulation. 2005 Oct 18;112(16):2383-5. [PMID: 16230495]

Stenmark KR, Davie NJ, Reeves JT, Frid MG. Hypoxia, leukocytes, and the pulmonary circulation. J Appl Physiol. 2005 Feb;98(2):715-21. [PMID: 15649883]

Stenmark KR, McMurtry IF. Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal? Circ Res. 2005 Jul 22;97(2):95-8. [PMID: 16037575]