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Niswander Lab




 

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Lori Bulwith, BS, Professional Research Assistant
Research Project:
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M. Gartz Hanson, PhD, Postdoctoral Fellow
Research Project:  Mouse models of human myopathies and mechanistic studies to reveal therapeutic targets
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Laura Harmacek, BS, Graduate Research Assistant
Research Project:  Epigenetic regulation of neural tube closure
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Juliette Petersen, BS, Graduate Research Assistant
Research Project:  Gene-enrionment interactions influence on the risk for neural tube defect
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Heather Ray, MS, Graduate Research Assistant
Research Project:  Novel mechanisms by which the ectoderm drives neural tube closure revealed by live imaging and genetic studies
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Jonathan Wilde, BS, Graduate Research Assistant
Research Project:  Epigenetic regulation of neural stem cell proliferation and differentiation
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Claire Tsai, Laboratory Manager


Feng, W, Choi, I., Clouthier, D., NISWANDER, L. and Trevor Williams, T. (2013). The Ptch1DL mouse: a new model to study lambdoid craniosynosytsosis and basal cell nevus syndrome associated skeletal defects. genesis (in press).

Massarwa, R. and NISWANDER, L. (2013). In Toto Live Imaging of Mouse Morphogenesis and New Insights into Neural Tube Closure. Development Jan;140(1):226-36. PMID: 23175632

Yates, L., Schnatwinkel, C., Hazelwood, L., Chessum, L., Paudyal, A., Hilton, H., Romero, R., Wilde, J., Bogani, D., Sanderson, J., Formstone, C., Murdoch, J.N., NISWANDER, L.A., Greenfield, A., Dean, C. (2013). Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Developmental Biology Jan 15;373(2):267-80. PMID: 23195221

Zhang, Y. and NISWANDER, L. (2013). Zic2 is required for enteric nervous system development and neurite outgrowth: a mouse model of enteric hyperplasia and dysplasia. Neurogastroenterol Motil. 2013 Jun;25(6):538-41. doi: 10.1111/nmo.12101. PMID: 23413832

Schnatwinkel, C. and NISWANDER, L. (2013). Multiparametric image analysis of lung branching morphogenesis. Developmental Dynamics Jun;242(6):622-37.doi: 10.1002/dvdy.23961. PMID: 23483685

Parker, J.J, Dionne, K.R., Massarwa, R., Klaassen, M., Foreman, N.K., NISWANDER, L., Canoll, P. Kleinschmidt-DeMasters, B.K. Waziri, A. (2013).  Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastoma. Neuro-Oncology (in press). PMID: 23749785

Zhang, Y., Kim, T-H. and NISWANDER, L. (2012). Phactr4 coordinates directional migration of Enteric Neural Crest Cells through β1 integrin signaling. Genes & Development 1, 69-81. PMID: 22215812

Chen, J., Lai, F. and NISWANDER, L. (2012). The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes & Development 26, 803-815. PMID: 22508726

Schnatwinkel, C and NISWANDER, L. (2012). Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice. PLoS One. 2012;7(9):e44871. PMID: 23028652

McKean, D. and NISWANDER, L. (2012). Defects in GPI Biosynthesis Perturb Cripto Signaling During Forebrain Development in Two New Mouse Models of Holoprosencephaly. Biology Open 1:874-883. PMID: 23213481

Becker-Heck, A.#, Zohn, I,#, Okabe, N.#, Pollock, A#, Baker, K., Sullivan-Brown, J., McSheene, J., Loges, N.T., Olbrich, H., Haeffner, K., Fliegauf, M., Horvath, J., Reinhardt, R., Nielsen, K.G., Marthin, J.K., Baktai, G., Geisler, R., NISWANDER, L., Omran, H., Burdine, R.D. (2011). The novel coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nature Genetics 43, 79-84. PMID: 21131974

Pyrgaki, C., Liu, A., and NISWANDER, L. (2011). Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Developmental Biology 353, 38-49. 21377456

Marean, A., Graf, A., Zhang, Y. and NISWANDER, L. (2011). Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Human Molecular Genetics 20, 3678-83. PMID: 21693562

Hubler, M., NISWANDER, L., Peters, J. and Sears, K. (2010). The developmental reduction of the marsupial coracoid: A case study in Monodelphis domestica. Journal of Morphology 271, 769-76. PMID: 20151407

Pyrgaki, C., Trainor, P., Hadjantonakis, A.-K. and NISWANDER, L. (2010). Dynamic Imaging of Mammalian Neural Tube Closure. Developmental Biology 344, 941-94. PMID: 20558153

Yates, L.L., Schnatwinkel, C., Murdoch, J.N., Bogani, D., Formstone, C.J., Townsend, S., Greenfield, A., NISWANDER, L.A., and Dean, C.H. (2010). The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Human Molecular Genetics 19, 2251-67. PMID: 20223754

Mao, J., McKean, D.M., Warrier, S. Corbin, J.G., NISWANDER, L. and Zohn, I.E. (2010). The Iron Exporter Ferroportin1 is Essential for Development of the Mouse Embryo, Forebrain Pattering and Neural Tube Closure. Development 137, 3079-88. PMID: 20702562

Weatherbee, S.D., NISWANDER, L.A., and Anderson, K.V. (2009). A mouse model for Meckel Syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling. Human Molecular Genetics 18, 4565-75. PMID: 19776033

Hoover, A.M., Wynkoop, A., Zeng, H., Jia, J., NISWANDER, L.A. and Liu, A. (2008). C2cd3 is required for cilia formation and Hedgehog signaling in the mouse.  Development 135, 4049-4058. PMID: 19004860

Sears, K.E., Behringer, R.R., Rasweiler, J.J. IV, and NISWANDER, L.A. (2007). The evolutionary and developmental basis of parallel reduction in mammalian zeugopod element. The American Naturalist 169, 105-117. PMID: 17206589

Zohn, I.E., De Domenico, I., Pollock, A., McVey Ward, D., Goodman, J.F., Liang, X., Sanchez, A.J., NISWANDER, L., and Kaplan, J. (2007). The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood 109, 4174-4180. PMID: 17289807

Zohn, I.E., Anderson, K.V., and NISWANDER, L. (2007). The Hectd1 Ubiquitin Ligase is Required for Development of the Head Mesenchyme and Neural Tube Closure. Developmental Biology 306, 208-221. PMID: 17442300

Kim, T-H., Goodman, J., Anderson, K.V. and NISWANDER, L. (2007). Phactr4 regulates neural tube closure by controlling PP1, Rb phosphorylation and cell cycle progression. Developmental Cell 13, 87-102. PMID: 17609112

Barna, M. and NISWANDER, L. (2007). Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes. Developmental Cell 12, 931-941. PMID: 17543865

Sears, K.E., Goswami, A., Flynn, J.J. and NISWANDER, L. (2007). The correlated evolution of Runx2 tandem repeats, transcriptional activity and facial length in Carnivora. Evolution and Development 9, 555-565. PMID: 17976052

Sears, K.E., Behringer, R.R., Rasweiler, J.J., and NISWANDER, L.A. (2006). The Development of Bat Flight: Morphological and Molecular Evolution of Bat Wing Digits. Proc Natl Acad Sci U S A 103, 6581-6586. PMID: 16618938

Atit, R.P., Sgaier, S.K., Mohamed, O.A., Taketo, M.M., Dufort, D., Joyner, A.L., NISWANDER, L. and Conlon, R.A. (2006). Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Developmental Biology 296, 164-176. PMID: 16730693

Zohn, I.E., Li, Y., Skolnik, E.Y., Anderson, K.V., Han, J. and NISWANDER, L. (2006). p38 and a p38-interacting protein are critical regulators of E-cadherin downregulation during mouse gastrulation. Cell 125, 957-969. PMID: 16751104

Weatherbee, S., Behringer, R.R., Rasweiler, J.J. and NISWANDER, L. (2006). Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification. Proc Natl Acad Sci U S A 103, 15103-15107. PMID: 17015842

Weatherbee, S.D., Anderson, K.V. and NISWANDER, L.A. (2006). LDL-receptor-related protein 4 is critical for formation of the neuromuscular junction. Development 133, 4993-5000. PMID: 17119023

Cretekos CJ, Weatherbee SD, Chen CH, Badwaik NK, NISWANDER L, Behringer RR, Rasweiler JJ 4th. (2005). Embryonic staging system for the short-tailed fruit bat, Carollia perspicillata, a model organism for the mammalian order Chiroptera, based upon timed pregnancies in captive-bred animals. Developmental Dynamics 233, 721-738. PMID: 15861401

Liu, A., Wang, B., NISWANDER, L. (2005). Mouse Intraflagellar Transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132, 3103-3111. PMID: 15930098

DiPaola,C.P; Farmer, J.C; Manova, K., NISWANDER, L.A. (2005). Molecular signaling in intervertebral disk development. Journal of Orthopaedic Research 23, 1112-9 PMID: 15936916

Timmer, J., Chesnutt, C. and NISWANDER, L. (2005). The Activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube. Developmental Biology 285, 1-10. PMID: 16039645

Barna, M., Pandolfi, P.P. and NISWANDER. L. (2005). Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development. Nature 436, 277-281. PMID: 16015334

Timmer, J., Manova, K., Anderson, K.V. and NISWANDER, L. (2005). Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. Proc Natl Acad Sci U S A 102, 11746-11750. PMID: 16087869

Dean, C.H., Miller, L-A., Smith, A.N., Dufort, D., Lang, R.A., and NISWANDER, L. (2005). Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland. Developmental Biology 286, 270-286. PMID: 16126193

Rouzankina, I., Abate-Shen, C. and NISWANDER, L. (2004). Dlx genes integrate positive and negative signals during feather bud development. Developmental Biology 265, 219-233. PMID: 14697365

Niemann, S., Zhao, C., Pascu, F., Stahl, U., Aulepp, U., NISWANDER, L., Weber, J.L., Müller, U. (2004). Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. American Journal of Human Genetics 74, 558-63. PMID: 14872406

Chesnutt, C. and NISWANDER, L. (2004). Plasmid-based short-hairpin RNA interference in the chicken embryo. genesis 39, 73-78. PMID: 15170691

Chesnutt, C., Burrus, L. Brown, A.M.C., and NISWANDER, L. (2004). Coordinate regulation of neural tube patterning and proliferation by TGF£] and WNT signaling. Developmental Biology 274, 334-337. PMID: 1538516

Atit, R., Conlon, R.A. and NISWANDER, L. (2003). EGF signaling patterns the feather array by promoting the interbud fate. Developmental Cell 4, 231-40. PMID: 1258606

Liu, A., Li, J.Y.H, Bromleigh, C., Lao, Z., NISWANDER, L. and Joyner, A. (2003). FGF17b and FGF18 have different midbrain regulatory properties from FGF8b and activated FGF receptors. Development 130, 6175-6185. PMID: 14602678

Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., NISWANDER, L. and Anderson, K. V. (2003). Hedgehog Signaling in the Mouse Requires Intraflagellar Transport Proteins. Nature 426, 83-87. PMID: 14603322

Holmes, G. Crooijmare, R., Groenen, M., NISWANDER, L. (2003.) ALC (ADJACENT TO LMX1 IN CHICK) is a novel dorsal limb mesenchyme marker. Gene Expression Patterns 3, 735-741. PMID: 14643681

Timmer, J., Wang, C. and NISWANDER, L. (2002). BMP signaling patterns the dorsal and intermediate neural tube via regulation of Homeobox and Helix-Loop-Helix transcription factors. Development 129, 2459-2468. PMID: 11973277

Pizette S. and NISWANDER L. (2001). Early steps in limb patterning and chondrogenesis. Novartis Foundation Symposium 232, 23-46. PMID: 11277083

Timmer, J., Johnson, J. and NISWANDER, L. (2001). The use of in ovo electroporation for the rapid analysis of neural-specific murine enhancers. Genesis 29, 123-132. PMID: 11252053

Holmes, G. and NISWANDER, L. (2001). Expression of slit-2 and slit-3 during chick development. Developmental Dynamics 222, 301-307. PMID: 11668607

Pizette, S., Abate-Shen, C. and NISWANDER, L. (2001). BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development 128, 4463-4474. PMID: 11714672

Pizette, S. and NISWANDER, L. (2000). BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes. Developmental Biology 219, 237-249. PMID: 10694419

Barna, M., Hawe, N., NISWANDER, L., Pandolfi, P. P. (2000). PLZF regulates limb and axial patterning. Nature Genetics 25, 166-172. PMID: 10835630

Crowe, R., Zikherman, J. A. and NISWANDER, L. (1999). Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation. Development 126, 987-998. PMID: 9927599

Pizette, S. and NISWANDER, L. (1999). BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development 126, 883-894. PMID: 9927590

Obara-Ishihara, T.*, Kuhlman, J.*, NISWANDER, L. and Herzlinger, D. (1999). The surface ectoderm is essential for nephric duct formation in intermediate mesoderm. Development 126, 1103-1108. (*, these authors contributed equally). PMID: 10021330

Crowe, R., Henrique, D., Ish-Horowicz, D., and NISWANDER, L. (1998). A new role for Delta in cell fate decisions: patterning the feather array. Development 125, 767-775. PMID: 9435296

Crowe, R. and NISWANDER, L. (1998). Disruption of scale development by Delta-1 misexpression. Developmental Biology 195, 70-74. PMID: 9520325

Bushdid, P. B., Brantley, D. M., Yull, F. E., Blaeuer, G. L., Hoffman, L. H., NISWANDER, L., and Kerr, L. D. (1998). Inhibition of NF-kB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature 392, 615-618. PMID: 9560159

Varley, J. E., McPherson, C. E., Zou, H., NISWANDER, L. and Maxwell, G. D. (1998). Expression of a constitutively active type I BMP receptor using a retroviral vector promotes the development of adrenergic cells in neural crest cultures. Developmental Biology 196, 107-118. PMID: 9527884

Gibson-Brown, J., Agulnik, S.I., Silver, L.M., NISWANDER, L., and Papaioannou, V.E. (1998) Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development. Development 125, 2499-2509. PMID: 9609833

Kuhlman, J. and NISWANDER, L. (1997). Limb deformity protein: Role in mesodermal induction of the apical ectodermal ridge. Development 124, 133-139. PMID: 9006074

Zou, H., Wieser, R., Massagué, J. and NISWANDER, L. (1997). Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes and Development 11, 2191-2203. PMID: 9303535

Laufer, E., Pizette, S., Zou, H., Orozco, O.E., NISWANDER, L. (1997). BMP expression in duck interdigital webbing: a reanalysis. Science 278, 305. PMID: 9340773

Zou, H., Choe, K-M., Lu, Y., Massagué, J., and NISWANDER, L. (1997). BMP signaling and vertebrate limb development. Cold Spring Harbor Symposis on Quantitative Biology, Vol. LXII, 269-272. PMID: 9598360

Yang, Y., Drossopoulou, G., Chuang, P.T., Duprez, D., Marti, E., Bumcrot, D., Vargesson, N., Clarke, J., NISWANDER, L., McMahon, A. and Tickle, C. (1997). Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation in the chick limb development. Development 124, 4393-4404. PMID: 9334287

Zou, H. and NISWANDER, L. (1996). Requirement for BMP signaling in interdigital apoptosis and scale formation. Science 272, 738-741. PMID: 8614838

NISWANDER, L. (1996). Growth factor interactions in limb development. Annals of the New York Academy of Sciences 785: 23-26. PMID: 8702137

Yang, Y. and NISWANDER, L. (1995). Interaction between the signaling molecules WNT and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell 80, 939-947. PMID: 7697724

Vogel, A., Roberts-Clarke, D. and NISWANDER, L. (1995). Effect of FGF on gene expression in chick limb bud cells in vivo and in vitro. Developmental Biology 171, 507-520. PMID: 7556932

NISWANDER, L., Tickle, C., Vogel, A., Martin, G.R. (1994). Function of FGF-4 in Limb Development. Journal of Molecular Reproduction and Development 39: 83-89. PMID: 7999365

NISWANDER, L., Jeffrey, S., Martin, G.R., and Tickle, C. (1994). Positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371, 609-612. PMID: 7935794

NISWANDER, L. and Martin, G.R. (1993). FGF-4 and BMP-2 have opposite effects on limb growth. Nature 361, 68-71. PMID: 8421496

NISWANDER, L. and Martin, G.R. (1993). FGF-4 regulates expression of Evx-1 in the developing limb. Development 119, 287-294. PMID: 7506139

NISWANDER, L., Tickle, C., Vogel, A., Booth, I., and Martin, G.R. (1993). FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75, 579-587. PMID: 8221896

Hollingsworth, Jr., R. E., Ostroff, R. M., Klein, M. B., NISWANDER, L. A, and Sclafani, R. A. (1992). Molecular genetic studies of Cdc7 protein kinase and induced mutagenesis in yeast. Genetics 132, 53-62. PMID: 1398063

Kelsey, G., Schedl, A., Ruppert, S., Klebig, M.L., NISWANDER, L., Magnuson, T., Rinchik, E.M., and Schütz, G. (1992). Physical mapping of alf/hsdr-1, a locus defined by albinodeletion complex of mouse required for neonatal survival. Genomics 14, 275-287. PMID: 1427844

Schedl, A., Ruppert, S., Kelsey, G., Thies, E., NISWANDER, L., Magnuson, T., Klebig, M.L., Rinchik, E.M., and Schütz, G. (1992). Chromosome jumping from flanking markers define a minimal region for alf/hsdr-1 within the albino-deletion complex. Genomics 14, 288-297. PMID: 1427845

NISWANDER, L. and Martin, G.R. (1992). Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114: 755-768. PMID: 1618140

NISWANDER, L. A., Kelsey, G., Schedl, A., Ruppert, S., Sharan, S. K., Holdener-Kelly, B., Rinchik, E., M., Edström, J.-E., and Magnuson, T. (1991). Molecular mapping of albino deletions associated with early embryonic lethality in the mouse. Genomics 9: 162-169. PMID: 2004758

Davidson, J. N., Gadiparthi, N. R., NISWANDER, L., Andreano, C., Tamer, C., and Chen, K.-C. (1990). Organization and nucleotide sequence of the 3' end of the human CAD gene. DNA and Cell Biology 9: 667-676. PMID: 1979741

NISWANDER, L.A., Yee, D., Rinchik, E. M., Russell, L. B. and Magnuson, T. (1989). The albino-deletion complex in the mouse defines genes necessary for development of embryonic and extraembryonic ectoderm. Development 105: 175-182. PMID: 2806116

NISWANDER, L.A., Edström, J.-E., Rinchik, E. M. and Magnuson, T. (1989). Genetics of early embryo survival. In: Transgenic Models in Medicine and Agriculture, ed. R. Church, (Alan R. Liss, Inc., New York).

NISWANDER, L. A., Yee, D., Rinchik, E. M., Russell, L. B. and Magnuson, T. (1988). The albino deletion complex and early postimplantation survival in the mouse. Development 102: 45-53. PMID: 3416773

Patterson, D., Vannais, D. B., NISWANDER, L. A. and Davidson, J. N. (1985) Identification and localization of DNA alteration in Chinese hamster ovary cell mutants (Urd-) defective in the first three enzymes of de novo pyrimidine synthesis. Somatic Cell and Molecular Genetics 11: 379-390. PMID: 2992101

Davidson, J. N., Rumsby, G. and NISWANDER, L. A. (1985). Expression of genes on human chromosome 21. Annals of the New York Academy of Sciences 450: 43-54. PMID: 2409886

Shigesada, K. , Stark, G. R. Maley, J. A., NISWANDER, L.A. and Davidson, J. N. (1985). Construction of a cDNA to the hamster CAD gene and its application toward defining the domain for aspartate transcarbamylase. Molecular and Cellular Biology 5: 1735-1742. PMID: 2862577

Rumsby, P. C., Campbell, P. C., NISWANDER, L. A. and Davidson, J. N. (1984). Organization of a mutifunctional protein in pyrimidine biosynthesis. Biochemical Journal 217: 435-440. PMID: 6365086

Davidson, J. N. and NISWANDER, L. A. (1983). Partial cDNA sequence to a hamster gene corrects defect in Escherichia coli pyrB mutant. Proc. Natl. Acad. Sci. USA 80: 6897-6901.
PMID: 6139812

Niswander Lab
RC1 South, 12th Floor
12801 E 17th Avenue, Campus Box 8108
Aurora, CO  80045
Phone:  303-724-3791
Email: lee.niswander@ucdenver.edu