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Developmental Biology - Publications


Massarwa R, Niswander L. In toto live imaging of mouse morphogenesis and new insights into neural tube closure. Development. 2013 Jan 1;140(1):226-36. [PMID: 23175632]

Yates LL, Schnatwinkel C, Hazelwood L, Chessum L, Paudyal A, Hilton H, Romero MR, Wilde J, Bogani D, Sanderson J, Formstone C, Murdoch JN, Niswander LA, Greenfield A, Dean CH. Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Dev Biol. 2013 Jan 15;373(2):267-80. [PMID: 23195221]


Chen J, Lai F, Niswander L. The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15. [PMID: 22508726]

Choe Y, Siegenthaler JA, Pleasure SJ. A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. Neuron. 2012 Feb 23;73(4):698-712. [PMID: 22365545]

Jao LE, Appel B, Wente SR. A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization. Development. 2012 Apr;139(7):1316-26. [PMID: 22357925]

Langworthy MM, Appel B. Schwann cell myelination requires Dynein function. Neural Dev. 2012;7:37. [PMID: 23167977]

McKean DM, Niswander L. Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012 Sep 15;1(9):874-83. [PMID: 23213481]

Ray HJ, Niswander L. Mechanisms of tissue fusion during development. Development. 2012 May;139(10):1701-11. [PMID: 22510983]

Schnatwinkel C, Niswander L. Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice. PLoS One. 2012;7(9):e44871. [PMID: 23028652]

Simmons T, Appel B. Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish. PLoS One. 2012;7(2):e32317. [PMID: 22384214]

Snyder JL, Kearns CA, Appel B. Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Dev. 2012;7:15. [PMID: 22554084]

Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J Biol Chem. 2012 Jan 6;287(2):1600-8. [PMID: 22128191]

Zannino DA, Sagerstrom CG, Appel B. olig2-Expressing hindbrain cells are required for migrating facial motor neurons. Dev Dyn. 2012 Feb;241(2):315-26. [PMID: 22275004]

Zarbalis K, Choe Y, Siegenthaler JA, Orosco LA, Pleasure SJ. Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice. Neural Dev. 2012;7: 2. [PMID: 22248045]

Zhang Y, Kim TH, Niswander L. Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity. Genes Dev. 2012 Jan 1;26(1):69-81. [PMID: 22215812]

Zhang Y, Niswander L. Phactr4: a new integrin modulator required for directional migration of enteric neural crest cells. Cell Adh Migr. 2012 Sep-2012 Oct 31;6(5 ):419-23. [PMID: 23076051]


Becker-Heck A, Zohn IE, Okabe N, Pollock A, Lenhart KB, Sullivan-Brown J, McSheene J, Loges NT, Olbrich H, Haeffner K, Fliegauf M, Horvath J, Reinhardt R, Nielsen KG, Marthin JK, Baktai G, Anderson KV, Geisler R, Niswander L, Omran H, Burdine RD. The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nat Genet. 2011 Jan;43(1):79-84. [PMID: 21131974]

Marean A, Graf A, Zhang Y, Niswander L. Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Hum Mol Genet. 2011 Sep 15;20(18):3678-83. [PMID: 21693562]

Niswander L, Bates D. The Developmental Basis of Congenital Limb. In: Polin RA, Fox WW, Abman SH, editors.(Chapter 174). Fetal and Neonatal Physiology. 4th ed. Philadelphia: Elsevier Saunders; 2011. 1917 p.

Pyrgaki C, Liu A, Niswander L. Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev Biol. 2011 May 1;353(1):38-49. [PMID: 21377456]

Takada N, Appel B. swap70 promotes neural precursor cell cycle exit and oligodendrocyte formation. Mol Cell Neurosci. 2011 Nov;48(3):225-35. [PMID: 21875669]


Hubler M, Niswander LA, Peters J, Sears KE . The developmental reduction of the marsupial coracoid: a case study in Monodelphis domestica. J Morphol. 2010 Jul;271(7):769-76. [PMID: 20151407]

Mao J, McKean DM, Warrier S, Corbin JG, Niswander L, Zohn IE. The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development. 2010 Sep;137(18):3079-88. [PMID: 20702562]

Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. Dynamic imaging of mammalian neural tube closure. Dev Biol. 2010 Aug 15;344(2):941-7. [PMID: 20558153]

Takada N, Kucenas S, Appel B. Sox10 is necessary for oligodendrocyte survival following axon wrapping. Glia. 2010 Jun;58(8):996-1006. [PMID: 20229602]

Takada N, Appel B. Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen. Dev Dyn. 2010 Jul;239(7):2041-7. [PMID: 20549738]

Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dean CH. The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet. 2010 Jun 1;19(11):2251-67. [PMID: 20223754]

Zhao X, He X, Han X, Yu Y, Ye F, Chen Y, Hoang T, Xu X, Mi QS, Xin M, Wang F, Appel B, Lu QR. MicroRNA-mediated control of oligodendrocyte differentiation. Neuron. 2010 Mar 11;65(5):612-26. [PMID: 20223198]


No Publications listed


Desai S, Loomis Z, Pugh-Bernard A, Schrunk J, Doyle MJ, Minic A, McCoy E, Sussel L. Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol. 2008 Jan;313(1):58-66. [PMID: 18022152]

Hoover AM, Wynkoop A, Zeng H, Jia J, Niswander LA, Liu A. C2cd3 is required for cilia formation and Hedgehog signaling in the mouse. Development. 2008 Dec;135(24):4049-58. [PMID: 19004860]

Kim H, Shin J, Kim S, Poling J, Park HC, Appel B. Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos. Dev Dyn. 2008 Aug;237(8):2081-9. [PMID: 18627107]

Kucenas S, Takada N, Park HC, Woodruff E, Broadie K, Appel B. CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nat Neurosci. 2008 Feb;11(2):143-51. [PMID: 18176560]

McFarland KA, Topczewska JM, Weidinger G, Dorsky RI, Appel B. Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum. Dev Biol. 2008 Jun;318(1):162-71. [PMID: 18423594]

Niswander L. Methods in avian embryology experimental and molecular manipulation of the embryonic chick limb. Methods Cell Biol. 2008;87:135-52. [PMID: 18485295]

Qu X, Jia H, Garrity DM, Tompkins K, Batts L, Appel B, Zhong TP, Baldwin HS. Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol. 2008 May;317(2):486-96. [PMID: 18407257]


Barna M, Niswander L. Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes. Dev Cell. 2007 Jun;12(6):931-41. [PMID: 17543865]

Chao CS, Loomis ZL, Lee JE, Sussel L Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007 Dec;312(2):523-32. [PMID: 17988662]

Doyle MJ, Loomis ZL, Sussel L. Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development. 2007 Feb;134(3):515-23. [PMID: 17202186]

Doyle MJ, Sussel L. Nkx2.2 regulates beta-cell function in the mature islet. Diabetes. 2007 Aug;56(8):1999-2007. [PMID: 17456846]

Kim TH, Goodman J, Anderson KV, Niswander L. Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev Cell. 2007 Jul;13(1):87-102. [PMID: 17609112]

Park HC, Shin J, Roberts RK, Appel B. An olig2 reporter gene marks oligodendroycte precursors in postembryonic spinal cord of zebrafish. Dev Dyn. 2007 Dec;236(12):3402-7. [PMID: 17969181]

Sarmah B, Winfrey VP, Olson GE, Appel B, Wente SR. A role for the inositol kinase Ipk1 in ciliary beating and length maintenance. Proc Natl Acad Sci USA. 2007 Dec;104(50):19843-8. [PMID: 18056639]

Sears KE, Behringer RR, Rasweiler JJ 4th, Niswander LA. The evolutionary and developmental basis of parallel reduction in mammalian zeugopod elements. Am Nat. 2007 Jan;169(1):105-17. [PMID: 17206589]

Sears KE, Goswami A, Flynn JJ, Niswander LA. The correlated evolution of Runx2 tandem repeats, transcriptional activity, and facial length in carnivora. Evol Dev. 2007 Nov-Dec;9(6):555-65. [PMID: 17976052]

Shin J, Poling J, Park HC, Appel B. Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development. 2007 May;134(10):1911-20. [PMID: 17442701]

Weatherbee SA, Niswander L. Mechanisms of chondrogenesis and osteogenesis in limbs. In: Hall BK, editor. Fins into limbs: evolution, development, and transformation. Chicago: The University of Chicago Press; 2007.

Zohn IE, Anderson KV, Niswander L. The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Dev Biol. 2007 Jun;306(1):208-21. [PMID: 17442300]

Zohn IE, De Domenico I, Pollock A, Ward DM, Goodman JF, Liang X, Sanchez AJ, Niswander L, Kaplan J. The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood. 2007 May;109(10):4174-80. [PMID: 17289807]


Atit R, Sgaier SK, Mohamed OA, Taketo MM, Dufort D, Joyner AL, Niswander L, Conlon RA. Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol. 2006 Aug;296(1):164-76. [PMID: 16730693]

Decker K, Goldman DC, Grasch CL, Sussel L. Gata6 is an important regulator of mouse pancreas development. Dev Biol. 2006 Oct;298(2):415-29. [PMID: 16887115]

Kirby B, Takada N, Latimer AJ, Shin J, Appel B. In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Nat Neurosci. 2006 Dec;9(12):1506-11. [PMID: 17099706]

Latimer AJ, Appel B. Notch signaling regulates midline cell specification and proliferation in zebrafish. Dev Biol. 2006 Oct;298(2):392-402. [PMID: 16876779]

Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W. Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development. 2006 Jan;133(1):89-98. [PMID: 16339193]

Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R. FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol. 2006 Aug;26(15):5735-43. [PMID: 16847327]

Sears KE, Behringer RR, Rasweiler JJ 4th, Niswander LA. Development of bat flight: morphologic and molecular evolution of bat wing digits. Proc Natl Acad Sci USA. 2006 Apr;103(17):6581-6. [PMID: 16618938]

Weatherbee SD, Anderson KV, Niswander LA. LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec;133(24):4993-5000. [PMID: 17119023]

Weatherbee SD, Behringer RR, Rasweiler JJ 4th, Niswander LA. Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification. Proc Natl Acad Sci USA. 2006 Oct;103(41):15103-7. [PMID: 17015842]

Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006 Jun;125(5):957-69. [PMID: 16751104]


Barna M, Pandolfi PP, Niswander L. Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development. Nature. 2005 Jul 14;436(7048):277-81. [PMID: 16015334]

Cretekos CJ, Weatherbee SD, Chen CH, Badwaik NK, Niswander L, Behringer RR, Rasweiler JJ 4th. Embryonic staging system for the short-tailed fruit bat, Carollia perspicillata, a model organism for the mammalian order Chiroptera, based upon timed pregnancies in captive-bred animals. Dev Dyn. 2005 Jul;233(3):721-38. [PMID: 15861401]

Dean CH, Miller LA, Lang RA, Niswander L. Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland. Dev Biol. 2005 Oct 1;286(1):270-86. [PMID: 16126193]

DiPaola CP, Farmer JC, Manova K, Niswander LA. Molecular signaling in intervertebral disk development. J Orthop Res. 2005 Sep;23(5):1112-9. [PMID: 15936916]

Dobson T, Minic A, Nielsen K, Amiott E, Krushel L. Internal initiation of Translation of the TrkB mRNA is mediated by multiple regions within the 5' leader. Nucleic Acids Res. 2005 May 20;33(9):2929-41. [PMID: 15908588]

Gebb SA, Fox K, Vaughn J, McKean D, Jones PL. Fetal oxygen tension promotes tenascin-C-dependent lung branching morphogenesis. Dev Dyn. 2005 Sep;234(1):1-10. [PMID: 16086306]

Ihida-Stansbury K, McKean DM, Gebb SA, Martin JF, Stevens T, Nemenoff R, Vaughn J, Lane K, Loyd J, Wheeler L, Morrell NW, Ivy D, Jones PL. Regulation and functions of the paired-related homeobox gene PRX1 in pulmonary vascular development and disease. Chest. 2005 Dec;128(6 Suppl):591S. [PMID: 16373852]

Liu A, Niswander LA. Signalling in development: Bone morphogenetic protein signalling and vertebrate nervous system development. Nat Rev Neurosci. 2005 Dec;6(12):945-954. [PMID: 16340955]

Liu A, Wang B, Niswander LA. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development. 2005 Jul;132(13):3103-11. Epub 2005 Jun 1. [PMID: 15930098]

Timmer J, Chesnutt C, Niswander L. The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube. Dev Biol. 2005 Sep 1;285(1):1-10. [PMID: 16039645]

Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L. Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11746-50. Epub 2005 Aug 8. [PMID: 16087869]

Zohn IE, Anderson KV, Niswander L. Using genomewide mutagenesis screens to identify the genes required for neural tube closure in the mouse. Birth Defects Res A Clin Mol Teratol. 2005 Sep;73(9):583-90. Review. [PMID: 15971254]