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William W. Hay, Jr., MD

Professor of Pediatrics
 

Co-Director, Colorado Clinical Translational Sciences Institute
Director, Child and Maternal Health Research, Colorado Clinical Translational Sciences Institute
Associate Program Director, Children's Hospital Colorado Clinical Translational Research Center
Director, Neonatal Clinical Research Center
Scientific Director, Perinatal Research Center

Contact
   Phone: 720-777-1234 (TBD)
   E-mail: (TBD)

Affiliations
Section of Neonatology, Department of Pediatrics
Perinatal Research Center
Clinical & Translational Research Center
Children's Hospital Colorado

Certifications
Pediatrics, Neonatal-Perinatal Medicine

William W. Hay, Jr., MD, earned his medical degree from Yale University School of Medicine in 1971. He completed his Pediatric Residency and Fellowship in Perinatal Medicine at the University of Colorado School of Medicine, in 1974, and 1978, respectively.

Dr. Hay joined the faculty of the Department of Pediatrics at the University of Colorado School of Medicine and Children’s Hospital Colorado in 1978. He was appointed Professor of Pediatrics in 1988. Dr. Hay currently serves as Director of the Neonatal Clinical Research Center, Scientific Director of the Perinatal Research Center, and Assistant Director of the Training Program in Neonatal-Perinatal Medicine.

Dr. Hay’s basic research is supported by NIH-funded research project grants to study various aspects of placental and fetal growth restriction, with specific attention to placental nutrient transfer and metabolism, fetal insulin secretion, and fetal insulin action. His research is aimed at understanding how disturbances in maternal nutrient supply to the placenta and fetus produce adaptations in fetal development that could underlie later life disorders such as obesity, insulin resistance, and diabetes.

His clinical research through the Children's Hospital Colorado Clinical Translational Research Center focuses on early postnatal intravenous nutrition of the extremely low birth weight infant, aimed at determining the optimal amount and mixture of amino acids and energy supplies to promote early and optimal growth of body weight and composition in preterm infants to prevent postnatal growth restriction. He also is a world’s expert in research devoted to neonatal applications of pulse oximetry to monitor blood oxygenation in newborn infants.

Dr. Hay is the recipient of numerous awards and honors. He is an active member of numerous scientific committees and associations. He has been a member of four NIH study sections over 14 years and served as chair of three of these. Dr. Hay is the Senior Editor of Current Pediatric Diagnosis and Treatment, the largest selling textbook of Pediatric medicine in the U.S. He is a peer reviewer for an extensive list of journals and is widely published in the medical literature. Dr. Hay is a popular invited lecturer both nationally and internationally.

  • Member, Pediatric Oversight Committee, NIH CTSA Consortium Child Health Oversight Committee, 2008-present
  • Member, APS/SPR Student Research Program Steering Committee, 2008-present
  • Secretary-Treasurer, International Pediatric Research Foundation, 2009-2014
  • Council Member, Western Society for Pediatric Research, 2007-2012
  • L. Joseph Butterfield Award, NICHD, 2011
  • President, Western Society for Pediatric Research, 2010-2011
  • Chair, NIH CTSA Consortium Child Health Oversight Committee Working Group on Pediatric-Adult Lifespan Research, 2008-2011
  • Editor, NeoReviews, American Academy of Pediatrics, 1998-2010
  • Editorial Board, American Journal of Physiology: Endocrinology and Metabolism, 2007-2009
  • Trustee, International Pediatric Research Foundation, 2004-2009
  • Editorial Board, Trophoblast Research, 2001-2009
  • Editorial Board, Reproduction, Fertility and Development, 1995-2009
  • President, APS, 2008
  • Co-Chair, NIH Symposium on Neonatal Hypoglycemia, 2008
  • Co-winner, 1st Society for Pediatric Research “Research Conference,” Interplays Between Early Nutrition, GI Microbial Ecology, the Immune System and Subsequent Health, 2007
  • Member, NCRR Institutional Clinical Translational Science Award, Special Emphasis Review Panels, 2006-2007
  • March of Dimes Agnes Higgins Award, 2006

Publications in PubMed (partial list)

  • Hay WW Jr, Levin M, Sondheimer J, Deterding R, editors. Current pediatric diagnosis and treatment. 19th ed. New York: McGraw-Hill; 2009.
  • Gitterman DP, Hay WW Jr. That sinking feeling, again? The State of NIH pediatric research spending, FY 1992-2010. Pediatr Res. 2008 Nov;64(5):462-9. [PMID: 18787420]
  • Manco-Johnson MM, Hacker MR, Jacobson L, Hay WW Jr. Pharmacokinetics of Protein C and Antithrombin in the fetal lamb: a model to predict human neonatal replacement dosing. Neonatology. 2008 Nov;95(4):279-285. [PMID: 19039246]
  • Genel M, McCaffree MA, Hendricks K, Dennery P, Hay WW Jr, Stanton B, Szilagyi P, Jenkins R. A national agenda for America’s children and adolescents in 2008: recommendations from the 15th annual Public Policy Plenary Symposium, Annual Meeting of the Pediatric Academic Societies, May 3, 2008. Pediatrics 2008 Oct;122: 843-9. [PMID: 18829810]
  • Rozance PJ, Limesand SW, Barry JS, Brown LD, Hay WW Jr. Title: Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Pediatr Res. 2008 Aug 13. [PMID: 18704001]
  • Rozance PJ, Limesand SW, Barry JS, Brown LD, Thorn SR, LoTurco D, Regnault TR, Friedman JE, Hay WW Jr. Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep. Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E365-70. [PMID: 18056789]
  • Hay WW Jr. American Pediatric Society Presidential Address 2008: Research in early life: benefit and promise. Pediatr Res. 2008 Jan;65(1):117-122. [PMID: 18787504]
  • Hay WW Jr. Intravenous nutrition for the extremely preterm infant. In: Pereira G, editor. Nutrition of the premature infant. Brazilian perinatology clinics. Brazil: Medbook editora cientifica; 2008.
  • Hay WW Jr. Nutrient delivery and metabolism in the fetus. In: Hod M, Jovanovic L, Di Renzo G, DeLeiva A, Langer O, editors. Textbook of diabetes and pregnancy. 2nd ed. Milton Park, UK: Informa Healthcare Medical Books, 2008.
  • Hay WW Jr. Strategies for feeding the preterm infant. Neonatology. 2008;94(4):245-54. [PMID: 18836284]
  • Hay WW Jr. Writing a successful research grant; strategies for a successful outcome. In: Bortolussi R, editor. Handbook for clinician scientists. HSC Research and Development Limited Partnership. Toronto, Ontario, Canada: Canadian Child Health Clinician Scientist Program; 2008.
  • Philip AGS, Hay WW Jr, Stevenson DK. Intrauterine growth restriction. In: Stevenson DK, Benitz W, Sunshine P, Hintz S, Druzin M, editors. Fetal and neonatal brain injury. 4th ed. Cambridge, UK: Cambridge University Press; 2008.
  • Limesand SW, Rozance PJ, Smith D, Hay WW Jr. Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1716-25. [PMID: 17895285]
  • Hay WW Jr, Thureen PJ. Indirect calorimetry: a potential but as yet unrealized technique for guiding nutritional management. J Pediatr. 2007 Nov-Dec;83(6):490-3. [PMID: 18074053]
  • Wallace JM, Milne JS, Aitken RP, Hay WW Jr. Sensitivity to metabolic signals in late-gestation growth-restricted fetuses from rapidly growing adolescent sheep. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1233-41. [PMID: 17711986]
  • Rozance PJ, Limesand SW, Zerbe GO, Hay WW Jr. Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2007 May;292(5):E1256-64. [PMID: 17213478]
  • Raiten DJ, Kalhan SC, Hay WW Jr. Maternal nutrition and optimal infant feeding practices: executive summary. Am J Clin Nutr. 2007 Feb;85(2):577S-83S. [PMID: 17284759]
  • Hay WW Jr. Nutrition and development of the fetus: carbohydrate and lipid metabolism. In: Walker W A, Watkins JB, Duggan CP, editors. Nutrition in pediatrics: basic science and clinical applications. 4th ed. Hamilton, Ontario, Canada: BC Decker Inc; 2007.
  • Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 18th ed. New York: McGraw Hill; 2007.
  • Hay WW Jr, Regnault TRH. Fetal requirements and placental transfer of nitrogenous compounds. In: Polin RA, Fox WW, Abman S H, editors. Fetal and neonatal physiology. 4th ed. Philadelphia: Elsevier/Saunders; 2007.
  • Hay WW Jr, Regnault TH, Brown LD. Fetal requirements and placental transfer of nitrogenous compounds. In: Polin RA, Fox WW, Abman S H, editors. Fetal and neonatal physiology. 4th ed. Philadelphia: Elsevier/Saunders; 2007.
  • Thureen PJ, Hay WW Jr. Nutritional requirements of the very low birth weight infant. In: Neu J, editor. Questions and controversies in neonatology series (Polin R, series consultant). Gastroenterology and nutrition volume. Philadelphia: Elsevier; 2007.
  • Brown LD, Hay WW Jr. Effect of hyperinsulinemia on amino acid utilization and oxidation independent of glucose metabolism in the ovine fetus. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1333-40. [PMID: 16868230]
  • Rozance PJ, Limesand SW, Hay WW Jr. Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E404-11. [PMID: 16569758]
  • Hay WW. Early postnatal nutritional requirements of the very preterm infant based on a presentation at the NICHD-AAP workshop on research in neonatology. J Perinatol. 2006 Jul;26 Suppl 2:S13-8. [PMID: 16801962]
  • Barry JS, Davidsen ML, Limesand SW, Galan HL, Friedman JE, Regnault TR, Hay WW Jr. Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction. Exp Biol Med. 2006 May;231(5):566-75. [PMID: 16636305]
  • Hay WW Jr. Recent observations on the regulation of fetal metabolism by glucose. J Physiol. 2006 Apr;572(Pt 1):17-24. [PMID: 16455683]
  • Wallace JM, Luther JS, Milne JS, Aitken RP, Redmer DA, Reynolds LP, Hay WW Jr. Nutritional modulation of adolescent pregnancy outcome -- a review. Placenta. 2006 Apr;27 Suppl A:S61-8. [PMID: 16442614]
  • Hay WW Jr, Thureen PJ. Early postnatal administration of intravenous amino acids to preterm, extremely low birth weight infants. J Pediatr. 2006 Mar;148(3):291-4. [PMID: 16615952]
  • Limesand SW, Rozance PJ, Zerbe GO, Hutton JC, Hay WW Jr. Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. Endocrinology. 2006 Mar;147(3):1488-97. [PMID: 16339204]
  • Hay WW. Placental-fetal glucose exchange and fetal glucose metabolism. Trans Am Clin Climatol Assoc. 2006;117:321-40. [PMID: 18528484]
  • Regnault TR, Hay WW Jr. In vivo techniques for studying fetoplacental nutrient uptake, metabolism, and transport. Methods Mol Med. 2006;122:207-24. [PMID: 16511983]
  • Rozance PJ, Hay WW Jr. Hypoglycemia in newborn infants: Features associated with adverse outcomes. Biol Neonate. 2006;90(2):74-86. [PMID: 16534190]
  • Thureen PJ, Hay, WW, Jr, editors. Neonatal nutrition and metabolism. 2nd ed. Cambridge: Cambridge University Press; 2006.
  • Hay WW Jr. Intravenous nutrition of the very preterm neonate. Acta Paediatr Suppl. 2005 Oct;94(449):47-56. [PMID: 16214766]
  • Hay WW Jr. Nutritional requirements of the very preterm infant. Acta Paediatr Suppl. 2005 Oct;94(449):37-46. [PMID: 16214765]
  • Wooding FB, Fowden AL, Bell AW, Ehrhardt RA, Limesand SW, Hay WW. Localisation of glucose transport in the ruminant placenta: implications for sequential use of transporter isoforms. Placenta. 2005 Sep-Oct;26(8-9):626-40. [PMID: 16085042]
  • Limesand SW, Jensen J, Hutton JC, Hay WW Jr. Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1297-305. [PMID: 15650129]
  • Magness RR, Reynolds LP, Hay WW. Endothelium focus issue: molecular and cellular signaling in the perinatal cardiovascular system. Endothelium. 2005 Jan-Apr;12(1-2):3-4. [PMID: 16036311]
  • Regnault TR, Friedman JE, Wilkening RB, Anthony RV, Hay WW Jr. Fetoplacental transport and utilization of amino acids in IUGR--a review. Placenta. 2005 Apr;26 Suppl A:S52-62. [PMID: 15837069]
  • Anderson MS, Thamotharan M, Kao D, Devaskar SU, Qiao L, Friedman JE, Hay WW Jr. Effects of acute hyperinsulinemia on insulin signal transduction and glucose transporters in ovine fetal skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R473-81. [PMID: 15539611]
  • Anderson S, Hay WW Jr. Intrauterine growth restriction and the small-for-gestational-age infant. In: MacDonald MG, Seshia MMK, Mullett MD, editors. Neonatology: pathophysiology and management of the newborn. 6th ed. Philadelphia: Pennsylvania: Lippincott-Williams & Wilkins; 2005.
  • Hay WW Jr. Growth and development: physiological aspects. In: Allen L, Prentice A, Caballero B, editors. Encyclopedia of human nutrition. 2nd ed. Oxford, UK: Academic Press; 2005.
  • Hay WW Jr., Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 17th ed. New York: McGraw-Hill; 2005.
  • Regnault TRH, Friedman J, Wilkening RB, Anthony RV, Hay WW Jr. A review: fetoplacental transport and utilization of amino acids in FGR. Placenta. Trophoblast Res. 2005;19:S53-S62. www.womenshealth-elsevier.com/doc/journals/pdf/TR11_2005.pdf
  • Wallace JM, Regnault TR, Limesand SW, Hay WW Jr., Anthony RV. Investigating the causes of low birth weight in contrasting ovine paradigms. J Physiol. 2005 May 15;565(Pt 1):19-26. Review. [PMID: 15774527]