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Nicholas K. Foreman, MD ChB

Professor of Pediatrics


Nicholas K. Foreman, MD ChB

Tanner Seebaum and Zachary Tschetter Chair in Neuro-Oncology
Director, Pediatric Neuro-Oncology Program

Contact
   Phone: 720-777-1234 (TBD)
   E-mail: (TBD)

Affiliations
Section of Hematology, Oncology and BMT, Department of Pediatrics
Children's Hospital Colorado

Certifications
Pediatrics, Pediatric Hematology-Oncology

Nicholas K. Foreman, MB ChB, received his medical degree from the University of Sheffield, England, in 1981. He completed his Residency in Pediatrics at the University of Sheffield in 1985 and a Fellowship in Pediatrics/Pediatric Oncology from Bristol University in 1987. He also completed a Fellowship in Pediatric Hematology-Oncology in 1992 at St. Jude Children’s Research Hospital in Memphis.

Dr. Foreman joined the faculty of the Department of Pediatrics at the University of Colorado School of Medicine and Children’s Hospital Colorado in 1995. He has held the Tanner Seebaum and Zachary Tschetter Chair in Neuro-Oncology since 2001. Dr. Foreman is a Professor of Pediatrics at the University of Colorado School of Medicine and Director of the Neuro-Oncology Program at Children’s Hospital Colorado.

Dr. Foreman directs an active clinical and laboratory research program focused on pediatric brain tumors. Major components of his research program include clinical trials for children with relapsed and refractory brain tumors and lab studies of the genetics of pediatric glial tumors that are designed to help develop new therapies. He is the recipient of many grants for his research.

Dr. Foreman's major scientific interests include:

    • Neuro-Oncology
    • Ependymoma:
      • therapy development
      • prognostic markers
    • Role of second look neuro-surgery
    • Protocol development for infants with brain tumors
    • High-dose therapy with peripheral stem cell rescue for resistant brain tumors
    • Gene therapy for cancer. Cytokine insertion in glioblastoma
    • Expression of cell adhesion molecules and their manipulation in glioblastoma and neuroblastoma
    • Quality of life after therapy for pediatric brain tumors

Dr. Foreman is a reviewer for many professional medical journals and a prolific author of both journal articles and book chapters. He is a much-requested speaker at national conferences and symposia. Dr. Foreman is a member of many professional committees, and he is Co-Chair of the Children’s Oncology Group Ependymoma Sub-Committee.

  • Tanner Seebaum and Zachary Tschetter Chair in Neuro-Oncology, 2001-present

Publications in PubMed (partial list)

  •  Maloney K, Greffe BS, Foreman NK, Graham DK, Giller RH, Quinones RR, Keating AK. Neoplastic disease. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 19th ed. New York: McGraw Hill; 2009.
  • Donson AM, Erwin NS, Kleinschmidt-DeMasters BK, Madden JR, Addo-Yobo SO, Foreman NK. Unique molecular characteristics of radiation-induced glioblastoma. J Neuropathol Exp Neurol. 2007 Aug;66(8):740-9. [PMID: 17882018]
  • Donson AM, Addo-Yobo SO, Handler MH, Gore L, Foreman NK. MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma. Pediatr Blood Cancer. 2007 Apr;48(4):403-7. [PMID: 16609952]
  • Komakula ST, Fenton LZ, Kleinschmidt-DeMasters BK, Foreman NK. Pilomyxoid astrocytoma: neuroimaging with clinicopathologic correlates in 4 cases followed over time. J Pediatr Hematol Oncol. 2007 Jul;29(7):465-70. [PMID: 17609624]
  • Kleinschmidt-DeMasters BK, Lovell MA, Donson AM, Wilkinson CC, Madden JR, Addo-Yobo SO, Lillehei KO, Foreman NK. Molecular array analyses of 51 pediatric tumors shows overlap between malignant intracranial ectomesenchymoma and MPNST but not medulloblastoma or atypical teratoid rhabdoid tumor. Acta Neuropathol. 2007 Jun;113(6):695-703. [PMID: 17431644]
  • Maloney K, Greffe BS, Foreman NK, Porter CC, Graham DK, Sawczyn K, Giller RH, Quinones RR, Keating AK. Neoplastic diseases. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 18th ed. New York: McGraw-Hill; 2007.
  • Addo-Yobo SO, Straessle J, Anwar A, Donson AM, Kleinschmidt-Demasters BK, Foreman NK. Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma. J Neuropathol Exp Neurol. 2006 Aug;65(8):769-75. [PMID: 16896310]
  • Foreman NK, Gore L, Wells D, Straessle J, Heideman R, Donson AM. Gefitinib is effective against juvenile pilocytic astrocytoma in vitro. Pediatr Blood Cancer. 2006 Sep;47(3):293-8. [PMID: 16206208]
  • Korones DN, Smith A, Foreman N, Bouffet E. Temozolomide and oral VP-16 for children and young adults with recurrent or treatment-induced malignant gliomas. Pediatr Blood Cancer. 2006 Jul;47(1):37-41. [PMID: 16047359]
  • Sidhu RS, Orsini E Jr, Giller R, Quinones R, Foreman NK, Thompson H, Brimhall B, Walton K, Croskell M, Le TN. Midpoint CD34 measurement as a predictor of PBPC product yield in pediatric patients undergoing high-dose chemotherapy. J Clin Apher. 2006 Oct;21(3):165-8. [PMID: 16425193]
  • Sowar K, Straessle J, Donson AM, Handler M, Foreman NK. Predicting which children are at risk for ependymoma relapse. J Neurooncol. 2006 May;78(1):41-6. [PMID: 16575538]
  • Sawczyn KK, Quinones R, Malcolm J, Foreman N, Garrington T, Gore L, Gao D, Giller R. Cord blood transplant in childhood ALL. Pediatr Blood Cancer. 2005 Dec;45(7):964-70. [PubMed]
  • Foreman NK, Gore L, Wells D, Straessle J, Heideman R, Donson AM. Gefitinib is effective against juvenile pilocytic astrocytoma in vitro. Pediatr Blood Cancer. 2005 Oct 3; [Epub ahead of print] [PubMed]
  • Krutilkova V, Trkova M, Fleitz J, Gregor V, Novotna K, Krepelova A, Sumerauer D, Kodet R, Siruckova S, Plevova P, Bendova S, Hedvicakova P, Foreman NK, Sedlacek Z. Identification of five new families strengthens the link between childhood choroid plexus carcinoma and germline TP53 mutations. Eur J Cancer. 2005 Jul;41(11):1597-603. [PubMed]
  • Foreman NK, Schissel D, Le T, Strain J, Fleitz J, Quinones R, Giller R. A study of sequential high dose cyclophosphamide and high dose carboplatin with peripheral stem-cell rescue in resistant or recurrent pediatric brain tumors. J Neurooncol. 2005 Jan;71(2):181-7. [PubMed]