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Amy R. Brooks-Kayal, MD

Professor of Pediatrics and Neurology


Amy Brooks-Kayal, MD

Section Head, Child Neurology
Chief and Ponzio Family Chair in Pediatric Neurology

Contact
   Phone: 720-777-1234 (TBD)
   E-mail: (TBD)

Affiliations
Section of Child Neurology, Department of Pediatrics
Brooks-Kayal Lab (.pdf)
Children's Hospital Colorado

Certifications
Pediatrics, Neurology with Special Qualification in Child Neurology, Clinical Neurophysiology

 

Medical Degree

  • Johns Hopkins University

Residency

  • Pediatrics, Children's Hospital of Philadelphia, 1991
  • Child Neurology, Hospital of the University of Pennsylvania and Children's Hospital of Philadelphia, 1995

Fellowships

  • Charles A. Dana Fellow in Neuroscience, Institute of Neuroscience

Dr. Brooks-Kayal is the Chief and Ponzio Family Chair of Pediatric Neurology at Children's Hospital Colorado, Professor of Pediatrics and Neurology and Co-Director of the Translational Epilepsy Research Program at the University of Colorado School of Medicine. She is interested in the development of new treatments for epilepsy. Dr. Brooks-Kayal’s research focuses on understanding the molecular and cellular mechanisms that result in development of epilepsy in order to develop new ways to prevent and treat this disorder. Her lab has identified changes in inhibitory neurotransmission, specifically GABA(A) receptor subunit expression, that may play a critical role in epilepsy development. Most recently, they have identified molecular signaling pathways, including BDNF and the CREB and JaK/STAT pathways, that regulate these receptor changes and shown that modulating these pathways can prevent these changes and inhibit epilepsy development. Her lab also studies the effects of early-life seizure activity and seizure treatment on brain development.  Learn more>>

  • Who’s Who in America, 2009-present
  • Best Doctors in America, 2009-present
  • Member, American Neurological Association, 2006-present
  • Member, SPR, 2000-present
  • National Research Council, Epilepsy Foundation, 1999-present
  • Member, Clinical Neuroplasticity and Neurotransmitters Study Section, NINDS, 2010-2016
  • Vice Chair, Merritt-Putnam Symposium, American Epilepsy Society, 2011-2014
  • Executive Committee, American Neurological Association, 2010-2012
  • U.S. News & World Report Top Doctor, 2011
  • Member, NIH Clinical Neuroplasticity and Neurotransmitters Study Section, 2010
  • Member, Disease Modification and Antepileptogensiss (AEG): Alignment of Clinical Targets and Criteria for Preclinical Studies Workshop, National Institute of Neurological Disorders and Stroke (NINDS), 2010
  • Board of Directors, American Epilepsy Society, 2007-2010
  • Member, Scientific Advisory Board, National EpiFellows Foundation, 2004-2010
  • NIH Eplipsy Benchmark Steward, 2007
  • American Academy of Neurology Leadership Development Program, 2007
  • Brooks-Kayal A: Alteration of Epileptogenesis Genes, Neurotherapeutics, 6(2):312-318, 2009.
  • Marsh E, Fulp C, Gomez E, Nasrallah I, Minarak J, Sudi J, Christian SL, Manani G, Labosky P, Dobyns W, Brooks-Kayal A, Golden JA: Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human carrier phenotype. Brain, 132:1563-76, 2009.
  • Raol YSH, Lapides DA, Keating J, Brooks-Kayal AR, Cooper EC: A KCNQ channel opener for neonatal seizures and status epilepticus, Ann Neurol, 65(3):326-336, 2009
  • Lund IV, Hu Y, Raol YSH, Benham RS, Faris R, Russek SJ, Brooks-Kayal AR: BDNF selectively regulates GABA-A receptor transcription by activation of the JAK/STAT pathway, Science Signaling, 1([1]41ra9), 2008. NIHMS 95677.
  • Lund IV, Hu Y, Raol YSH, Benham RS, Faris R, Russek SJ, Brooks-Kayal AR: BDNF selectively regulates GABA-A receptor transcription by activation of the JAK/STAT pathway, Science Signaling, 1([1]41ra9), 2008. NIHMS 95677.
  • Hu Y, Lund IV, Gravielle M, Farb DH, Brooks-Kayal AR, Russek SJ: Surface Expression of GABA-A Receptors is transcriptionally controlled by the interplay of CREB and its Binding Partner ICER. J. Biol Chem, 283(14):9328-9340, 2008.
  • Marsh ED, Minarcik J, Campbell K, Brooks-Kayal AR, Golden JA: FACS-array gene expression analysis during early development of mouse telencephalic interneurons. Dev Neurobiol. 68(4):434-45, 2008.
  • Roberts DS, Hu Y, Lund IV, Brooks-Kayal AR, Russek SJ: BDNF-induced synthesis of early growth response factor 3 (EGR3) controls the levels of type-A GABA receptor alpha 4 subunits in hippocampal neurons. J Biol Chem 281(40): 29431, 2006.
  • Raol YSH, Zhang G, Lund I, Porter B, Maronski M and Brooks-Kayal AR: Increased GABA (A) receptor alpha 1 subunit expression in hippocampal dentate gyrus after early-life status epilepticus. Epilepsia 47(10): 1665-1673, 2006.
  • Raol YSH, Lund I, Porter B, Bandyopadhyay S, Zhang G, Roberts D, Wolfe JW, Russek SJ and Brooks-Kayal AR: Enhancing GABA (A) receptor alpha 1 in hippocampal dentate gyrus inhibits epilepsy development in an animal model of TLE. J Neurosci Vol. 26: 11342-11346, 2006.
  • Porter B, Cui X, and Brooks-Kayal AR: Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons. Eur J. Neurosci 23(11): 2857-63, 2006.
  • Frye C, Rhodes M, Raol YSH, Brooks-Kayal AR: Early postnatal stimulation alters pregnane neurosteroids in the Hippocampus. Psychopharmacology 186(3): 343-50, 2006