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Amy R. Brooks-Kayal, MD

Professor of Pediatrics and Neurology

Amy Brooks-Kayal, MD

Section Head, Child Neurology
Chief and Ponzio Family Chair in Pediatric Neurology

   Phone: 720-777-1234 (TBD)
   E-mail: (TBD)

Section of Child Neurology, Department of Pediatrics
Brooks-Kayal Lab (.pdf)
Children's Hospital Colorado

Pediatrics, Neurology with Special Qualification in Child Neurology, Clinical Neurophysiology

Medical Degree

  • Johns Hopkins University


  • Pediatrics, Children's Hospital of Philadelphia, 1991
  • Child Neurology, Hospital of the University of Pennsylvania and Children's Hospital of Philadelphia, 1995


  • Charles A. Dana Fellow in Neuroscience, Institute of Neuroscience

Dr. Brooks-Kayal is the Chief and Ponzio Family Chair of Pediatric Neurology at Children's Hospital Colorado, Professor of Pediatrics and Neurology and Co-Director of the Translational Epilepsy Research Program at the University of Colorado School of Medicine. She is interested in the development of new treatments for epilepsy. Dr. Brooks-Kayal’s research focuses on understanding the molecular and cellular mechanisms that result in development of epilepsy in order to develop new ways to prevent and treat this disorder. Her lab has identified changes in inhibitory neurotransmission, specifically GABA(A) receptor subunit expression, that may play a critical role in epilepsy development. Most recently, they have identified molecular signaling pathways, including BDNF and the CREB and JaK/STAT pathways, that regulate these receptor changes and shown that modulating these pathways can prevent these changes and inhibit epilepsy development. Her lab also studies the effects of early-life seizure activity and seizure treatment on brain development.  Learn more>>

  • Fellow, American Neurological Association, 2013-present
  • Who’s Who in America, 2009-present
  • Best Doctors in America, 2009-present
  • Member, American Neurological Association, 2006-present
  • Member, Clinical Neuroplasticity and Neurotransmitters Study Section, NINDS, 2010-2016
  • Chair, Center without Walls Special Emphasis Panel, NINDS, 2014
  • 1st Vice-President, American Epilepsy Society, 2013-2014
  • Chair, Clinical Neuroplasticity and Neurotransmission NIH Review Panel, 2013-2014
  • U.S. News & World Report Top Doctor, 2013-2014
  • Chair, Merritt-Putnam Symposium, American Epilepsy Society, 2012-2014
  • 2nd Vice-President, American Epilepsy Society, 2012-2013
  • Member, American Neurological Association Executive Committee, 2010-2013
  • Member, SPR, 2000-2012
  • National Research Council, Epilepsy Foundation, 1999-2012
  • Councilor, Professors of Child Neurology, 2011
  • Vice Chair, Merritt-Putnam Symposium, American Epilepsy Society, 2011
  • Member, Disease Modification and Antepileptogensiss (AEG): Alignment of Clinical Targets and Criteria for Preclinical Studies Workshop, National Institute of Neurological Disorders and Stroke (NINDS), 2010
  • Board of Directors, American Epilepsy Society, 2007-2010
  • Member, Scientific Advisory Board, National EpiFellows Foundation, 2004-2010
  • NIH Eplipsy Benchmark Steward, 2007
  • American Academy of Neurology Leadership Development Program, 2007
  • Thomas AX, Brooks-Kayal AR. Excitation-inhibition epilepsies. In: Rubestein J, Rakic P, editors. Comprehensive developmental neuroscience: neural circuit development and function in the brain. San Diego: Academic Press/Elsevier: 2013.
  • Brooks-Kayal AR, Russek, SJ. Regulation of GABA(A) receptor gene expression and epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's basic mechanisms of the epilepsies. 4th ed. New York: Oxford University Press, Inc.; 2012.
  • Chapman KE, Raol YH, Brooks-Kayal A. Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette. Eur J Neurosci. 2012 Jun;35(12):1857-65. [PMID: 22708596]
  • Galanopoulou AS, Buckmaster PS, Staley KJ, Moshe SL, Perucca E, Engel J Jr, Loscher W, Noebels JL, Pitkanen A, Stables J, White HS, O'Brien TJ, Simonato M, American Epilepsy Society Basic Science Committee And The International League Against Epilepsy Working Group On Recommendations For Preclinical Epilepsy Drug Discovery (Brooks_Kayal AR). Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia. 2012 Mar;53(3):571-82. [PMID: 22292566]
  • Grabenstatter HL, Russek SJ, Brooks-Kayal AR. Molecular pathways controlling inhibitory receptor expression. Epilepsia. 2012 Dec;53 Suppl 9:71-8. [PMID: 23216580]
  • Kim JH, Roberts DS, Hu Y, Lau GC, Brooks-Kayal AR, Farb DH, Russek SJ. Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons. J Neurochem. 2012 Jan;120(2):210-9. [PMID: 22035109]
  • Knupp K, Parsons JA, Brooks-Kayal AR. Channelopathies. In: Swaiman KF, Ashwal S, Ferriero DM, Schor NF, editors. Swaiman's pediatric neurology: principles and practice. 5th ed. Edinburgh: Elsevier Saunders; 2012.
  • Raible DJ, Frey LC, Cruz Del Angel Y, Russek SJ, Brooks-Kayal AR. GABA(A) receptor regulation after experimental traumatic brain injury. J Neurotrauma. 2012 Nov 1 ;29(16):2548-54. [PMID: 22827467]
  • Raol YH, Brooks-Kayal AR. Experimental models of seizures and epilepsies. Prog Mol Biol Transl Sci. 2012;105:57-82. [PMID: 22137429]
  • Baram TZ, Jensen FE, Brooks-Kayal A. Does acquired epileptogenesis in the immature brain require neuronal death. Epilepsy Curr. 2011 Jan;11(1):21-6. [PMID: 21461261]
  • Brooks-Kayal A. Molecular mechanisms of cognitive and behavioral comorbidities of epilepsy in children. Epilepsia. 2011 Jan;52 Suppl 1:13-20. [PMID: 21214535]
  • Gonzalez MI, Brooks-Kayal A. Altered GABA(A) receptor expression during epileptogenesis. Neurosci Lett. 2011 Jun 27;497(3):218-22. [PMID: 21376781]
  • Kedia S, Stroud B, Parsons J, Schreiner T, Curtis DJ, Bagdure D, Brooks-Kayal AR, Glode MP, Dominguez SR. Pediatric neurological complications of 2009 pandemic influenza A (H1N1). Arch Neurol. 2011 Apr;68(4):455-62. [PMID: 21149805]
  • Lemos JC, Zhang G, Walsh T, Kirby LG, Akanwa A, Brooks-Kayal A, Beck SG. Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses. Neuropsychopharmacology. 2011 Mar;36(4):721-34. [PMID: 21160465]
  • Brooks-Kayal A. Epilepsy and autism spectrum disorders: are there common developmental mechanisms? Brain Dev. 2010 Oct;32(9):731-8. [PMID: 20570072]
  • Brooks-Kayal AR, Raol YH, Russek SJ. Alteration of epileptogenesis genes. Neurotherapeutics. 2009 Apr;6(2):312-8. [PMID: 19332325]
  • Jacobs MP, Leblanc GG, Brooks-Kayal A, Jensen FE, Lowenstein DH, Noebels JL, Spencer DD, Swann JW. Curing epilepsy: progress and future directions. Epilepsy Behav. 2009 Mar;14(3):438-45. [PMID: 19341977]
  • Marsh ED, Brooks-Kayal AR. Effects of early life seizures and anti-epileptic drug treatment on human brain development in human models. In: Janigro D, editor. Mammalian brain development. New York: Humana Press; 2009. p. 41-52.
  • Marsh E, Fulp C, Gomez E, Nasrallah I, Minarcik J, Sudi J, Christian SL, Mancini G, Labosky P, Dobyns W, Brooks-Kayal A, Golden JA. Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Brain. 2009 Jun;132(Pt 6):1563-76. [PMID: 19439424]
  • Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol. 2009 Mar;65(3):326-36. [PMID: 19334075]
  • Lund IV, Hu Y, Raol YSH, Benham RS, Faris R, Russek SJ, Brooks-Kayal AR: BDNF selectively regulates GABA-A receptor transcription by activation of the JAK/STAT pathway, Science Signaling, 1([1]41ra9), 2008. NIHMS 95677.
  • Lund IV, Hu Y, Raol YSH, Benham RS, Faris R, Russek SJ, Brooks-Kayal AR: BDNF selectively regulates GABA-A receptor transcription by activation of the JAK/STAT pathway, Science Signaling, 1([1]41ra9), 2008. NIHMS 95677.
  • Hu Y, Lund IV, Gravielle M, Farb DH, Brooks-Kayal AR, Russek SJ: Surface Expression of GABA-A Receptors is transcriptionally controlled by the interplay of CREB and its Binding Partner ICER. J. Biol Chem, 283(14):9328-9340, 2008.
  • Marsh ED, Minarcik J, Campbell K, Brooks-Kayal AR, Golden JA: FACS-array gene expression analysis during early development of mouse telencephalic interneurons. Dev Neurobiol. 68(4):434-45, 2008.
  • Roberts DS, Hu Y, Lund IV, Brooks-Kayal AR, Russek SJ: BDNF-induced synthesis of early growth response factor 3 (EGR3) controls the levels of type-A GABA receptor alpha 4 subunits in hippocampal neurons. J Biol Chem 281(40): 29431, 2006.
  • Raol YSH, Zhang G, Lund I, Porter B, Maronski M and Brooks-Kayal AR: Increased GABA (A) receptor alpha 1 subunit expression in hippocampal dentate gyrus after early-life status epilepticus. Epilepsia 47(10): 1665-1673, 2006.
  • Raol YSH, Lund I, Porter B, Bandyopadhyay S, Zhang G, Roberts D, Wolfe JW, Russek SJ and Brooks-Kayal AR: Enhancing GABA (A) receptor alpha 1 in hippocampal dentate gyrus inhibits epilepsy development in an animal model of TLE. J Neurosci Vol. 26: 11342-11346, 2006.
  • Porter B, Cui X, and Brooks-Kayal AR: Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons. Eur J. Neurosci 23(11): 2857-63, 2006.
  • Frye C, Rhodes M, Raol YSH, Brooks-Kayal AR: Early postnatal stimulation alters pregnane neurosteroids in the Hippocampus. Psychopharmacology 186(3): 343-50, 2006