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Frank J. Accurso, MD

Professor of Pediatrics and Physiology and Biophysics
 

Section Head, Pulmonology
Research Director, Cystic Fibrosis Center
Asher Family Chair for Cystic Fibrosis
Medical Director, Core Laboratory, Children's Hospital Colorado Clinical Translational Research Center
Professor of Epidemiology, Colorado School of Public Health

Contact
   Phone: 720-777-1234 (TBD)
   E-mail: (TBD)

Affiliations
Section of Pulmonology, Department of Pediatrics
Clinical & Translational Research Center
Children's Hospital Colorado

Certifications
Pediatrics, Pediatric Pulmonology, Pediatric Critical Care Medicine

Frank J. Accurso, MD, received his medical degree from Albert Einstein College of Medicine in New York in 1974. His residency in Pediatrics and fellowship in Pediatric Pulmonology were completed at the University of Colorado School of Medicine in 1977 and 1980, respectively. Dr. Accurso joined the faculty of the Departments of Pediatrics at the University of Colorado School of Medicine and Children’s Hospital Colorado in 1979. He has served as Director of the Cystic Fibrosis Center since 1987 and Section Head of Pulmonology since 2003.

Dr. Accurso is internationally known for his work with newborn screening and the description of early lung disease in infants with cystic fibrosis. He has been acclaimed as one of the top clinical researchers and care providers by the Cystic Fibrosis Foundation. Following the selection of the University of Colorado as one of the Cystic Fibrosis Foundation's Therapeutics Development Centers, he has been increasingly active in the development and study of new therapies and techniques for outcomes research. Dr. Accurso’s research is supported by the NIH and the Cystic Fibrosis. He is also a consultant or Advisory Board member for many corporations.

Dr. Accurso has been honored with many awards for his work. He is a member of numerous committees, institutionally and nationwide, and is a sought-after reviewer for medical journals, as well as a widely published author.

  • Member, Board of Trustees, National Cystic Fibrosis Foundation, 2003-present
  • 5280 Magazine’s Top Doctors in Denver, 2005-2009
  • Who’s Who in America, 2009
  • Best Doctors in America, 2009
  • Breath of Life Award, Denver Chapter, Cystic Fibrosis Foundation, 2008
  • Castle Connolly's Top Doctors, 2008
  • Editorial Board Member, Advances in Pediatrics, 2004-2007
  • Career Teaching Scholar Award, Department of Pediatrics, UCSOM, 2006
  • Deputy Editor, American Journal of Respiratory and Critical Care Medicine, 2004-2006
  • Outstanding Research Mentor Award, Clinical Science Program, University of Colorado Denver, 2004
  • Paul di Sant'Agnese Award for Scientific Achievement in Cystic Fibrosis, National Cystic Fibrosis Foundation, 2003
  • Outstanding Affiliated/Clinical Faculty Award, Department of Biometrics and Preventive Medicine, University of Colorado, 2003

Publications in PubMed

  • Siparksy G, Accurso FJ. Pediatric laboratory medicine and reference ranges. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 19th ed. New York: McGraw Hill; 2009.
  • Saavedra MT, Hughes GJ, Sanders LA, Carr M, Rodman DM, Coldren CD, Geraci MW, Sagel SD, Accurso FJ, West J, Nick JA. Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease. Am J Respir Crit Care Med. 2008 Nov;178(9):929-38. [PMID: 18723435]
  • Laguna TA, Wagner B, Kaess H, Mann S, Accurso FJ. Urinary and sputum desmosine levels during pulmonary exacerbation in cystic fibrosis. 22nd North American Cystic Fibrosis Conference; 2008 Oct 23-25; Orlando, FL. Pediatr Pulmonol Suppl. 43:S31:378; 2008.
  • Laguna TA, Wagner BD, Accurso FJ. The applicability of urinary creatinine as a method of specimen nomalization in the cystic fibrosis population. 22nd North American Cystic Fibrosis Conference; 2008 Oct 23-25; Orlando, FL. Pediatr Pulmonol Suppl. 43:S31:378; 2008.
  • Laguna TA, Sagel SD, Sontag MK, Accurso FJ. The clinical course of a Mexican female with cystic fibrosis and the novel genotype S531P/S531P. J Cyst Fibros. 2008 Sep;7(5):454-6. [PMID: 18463004]
  • Laguna TA, Sontag MK, Osberg I, Wagener JS, Accurso FJ, Sokol RJ. Decreased total serum coenzyme-Q10 concentrations: a longitudinal study in children with cystic fibrosis. J Pediatr. 2008 Sep;153(3):402-7. [PMID: 18534204]
  • Farrell PM, Rosenstein BJ, White TB, Accurso FJ, Castellani C, Cutting GR, Durie PR, Legrys VA, Massie J, Parad RB, Rock MJ, Campbell PW 3rd. Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report. J Pediatr. 2008 Aug;153(2):S4-S14. [PMID: 18639722]
  • Gerszten RE, Accurso F, Bernard GR, Caprioli RM, Klee EW, Klee GG, Kullo I, Laguna TA, Roth FP, Sabatine M, Srinivas P, Wang TJ, Ware LB. Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs. Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L16-22. [PMID: 18456800]
  • Accurso FJ. Update in cystic fibrosis 2007. Am J Respir Crit Care Med. 2008 May;177(10):1058-61. [PMID: 18460460]
  • Cooley J, McDonald B, Accurso FJ, Crouch EC, Remold-O'Donnell E. Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease. J Leukoc Biol. 2008 Apr;83(4):946-55. [PMID: 18211966]
  • Accurso FJ, Sontag MK. Gene modifiers in cystic fibrosis. J Clin Invest. 2008 Mar;118(3):839-41. [PMID: 18292812]
  • Papas KA, Sontag MK, Pardee C, Sokol RJ, Sagel SD, Accurso FJ, Wagener JS. A pilot study on the safety and efficacy of a novel antioxidant rich formulation in patients with cystic fibrosis. J Cyst Fibros. 2008 Jan;7(1):60-7. [PMID: 17569601]
  • Accurso FJ, Rowe SM, Durie PR, Konstan MW, Dunitz J, Hornick DB, Sagel SD, Boyle MP, Uluer AZ, Upadhyay D, Ramsey BW, Freedman SD, Dong Q, Ahmad AM, Stone AJ, Olson ER, Ordonez CL, Clancy JP, Campbell PW, Ashlock MA. Interim results of phase 2A study of VX-770 to evaluate safety, pharmacokinetics, and biomarkers of CFTR activity in cystic fibrosis subjects with G551D. Pediatr Pulmonol Suppl. 2008;31:295.
  • Harris JK, Zemanick ET, Wagner BD, Sagel SD, Accurso F. Large scale multiplex sequencing for ribosomal RNA metagenomics from cystic fibrosis airway samples. Pediatr Pulmonol Suppl. 2008;31:323.
  • Konstan MW, Strausbaugh SD, Ahrens RC, Accurso FJ, Graff GR, Nasr SZ. A randomized, double-blind, placebo-controlled, multicenter, cross-over study to evaluate the effectiveness and safety of a novel pancrelipase (Pacrecarb MS-16) in reducing steatorrhea in children and adults with cystic fibrosis. Pediatr Pulmonol Suppl. 2008;31:425.
  • Lingard C, Sontag MK, Fordyce J, Wagener JS, Accurso FJ, Sokol R. Children with CF and meconium ileus are at higher risk for vitamin D deficiency compared to those diagnosed by newborn screening. Pediatr Pulmonol Suppl. 2008;31:429.
  • Milla C, Chmiel J, McCoy KS, Accurso FJ, Billings J, Boyle MP, Atkinson J, Liou T, Clancy JP, Pilewski J, Acton J, Pearce T. A phase ½ randomized, double-blind, placebo-controlled, single-dose, dose escalation study of KB001 in cystic fibrosis patients infected with Pseudomonas Aeruginosa. Pediatr Pulmonol Suppl. 2008;31:341.
  • Nick JA, Chacon C, Brayshaw S, Jones M, Barboa C, Young RL, Janssen JF, Gleeksman C, Huitt GA, Iseman MD, Daley CL, Accurso F, Saavedra MT, Sontag MK. Diagnosis, patterns of care, and long-term survival in nonclassic cystic fibrosis. Pediatr Pulmonol Suppl. 2008;31:402.
  • Saavedra MR, Hughes G, Sanders L, Carr M, Rodman D, Coldren C, Geraci M, Sagel SD, Accurso FJ, West J, Nick JA. Novel markers for clinical trials; circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease. Pediatr Pulmonol Suppl. 2008;31:316.
  • Sontag MK, Hughes-Austin J, Accurso F. Relationship of CFTR mutation to longitunial clinical outcome in cystic fibrosis. Pediatr Pulmonol Suppl. 2008;31:400.
  • Sontag MK, Wagener JS, Accurso FJ, Sagel SD. Consistent incidence of cystic fibrosis in a long-term newborn screen population. Pediatr Pulmonol Suppl. 2008;31:272.
  • Van Goor F, Hadida S, Negulescu P, Clancy JP, Accurso FJ, Ashlock MA, Ordonez C, Dong Q, Olson E, Grootenhuis P. Relationship of VX-770 activity on CFTR function in a cell culture system to the activity observed in a clinical study of VX-770. Pediatr Pulmonol Suppl. 2008;31:314.
  • Baker CD, Federico MJ, Accurso FJ. Case report: skin discoloration following administration of colloidal silver in cystic fibrosis. Curr Opin Pediatr. 2007 Dec;19(6):733-5. [PMID: 18025945]
  • Harris JK, De Groote MA, Sagel SD, Zemanick ET, Kapsner R, Penvari C, Kaess H, Deterding RR, Accurso FJ, Pace NR. Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis. Proc Natl Acad Sci USA. 2007 Dec;104(51):20529-33. [PMID: 18077362]
  • Moss RB, Milla C, Colombo J, Accurso F, Zeitlin PL, Clancy JP, Spencer LT, Pilewski J, Waltz DA, Dorkin HL, Ferkol T, Pian M, Ramsey B, Carter BJ, Martin DB, Heald AE. Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: a randomized placebo-controlled phase 2B trial. Hum Gene Ther. 2007 Aug;18(8):726-32. [PMID: 17685853]
  • Rowe SM, Accurso F, Clancy JP. Detection of cystic fibrosis transmembrane conductance regulator activity in early-phase clinical trials. Proc Am Thorac Soc. 2007 Aug;4(4):387-98. [PMID: 17652506]
  • Gibson RL, Emerson J, Mayer-Hamblett N, Burns JL, McNamara S, Accurso FJ, Konstan MW, Chatfield BA, Retsch-Bogart G, Waltz DA, Acton J, Zeitlin P, Hiatt P, Moss R, Williams J, Ramsey BW. Duration of treatment effect after tobramycin solution for inhalation in young children with cystic fibrosis. Pediatr Pulmonol. 2007 Jul;42(7):610-23. [PMID: 17534969]
  • Rancourt RC, Lee RL, O’Neill H, Accurso FJ, White CW. Reduced thioredoxin increases pro-inflammatory cytokines and neutrophil influx in rat airways: modulation by airway mucus. Free Radic Biol Med. 2007 May;42(9):1441-53. [PMID: 17395017]
  • Accurso FJ. Update in cystic fibrosis 2006. Am J Respir Crit Care Med. 2007 Apr;175(8):754-7. [PMID: 17405941]
  • Mayer-Hamblett N, Aitken ML, Accurso FJ, Kronmal RA, Konstan MW, Burns JL, Sagel SD, Ramsey BW. Association between pulmonary function and sputum biomarkers in cystic fibrosis. Am J Respir Crit Care Med. 2007 Apr;175(8):822-8. [PMID: 17234902]
  • Comeau AM, Accurso FJ, White TB, Campbell PW 3rd, Hoffman G, Parad RB, Wilfond BS, Rosenfeld M, Sontag MK, Massie J, Farrell PM, O'Sullivan BP. Guidelines for implementation of cystic fibrosis newborn screening programs: Cystic Fibrosis Foundation workshop report. Pediatr. 2007 Feb;119(2):e495-518. [PMID: 17272609]
  • Hunsucker SW, Accurso FJ, Duncan MW. Proteomics in pediatric research and practice. Adv Pediatr. 2007;54:9-28. [PMID: 17918464]
  • Kerby GS, Accurso FJ, Deterding RR, Balasubramaniam V, Sagel SD, Cavanaugh K. Respiratory tract and mediastinum. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 18th ed. New York: McGraw-Hill; 2007.
  • Siparsky G, Accurso FJ. Chemistry and hematology reference intervals. In: Hay WW Jr, Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 18th ed. New York: McGraw Hill; 2007.
  • Sontag MK, Corey M, Hokanson JE, Marshall JA, Sommer SS, Zerbe GO, Accurso FJ. Genetic and physiologic correlates of longitudinal immunoreactive trypsinogen decline in infants with cystic fibrosis identified through newborn screening. J Pediatr. 2006 Nov;149(5):650-7. [PMID: 17095337]
  • Kaye CI, Accurso F, La Franchi S, Lane PA, Hope N, Sonya P, G Bradley S, Michele A LP. Newborn screening fact sheets. Pediatrics. 2006 Sep;118(3):e934-63. [PMID: 16950973]
  • Kaye CI, Accurso F, La Franchi S, Lane PA, Northrup H, Pang S, Schaefer GB. Introduction to the newborn screening fact sheets. Pediatrics. 2006 Sep;118(3):1304-12. [PMID: 16960984]
  • Accurso FJ. Update in cystic fibrosis 2005. Am J Respir Crit Care Med. 2006 May;173(9):944-7. [PMID: 16632633]
  • Swiercz W, Cios KJ, Staley K, Kurgan L, Accurso F, Sagel S. A new synaptic plasticity rule for networks of spiking neurons. IEEE Trans Neural Netw. 2006 Jan;17(1):94-105. [PMID: 16526479]
  • Lee RL, Rancourt RC, del Val G, Pack K, Pardee C, Accurso FJ, White CW. Thioredoxin and dihydrolipoic acid inhibit elastase activity in cystic fibrosis sputum. Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L875-82. [PMID: 16214824]
  • Accurso FJ, Sontag MK, Wagener JS. Complications associated with symptomatic diagnosis in infants with cystic fibrosis. J Pediatr. 2005 Sep;147(3 Suppl):S37-41. [PMID: 16202780]
  • Sontag MK, Hammond KB, Zielenski J, Wagener JS, Accurso FJ. Two-tiered immunoreactive trypsinogen-based newborn screening for cystic fibrosis in Colorado: screening efficacy and diagnostic outcomes. J Pediatr. 2005 Sep;147(3 Suppl):S83-8. [PMID: 16202790]
  • Condino AA, Hoffenberg EJ, Accurso F, Penvari C, Anthony M, Gralla J, O'Connor JA. Frequency of ASCA seropositivity in children with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):23-6. [PMID: 15990625]
  • Bush A, Accurso F, Macnee W, Lazarus SC, Abraham E. Cystic fibrosis, pediatrics, control of breathing, pulmonary physiology and anatomy, and surfactant biology in AJRCCM in 2004. Am J Respir Crit Care Med. 2005 Mar 15;171(6):545-53. [PMID: 15753484]
  • Rodman DM, Polis JM, Heltshe SL, Sontag MK, Chacon C, Rodman RV, Brayshaw SJ, Huitt GA, Iseman MD, Saavedra MT, Taussig LM, Wagener JS, Accurso FJ, Nick JA. Late diagnosis defines a unique population of long-term survivors of cystic fibrosis. Am J Respir Crit Care Med. 2005 Mar 15;171(6):621-6. [PMID: 15591474]
  • Kerby GS, Larsen GL, Accurso FJ, Deterding RR, Balasubramaniam V, Sagel SD. Respiratory tract and mediastinum. In: Hay WW Jr., Levin MJ, Sondheimer JM, Deterding RR, editors. Current pediatric diagnosis and treatment. 17th ed. New York: McGraw-Hill; 2005.