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Steven H. Abman, MD

Professor of Pediatrics
 

Director, Pediatric Heart Lung Center

Contact
   Phone: 720-777-1234 (TBD)
   E-mail: (TBD)

Affiliations
Section of Pulmonology, Department of Pediatrics
Pediatric Heart Lung Center
Perinatal Research Center
Children's Hospital Colorado

Certifications
Pediatrics, Pediatric Pulmonology, Pediatric Critical Care Medicine

Steven H. Abman, MD, earned his medical degree from Northwestern University Medical School in Chicago, in 1979. He completed his Pediatric Residency at the University of Colorado School of Medicine in 1982 and was honored with the Bruce M. Garber Memorial Award for “Outstanding Resident” by the Department of Pediatrics. After serving as Chief Resident in Pediatrics, Dr. Abman completed his Fellowship in Pediatric Pulmonary and Critical Care Medicine at the University of Colorado School of Medicine Department of Pediatrics and The Children's Hospital and joined our faculty in 1986. He was appointed full Professor of Pediatrics with tenure in 1996, and he currently serves as the Director of the Pediatric Heart Lung Center. He established the clinical Pulmonary Hypertension Program and Ventilator Care Program at Children’s Hospital Colorado.

Dr. Abman is an internationally renowned investigator in a number of areas of pediatric pulmonology. He has made important contributions to vascular biology and growth and development of the lung through his basic investigations. In addition, he has led important clinical research studies in pediatric pulmonary hypertension, bronchopulmonary dysplasia, and other disorders. Dr. Abman’s pioneering work in the use of nitric oxide to treat infants and children with pulmonary hypertension resulted in his receiving the prestigious Excellence in Pediatric Research Award from the American Academy of Pediatrics. Dr. Abman’s research is supported by the NIH and other agencies.

Dr. Abman is the recipient of many awards. He serves as Associate Editor for the American Journal of Respiratory and Critical Care Medicine and was selected for the Editorial Boards of numerous other medical journals. He has served as a standing member of the NIH Heart Lung Blood Institute study sections and is an active reviewer for research grants. Dr. Abman has published more than 300 manuscripts in medical journals and books. He is a popular invited speaker and guest professor both nationally and internationally. He is active in training and mentoring numerous students, residents, postdoctoral fellows, visiting scientists and faculty through his work in the Pediatric Heart Lung Center.

  • Associate Editor, American Journal of Respiratory and Critical Care Medicine, 2006-present
  • Invited Speaker, Resident Research Day, Children's Hospital Colorado, 2011
  • William H. Tooley Professor Lectureship, Division of Neonatology and Cardiovascular Research Institute, University of California San Francisco, California, 2010
  • First Annual Maddie Morgan - Butterflies for Maddie Pulmonology Lectureship, University of Louisville, Kentucky, 2010
  • Frank Sterner Lectureship, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, 2010
  • David Schiff Memorial Lectureship, Department of Pediatrics, University of Alberta, Edmonton, Canada, 2008
  • Nils W. Svenningsen Memorial Lecture, 22nd International Workshop on Surfactant Replacement, Ancona, Italy, 2007
  • International Fellow, Pulmonary Vascular Research Institute, 2007
  • International Task Force, 4th World Symposium on Pulmonary Hypertension, 2007
  • Jerry Elliot Memorial Lecture, 27th Annual Western Conference on Perinatal Research, Rancho Mirage, California, 2006
  • Best Doctors in America, 2001-2003
  • James E. Strain Award in Pediatrics, The Children's Hospital Medical Staff, 2003

Publications in Pubmed (partial list)

  • Gien J, Seedorf GJ, Balasubramaniam V, Tseng N, Markham NE, Abman SH. Chronic intrauterine pulmonary hypertension increases endothelial cell rho-kinase activity and impairs angiogenesis in vitro. Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L680-7. [PMID: 18621906]
  • Tourneux P, Chester MA, Grover TR, Abman S. Fasudil inhibits the myogenic response in the fetal pulmonary circulation. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1505-13. [PMID: 18676688]
  • Abman SH, Mourani PM, Sontag M. Bronchopulmonary dysplasia: a genetic disease. Pediatrics. 2008 Sep;122(3):658-9. [PMID: 18762536]
  • Abman SH. The dysmorphic pulmonary circulation in bronchopulmonary dysplasia: a growing story. Am J Respir Crit Care Med. 2008 Jul;178(2):114-5. [PMID: 18594120]
  • Mourani PM, Ivy DD, Rosenberg AA, Fagan TE, Abman SH. Left ventricular diastolic dysfunction in bronchopulmonary dysplasia. J Pediatr. 2008 Feb;152(2):291-3. [PMID: 18206706]
  • Mourani PM, Sontag MK, Younoszai A, Ivy DD, Abman SH. Clinical utility of echocardiography for the diagnosis and management of pulmonary vascular disease in young children with chronic lung disease. Pediatrics. 2008 Feb;121(2):317-25. [PMID: 18245423]
  • Ivy DD, Doran AK, Smith KJ, Mallory GB Jr, Beghetti M, Barst RJ, Brady D, Law Y, Parker D, Claussen L, Abman SH. Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension. J Am Coll Cardiol. 2008 Jan;51(2):161-9. [PMID: 18191742]
  • Muehlethaler V, Kunig AM, Seedorf G, Balasubramaniam V, Abman SH. Impaired VEGF and nitric oxide signaling after nitrofen exposure in rat fetal lung explants. Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L110-20. [PMID: 17993583]
  • Abman SA, Baker CD, Balasubramaniam V. Growth and development of the lung circulation: mechanisms and clinical implications. In: Bancalari E, editor. The newborn lung: neonatology questions and controversies. Philadelphia: Saunders; 2008.
  • Croom KF, Curran MP, Abman SH, Channick RN, Heresi GA, Rubin LJ, Torbicki A. Sildenafil: a review of its use in pulmonary arterial hypertension. Drugs. 2008;68(3):383-97. [PMID: 18257613]
  • Gien J, Seedorf GJ, Balasubramaniam V, Markham N, Abman SH. Intrauterine pulmonary hypertension impairs angiogenesis in vitro: role of vascular endothelial growth factor nitric oxide signaling. Am J Respir Crit Care Med. 2007 Dec;176(11):1146-53. [PMID: 17823355]
  • Tang JR, Seedorf G, Balasubramaniam V, Maxey A, Markham N, Abman SH. Early inhaled nitric oxide treatment decreases apoptosis of endothelial cells in neonatal rat lungs after vascular endothelial growth factor inhibition. Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1271-80. [PMID: 17827251]
  • Kunig AM, Parker TA, Nogee LM, Abman SH, Kinsella JP. ABCA3 deficiency presenting as persistent pulmonary hypertension of the newborn. J Pediatr. 2007 Sep;151(3):322-4. [PMID: 17719949]
  • Kinsella JP, Abman SH. Inhaled nitric oxide in the premature newborn. J Pediatr. 2007 Jul;151(1):10-5. [PMID: 17586183]
  • Grover TR, Asikainen TM, Kinsella JP, Abman SH, White CW. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs. Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1345-51. [PMID: 17307811]
  • Badesch DB, Abman SH, Simonneau G, Rubin LJ, McLaughlin VV. Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines. Chest. 2007 Jun;131(6):1917-28. [PMID: 17565025]
  • Balasubramaniam V, Mervis CF, Maxey AM, Markham NE, Abman SH. Hyperoxia reduces bone marrow, circulating, and lung endothelial progenitor cells in the developing lung: implications for the pathogenesis of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1073-84. [PMID: 17209139]
  • Thebaud B, Abman SH. Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease. Am J Respir Crit Care Med. 2007 May;175(10):978-85. [PMID: 17272782]
  • Abman SH. Cor pulmonale and pulmonary complications of cardiac abnormalities. In: Taussig LM, Landau LI, editors. Pediatric respiratory medicine. 2nd ed. Philadelphia: Mosby; 2007.
  • Abman SH. Recent advances in the pathogenesis and treatment of persistent pulmonary hypertension of the newborn. Neonatology. 2007;91(4):283-90. [PMID: 17575471]
  • Kunig AM, Balasubramaniam V, Markham NE, Seedorf G, Gien J, Abman SH. Recombinant human VEGF treatment transiently increases lung edema but enhances lung structure after neonatal hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1068-78. [PMID: 16829629]
  • Parker TA, Roe G, Grover TR, Abman SH. Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung. Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L976-82. [PMID: 16815887]
  • Abman SH. Fifty years ago in the Journal of Pediatrics. Pulmonary endarteritis with cor pulmonale in infancy: report of a case. Chambers V, Wellington JS. J Pediatr. 1956 48:437-44. J Pediatr. 2006 Oct;14 (4):474.
  • Balasubramaniam V, Maxey AM, Morgan DB, Markham NE, Abman SH. Inhaled NO restores lung structure in eNOS-deficient mice recovering from neonatal hypoxia. Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L119-27. [PMID: 16443642]
  • Kinsella JP, Cutter GR, Walsh WF, Gerstmann DR, Bose CL, Hart C, Sekar KC, Auten RL, Bhutani VK, Gerdes JS, George TN, Southgate WM, Carriedo H, Couser RJ, Mammel MC, Hall DC, Pappagallo M, Sardesai S, Strain JD, Baier M, Abman SH. Early inhaled nitric oxide therapy in premature newborns with respiratory failure. N Engl J Med. 2006 Jul;355(4):354-64. [PMID: 16870914]
  • Balasubramaniam V, Maxey AM, Fouty BW, Abman SH. Nitric oxide augments fetal pulmonary artery endothelial cell angiogenesis in vitro. Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1111-6. [PMID: 16399787]
  • Kinsella JP, Greenough A, Abman SH. Bronchopulmonary dysplasia. Lancet. 2006 Apr;367(9520):1421-31. [PMID: 16650652]
  • Montgomery GS, Sagel SD, Taylor AL, Abman SH. Effects of sildenafil on pulmonary hypertension and exercise tolerance in severe cystic fibrosis-related lung disease. Pediatr Pulmonol. 2006 Apr;41(4):383-5. [PMID: 16479610]
  • Walsh MC, Szefler S, Davis J, Allen M, Van Marter L, Abman S, Blackmon L, Jobe A. Summary proceedings from the bronchopulmonary dysplasia group. Pediatrics. 2006 Mar;117(3 Pt 2):S52-6. [PMID: 16777823]
  • Abman SH. Pulmonary hypertension in older children: new approaches and therapies. Paediatr Respir Rev. 2006;7 Suppl 1:S177-9. [PMID: 16798555]
  • Abman SH. Persistent pulmonary hypertension of the newborn: pathophysiology and treatment. Adv Pulm Hypertens. 2006;5(2):22-30.
  • Deruelle P, Balasubramaniam V, Kunig AM, Seedorf GJ, Markham NE, Abman SH. BAY 41-2272, a direct activator of soluble guanylate cyclase, reduces right ventricular hypertrophy and prevents pulmonary vascular remodeling during chronic hypoxia in neonatal rats. Biol Neonate. 2006;90(2):135-44. [PMID: 16582538]
  • Balasubramaniam V, Maxey A, Abman S. Inhaled nitric oxide reverses hypoxia induced lung hypoplasia in endothelial nitric oxide synthase-deficient mice. Chest. 2005 Dec;128(6 Suppl):613S-614S. [PMID: 16373866]
  • Grover TR, Parker TA, Abman SH. Vascular endothelial growth factor improves pulmonary vascular reactivity and structure in an experimental model of chronic pulmonary hypertension in fetal sheep. Chest. 2005 Dec;128(6 Suppl):614S. [PMID: 16373867]
  • Deruelle P, Grover TR, Abman SH. Pulmonary vascular effects of nitric oxide-cGMP augmentation in a model of chronic pulmonary hypertension in fetal and neonatal sheep. Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L798-806. [PMID: 15964898]
  • Kunig AM, Balasubramaniam V, Markham NE, Morgan D, Montgomery G, Grover TR, Abman SH. Recombinant human VEGF treatment enhances alveolarization after hyperoxic lung injury in neonatal rats. Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L529-35. [PMID: 15908474]
  • Kinsella JP, Abman SH. Inhaled nitric oxide therapy in children. Paediatr Respir Rev. 2005 Sep;6(3):190-8. [PMID: 16153568]
  • Kinsella JP, Parker TA, Davis JM, Abman SH. Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambs. Am J Respir Crit Care Med. 2005 Sep 15;172(6):745-9. [PMID: 15947289]
  • Grover TR, Parker TA, Markham NE, Abman SH. rhVEGF treatment preserves pulmonary vascular reactivity and structure in an experimental model of pulmonary hypertension in fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L315-21. [PMID: 15833763]
  • Parker TA, Grover TR, Kinsella JP, Falck JR, Abman SH. Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation. Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L261-7. [PMID: 15821014]
  • Rosenzweig EB, Ivy DD, Widlitz A, Doran A, Claussen LR, Yung D, Abman SH, Morganti A, Nguyen N, Barst RJ. Effects of long-term bosentan in children with pulmonary arterial hypertension. J Am Coll Cardiol. 2005 Aug 16;46(4):697-704. [PMID: 16098438]
  • Lin YJ, Markham NE, Balasubramaniam V, Tang JR, Maxey A, Kinsella JP, Abman SH. Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal rats. Pediatr Res. 2005 Jul;58(1):22-9. [PMID: 15879297]
  • Deruelle P, Grover TR, Storme L, Abman SH. Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus. Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L727-33. [PMID: 15608146]
  • Grover TR, Parker TA, Balasubramaniam V, Markham NE, Abman SH. Pulmonary hypertension impairs alveolarization and reduces lung growth in the ovine fetus. Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L648-54. [PMID: 15579625]
  • Kinsella JP, Ivy DD, Abman SH. Pulmonary vasodilator therapy in congenital diaphragmatic hernia: acute, late, and chronic pulmonary hypertension. Semin Perinatol. 2005 Apr;29(2):123-8. [PMID: 16052736]
  • Stenmark KR, Abman SH. Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia. Annu Rev Physiol. 2005;67:623-61. [PMID: 15709973]