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Owen Vaughan, PhD


​Owen Vaughan, PhD
Instructor, Division of Reproductive Sciences​

Education:
BA Natural Sciences (2008) and PhD Perinatal Physiology (2011), University of Cambridge, UK
 

Contact:

Mail Stop 8613

Lab RC2-3420A

Owen.Vaughan@cuanschutz.edu​

 

Research Interests: My research concerns the endocrine regulation of placental and fetal metabolism, and the developmental programming of cardiometabolic disease. In particular, my work focuses on the role of the placenta in mediating the effects of environmental factors like maternal nutrition, stress, obesity and hypoxia on intrauterine development.  I am currently studying the role of fetal circulating microRNAs in the developmental origins of heart disease.​


Recent publications:

1.    Vaughan, OR, Rosario, FJ, Powell, TL and Jansson, T (2019) Adiponectin supplementation in obese pregnant mice prevents adult offspring cardiac diastolic dysfunction. Int J Obesity doi: 10.1038/s41366-019-0374-4

2.    Vaughan, OR, Powell TL, Jansson, T (2019) Apelin is a novel regulator of human trophoblast amino acid transport. Am J Physiol Endo Metab doi: 10.1152/ajpendo.00012.2019

3.    Sferruzzi-Perri, AN, Higgins, JS, Vaughan, OR, Murray, AJ and Fowden, AL (2019) Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth. Proc Natl Acad Sci USA 116: 1621-1626

4.    Vaughan, OR, Rossi, C, Ginsberg, Y, White, A, Hristova, M, Sebire, N, Martin, J, Zachary, IC, Peebles, DM and David, AL (2018) Perinatal and long-term effects of maternal uterine artery adenoviral VEGF-A165 gene therapy in the growth restricted guinea pig fetus. Am J Physiol Regul Integr Comp Physiol 315:R344-353

5.    Vaughan, OR, De Blasio, MH and Fowden, AL (2018) Ovine uteroplacental and fetal metabolism during and after fetal cortisol overexposure in late gestation. Am J Physiol Regul Integr Comp Physiol 314:R791-801

6.    Vaughan, OR, De Blasio, MJ, Fowden AL (2016) A physiological increase in maternal cortisol alters uteroplacental metabolism in the pregnant ewe. J Physiol 594:6407-6418

7.    Vaughan, OR, H.M. Fisher, K.N. Dionelis, E.C. Jefferies, J.S. Higgins, B. Musial, A.N. Sferruzzi-Perri and A.L. Fowden (2015) Corticosterone alters materno-fetal glucose partitioning and insulin signalling in pregnant mice. J Physiol 593:1307

8.    Vaughan, OR, Phillips, HM, Everden, AJ and Fowden, AL (2015) Dexamethasone treatment of F0 pregnant mice leads to parent of origin-specific changes in placental function of the F2 generation. Reprod Fertil Dev 27:704-11

 

Complete list of publications at Google Scholar

 

Funding: Colorado CCTSI Child and Maternal Health Pilot Grant; University of Colorado Nutrition and Obesity Research Centre Pilot Study.​