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Ovarian Biology Research Lab (Skaznik-Wikiel Lab)



  (Left to right: Natalie Hohos, Gosia Skaznik-Wikiel, Emily Elliott)

In our lab we investigate the effects of obesity and high-fat diet on fertility and ovarian function.  We are specifically interested in exploring mechanisms involved in high-fat diet associated ovarian dysfunction.  In addition, we study dietary and non-dietary interventions that could be used to reverse detrimental effects of high-fat diet on fertility.  Another area of study in our lab focuses on the role of cytokines (particularly granulocyte-colony stimulating factor) in normal and abnormal ovarian function.

​Skaznik-Wikiel Lab

Malgorzata E. Skaznik-Wikiel, MD, Assistant Professor, Principal Investigator

Natalie Hohos, PhD, Postdoctoral Fellow

Emily Elliott, BS, Professional Research Assistant

Asma Giornazi, Undergraduate Student

Research Complex 2, Room 3450

Phone: (303) 724 3514


2018 ASRM In-Training Award for Research, American Society for Reproductive Medicine 74th Annual                Meeting

2018 ASRM Nutrition Special Interest Group Research Award, American Society for Reproductive Medicine          74th Annual Meeting

2018 Women's Health Research Day Poster Award, University of Colorado | Anschutz Medical Campus

2017 Women's Health Research Day Poster Award, University of Colorado | Anschutz Medical Campus

2015 ASRM Nutrition Special Interest Group Research Award, American Society for Reproductive Medicine           72nd Annual Meeting

2015 Travel Grant, American Society for Reproductive Medicine 71st Annual Meeting

2014 Oncofertility Conference Abstract Award Travel Grant, Oncofertility Conference

2012 Scientific Program Prize Paper Award, American Society for Reproductive Medicine 68th Annual                  Meeting

2009 Society for Reproductive Investigation Wyeth President's Presenter Award, Society for Gynecologic             Investigation 56th Annual Scientific Meeting

2005 Society for Reproductive Investigation Wyeth President's Presenter Award, Society for Gynecologic             Investigation 52nd Annual Scientific Meeting

1.    Hohos NM, Elliott EM, Cho KJ, Lin IS, Rudolph M, Skaznik-Wikiel, ME. High-Fat Diet-Induced Ovarian Gene Expression is Restored with Chronic Omega-3 Fatty Acid Supplementation. Mol Cell Endocrinol 2020; 499: 110615

2.    Caine EA, Scheaffer SM, Broughton DE, Salazar V, Govero J, Poddar S, Osula A, Halabi J, Skaznik-Wikiel ME, Diamond MS, Moley KH. Zika virus causes acute infection and inflammation in the ovary of mice without apparent defects in fertility. J Infect Dis 2019 (Epub ahead of print)

3.    Gilbert SB, Allshouse AA, Skaznik-Wikiel ME. Gender inequality in salaries among reproductive endocrinology and infertility subspecialists in the United States. Fertil Steril 2019; 111(6): 1194-2000

4.    Hohos NM, Cho KJ, Swindle DC, Allshouse AA, Rudolph M, Skaznik-Wikiel ME. Fat-1 Transgene is Associated with Improved Reproductive Outcomes. Endocrinology 2018; 159(12): 3981-3992

5.    Hohos NM, Cho KJ, Swindle DC, Skaznik-Wikiel ME. High-fat diet exposure, regardless of induction of obesity, is associated with altered expression of genes critical to normal ovulatory function. Mol Cell Endocrinol. 2017 (Epub ahead of print)

6.    Hohos, NM, Skaznik-Wikiel ME. High-Fat Diet and Female Fertility. Endocrinology 2017 Aug 1:158(8):2407-2419

7.    ​​Skaznik-Wikiel ME, Swindle DC, Allshouse AA, Polotsky AJ, McManaman JL.  High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice.  Biol Reprod 2016 May, 94(5):108

8.    Skaznik-Wikiel ME, McGuire MM, Sukhwani M, Donohue J, Chu T, Krivak Tc, Rajkovic A, Orwig K.  Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy.  Fertil Steril 2013 Jun;99(7):2045-54

9.    Skanik-Wikiel ME, Sharma RK, Selesniemi K, Lee HJ, Tilly JL, Falcone T.  Granulocyte colony stimulating factor in conjunction with vascular endothelial growth factor maintains primordial follicle numbers in transplanted mouse ovaries.  Fertil Steril 2011; 95(4): 1405-9

10. Lee HJ, Sakamoto H, Luo H, Skaznik-Wikiel ME, Friel A, Niikura T, Tilly JC, Niikura Y, Klein R, Styer AK, Zukerberg LR, Tilly JL, Rueda BR.  Loss of CABLES1, a Cyclin-Dependent Kinase-Interacting Protein that Inhibits Cell Cycle Progression, Results in Germline Expansion at the Expense of Oocyte Quality in Adult Female Mice.  Cell Cycle 2007 Nov;6(21):2678-84.

11. Skaznik-Wikiel M, Tilly JC, Lee HJ, Niikura Y, Kaneko-Tarui T, Johnson J, Tilly JL.  Serious doubts over "Eggs forever?" Differentiation 2007 Feb; 75(2):93-9

12. Skanzik-Wikiel, ME, Kaneko-Tarui T, Kashiwagi A, Pru JK.  Sphingosine-1-Phosphate Receptor Expression and Signaling Correlate with Uterine Prostaglandin-Endoperoxide Synthase 2 Expression and Angiogenesis during Early Pregnancy.  Biol Reprod 2006; 74(3):569-76

13. Johnson J, Bagley J, Skaznik-Wikiel M, Lee HJ, Adams GB, Niikura Y, Tschudy KS, Tilly JC, Cortes ML, Forkert R, Spitzer T, Iacomini J, Scadden DT, Tilly JL.  Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood.  Cell 2005; 122(2): 303-15​

​​Colorado Nutrition Obesity Research Center Pilot Grant (Skaznik-Wikiel) 8/1/2018 - 7/31/2020

Project title: "Molecular role of endothelin-2 in high-fat diet-induced ovulatory dysfunction"

NIH K12 BIRCWH Grant (Skaznik-Wikiel) 7/2019 - 6/2021

Project Title: "The Role of P13K/AKT/NF-kB Signaling Pathway in High-Fat Diet-Induced Ovarian Dysfunction and Ovarian Aging"