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Reproductive Sciences Journal Club

Basic Reproductive Sciences Journal Club is held once or twice a month on Fridays from 12:30 - 1:30 pm in the RC2 3rd floor conference room (P15-3015), unless otherwise noted.

Our journal club includes a thorough presentation of the selected article and lively discussion and critique. Light lunch is provided. Students and others affiliated​ with the Division of Basic Reproductive Sciences lead the sessions with faculty, post doc, and staff participation. Article titles and PubMed ID's are given, below.

For additional information, or to volunteer for a presentation, suggest a speaker, or request an article, please contact:

Heidi Wilson, PhD​, Reproductive Sciences Journal Club Director. 

Melinda Ready​, Reproductive Sciences Journal Club Coordinator. Office: (303) 724-3506

Sponsored by the Department of Obstetrics & Gynecology and the Division of Basic Reproductive Sciences

​​​Date ​Presenter​ Paper Citation​
10/24/2014 ​Becca Green ​In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. E.J. Radford et al., Science 345, 1255903 (2014). DOI: 10.1126/science. 1255903

PMID: 25011554​
​11/21/2014 ​Linnea Schmidt ​Cytological studies of human meiosis: sex-specific differences in recombination originate at, or prior to, establishment of double-strand breaks. PLoS ONE 8(12): e85075. SOI: 10.1371/journal.pone.0085075

PMID: 24376867
​12/12/2014 ​Adrianne Stefanski ​The midblastula transition defines the onset of Y RNA-dependent DNA replication in Xenopus laevis. Mol Cell Biol 2011, 31:3857-3870. DOI: 10.1128/MCG.05411-11. EPUB 2011 Jul 26.

PMID: 21791613
​01/09/2015 ​Taylor Soderborg ​The gut microbiota influences blood-brain barrier permeability in mice. Braniste, V., Al-Asmakh, M., Kowal, C., et al. (2014) Science Translational Medicine 6(263): 263ra158. SOI: 10.1126/scitranslmed. 300975

PMID: 25411471​
​01/23/2015 ​Michael Oliphant  ​ERα​-regulated Lipocalin 2 Expression in Adipose Tissue Links Obesity with Breast Cancer Progression. J. Biol. Chem. jbc. M114.606459. First Published on December 2, 2014, DOI: 10.1074/jbc.M114-606459

PMID: 25468909
​02/13/2015 ​Ally Booth ​Exposure of Femal Macaques to Wester-Style Diet with or without Chronic Testosterone in vivo Alters Secondary Follicle Function during Encapsulated 3-Dimensional Culture. Xuj, McGee WK, Bishop CV, Park BS, Cameron JL, Zelinski MB, Stouffer RL. Endocrinology (2014) [Epub ahead of print]

PMID: 25545382
​03/13/2015 ​Sydney Coats

​Effect of pre-and postnatal growth and post-weaning activity on glucose metabolism in the offspring. J Endocrinol. 2015 Feb;224(2):171-82. doi: 10.1530/JOE-14-0600. Epub 2014 Nov 21. 

PMID: 25416820

​Rebe​cca Foright
Hypothalamic POMC neurons promote cannabinoid-induced feeding. Marco Koch1,2, Luis Varela1, Jae Geun Kim1{, Jung Dae Kim1,3, Francisco Herna´ndez-Nun˜o1, Stephanie E. Simonds4, Carlos M. Castorena5, Claudia R. Vianna5, Joel K. Elmquist5, Yury M. Morozov6, Pasko Rakic6,7, Ingo Bechmann2, Michael A. Cowley4, Klara Szigeti-Buck1, Marcelo O. Dietrich1,6, Xiao-Bing Gao1, Sabrina Diano1,3,6 & Tamas L. Horvath1,3,6,7

​04/24/2015 ​Andrew Libby

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents. Luck H, et al. Cell Metabolism. 2015 Apr 7; 21(4): 527-42.

PMID: 25863246

David Presby

​AMPK Regulates Energy Expenditure by Modulating NAD+ Metabolism and SIRT1 Activity. Cantó C, et al. Nature 2009 Apr 23; 458(7241): 1056-60.

PMID: 19262508​
​05/8/2015​ ​Thomas Jansson, MD PhD, Chief, Division of Basic Reproductive Sciences
​How to Write an Irresistible Specific Aims Page.

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 Date Presenter Paper Citation
09/10/2013 Winn and Hurt Labs Reduced cystathionine γ-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator. Cindrova-Davies T, et al. Am J Pathol. 2013 Apr;182(4):1448-58​. PMID:23410520
10/04/2013 Jaime Fornetti In vitro mimicking of estrous cycle stages in porcine oviduct epithelium cells: estradiol and progesterone regulate differentiation, gene expression, and cellular function. Chen S, Einspanier R, Schoen J. Biol Reprod. 2013 Sep 12;89(3):54. PMID: 23904510
11/15/2013 Becca Green Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells. Adachi, K et al. Molecular Cell 52, 1-13, November 7, 2013. PMID: 24120664
12/06/2013 Adrianne Stefanski Parental olfactory experience influences behavior and neural structure in subsequent generations. Dias, B. and Ressler, K. Nature Neuroscience, 2013 Dec 1. doi:10.1038/nn.3594
01/10/2014 Linnea Schmidt Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. Oury, F, Ferron, M, Huizhen, W, Confavreux, C, Xu, L, et al. The Journal of Clinical Investigation, 2013;123(6)2421-2433. PMID: 23728177
02/14/2014 Emily Busta Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes”. Lambrot, R, Xu, C, Saint-Phar, S, Chountalos, G., et al. Nat. Commun. 4:2889 doi: 10.1038/ncomms3889 (2013). PMID: 24326934
03/07/2014 Allyson Booth
Caffeine-induced activated glucocorticoid metabolism in the hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats. Xu, D, Zhang, B, Liang, G, et al. PLoS ONE 7(9):e44497 (2012) PMID: 22970234
04/04/2014 Michael Oliphant Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression Kim, ST, Moley, KH Reproduction (2008) 136:313-322 PMID: 18558660
05/20/2014 Oliwier Dziadkowiec, PhD
Director, Center for Nursing Research
UCD College of Nursing
Erroneous analyses of interactions in neuroscience: a problem of significance. Nieuwenhuis, S, Forstmann, BU, Wagenmakers, E-J. Nature Neuroscience (2011) 14:1105-1107 PMID: 21878926
 Date Presenter Paper Citation
9/21/2012 Margaret Heerwagen Cross talk between PKC and CREB in the induction of COX-2 by PGF2α in human amnion fibroblasts. GuoCM, et al. Endocrinology. 2012; 153(10):0000–0000 epub ahead of print 8/23/2012. PMID: 22919060
10/19/2012 Jaime Fornetti NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Park, C.B., et al. Biology of Reproduction. 2012 86(6):194, 1-13. PMID:22378764
11/09/2012 Linnea Schmidt Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude. Yung, HW et al. FASEB J 2012 May; 26(5): 170-1981. PMID 22267338
12/07/2012 Adrianne Stefanski Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-Like Cells in Mice. Hayashi K, Ogushi S, Kurimoto K, Shimamoto S, Ohta H, Saitou M. Science. 2012 Oct 4. pp. 971-975. PMID: 23042295
01/18/2013 Emily Busta Insulin rescues impaired spermatogenesis via the hypothalamic-pituitary-gonadal axis in akita diabetic mice and restores male fertility. Schoeller Erica, Albanna G, Frolova A, Moley K. Diabetes 2012; 61:1869-1878. PMID:22522616
02/15/2013 Rebecca Green Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation. Penaherrera MS, Jiang R, Avila L, et al. Human Reproduction 2012; 27(6):1745-1753 PMID: 22431562
03/08/2013 Allyson Booth Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice, Witham EA, et al, Endo​crinology, September 2012, 153(9):4522-4532. PMID: 22778229
04/12/2013 Claire Gustafson Premature delivery influences the immunological composition of colostrum and transitional and mature human milk. Catellote C, Casillas R, Ramirez-Santana C, Perez-Cano FJ, Castell M, Moretones MG, Lopez-Sabater MC, Franch A. J. Nutr. 2011, 141(6):1181-7 PMID: 21508211
05/10/2013 Amanda Allshouse
Faculty Session
Whole animal experiments should be more like human randomized controlled trials. Muhlhausler BS, Bloomfield FH, Gillman, MW. PLoS Biol 11(2): e1001481. PMID: 23424284
 Date Presenter Paper Citation
9/20/2011 Becca Green The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells. Matson CK, et al. Developmental Cell. 2010; 19: 612-624. PMID: 20951351 AND DMRT1 prevents female reprogramming in the postnatal mammalian testis. Matson CK, et al. Nature. 2011; 476: 101-104. PMID: 21775990
10/20/2011 Jamie Fornetti Activation of the maternal immune system induces endocrine changes in the placenta via IL-6. Hsiao EY and Patterson PH. Brain, Behavior, and Immunity. 2011; 25: 604-15. PMID: 21195166
11/18/2011 Margaret Heerwagen Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Salker MS, et al. Nature Medicine. 2011; 17: 1509-13. PMID: 22001908
1/20/2012 Becca Green Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity. Daikoku T, Cha J, Sun XF, et al. Developmental Cell. 2011; 21: 1014–1025. PMID: 22100262
2/17/2012 Emily Busta Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans. Budatha, et al. Journal of Clinical Investigation. 2011; 121(5): 2045-59. PMID: 21519142
4/6/2012 Joe Hurt and Laxmi Kondapalli
Faculty Session​
Faculty lecture and paper discussion: "How to read clinical literature: A crash course for the basic scientist." Immediate versus delayed medical treatment for first-trimester miscarriage: a randomized trial. American Journal of Obstetrics & Gynecology. 2012; 206: 215.e1-6. PMID: 22381604
4/20/2012 Linnea Schmidt Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. White, et al. Nature Medicine. 2012; 18(3): 413-21. PMID: 22366948
5/25/2012 Adrianne Stefanski Phase III trial of a weekly methotrexate or pulsed dactinomycin for low-risk gestational trophoblastic neoplasia: a gynecologic oncology group study. Osborne, et al. Journal of Clinical Oncology. 2011; 29(7): 825-31. PMID: 21263100


Date​ ​​Presenter ​​Paper Citation
9/18/2015​ ​Natalia Grindler Fertility and Sterility. 2013 Sep; 100(3):818-24.
The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
Ruiz-Alonso M1, Besa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C.

​10/16/2015 ​Linnea Schmidt Science. 2015 Oct 1. pii:aad0836.
Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.
Miyata H, Satouh Y, Mashiko D, Muto M, Nozawa K, Shiba K, Fujihara Y, Isotani A, Inaba K, Ikawa M.

​11/20/2015 ​Chris Breed Nat Commun. 2015 Aug 3;6:7956.
An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer.
Janzen DM, Tiourin E, Salehi JA, Paik DY, Lu J, Pellegrini M, Memarzadeh S.
​12/18/2015 ​Allyson Roof ​​​
2/19/2016​ ​Andrew Libby
​3/25/2016 ​Sydney Coates
4/15/2016​ ​Michael Oliphant ​​
5/20/2016​ ​Taylor Soderborg
​6/16/2016 ​Priya Pantham