Skip to main content
Sign In

Welcome to the Department of Neurology

Neurology Banner Image
 

Selected Publications

Welcome to the Tyler Lab


 

Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection.
Blakely PK, Kleinschmidt-DeMasters BK, Tyler KL, Irani DN.

J Neuropathol Exp Neurol. 2009 Oct;68(10):1061-72.
PMID: 19918118 [PubMed - indexed for MEDLINE]
Related Articles

Cardiac cell-specific apoptotic and cytokine responses to reovirus infection: determinants of myocarditic phenotype.
Miyamoto SD, Brown RD, Robinson BA, Tyler KL, Long CS, Debiasi RL.
J Card Fail. 2009 Aug;15(6):529-39. Epub 2009 Mar 3.
PMID: 19643365 [PubMed - in process]                           
Related Articles

Fas-mediated apoptotic signaling in the mouse brain following reovirus infection.
Clarke P, Beckham JD, Leser JS, Hoyt CC, Tyler KL.
J Virol. 2009 Jun;83(12):6161-70. Epub 2009 Mar 25.
PMID: 19321603 [PubMed - indexed for MEDLINE]           
Related Articles

Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection.
Beckham JD, Tuttle K, Tyler KL.
J Virol. 2009 May;83(10):5035-45. Epub 2009 Mar 11.
PMID: 19279118 [PubMed - indexed for MEDLINE]           
Related Articles

Apoptosis in animal models of virus-induced disease.
Clarke P, Tyler KL.
Nat Rev Microbiol. 2009 Feb;7(2):144-55. Review.
PMID: 19148180 [PubMed - indexed for MEDLINE]           
Related Articles

Experimental reovirus-induced acute flaccid paralysis and spinal motor neuron cell death.
Goody RJ, Schittone SA, Tyler KL.
J Neuropathol Exp Neurol. 2008 Mar;67(3):231-9.
PMID: 18344914 [PubMed - indexed for MEDLINE]           
Related Articles

JAK-STAT signaling pathways are activated in the brain following reovirus infection.
Goody RJ, Beckham JD, Rubtsova K, Tyler KL.
J Neurovirol. 2007 Aug;13(4):373-83.
PMID: 17849321 [PubMed - indexed for MEDLINE]           
Related Articles

Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria.
Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA.
J Biol Chem. 2007 Oct 5;282(40):29296-304. Epub 2007 Aug 9.
PMID: 17690097 [PubMed - indexed for MEDLINE]           
Related Articles

Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase.
Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL.
J Virol. 2007 Jul;81(13):6984-92. Epub 2007 May 2.
PMID: 17475657 [PubMed - indexed for MEDLINE]           
Related Articles

Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis.
Clarke P, Tyler KL.
Apoptosis
. 2007 Jan;12(1):211-23.
PMID: 17136319 [PubMed - indexed for MEDLINE]                      
Related Articles

Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons.
Le SS, Loucks FA, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA.
J Neurochem. 2005 Aug;94(4):1025-39.
PMID: 16092944 [PubMed - indexed for MEDLINE]                     
Related Articles

Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury.
Goody RJ, Hoyt CC, Tyler KL.
Exp Neurol. 2005 Oct;195(2):379-90.
PMID: 16004984 [PubMed - indexed for MEDLINE]
Related Articles

Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis.
Clarke P, Debiasi RL, Meintzer SM, Robinson BA, Tyler KL.
Apoptosis. 2005 May;10(3):513-24.
PMID: 15909114 [PubMed - indexed for MEDLINE]
Related Articles

Mechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation.
Clarke P, Debiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL.
Viral Immunol. 2005;18(1):89-115. Review.
PMID: 15802955 [PubMed - indexed for MEDLINE]
Related Articles

Mechanisms of apoptosis during reovirus infection.
Clarke P, Richardson-Burns SM, DeBiasi RL, Tyler KL.
Curr Top Microbiol Immunol. 2005;289:1-24. Review.
PMID: 15791949 [PubMed - indexed for MEDLINE]
Related Articles 

Nonstructural protein sigma1s is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous system.
Hoyt CC, Richardson-Burns SM, Goody RJ, Robinson BA, Debiasi RL, Tyler KL.
J Virol. 2005 Mar;79(5):2743-53.PMID: 15708993 [PubMed - indexed for MEDLINE]
Related Articles