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Selected Publications

Welcome to the Tyler Lab


Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection.
Blakely PK, Kleinschmidt-DeMasters BK, Tyler KL, Irani DN.

J Neuropathol Exp Neurol. 2009 Oct;68(10):1061-72.
PMID: 19918118 [PubMed - indexed for MEDLINE]
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Cardiac cell-specific apoptotic and cytokine responses to reovirus infection: determinants of myocarditic phenotype.
Miyamoto SD, Brown RD, Robinson BA, Tyler KL, Long CS, Debiasi RL.
J Card Fail. 2009 Aug;15(6):529-39. Epub 2009 Mar 3.
PMID: 19643365 [PubMed - in process]                           
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Fas-mediated apoptotic signaling in the mouse brain following reovirus infection.
Clarke P, Beckham JD, Leser JS, Hoyt CC, Tyler KL.
J Virol. 2009 Jun;83(12):6161-70. Epub 2009 Mar 25.
PMID: 19321603 [PubMed - indexed for MEDLINE]           
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Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection.
Beckham JD, Tuttle K, Tyler KL.
J Virol. 2009 May;83(10):5035-45. Epub 2009 Mar 11.
PMID: 19279118 [PubMed - indexed for MEDLINE]           
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Apoptosis in animal models of virus-induced disease.
Clarke P, Tyler KL.
Nat Rev Microbiol. 2009 Feb;7(2):144-55. Review.
PMID: 19148180 [PubMed - indexed for MEDLINE]           
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Experimental reovirus-induced acute flaccid paralysis and spinal motor neuron cell death.
Goody RJ, Schittone SA, Tyler KL.
J Neuropathol Exp Neurol. 2008 Mar;67(3):231-9.
PMID: 18344914 [PubMed - indexed for MEDLINE]           
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JAK-STAT signaling pathways are activated in the brain following reovirus infection.
Goody RJ, Beckham JD, Rubtsova K, Tyler KL.
J Neurovirol. 2007 Aug;13(4):373-83.
PMID: 17849321 [PubMed - indexed for MEDLINE]           
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Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria.
Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA.
J Biol Chem. 2007 Oct 5;282(40):29296-304. Epub 2007 Aug 9.
PMID: 17690097 [PubMed - indexed for MEDLINE]           
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Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase.
Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL.
J Virol. 2007 Jul;81(13):6984-92. Epub 2007 May 2.
PMID: 17475657 [PubMed - indexed for MEDLINE]           
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Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis.
Clarke P, Tyler KL.
. 2007 Jan;12(1):211-23.
PMID: 17136319 [PubMed - indexed for MEDLINE]                      
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Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons.
Le SS, Loucks FA, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA.
J Neurochem. 2005 Aug;94(4):1025-39.
PMID: 16092944 [PubMed - indexed for MEDLINE]                     
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Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury.
Goody RJ, Hoyt CC, Tyler KL.
Exp Neurol. 2005 Oct;195(2):379-90.
PMID: 16004984 [PubMed - indexed for MEDLINE]
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Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis.
Clarke P, Debiasi RL, Meintzer SM, Robinson BA, Tyler KL.
Apoptosis. 2005 May;10(3):513-24.
PMID: 15909114 [PubMed - indexed for MEDLINE]
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Mechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation.
Clarke P, Debiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL.
Viral Immunol. 2005;18(1):89-115. Review.
PMID: 15802955 [PubMed - indexed for MEDLINE]
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Mechanisms of apoptosis during reovirus infection.
Clarke P, Richardson-Burns SM, DeBiasi RL, Tyler KL.
Curr Top Microbiol Immunol. 2005;289:1-24. Review.
PMID: 15791949 [PubMed - indexed for MEDLINE]
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Nonstructural protein sigma1s is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous system.
Hoyt CC, Richardson-Burns SM, Goody RJ, Robinson BA, Debiasi RL, Tyler KL.
J Virol. 2005 Mar;79(5):2743-53.PMID: 15708993 [PubMed - indexed for MEDLINE]
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