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Research Training


 

The Research Training is a major component in the Nephrology Fellowship. The Division is fortunate in having outstanding clinical, translational, and basic research opportunities. The Division has an exceptional faculty with over 20 NIH funded grants, placing the Division in the top ten in the country for research funding. Great attention is given to the fellows, with an active mentoring program and access to a Division Biostatistician. Opportunities are available for those who would like to pursue a Masters of Public Health or a Masters of Clinical Investigation, and it is also possible to combine a PhD with training. Funding is provided in part by an NIH T32 training grant that has been in operation for over 30 years.

General topics are shown below:

Clinical Research:

1. Epidemiology and Genetics:

  • Polycystic Kidney Disease (B.Gitomer; G. Brosnahan)
  • Chronic Kidney Disease, Calcium, Phosphorus and Vitamin D metabolism (M. Chonchol; D. Spiegel; J. Kendrick)
  • Risk factors for hypertension, metabolic syndrome and diabetes (D. Jalal; M. Chonchol)
  • Transplant Outcomes Research (A. Wiseman)
  • Chronic Kidney Disease and Fibroblast Growth Factor 23 (M. Chonchol; J. Kendrick)
  • Dietary Sodium and Potassium Intake and Hypertension, Cardiovascular Disease and Kidney Disease (J. Kendrick)

 

2. Clinical Trials

  • HALT trial for PKD (G. Brosnahan; R. Schrier)
  • Lowering uric acid to improve vascular function in CKD (D. Jalal)
  • Various clinical trials in renal transplant patients (A. Wiseman; L. Chan)
  • Progression of Kidney Disease (T. Berl; M. Chonchol)
  • Vitamin D Supplementation and Vascular Function in Patients with Chronic Kidney Disease (J. Kendrick)
  • Tolvaptan trials in Polycystic Kidney Disease (C. Edelstein)
  • Medical Informatics (D. Spiegel)

 

3. Basic and Translational Research

  • Cellular and molecular biology of hormone signaling (R. Nemenoff; M.Weiser-Evans; S. Furgeson)
  • Vasopressin and aquaporin biology (R. Schrier; M. Cadnapaphornchai)
  • Pathogenesis of acute renal failure (R. Schrier; W. Wang; C. Edelstein)
  • Systemic manifestations of acute kidney injury (S. Faubel)
  • Organ preservation and effects of hibernation on kidney function (A. Jani; C. Rivard)
  • Experimental models of polycystic kidney disease (C. Edelstein)
  • Diabetic Nephropathy: pathogenesis and treatment (T. Nakagawa; R. Johnson; M. Levi)
  • Complement in ARF/Reperfusion injury (J. Thurman)
  • Regulation of phosphate transport (M. Levi)
  • Biology of transplant rejection (A. Wiseman; J. Cooper)
  • Pathogenesis of essential hypertension (R. Johnson; T. Nakagawa; R. Nemenoff; S. Furgeson)
  • Fructose in kidney disease and metabolic syndrome (T. Nakagawa; R. Johnson; C. Rivard,)
  • Uric acid in the pathogenesis of hypertension and kidney disease (T. Nakagawa; R. Johnson)
  • Lipids and renal disease (M. Levi)
  • Minimal change disease and glomerulonephritis (R. Johnson; G. Garcia)
  • Genetic mouse models of disease (R. Nemenoff; M. Weiser-Evans)
  • Genetics of polycystic kidney disease (B. Gitomer)
  • Pathogenesis of vascular fibroproliferative disease (M. Weiser-Evans; R. Nemenoff)
  • Intracellular trafficking in renal cells and effects of albuminuria on podocytes (J. Blaine)


Microscopy Core: Available for research fellows is the use of an advanced microscopy core that provides state of the art confocal microscopy and intravital microscopy for the imaging of cellular and subcellular structures (see Microscopy Core)

Statistical Advice: The Renal Division also has a statistician who can be consulted for specific research questions and advice. There is also a monthly lecture in statistics, also provided to the Division.