Researchers at the University of Colorado School of Medicine have identified a potential treatment target for patients with a common type of heart failure.
In a study published in the February 7 issue of the journal Science Translational Medicine, the researchers tested the effect of an investigational drug called givinostat in treating diastolic dysfunction, which is a heart relaxation abnormality that contributes to heart failure with preserved ejection fraction (HFpEF).
HFpEF refers to cases where the heart can pump blood normally, but is not able to fill as efficiently as a healthy heart. Millions of people worldwide suffer from HFpEF, which can be caused by hypertension, diabetes, aging or other conditions. Individuals with HFpEF die at an alarming rate and, unfortunately, there are no effective drugs to treat this form of heart failure.