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Genetic clues to high rate of asthma in African ancestry found with 4 chromosomal regions


“In the largest GWAS of asthma in African ancestry populations to date, we found strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, and we also identified two novel loci on chromosome 8 that may be specific to asthma risk in African ancestry populations,” said the study’s first author Michelle Daya, assistant professor in the division of Biomedical Informatics and Personalized Medicine at the CU School of Medicine.
 
“From this study, we can say chromosome 17q is important for the development of asthma not just in populations of European or Asian ancestry, but also those of African ancestry. This is a big step forward in untangling what is happening at this loci,” opined Kathleen Barnes, the senior author on the study and director of the Colorado Center for Personalized Medicine at CU Anschutz.
 

Devdiscourse, Feb. 20, 2019

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