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Chronic inflammation of obesity, autoimmune conditions leads to imbalanced blood system and potentia


A study published today in the journal NATURE: Cell Biology shows that chronic exposure to an inflammatory “emergency” signal, interleukin-1, causes blood-forming bone marrow stem cells to produce cells needed to fight infection and repair injury, but at the expense of their own ability to self-renew and maintain a healthy blood system. This results in overproduction of aggressive immune cells capable of severely damaging tissues. Elevated interleukin-1 (IL-1) accompanies the chronic inflammation associated with human conditions including obesity, diabetes and autoimmune disorders. The imbalance of blood system cell types can result in inefficient oxygen delivery, immunodeficiency, and could predispose the development of cancer.

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