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The SHAPE 2 Study

Sex Hormones & Atherosclerosis Prevention in Perimenopausal Women


The IMAGE Group and the Division of Geriatrics
at the University of Colorado Anschutz Medical Campus  is currently recruiting healthy women between 18-40 years, 40-55 years, and 45-70 years of age.

Purpose of the Study:

As women get older and go through menopause, reproductive hormones (e.g., estrogen) decrease to low levels. Also, with aging the arteries that are located around the heart get stiffer. Over time this increase in arterial stiffness can lead to a number of health problems including high blood pressure and heart disease. In this study we want to find out if a short-term drop in estrogen levels can cause arteries to become stiffer, and the reasons why they become stiffer. Additionally, if you are a postmenopausal woman, we want to find out if a short-term increase in estrogen levels causes your arteries to become more flexible (less stiff).

  • Tests are conducted at the University of Colorado Anschutz Medical Campus
  • There is no cost to you for taking part in the study
  • Compensation will be provided for your time

Study Qualifications:

  • Healthy, non-smoking women with normal blood pressure and not taking oral contraceptives or hormone therapy who fit into one of these categories:
    • 21-35 years who have normal menstrual cycles
    • 40-55 years who have irregular menstrual cycles (perimenopause)
    • 45-70 years who no longer have menstrual cycles (postmenopause)

Benefits for Study Volunteers Include:

  • Physician supervised exercise stress test
  • Measurement of body composition and bone density
  • Ultrasound of the blood vessels and heart
  • Fitness test

For more information please E-Mail: Shape.Study@ucdenver.edu

The principal investigator for this study is Kerrie Moreau, PhD.
This study is approved by the
Colorado Multiple Institutional Review Board (Protocol #06-0537)