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The POWER Study

Prevention of Obesity in Women via Estradiol Regulation

Prevention of
Obesity in
Women via
Regulation (POWER)

The IMAGE group’s latest study, POWER, will examine the role that the female sex hormone estrogen plays in preventing excess fat gain in women. At the time of menopause, there are increases in the rates of fat gain (especially in the stomach region) and muscle loss. Why this happens is not known, but it is thought to be related to the loss of the estrogen, because postmenopausal women who take estrogen gain less fat and lose less lean mass than those who do not take estrogen.

  • Is your body changing without your consent?
  • Curious about how estrogen may play a role?
  • Interested in starting an exercise program?

All women in the POWER study will receive a drug that causes estrogen levels to decrease to postmenopausal levels. During the 5 months of hormone suppression, some women will receive estrogen replacement (a skin patch) and some will receive a placebo patch (no estrogen). This will help us determine if it is a lack of estrogen that causes the changes in metabolism that lead to muscle loss and fat gain. Also during the 5 months of hormone suppression, some women will participate in a supervised exercise program and some will not. Thus, women who participate in this study will be randomly placed into one of four groups:


Group A Group B
Hormone suppressor, plus estrogen patch, plus exercise training Hormone suppressor, plus estrogen patch, plus no exercise training*
Group C Group D
Hormone suppressor, plus placebo patch, plus exercise training Hormone suppressor, plus placebo patch, plus no exercise training*>


*Participants randomized into the “no exercise” groups will have the opportunity to take part in an exercise program with us after completing the study.

The main inclusion criteria for this study include:

  • Healthy women aged 18-45 years
  • Regular menstrual cycles
  • No current use of hormonal contraceptives

Benefits for study volunteers include:

  • Measurement of body composition and bone density
  • Fitness testing
  • Comprehensive diet analysis
  • Personalized and supervised exercise program

The Principal Investigator of the POWER study is Wendy Kohrt, PhD. For more information please contact Anne Stavros 720-848-6399 or This study is funded by the National Institute on Aging and has been approved by the Colorado Multiple Institutional Review Board (protocol # 06-0512)


Frequently Asked Questions Regarding the Power Study:

  1. What will I be paid for participation in this study?
    The compensation for finishing this study is $1,000. If the study is not completed for any reason, compensation is provided at $80 for each of the five Lupron shots and up to $200 for each of the three testing phases.
  2. Where do I go for study testing?
    All of our testing will be on the Anschutz Medical Campus (Fitzsimons Campus) in Aurora.
  3. How long will I be in this study?
    Participating in the POWER study should take approximately one year from the start of the screening process until the completion of the study.
  4. What are the benefits I will receive from this study?
    The POWER study will allow you to learn more about your current health including your bone density, percent body fat, aerobic and muscular fitness, resting metabolic rate, and routine blood tests. You will also receive a personalized exercise training program either during or after the research study.
  5. Why would I want my hormones suppressed for five months?
    The Lupron injections will give you a reversible preview into what menopause will be like. This will let you understand how to deal with some of the symptoms that your mothers, sisters, coworkers and friends may be going through right now. Because the body composition changes at the time of menopause put women at risk for osteoporosis, diabetes, and heart disease, learning more about your current health status and understanding the importance of an active lifestyle will be an invaluable tool for dealing with menopause when that time comes for you.
  6. I’m interested, what is the next step?
    If you are interested in participating, let me know and I will send you the consent form so that you can read through it and find out all of the specific details about the study. You will also need to fill out a screening form that will ask you some general information regarding your health, so that we can make sure that you will qualify for the study. Please feel free to call me with any questions or concerns you have, I know this is a lot of information to take in at once. Also, the link below contains more information regarding the POWER Study

Channel 4 CBS
Estrogen Studied In Weight Gain
Estrogen is a powerful hormone. When its levels drop during menopause, some dramatic changes in the body can occur; bone loss, muscle loss and weight gain. A study underway at the University of Colorado School of Medicine is looking into what women can do to battle the bulge after menopause.

Thank you!
Kim Harner