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Leonard Dragone MD


 

Dr. Dragone is interested in developing strategies to manipulate lymphocyte-signaling pathways to treat autoimmune disease. He is defining how alterations in ubiquitinylation as well as NEDDylation alter signaling through the T-cell receptor complex in mouse models of inflammatory arthritis and systemic lupus erythematosus (SLE) to determine their role in autoimmune pathogenesis.  In addition, he is defining the mechanism of pregnancy-induced arthritis amelioration as a means of identifying new signaling pathways that may be targeted to treat autoimmune disease.