Cecile Rose, M.D.
Associate Professor of Medicine
University of Colorado Denver
Pulmonary Sciences & Critical Care Medicine
Education & Training
Northwestern University, Evanston, IL
1983 B.A. African Studies
School of Medicine, University of Illinois, Chicago, IL
School of Public Health, University of Illinois, Chicago
1983 M.P.H. Public Health
PROFESSIONAL EXPERIENCE 1
980-1983 Resident, Internal Medicine, Medical College of Virginia, Richmond, Virginia
1983 Board Certified: Internal Medicine
1983-1985 Fellow, Pulmonary Medicine, Medical College of Virginia, Richmond, Virginia
1983-1985 Instructor, Division of Clinical Toxicology and Environmental Medicine, Department of Medicine, Medical College of Virginia, Richmond, Virginia
1984-1985 Visiting Research Fellow, Pulmonary Branch, National Heart, Lung and Blood Institute
1984-1988 Director, Occupational/Environmental Medicine Clinic, Department of Internal Medicine, Medical College of Virginia, Richmond, Virginia
1985-1988 Assistant Professor, Division of Clinical Toxicology and Environmental Medicine and Pulmonary Division, Department of Medicine, Medical College of Virginia, Richmond, Virginia
1988-present Staff Physician, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado
1988-1994 Assistant Professor of Medicine, University of Colorado School of Medicine, Denver, Colorado
1994-present Occupational Medicine Program Director, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado
1994-present Associate Professor of Medicine and Preventive Medicine and Biometrics, Division of Pulmonary Medicine, Department of Medicine, University of Colorado School of Medicine, National Jewish Medical and Research Center, Denver, Colorado
Honors and Activities
1985-1989 NIOSH-Certified B-Reader, by American College of Radiology for Pneumoconioses
1987 Board Certified: Pulmonary Medicine, American Board of Internal Medicine
1987 Board Certified: General Preventive/Occupational Medicine, American Board of Preventive Medicine
1983 Diplomate, Internal Medicine, American Board of Internal Medicine
1988-1994 Environmental Health, Reviewer
1990-1994 Chest, Reviewer
1991-1995 Study Section, National Institute for Occupational Safety and Health, Bethesda, MD
1993-present American Journal of Industrial Medicine, Reviewer
1993, 1996, 1999 Level II Workers’ Compensation Accreditation, State of Colorado
1995 British Journal of Industrial Medicine, Reviewer
Selected peer-reviewed publications (in chronological order)
1. Saady JJ, Rose CS. A case of nonfatal sodium fluoride ingestion. J Anal Toxicol 1988; 12: 270-271.
2. Hart RP, Rose CS. Neuropsychological effects of occupational exposure to cadmium. J Clin Exp Neuropsychol 1989; 11:933-943.
3. Rosenberg SJ, Freedman MR, Schmaling KB, Rose CS. Personality styles of patients asserting environmental illness. J Occup Med 1990; 32:678-681.
4. Rose CS, King TE. Hypersensitivity pneumonitis and indoor pools (clinical consultation). J Respir Dis 1990; 11:1047-1048.
5. Kern DG, Christiani DC, Kelsey KT, Hu H, Frumkin H, Kreiss K, Rose CS, Newman LS, Jarvis J, Garabrant D, Robins TG, Franzblau A, Kipen HM, Gochfeld M, Rosenstock L, Barnhart S. Letter to the editor: Asbestos-related diseases. N Engl J Med 1991; 324:195-196
6. Rose CS, Heywood PG, Costanzo RM. Olfactory impairment after chronic occupational cadmium exposure. J Occup Med 1992; 34:600-605.
7. Lynch DM, Rose CS, Way D, King TE. Hypersensitivity pneumonitis: sensitivity of high-resolution CT in a population-based study. Am J Roentgenol 1992; 159:469-472. 8. Rose CS, King TE. Controversies in hypersensitivity pneumonitis (editorial). Am Rev Respir Dis 1992; 145:1-2.
9. Rose CS. Bioaerosols. West J Med, 1994; 160(6):566.
10. Epling CA, Rose CS, Martyny JW, Zhen B, Alexander W, Waldron JA, Kreiss K. Endemic work-related febrile respiratory illness among construction workers. Am J Ind Med 1995; 28:193-205.
11. Rose CS, Robins T, Harkaway P. Biopsy-confirmed hypersensitivity pneumonitis in automobile production workers exposed to metalworking fluids – Michigan, 1994-1995. MMWR July 19, 1996,; 606-609.
12. Newman LS, Rose CS, Maier LS. Medical progress: Sarcoidosis. N Engl J Med 1997; 336:1224-1234. 13. Rose CS, Martyny JW, Newman LS, Milton DK, King TE, Beebe JL, McCammon JB, Hoffman RE, Kreiss K. “Lifeguard lung:” Endemic granulomatous pneumonitis in an indoor swimming pool. Am J Public Health 1998; 88:1795-1800.
14. Rose CS. Diagnosis and prevention of lung diseases associated with microbial bioaerosols. Semin Respir Crit Care Med 1999; 20(6):511-520.
15. Hunninghake GW, Costabel U, Masayuki A, Baughman R, Cordier JF, du Bois R, Ekland A, Kitaichi M, Lynch J, Rizzato G, Rose C, Selroos O, Semenzato G, Sharma OP. ATS/ERD/WASOG Statement on sarcoidosis. Sarcoidosis Vasculitis and Diffuse Lung Diseases 1999;
16:149-173. 16. Bauer RA, Sawyer RT, Daniloff E, Balkissoon R, Rose CS, Newman LS. Bronchoalveolar lavage macrophage-lymphocyte clusters are linked to lymphocytosis not granulomatous disease. Sarcoidosis, Vasculitis and Diffuse Lung Diseases 2000; 17:174-180.
17. Maier LA, Sawyer RT, Tinkle SS, Barker EA, Balkissoon, Rose C, Newman LS. IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. Eur Respir J 2001; 17:403-415.
18. Lundgren RA, Maier LA, Rose CS, Balkissoon RC, Newman LS. Indirect and direct gas exchange at maximum exercise in beryllium sensitization and disease. Chest 2001; 120:1702-1708. Books and Reviews 1. Rose CS. Water-related lung diseases. In: Beckett WS, Bascom R (eds.), Occupational Medicine: State of the Art Reviews, Philadelphia: Hanley and Belfus, Inc., 1992; 7(2):271-286.
2. Rose CS, Newman LS. Hypersensitivity pneumonitis and chronic beryllium disease. In: Schwarz MI and King TE, Jr. (eds.), Interstitial Lung Disease, St. Louis: Mosby Yearbook, 2nd Edition, 1992:231-253.
3. Rose CS. Inhalation fevers. In: Rom WN (ed.), Environmental and Occupational Medicine, Boston: Little, Brown, and Company, 2nd Edition, 1992:373-380.
4. Rose CS. Hypersensitivity pneumonitis. In: Rosenstock L, Cullen MR (eds.), Textbook of Clinical Occupational and Environmental Medicine, Philadelphia: WB Saunders Co., 1994:242-248.
5. Rose CS. Fungi. In: Wald PH, Stave GM (eds.), Physical and Biological Hazards of the Workplace, New York: Van Nostrand Reinhold, 1994:392-416.
6. Rose CS. Hypersensitivity pneumonitis. In: Harber P, Schenker MB, Balmes JR (eds.), Occupational and Environmental Respiratory Disease, St. Louis: Mosby – Year Book, Inc., 1996:201-215.
7. Rose CS. Overview: Indoor air and human health revisited (introduction). In: Gammage RB, Berven DA (eds.), Indoor Air and Human Health, New York: CRC Press, Inc., Lewis Publishers, 2nd Edition, 1996:127-128.
8. Rose CS. Building-related hypersensitivity diseases: Sentinel event management and evaluation of building occupants. In: Gammage RB, Berven DA (eds.), Indoor Air and Human Health, New York: CRC Press, Inc., Lewis Publishers, 2nd Edition, 1996:211-222.
9. Rose CS. Hypersensitivity pneumonitis and other disorders caused by organic agents. In: Parsons PE, Hefner JE (eds.), Pulmonary/Respiratory Therapy Secrets, Philadelphia: Hanley and Belfus, Inc., 1997:298-302.
10. Rose CS, Blanc PD. Inhalation fever. In: Rom WM (ed.), Environmental and Occupational Medicine, Philadelphia: Lippincott-Raven, 3rd Edition, 1998:467-480.
11. Weill D, Rose CS, King TE. Treatment and prognosis of hypersensitivity pneumonitis (extrinsic allergic alveolitis). In: Weinberger SE (ed.), UpToDate in Pulmonary Disease and Critical Care (CD-ROM), Wellesley, MA, 1998. 1
2. Rose CS, Kreiss K, Milton DK, Nardell EA. Medical roles and recommendations. In: Macher J (ed.), Bioaerosols: Assessment and Control. Cincinnati: American Conference of Government Industrial Hygienists, 1999, Chapter 8.
13. Rose CS. Antigens. In: Macher J (ed.), Bioaerosols: Assessment and Control. Cincinnati: American Conference of Government Industrial Hygienists, 1999, Chapter 25.
14. Rose CS. Hypersensitivity pneumonitis and other disorders caused by organic agents. In: Bowler RM, Cone JE (eds.), Occupational Medicine Secrets, Philadelphia: Hanley and Belfus, Inc., 1999:203-207.
15. Lynch DM, Rose CS. Occupational lung diseases. In: Textbook of Pulmonary Radiography (in preparation). C. Research Support ONGOING
1. 1 U01 HL60263-01A1 Newman (PI) 05/01/99-04/30/04 NIH/Henry Ford Sarcoidosis Genetic Linkage Consortium (SAGA) The major goal of this project is to detect genetic and environmental risk factors in African American families with sarcoidosis. Role: Co-PI
2. 1 RO1 CA84059-01A1 Thompson (PI) 07/01/00-06/30/03 NCI – Colorado State University (subcontract) Selenium and Lung Cancer Risk The major goal of this project is to evaluate early markers of lung cancer risk in asbestos-exposed workers who are randomized to receive oral selenium versus placebo. Role: Co-PI
3. Association of Occupational and Environmental Clinics Anderson (PI) 06/01/01-05/31/04 Pediatric Environmental Health Specialty Unit The major goals of this project are to provide education to healthcare providers and parents on environmental hazards faced by children and to create a network of experts in the field of pediatric environmental health. Role: Co-PI
4. Black Lung Clinic Program 08/01/02-07/31/05 HRSA Colorado Regional Black Lung Clinic The major goal of this project is to establish a Colorado regional black lung clinic for miners. Role: PI COMPLETED
1. Agency for Toxic Substances and Disease Registry Rose (PI) 07/28/01- 09/07/01 Libby, Montana Spirometry Program This project provides spirometry testing of Libby, Montana residents previously exposed to tremolite-contaminated vermiculite. Role: PI
2. NHLBI-HR-94-21 Newman (PI) 07/17/95-05/16/01 National Heart, Lung and Blood Institute Clinical Centers for Etiology of Sarcoidosis: A Case Control Study The major goals of this project are to participate in a multi-center study of the natural history of sarcoidosis and conduct a multi-center case control study of the etiology of sarcoidosis. It will end prior to the start of the proposed ACCESS II. Role: Co-PI DESCRIPTION OF RESEARCH INTERESTS
Environmental and Occupational Lung Disease
My research focuses on occupational and environmental lung diseases caused by exposure to inhaled antigens (especially bioaerosols), with an emphasis on hypersensitivity pneumonitis. We are investigating the etiology, epidemiology, exposure variables, clinical features, and prevention of hypersensitivity pneumonitis. We are also exploring the etiology of sarcoidosis in a large case-control study. We are part of a multicenter study of sarcoidosis in African-Americans. We are investigating early biomarkers of lung cancer risk in asbestos exposed workers.