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John V. Weil, M.D.

Professor of Medicine



John V. Weil, M.D.
Professor of Medicine

University of Colorado Denver


John.Weil@ucdenver.edu

 

 

EDUCATION/TRAINING

Yale College - New Haven, CT
1957 B.S. Biochemistry

Yale School of Medicine - New Haven, CT
1961 M.D. 
1961-1964 Intern/Resident 1964-1968 Assist Resident Medicine


PROFESSIONAL EXPERIENCE

1964-1966
Officer, USPHS Heart Control Program & Cardiology Research Fellowship - UCD

1966-1967
Cardiology Research Fellowship, Cardiovascular Pulmonary Research Laboratory - UCD

1968-1970
Established Investigator, Colorado Heart Association

1971-1977
Associate Professor of Medicine - UCD

1972-1976
Director, Housestaff Training Program in Internal Medicine - UCD

1977-Present
Professor of Medicine - UCD

1982-1998
Director, Cardiovascular Pulmonary Research Laboratory - UCD

1981-1985
Chairman, NIH Respiration & Applied Physiology Study Section

1986-1991
Member, Pulmonary Disease Advisory Committee - NHLBI

1985-1990
Associate Editor, American Review of Respiratory Disease

1992-1993
NHLBI Parent Review Committee SCORs in Acute Lung Injury, Sleep & Cystic Fibrosis

1992-1997
NHBLI Program Project Grant Committee A/B

SELECTED PUBLICATIONS

Zwillich CW, Sahn SA, Weil JV. Effects of hypermetabolism on ventilation and chemosensitivity. J Clin Invest 60:900-906, 1977.


Collins DD, Scoggin CH, Zwillich CW, Weil JV. Hereditary aspects of decreased hypoxic response. J Clin Invest 212:105-110, 1978.


McGrath RL, Weil JV. Adverse effects of polycythemia and hypoxia on hemodynamics. Circ Res 43:793-798, 1978


Mountain R, Zwillich CW, Weil JV. Hypoventilation in obstructive lung disease: The role of familial factors. New Eng J Med 298:521-525, 1978.


Dauber IM, Pluss WT, vanGrondell A, Trow RS, Weil JV. Specificity and sensitivity of noninvasive measurement of pulmonary vascular protein leak. J Appl Physiol 59:564-574, 1985.


Moore LG, Harrison GL, McCullough RE, McCullough RG, Micco AJ, Tucker A, Weil JV, Reeves JT. Low acute hypoxic ventilatory response and hypoxic depression in acute altitude sickness. J Appl Physiol 61:1407-1413, 1986.


White DP, Gleeson K, Pickett CK, Reeves JT, Rannels AM, Cymerman A, Weil JV. Altitude acclimatization: Influence on periodic breathing and chemoresponsiveness during sleep. J Appl Physiol 63:401-412, 1987.


Vizek M, Pickett CK, Weil JV. Increased carotid body hypoxic sensitivity during acclimatization to hypobaric hypoxia. J Appl Physiol 63:2403-2410, 1987.


Vizek M, Pickett CK, Weil JV. Biphasic ventilatory response of adult cats to sustained hypoxia has central origin. J Appl Physiol 63:1658-1664, 1987.


Stelzner TJ, O'Brien RF, Sato K, Weil JV. Hypoxia-induced increases in pulmonary transvascular protein escape in rats: Modulation by glucocorticoids. J Clin Inv 82:1840-1847, 1988.


Pickett CK, Regensteiner JG, Woodard WD, Hagerman DD, Weil JV, Moore LG. Influences of combined progestin and estrogen on sleep-disordered breathing in postmenopausal women. J Appl Physiol 66:1656-1661, 1989.


McClellan MD, Dauber IM, and Weil JV. Elevated intracranial pressure increases pulmonary vascular permeability to protein. J Appl Physiol 67:1185-1191, 1989.


Welsh CH, Lien DC, Worthen GS, Henson, Weil JV. Endotoxin pretreated neutrophils increase pulmonary vascular permeability in the dog. J Appl Physiol 66:112-119, 1989.


Stelzner TJ, Weil JV, O'Brien RF. Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties. J Cell Physiol 139:157-166, 1989.


Dauber IM, VanBenthuysen KM, McMurtry IF, Wheeler GS, Lesnefsky EJ, Horwitz LD, and Weil JV. Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion. Circ Res 66:986-998, 1990.


Zamora MR, O'Brien RF, Rutherford RB, and Weil JV. Serum endothelin-1 concentrations and cold provocation in primary Raynaud's phenomenon. Lancet 336:1144-47, 1990.


Tatsumi K, Pickett CK, Weil JV. Attenuated carotid body hypoxic sensitivity after prolonged hypoxic exposure. J Appl Physiol 70:748-755, 1991.


Tatsumi K, Hannhart B, Pickett CK, Weil JV, Moore LG. Influence of gender and sex hormoones on hypoxic ventilatory response in cats. J Appl Physiol 71:1746-1750, 1991.


Dauber IM, Lesnefsky EJ, Ashmore RC, Martel DM, Sheridan FM, Weil JV. Horwitz LD. Coronary vascular injury due to ischemia-reperfusion is reduced by pentoxifylline. J Pharmacol Exp Ther 260:1250-1256, 1992.


Tatsumi K, Pickett CK, Weil JV. Effects of haloperidol and domperidone on ventilatory roll off during sustained hypoxia in cats. J Appl Physiol 72(5):1945-1952, 1992.


Tatsumi K, Pickett CK, Jacoby CR,Weil JV, Moore LG. Role of endogenouse female hormones in hypoxic chemosensitivity. J Appl Physiol. 1997 Nov: 83(5): 1706-1710.


Tatsumi K, Pickett CK, Weil JV. Possible role of dopamine in ventilatory acclimatization to high altitude. Resp Physiol 99:63-73, 1995.


Weil JV, Castro O, Malik AB, Rodgers G, Bonds DR, Jacobs TP. NHLBI Workshop Summary. Pathogenesis of lung disease in sickle hemoglobinopathies. Am Rev Respir Dis 148:249-256, 1993.


Dauber IM, Parsons PE, Welsh CH, Giclas PC, Whitman GJR, Wheeler GS, Horwitz LD, Weil JV. Peripheral bypass-induced pulmonary and coronary vascular injury: Association with increased levels of tumor necrosis factor. Circulation 88:726-35, 1993.


Tatsumi K, Pickett CK, Weil JV. Decreased carotid body hypoxic sensitivity in chronic hypoxia: Role of dopamine. Resp Physiol (In Press).


Weil JV, Stevens T, Pickett CK, Tatsumi K, Dickinson M, Jacoby C, Rodman DM. Strain-associated differences in hypoxic chemosensitivity of the carotid body in rats. (Submitted).
Tatsumi K, Hannhart B, Pickett CK, Weil JV, Moore LG. Effects of testosterone on hypoxic ventilatory and carotid body neural responsiveness. Am J Respir Crit Care Med 149:1248-1253, 1994.


Weil JV. Ventilatory responses to CO2 and hypoxia after sustained hypoxia in awake cats [editorial] J Appl Physiol (1994 Jun) 76(6):2251-1, 1994.


Tatsumi K, Pickett CK, Weil JV. Possible role of dopamine in ventilatory acclimatization to high altitude. Respiration Physiology. 99(1):63-73, 1995


Tatsumi K, Pickett CK, Weil JV. Decreased carotid body sensitivity in chronic hypoxia: role of dopamine Respiration Physiology 101:47-57,1995


Kuypers FA, Styles L, Schalkwijk CG, Hassell KL, Vischinsky E, Lubin BH, Weil JV, Lane PA. Increased serum levels of phospholipase A2 and free fatty acid in sickle cell disease associated with acute chest syndrome (ACS). Colloque INSERM 234:501-503, 1995


Tatsumi K, Pickett CK, Weil JV. Decreased carotid body hypoxic sensitivity in chronic hypoxia: Role of dopamine. Resp Physiology 101:47-57, 1995.


Conger JD, Weil JV. Abnormal vascular function following ischemia-reperfusion injury. J Invest Med 43(5):431-42, 1995.


Lane PA, O'Connell JL, Hassell KL, Weil JV. Free fatty acids increase permeability of cultured pulmonary artery endothelium: Implications for pathogenesis of acute chest syndrome in sickle cell disease (Abstract). Pediatr Res 37:161A, 1995.


Weil JV, Stevens T, Pickett CK, Tatsumi K, Dickinson M. Jacoby C. Rodman DM. Strain associated differences in hypoxic chemosensitivity of the carotid body in rats. Am J Physiol. 1998 May 274(5 Pt1):L767-L774.





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