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Edward David Chan, M.D.

Professor of Medicine


 

 

Edward David Chan, M.D.
Professor of Medicine

University of Colorado 
Pulmonary Sciences & Critical Care Medicine 
Phone: 303-724-0000; Email: chane@njhealth.org
 

EDUCATION & TRAINING

University of Colorado, Colorado Springs, CO
1982 B.A. Biology/Chemistry

Columbia University College of Physicians & Surgeons, New York, NY
1986 M.D. 

St. Lukes-Roosevelt Hospital Center, University Hospital, New York, NY
1986-1989 Residency Internal Medicine

University of Colorado Denver, Denver, CO 
1993-1997 Fellowship Pulmonary Science & Critical Care Medicine

    PROFESSIONAL EXPERIENCE

    1989-1991
    Chief of Internal Medicine Clinic, Clinical Laboratory Director, CME Coordinator; F.E. Warren Air Force Base Hospital, Cheyenne, WY

    1991-1993
    Staff Internist, Infection Control Committee Chairman, QA Monitor of Internal Medicine Clinic; United States Air Force Academy Hospital, Colorado Springs, CO

    1993-1997
    Pulmonary and Critical Care Fellow, University of Colorado Denver, Denver, CO

    1994-1999
    Pulmonary Research Fellow, National Jewish Medical and Research Center, Denver, CO

    1999-Present
    Clinical Staff Member, National Jewish Health, Denver, CO

    2006-Present
    Director of MICU, Denver Veterans Affairs Medical Center

    SELECTED PUBLICATIONS

    Chan ED. Reye's syndrome in a young adult. Military Medicine 1993; 158: 65-68.

    Chan ED, Winston BW, Jarpe MB, Wynes MW, Riches DWH. Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNFa Proc Natl Acad Sci USA 1997; 94: 13169-13174.

    Chan ED, Winston BW, Uh S-T, Wynes MW, Rose DM, Riches DWH. Evaluation of the Role of Mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFNg and TNFa in mouse macrophages. J Immunol 1999; 162: 415-422.

    Chan ED, Reves R, Belisle JT, Brennan PJ, Hahn WE. Diagnosis of tuberculosis by a visually detectable immunoassay for lipoarabinomannan. Am J Respir Crit Care Med 2000; 161: 1713-1719.

    Chan ED, Riches DWH.  IFNg + LPS-induction of iNOS is modulated by ERK, JNK/SAPK, and p38mapk in a mouse macrophage cell line. Am J Physiol Cell Physiol 2001; 280: C441-C450.

    Chan ED, Riches DWH, White CW.  Redox paradox: Effect of N-acetylcysteine and serum on oxidation-reduction sensitive signaling pathways ERK, p38mapk, and JNK. Am J Respir Cell Mol Biol 2001; 24: 627-632.

    Chan ED, Morris KR, Belisle JT, Hill P, Remigio LK, Brennan PJ, Riches DWH.  Induction of iNOS-NO by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NFkB signaling pathways. Infect Immun 2001; 69: 2001-2010.

    Chan ED, Chan J, Schluger NW.  What is the role of nitric oxide in murine and human host-defense against tuberculosis? Current knowledge. Am J Respir Cell Mol Biol 2001; 25: 606-612.

    Chan ED and Iseman MD.  Brief synopsis of the current medical treatment for tuberculosis.  Br Med J 2002; 325: 1282-1286.

    Choi H-S, Rai PR, Chu H-W, Cool C, Chan ED.  Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis.  Am J Respir Crit Care Med 2002; 166: 178-186.

    Chan ED, Morales DV, Welsh CH, McDermott MT, Schwarz MI. Calcium deposition with or without bone formation in the lung. Am J Respir Crit Care Med 2002; 165: 1654-1669.

    Chmura K, Cool C, Kircher T, Chan ED. Painful lymphadenopathy and fulminant sepsis in a previously healthy 16-year old girl. Chest 2003; 124: 379-382.

    Morris KR, Lutz RD, Choi H-S, Kamitani T, Chmura K, Chan ED. Role of the NFkB signaling pathway and kB cis-regulatory elements on the IRF-1 and iNOS promoter regions in mycobacterial lipoarabinomannan induction of nitric oxide. Infect Immun 2003; 71: 1442-1452.

    Chan ED, Laurel V, Strand M, Chan JF, Hyunh M-L, Goble M, Iseman MD.  Treatment and outcome analysis of 205 patients with multidrug-resistant tuberculosis.  Am J Respir Crit Care Med 2004; 169: 1103-1109.

    Bai X, Wilson SE, Chmura K, Feldman NE, Chan ED.  Morphometric analysis of Th1 and Th2 cytokine expression in human pulmonary tuberculosis.  Tuberculosis 2004; 84: 375-385.

    Wieland CW, Florquin S, Chan ED, Leemans JC, Weijer S, Verbon A, Fantuzzi G, van der Poll T. Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice.  Int Immunol 2005; 17: 1399-1408.

    Sullivan A, Chmura K, Cool CD, Keith R, Schwartz GG, Voelkel N, Chan ED.  Pulmonary capillary hemangiomatosis: An immunohistochemical analysis of vascular remodeling. Eur J Med Res 2006; 11: 187-193.

    Chan MM*, Chmura K*, Chan ED.  Increased NaCl-induced IL-8 production by human bronchial epithelial cells is enhanced by the DF508/W1282X mutation of the cystic fibrosis transmembrane conductance regulator gene. Cytokine 2006; 33: 309-316.

    Netea MG, Azam T, Lewis EC, Joosten LAB, Wang M, Langenberg D, Meng X, Chan ED, Yoon D-Y, Ottenhoff T, Kim S-H, Dinarello CA.  Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon- dependent mechanism.  PLoS Med 2006; 3:e277.

    Chan ED, Kaminska AM, Gill W, Chmura K, Feldman NE, Bai X, Floyd CM, Fulton KE, Huitt GA, Strand MJ, Iseman MD, Shapiro L. Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages.  Scad J Infect Dis 2007; 39: 690-696.

    Chan ED, Strand MJ, Iseman MD.  Treatment outcomes in extensively resistant tuberculosis. N Engl J Med 2008; 359: 657-659.

    Ordway D, Henao-Tamayo M, Smith E, Shanley C, Harton M, Troudt JL, Bai X, Basaraba RJ, Orme IM, Chan ED. Animal model of Mycobacterium abscessus lung infection. J Leuk Biol 2008; 83: 1502-1511.

    Chmura K, Bai X, Nakamura M, Kandasamy P, McGibney M, Kuronuma K, Mitsuzawa H, Voelker DR, Chan ED.  Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells. Am J Physiol Lung Cell Mol Physiol 2008; 295:L220-30.

    Chan ED, Iseman MD. Multi-drug resistant and extensively drug-resistant tuberculosis: a review. Curr Opin Infect Dis 2008; 21:587-595.

    Chan ED, Strand MJ, Iseman MD. MDR-TB resistant to fluoroquinolones and streptomycin but susceptible to second-line injectables has better prognosis than XDR-TB. Clin Infect Dis 2009; 48:e50-52.

    Morris KR, Lutz RD, Bai X, McGibney MT, Cook D, Ordway D, Chan ED, Suppression of IFNg + mycobacterial lipoarabinomannan-induced NO by IL-4 is due to decreased IRF-1 expression. Tuberculosis 2009; 89: 294-303.

    Chan ED and Iseman MD. Slender, older women appear to be more susceptible to nontuberculous mycobacterial lung disease. Gender Med 2010;7:5-18.

    Chan ED, Bai X, Kartalija M, Orme IM, Ordway DJ. Host immune response to rapidly-growing mycobacteria, an emerging cause of chronic lung disease. Am J Respir Cell Mol Biol 2010; 43: 387-393.

    Bai X, Kim S-H, Azam T, McGibney MT, Huang H, Dinarello CA, Chan ED. IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J Immunol 2010; 184: 3830-3840.

    Oberley-Deegan RE, Rebits BW, Weaver MR, Tollefson AK, Bai X, McGibney M, Ovrutsky AR, Chan ED, Crapo JD.  An oxidative environment promotes the growth of Mycobacerium abscessus. Free Rad Biol Med 2010; 49: 1666-1673.

    Bai X, Chmura K, Ovrutsky AR, Bowler RP, Scheinman RI, Oberley-Deegan RE, Liu H, Shang S, Ordway D, Chan ED.  Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription.  Tuberculosis 2011; 91: 26-35.

    Walter ND, Rice PL, Redente EF, Kauvar EF, Lemond L, Aly T, Wanebo K, Chan ED.  Wound Healing after trauma may predispose to lung cancer metastasis: Review of potential mechanisms.  Am J Respir Cell Mol Biol 2011; 44: 591-596.

    Kandasamy P, Zarini S, Chan ED, Leslie CC, Murphy RC, Voelker DR.  Pulmonary surfactant phosphatidylglycerol inhibits Mycoplasma pneumoniae stimulated eicosanoid production from human and mouse macrophages. J Biol Chem 2011; 286: 7841-7853.

    Shang S, Ordway D, Henao-Tamayo M, Bai X, Oberley-Deegan R, Shanley C, Orme IM, Case S, Minor M, Ackart D, Hascall-Dove L, Ovrutsky AR, Kandasamy P, Voelker DR, Lambert C, Freed BM, Iseman MD, Basaraba RJ, Chan ED. Cigarette smoke increases susceptibility to tuberculosis – evidence from in vivo and in vitro models. J Infect Dis 2011; 203: 1240-1248.

    Shang S, Harton M, Henao-Tamayo M, Shanley C, Palanisamy GS, Caraway M, Chan ED, Basaraba RJ, Orme IM, and Ordway DJ.  Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis. Tuberculosis 2011; 91: 378-385.

    Honda JR, Shang S, Shanley CA, Caraway ML, Henao-Tamayo M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ, Flores SC.  Immune responses of HIV-1 Tat transgenic mice to Mycobacterium tuberculosis W-beijing sa161. Open AIDS J 2011; 5: 86-95.

    Bai X, Ovrutsky AR, Kartalija M, Chmura K, Kamali A, Honda JR, Oberley-Deegan RE, Dinarello CA, Crapo JD, Chang L-Y, Chan ED.  IL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung disease. Int Immunol 2011; 23: 679-691.

    Walter ND, Strong M, Belknap R, Ordway DJ, Daley CL, Chan ED. Translating basic science insight into public health action for multidrug- and extensively drug resistant-tuberculosis. Respirology 2012 (E-pub).