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Brian J. Day, Ph.D.
Associate Professor of Medicine
University of Colorado Denver
dayb@njc.org
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Education & Training
University of Montana, Missoula, MT
1984 B.S. Biochemistry
Purdue University, West Lafayette, IN
1992 Ph.D. Pharmacology & Toxicology
Duke University, Durham, NC
1992-1995 Postdoctoral Pulmonary Toxicology
Professional Experience
1992 to 1995
Integrated Toxicology and Pulmonary Fellow, Duke University, Durham, North Carolina
1995 to 1997
Research Assistant, Professor, Department of Medicine, Duke University, Durham, North Carolina
1997 to 2001
Assistant Faculty Member, Department of Medicine, National Jewish Medical and Research Center
1997 to 2001
Assistant Professor, Department of Medicine, University of Colorado Denver, Denver, Colorado
1998-2001
Assistant Professor, Department of Pharmaceutical Science, School of Pharmacy, University of Colorado Denver, Denver, Colorado
2001-Present
Associate Professor, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado
2001-Present
Associate Professor, Department of Medicine and Pharmaceutical Science, University of Colorado Denver, Denver, Colorado
Honors and Awards
•1988, 1992 Purdue University Keinly Teaching Award
•1990 - 1992 Purdue University David Ross Fellowship
•1992 - 1994 Duke University Integrated Toxicology Fellowship
•1994 - 1995 Duke University Pulmonary Research Fellowship
•1995 Co-Chairman of the "Oxidant Injury and Antioxidants Session" at the Annual Meeting of the Oxygen Society
•1995 - 1996 American Lung Association of North Carolina Research Grant
•1996 - 1998 American Lung Association Research Grant
•1998 Guest speaker at the North American Cystic Fibrosis Conference
•1999 Guest Speaker at the Cystic Fibrosis Williamsburg Conference
•2000 Co-Chairman of the “Role of Antioxidants in Oxidant Stress Session” at the American Thoracic Society Meeting in Toronto
•2000 Oral presentation in the “Oxidants and Antioxidants in Health and Disease Session” at the Annual Meeting of the Oxygen Society in San Diego
•2001 Oral presentation in the “Biology of Lung Cancer Genesis and Metastasis Session” at the American Thoracic Society Meeting in San Francisco
•2001 Guest Speaker at Emory University Medical School Department of Pathology’s Seminar Series
•2002 Chairman of “Cytochrome P450I Session” at the Annual Meeting of the Society of Toxicology in Nashville
•2002 Guest Speaker at the Cystic Fibrosis Foundation Williamsburg Conference
Professional Affiliations
1981 - 1984 Student American Pharmaceutical Association
1983 - Rho Chi Honor Society
1985 - Present Montana State Pharmaceutical Association
1990 - Phi Kappa Phi Honor Society
1990 - Present Society of Toxicology
1994 - Present American Thoracic Society
1995 - Present Oxygen Society
1998 - Present American Heart Association
1998 - Present American Chemical Society
Selected Publications from 1999-Present
•Day BJ, Batinic-Haberle I and Crapo JD. Metalloporphyrins are potent inhibitors of lipid peroxidation. Free Radic Biol Med 26:730-736, 1999.
•Hildeman D, Mitchell T, Teague TK, Henson P, Day BJ, Kappler J, and Marrack P. Reactive oxygen species regulate activation induced T cell apoptosis. Immunity 10:735-744, 1999.
•Day BJ, Patel M, Calavetta L, Chang LY and Stamler JS. A mechanism for paraquat toxicity that involves nitric oxide synthase. Proc Natl Acad Sci 96:12760-12765, 1999.
•Milano, J and Day, BJ. A catalytic antioxidant metalloporphyrin blocks hydrogen peroxide induced mitochondrial DNA damage. Nucleic Acid Res. 28:968-973, 2000.
•Velsor, L., van Heeckeran, A., and Day, BJ Antioxidant imbalance in the lungs of the cystic fibrosis transmembrane conductance regulator protein mutant mouse. Am. J. Physiol. 281:L31-L38, 2001.
•Kachadourian, R, Liochev, SI, Cabelli, DE, Patel, M, Fridovich, I, and Day, BJ 2-Methoxyestradiol (2-ME) does not inhibit superoxide dismutase. Arch. Biochem. Biophys. 392:349-353, 2001.
•Lewis W, Copeland WC, Day BJ. Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors. Lab Invest 81:777-90, 2001.
•Oury TD, Thakker K, Menache M, Chang LY, Crapo JD, Day BJ. Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin. Am J Respir Cell Mol Biol 25: 164-9, 2001.
•Kachadourian R, Menzeleev R, Agha B, Bocckino SB, Day BJ. High-performance liquid chromatography with spectrophotometric and electrochemical detection of a series of manganese(III) cationic porphyrins. J Chromatogr B Biomed Sci Appl. 2002 Feb 5;767(1):61-7.
•Gow AJ, Chen Q, Hess DT, Day BJ, Ischiropoulos H, Stamler JS. Basal and stimulated protein s-nitrosylation in multiple cell types and tissues. J Biol Chem. 2002 Mar 22;277(12):9637-40.
•Graziewicz, MA, Day, BJ, and Copeland, WC The mitochondrial DNA polymerase as a target of oxidative damage. Nucleic Acid Res. 30:2817-2824, 2002.
•Gauuan, PJF, Trova, MP, Gregor-Boros, L, Bocckino, SB, Crapo, JD, and Day, BJ. Superoxide dismutase (SOD) mimetics: An SAR study of MnTBAP analogs. Bioorganic Med. Chem. Lett. 10:3013-3021, 2002.
•Hines, IN, Hoffman, JM, Scheerens, H, Day BJ, Harada, H, Pavlick, KP, Bharwani, S, Wolf, R, Gao, B, Flores, S, McCord, JM, and Grisham, MB. Regulation of post-ischemic liver injury following different durations of ischemia. Am. J. Physiol.Gastrointest Liver Physiol. 284(3):G536-545, 2003.
•Kachadourian, R, Flaherty, MM, Crumbliss, AL, Patel, M, Day, BJ. Synthesis and in vitro antioxidant properties of manganese(III) beta-octabromo-meso-tetrakis(4-carboxyphenyl)porphyrin. J Inorg Biochem. 95(4):240-248, 2003.
•Trova, MP, Gauuan, PJ, Pechulis, AD, Bubb, SM, Bocckion, SB, Crapo, JD, Day, BJ. Superoxide dismutase mimetics. Part 2: Synthesis and structure - Activity relationship of glyoxylate- and glyoxamide-derived metalloporphyrins. Bioorg Med Chen. 11(13):2695-2707, 2003.
