Presented by the Division of Pulmonary Sciences and Critical Care Medicine
and the Aspen Lung Conference
Sponsored by the University of Colorado School of Medicine
Office of Continuing Medical Education
THOMAS L. PETTY
ASPEN LUNG CONFERENCE
57th Annual Meeting
"Rebuilding the Injured Lung”
June 4-7, 2014
Tuesday, June 3, 2014 -- Evening
5:00-7:00 PM Evening Registration -- Wine and Cheese Reception Gant Conference Center
Wednesday, June 4, 2014-- Morning
8:00-8:30 AM Introduction David W.H. Riches, Ph.D., Chair
Ellen L. Burnham, M.D., Co-Chair
Gregory P. Downey, M.D., Co-Chair
Marc Moss, M.D., Co-Chair
Eric P. Schmidt, M.D., Co-Chair
Acute Lung Injury
8:30-9:05 AM STATE OF THE ART
V. Marco Ranieri, M.D.
University of Turin, Italy
“Mechanisms and Clinical Consequences of Acute Lung Injury”
9:05-9:30 AM Discussion
9:30-9:45 AM PULMONARY ATELECTRAUMA: BIOPHYSICAL INSIGHTS INTO MECHANISMS OF DAMAGE AND PREVENTION. Donald P. Gaver*, A.-M. Job, B.J. Smith, E. Yamaguchi, Department of Biomedical Engineering, Tulane University, New Orleans, LA.
9:45-10:00 AM A COMPARATIVE GENOMICS ANALYSIS OF GENE EXPRESSION PROFILES DEMONSTRATES A DISTINCT AND REPLICABLE MOLECULAR SIGNATURE FOR ARDS. M. Moll1, T. Dolinay2, A.M.K. Choi3, R.M. Baron4, N.J. Thomas MD5, H.R. Wong6, R. Bascom7, Judie A. Howrylak7*, 1Department of Internal Medicine, Boston University, Boston, MA; 2Department of Medicine, Division of Pulmonary and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA; 3Department of Medicine, Weill Cornell Medical College, New York, NY; 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; 5Department of Pediatrics, Division of Pediatric Critical Care Medicine, Penn State, Milton S. Hershey Children’s Hospital, Hershey, PA; 6Department of Pediatrics, Division of Pediatric Critical Care Medicine, Cincinnati Children’s Hospital, Cincinnati, OH; 7Department of Medicine, Division of Pulmonary and Critical Care Medicine, Milton S. Hershey Medical Center, Hershey, PA.
10:00-10:30 AM ......Coffee Break
Wednesday, June 4, 2014 -- Morning
10:30-11:05 AM REUBEN M. CHERNIACK LECTURE
"CONCEPTUAL APPROACHES TO LUNG
INJURY AND REPAIR”
Peter M. Henson, M.D., Ph.D., B.V.M.S.
Professor of Pediatrics
Program in Cell Biology
Integrated Department of Immunology
National Jewish Health
11:05-11:30 AM Discussion
11:30-11:45 AM Nrf2-regulated signaling is crucial for alveolar macrophage-mediated Efferocytosis During hyperoxic Lung Injury And Repair. N. M. Reddy, C.R. Tamatam, Sekhar P. Reddy*, Division of Development Biology and Basic Research, Department of Pediatrics, University of Illinois College of Medicine, Chicago, IL.
11:45-12:00 TNF-α INDUCED MYOFIBROBLAST PLASTICITY AS A MECHANISM OF REPAIR AFTER FIBROTIC LUNG INJURY. Elizabeth F. Redente*, D.W.H. Riches, Department of Pediatrics, National Jewish Health, Denver, CO.
12:00-1:30 PM ......Lunch (lunch not provided by conference)
Wednesday, June 4, 2014 -- Afternoon
Progressive Lung Injury, Repair and Fibrosis
1:30-2:05 PM PARKER B. FRANCIS LECTURESHIP
"MECHANISMS OF ALVEOLAR EPITHELIAL INJURY,
REPAIR AND FIBROSIS”
Professor Rachel Chambers, Ph.D.
Professor of Respiratory Cell and Molecular Biology
Division of Medicine
Faculty of Medical Sciences
Centre for Respiratory Research, Rayne Institute
London, England, United Kingdom
2:05-2:30 PM Discussion
2:30-2:45 PM MODULATION OF TRIM72 ALTERS THE REPAIR CAPACITY OF LUNG EPITHELIAL CELLS. S.C. Kim1, T. Kellet1, S. Wang2, V.C. Shukla3, B. Zhou4, U.P. Flodby4, K. Shilo5, M. Takeshima6, H. Takeshima6, S.N. Ghadiali3, R.D. Hubmayr2, Xiaoli Zhao1*, 1College of Pharmacy, The Ohio State University (OSU), Columbus, OH/US, 2Mayo Clinic Rochester, Rochester, MN/US, 3Biomedical Engineering, OSU, 4Will Rogers Institute, Pulmonary Research Center, University of Southern California, Los Angeles, CA/US, 5Pathology Department, OSU, 6Kyoto University, Kyoto/Japan.
2:45-3:00 PM HIF dependent cxcr4/sdf1 signaling Promotes Alveolar Type II Cell Spreading and the Resolution of Epithelial Permeability after Lung Injury. J. McClendon1, E.F. Redente1, Y. Ito1, T. Eckle2, H. Eltzschig2, S.P. Colgan2, A. Ahmad2, A. Gandjeva2, R. Tuder2, R.J. Mason1,2, P.M. Henson1,2, Rachel L. Zemans1,2*, 1National Jewish Health, Denver, CO and 2University of Colorado Denver, Aurora, CO.
3:00-3:30 PM ......Break
3:30-4:05 PM STATE OF THE ART
Dean Sheppard, M.D.
University of California, San Francisco
“Epithelial-Mesenchymal Interactions in Repair and Fibrosis”
4:05-4:30 PM Discussion
4:30-4:45 PM FOXP3+ REGULATORY T CELL DNA DEMETHYLATION ACCELERATES RESOLUTION OF ACUTE LUNG INJURY. Benjamin D. Singer*, J.R. Mock, K.W. Gibbs, B.T. Garibaldi, N.R. Aggarwal, V. Sidhaye, L.S. King, F.R. D’Alessio, Johns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD.
4:45-5:00 PM ROLE OF SULF2 IN ALVEOLAR EPITHELIAL INJURY AND REPAIR. L. Auduong, E.A. Hogan, Xinping Yue*, Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA.
5:00 PM POSTER VIEWING --- SOCIAL HOUR
Thursday, June 5, 2014 -- Morning
Mesenchyme, Matrix and Mechanotransduction
8:00-8:35 AM STATE OF THE ART
Daniel J. Tschumperlin, Ph.D.
Mayo Clinic, Rochester
“Matrix, Mesenchyme and Mechanotransduction”
8:35-9:00 AM Discussion
9:00-9:15 AM ALTERED FIBROBLAST REPAIR FUNCTION IN COPD IS EPIGENETIC. Hesham Basma1, Y. Gunji1, S. Iwasawa1, A. Nelson1, M. Farid1, J. Ikari1, X. Liu1, X. Wang1, J. Michalski1, L. Smith2, J. Iqbal3, R. El Behery3, W. West3 S. Yelamanchili4, D. Rennard4, O. Holz5, K.-C. Mueller6, H. Magnussen6, K. Rabe6, P.J. Castaldi7,8, S.I. Rennard1, 1Division of Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska. 2College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska. 3Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska. 4Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska. 5Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM). 1D-30625 Hannover, Germany. 6Research Institute at LungClinic Grosshansdorf, Airway Research Center North, Member of the German Center for Lung Research, Germany. 7Channing Division of Network Medicine. 8Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA.
9:15-9:30 AM Role of integrin α8 in bleomycin induced lung injury. C.F. Hung1, N.M. Mark1, Y.H. Chow1, N. Nishimichi2, Y. Yokosaki2, Lynn M Schnapp*1,3, 1Center for Lung Biology, University of Washington, Seattle, WA 2Hiroshima University, Japan, 3Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC.
9:30-10:00 AM ......Coffee Break
10:00-10:35 AM ROGER S. MITCHELL LECTURE
“LUNG MATRIX STIFFNESS AND FIBROBLAST FUNCTION”
Eric S. White, M.D.
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
Graduate Program in Cellular & Molecular Biology
University of Michigan Medical School
Graduate Program in Biomedical Sciences
Ann Arbor, Michigan
10:35-11:00 AM Discussion
11:00-11:15 AM TRPV4 ION CHANNEL MEDIATES MECHNOSENSING, MYOFIBROBLAST DIFFERENTIATION AND PULMONARY FIBROSIS IN MICE. S.O. Rahaman1*, L.M. Grove1, B.D. Southern1, R.G. Scheraga1, S. Abraham1, K.A. Niese1, S. Ghosh1, D.J. Tschumperlin6, Mitchell A. Olman1*, 1Cleveland Clinic, Department of Pathobiology, Cleveland, OH; 2Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN.
11:15-11:30 AM INTEGRIN-α2 CONTROLS TYPE I COLLAGEN EXPRESSION IN IPF BY REGULATING MICRORNA-29 EXPRESSION. Jeremy Herrera*, M. Parker, M. Peterson, K. Smith, C.A. Henke, P.B. Bitterman, University of Minnesota, Department of Medicine, Minneapolis, MN.
12:00 Noon Picnic – T Lazy 7 - The Ranch
Friday, June 6, 2014 -- Morning
Challenges to Rebuilding the Injured Lung
8:00-8:35 AM THOMAS A. NEFF LECTURE
"LUNG RECONSTRUCTION FOR TRANSPLANTATION:
MULTIPLE STRATEGIES FOR CLINICAL APPLICATION”
Professor Oliver Eickelberg, M.D .
Chairman, Comprehensive Pneumology Center
Ludwig-Maximilians-Universität and Helmholtz Zentrum München
Director, Institute of Lung Biology and Disease (iLBD)
Helmholtz Zentrum München
Neuherberg / München, Germany
8:35-9:00 AM Discussion
9:00-9:15 AM TREATMENT WITH LYMPHANGIOGENIC BLOCKING ANTIBODIES ABROGATES INFLAMMATION IN A BLEOMYCIN MODEL OF PULMONARY FIBROSIS. Abigail R. Lara*, A. Rutebemberwa, M.J. Perez, L.P. Smith, R.M. Tuder, University of Colorado Anschutz Medical Campus, Aurora, CO, National Jewish Health, Denver, CO.
9:15-9:30 AM REVERSAL OF FIBROSIS IN CHRONIC REJECTION IN MOUSE AIRWAYS THROUGH COMBINED RELAXIN AND LOX INHIBITOR THERAPY. Yu-chun Lin*, X. Jiang, M.R. Nicolls, Stanford University/ VA Palo Alto Health Care System, Palo Alto, CA.
9:30-10:00 AM ......Coffee Break
10:00-10:35 AM STATE OF THE ART
Dan Dongeun Huh, Ph.D.
University of Pennsylvania, Philadelphia
“Microengineered Physiological Bio-Mimicry for Lung Research”
10:35-11:00 AM Discussion
11:00-11:15 AM ALVEOLAR BARRIER FUNCTION IN ALCOHOLIC LUNG SYNDROME IS IMPAIRED BY TIGHT JUNCTION DESTABILIZATION. B.L. Schlingmann, C. Ward, S.A. Molina, C.E. Overgaard, D.M. Guidot, Michael Koval*, Emory University School of Medicine, Division of Pulmonary Medicine and Department of Cell Biology, Atlanta, GA.
11:15-11:30 AM E3 LIGASE SUBUNIT FBXO15 AND PINK1 KINASE IMPAIR CARDIOLIPIN SYNTHASE 1 STABILITY AND MITOCHONDRIAL FUNCTION IN EXPERIMENTAL LUNG INJURY. B.B. Chen, T.A. Coon, J.R. Glasser, C. Zou, B. Ellis, T. Das, A.C. McKelvey, S. Rajbhandari, T. Lear, C. Kamga1, S. Shiva1, C. Li2, J.M. Pilewski, J. Callio3, C.T. Chu3, A. Ray, P. Ray, Y.Y. Tyurina4, V.E. Kagan4, Rama K. Mallampalli5*, Department of Medicine, Acute Lung Injury Center of Excellence, Department of Cell Biology and Physiology, Vascular Medicine Institute1 and the Departments of Pathology3 and Environmental and Occupational Health4, University of Pittsburgh, Pittsburgh, PA, and the Department of Neurology, Mt. Sinai School of Medicine2, New York, NY, and the Medical Specialty Service Line, Veterans Affairs Pittsburgh Healthcare System5.
11:30-1:30 PM ......Lunch (lunch not provided by conference)
Friday, June 6, 2014 -- Afternoon
Stem Cell Approaches to Rebuilding the Injured Lung
1:30-2:05 PM STATE OF THE ART
Harald C. Ott, M.D., Ph.D.
Harvard Medical School, Boston
“Using Nature’s Platforms to Engineer Bioartificial Organs”
2:05-2:30 PM Discussion
2:30-2:45 PM PRECLINICAL TESTING OF THERAPEUTIC WNT/β-CATENIN ACTIVATION IN HUMAN 3D LUNG TISSUE CULTURES. F. Uhl, S. Vierkotten, G. Burgstaller, M. Lindner, O. Eickelberg, Melanie Königshoff*, Comprehensive Pulmonology Center (CPC), Helmholtz Zentrum München, Munich, Germany.
2:45-3:00 PM INTEGRIN LINKED KINASE ACTS UPSTREAM OF THE HIPPO PATHWAY TO REGULATE AIRWAY EPITHELIAL STEM CELL QUIESCENCE. T. Volckaert, A. Matschulat, Stijn De Langhe*, National Jewish Health, Denver, CO.
3:00-3:30 PM ......Break
3:30-4:05 PM GILES F. FILLEY LECTURE
"APPLICATION OF EMBRYONIC INDUCED PLEURIPOTENT
STEM CELLS IN LUNG REGENERATION”
Darrell N. Kotton, M.D.
Associate Professor of Medicine and Pathology and Laboratory Medicine
Director, Center for Regenerative Medicine (CReM)
Boston University School of Medicine
The Pulmonary Center
4:05-4:30 PM Discussion
4:30-4:45 PM ENHANCED LUNG EPITHELIAL SPECIFICATION OF HUMAN IPSCs ON DECELLULARIZED LUNG SCAFFOLDS. Sarah E. Gilpin*, X. Ren, T. Okamoto, J.P. Guyette, H. Mou, J. Rajagopal, D.J. Mathisen1, J.P. Vacanti, H.C. Ott, 1Massachusetts General Hospital, Boston, MA, 2Harvard Medical School, Boston, MA.
4:45-5:00 PM HARNESSING THE MESENCHYMAL STEM CELL (hMSC) SECRETOME TO COUPLE THE RV/PA DURING PULMONARY FIBROSIS (PF). J. Njah; M. Di Giuseppe; J. Hu, A. Mora; Luis A. Ortiz*, Graduate School of Public Health and Department of Medicine University of Pittsburgh, Pittsburgh, PA.
5:00 PM POSTER VIEWING -- Wine and Cheese Reception
Saturday, June 7, 2014 -- Morning
Strategic Approaches to Improving Therapy
8:00-8:35 AM THOMAS L. PETTY LECTURE
Introduction by Dennis E. Doherty, M.D., FCCP
Secretary/Treasurer-National Lung Health Education Program
Professor of Medicine
Lexington VAMC/University of Kentucky
"THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELLS”
Michael A. Matthay, M.D.
Professor in Residence/Department of Medicine
University of California San Francisco School of Medicine
San Francisco, California
[Sponsored by the National Lung Health Education Program]
8:35-9:00 AM Discussion
9:00-9:15 AM OXIDATIVE INJURY DUE TO CELL-FREE HEMOGLOBIN IN SEPSIS AND ARDS: RESULTS OF A RANDOMIZED CLINICAL TRIAL OF ACETAMINOPHEN. D.R. Janz, J.A. Bastarache, T.W. Rice, G.R. Bernard, J.A. Oates, L.J. Roberts II, Lorraine B. Ware*, Department of Medicine, Vanderbilt University, Nashville, TN.
9:15-9:30 AM REGULATING THE INNATE IMMUNE SYSTEM TO DECREASE LUNG INJURY. D. Pilling, A. Maharjan, N. Cox, Richard H. Gomer*, Department of Biology, Texas A&M University, College Station, TX.
9:30-10:00 AM ......Coffee Break
10:00-10:35 AM STATE OF THE ART
Gordon D. Rubenfeld, M.D., M.Sc.
University of Toronto, Canada
“The Trials and Tribulations of Conducting Multicenter Clinical Trials”
10:35-11:00 AM Discussion
11:00-11:15 AM A GWAS IN THE ISPAAR CONSORTIUM IDENTIFIES FARP1 AS A NOVEL RISK LOCUS FOR ARDS. Mark M. Wurfel*1, J.D. Christie2, C.S. Calfee3, M.A. Matthay3, I. Barnett4, N.J. Meyer2, O.D. O’Mahony1, G.E. O'Keefe1, H. Hakonarson5, G.P. Jarvik1, K.R. Walley6, J.A. Russell6, X. Lin4, D.C. Christiani4, and ARDSNet Investigators. 1University of Washington, 2University of Pennsylvania, 3University of California San Francisco, 4Harvard School of Public Health, 5Children's Hospital of Philadelphia, 6University of British Columbia.
11:15-11:30 AM LATENT CLASS MODELS IDENTIFY TWO SUBPHENOTYPES IN ARDS WITH DIFFERENTIAL RESPONSE TO POSITIVE END-EXPIRATORY PRESSURE. Carolyn S. Calfee1*, K. Delucchi1, P.E. Parsons2; B.T. Thompson3; L.B. Ware4; M.A. Matthay1, and the NHLBI ARDS Network, 1UCSF; 2University of Vermont; 3Massachusetts General Hospital; 4Vanderbilt University.
11:30-12:30 PM CONFERENCE SUMMARY
Peter B. Bitterman, M.D.
Professor of Medicine
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine
University of Minnesota Medical Center
12:30 PM Discussion and Adjourn
POSTER VIEWING - SOCIAL HOUR
Wednesday, June 4, 2014
POSTERS – Lung Injury
PROTEIN PHOSPHATASE REGULATION OF APICAL-BASAL POLARITY AS A NEW MECHANISM FOR LUNG EPITHELIAL PROGENITOR CELL BEHAVIOR AND PROTECTION AGAINST LUNG FIBROSIS. R. Reddy, D. Warburton, Ahmed El-Hashash*, Children’s Hospital Los Angeles, Keck School of Medicine and Ostrow School of Dentistry, University of Southern California, Los Angeles, CA.
MICRORNAs AS NOVEL REGULATORS OF MECHANOTRANSDUCTION AND LUNG INJURY INFLAMMATION. Samir N. Ghadiali1,2,4*, K. Nelson1, C. Bobba1, P. Nana-Sinkam2,4, X. Zhao4,5, Bryan Whitson3,4, 1Biomedical Engineering, 2Internal Medicine and 3Surgery, 4Davis Heart and Lung Research Institute, 5College of Pharmacy, The Ohio State University, Columbus, OH.
GENETIC ABLATION OF CARM1 EXPRESSION ENHANCES SUSCEPTIBILITY TO ELASTASE-INDUCED EMPHYSEMA IN MICE. R.S.J. Sarker1, A. Bohla1, O.V. Amarie1, O. Eickelberg1,2,3, Ali Önder Yildirim1,3*, 1Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München and 2University Hospital of the Ludwig Maximilians University (LMU), 3Member of the German Center for Lung Research (DZL), Munich, Germany.
DJ-1 PATHWAY IMPAIRMENT IN ALVEOLAR TYPE II CELLS IN EMPHYSEMA. E. Messier1, K. Bahmed2, R. Mason1, R. Tuder2, W. Zhou2, M. Edwards2, R. Bowler1, C. Freed2, H.W. Chu1, Beata Kosmider1*, 1Department of Medicine, National Jewish Health, Denver, CO; 2School of Medicine, University of Colorado Denver, Aurora, CO.
CONCOMITANT ADMINISTRATION OF CORTICOSTEROIDS WITH ANTIOXIDANTS IMPROVES PROTECTION AGAINST CHLORINE-INDUCED LUNG INJURY IN MICE. Elisabeth Wigenstam*, B. Koch, S. Jonasson, Swedish Defence Research Agency, Division of CBRN Defence and Security, Umeå, Sweden.
OXIDATIVE STRESS AND LUNG PERMEABILITY AFTER CHLORINE-INDUCED ACUTE LUNG INJURY IN MICE. Linda Elfsmark*, L. Ågren, C. Akfur, B. Ekstrand-Hammarström, A. Bucht, Division of CBRN Defence and Security, Swedish Defence Research Agency, and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
AUTOPHAGY IS MEDIATED BY OXIDATIVE SIGNALING IN LIPOPOLYSACCHARIDE INDUCED ACUTE LUNG INJURY MODEL. Y.J. Lee1, Y.-J. Cho1, Sang-Min Lee2*, 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Aspirin-triggered ω-3 fatty acids reduces pulmonary NF-κB activation in a murine model of ventilator-induced lung injury. Young-Jae Cho1*, Y.J. Lee1, E.Y. Eo1, S.-M. Lee2, C.-T. Lee1, J.H. Lee1, 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital; 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
POSTERS – Wednesday, June 4, 2014 – Lung Injury - continued
TARGETING FcγR RECEPTOR SIGNALING AS A NOVEL THERAPY FOR ALI/ARDS. A. Krupa, J. Florence, Anna Kurdowska*, University of Texas Health Northeast / UTHSCT, Tyler, TX.
PERICYTE ACTIVATION AND EXPRESSION OF ADHERENCE MOLECULES IN STERILE LUNG INJURY. Bonnie L. Hastings*, K.L. Mittelsteadt, C.F. Hung, W.A. Altemeier, University of Washington, Pathology, Seattle, WA.
N-cadherin and AMPKα1 contribute to the pulmonary endothelial response to LPS. M.-Y. Jiang, T. Yu, P. Wolkowicz, Judy Creighton*, University of Alabama at Birmingham, Birmingham, AL.
CELL-FREE HEMOGLOBIN IN ARDS: NOT AN INNOCENT BYSTANDER. Lorraine B. Ware*, C.M. Shaver, C.P. Upchurch, H. Nagata, D.R. Janz, J.M. May, S.I. Dikalov, L.J. Roberts II, J.A. Bastarache, Department of Medicine, Vanderbilt University, Nashville, TN.
THE ADENYLATE CYCLASE-CYCLIC AMP PATHWAY ROLE IN THE pH-DEPENDENT REPAIR OF INJURED ALVEOLAR EPITHELIAL CELLS. Dante N. Schiavo*, B.D. Westerly, D.L. McCall, R.A. Oeckler, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN.
THERAPEUTIC EXERCISE LIMITS ACTIVATION AND RECRUITMENT OF NEUTROPHILS TO THE LUNG. D. Clark Files1,2,*, C. Liu1, A. Pereyra3, M.C. Seeds1,2, O. Delbono3, P.E. Morris1,2, 1Internal Medicine-Pulmonary, Critical Care, Allergy and Immunology, Wake Forest School of Medicine, Winston-Salem, NC ,2Wake Forest Critical Care Translational Research Center, 3Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, NC.
DIFFERENCES IN DEGREE, DIFFERENCES IN KIND: CHARACTERIZING LUNG INJURY IN TRAUMA. Benjamin M. Howard*, L.Z. Kornblith, C.M. Hendrickson, B.J. Redick, M.F. Nelson, R.A. Callcut, C.S. Calfee, M.J. Cohen, Departments of Surgery and Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA.
ELEVATED SERUM IL-17A LEVELS DIFFERENTIATE SEPSIS-ASSOCIATED FROM TRAUMA-ASSOCIATED ARDS. Carmen Mikacenic1*, F. Radella1, R. Stapleton2, M. Wurfel1. 1University of Washington and 2University of Vermont.
RECOVERY FROM SECRETORY A2 PHOSPHOLIPASE-MEDIATED SURFACTANT INJURY IN A MURINE MODEL OF ACUTE LUNG INJURY. Robert Duncan Hite1*, D.C. Files2, M.J. Satusky2, L.N. Ireland2, M.B. Waite2, M.C. Seeds2, 1Cleveland Clinic Foundation; Cleveland, OH and 2Wake Forest School of Medicine; Winston-Salem, NC.
ENDOTHELIAL GLYCOCALYX RECONSTITUTION AS A THERAPEUTIC STRATEGY IN SEPSIS-INDUCED LUNG INJURY. Yimu Yang*, G. Li, L. Li, L. Fu, A. Nitsch, F. Zhang, R.J. Linhardt, E.P. Schmidt, University of Colorado Denver, Aurora CO; Rensselaer Polytechnic Institute, Troy NY.
AVERTING PULMONARY VASCULAR INJURY WITH AN OPTIMIZED HUMAN APYRASE (CD39 HOMOLOG). V. Reinikovaite, R. Chen#, C. Cool, J. Parr, J. Sévigny##, M. Zamora, Laima Taraseviciene-Stewart*, University of Colorado Denver, School of Medicine, Department of Medicine, Aurora, CO; #APT-Therapeutics Inc, St. Louis, ##University of Laval, Quebec, Canada.
IL-4-IL-4R PATHWAY MODULATES MACROPHAGE DERIVED RESOLUTION OF EXPERIMENTAL ALI. Neil R. Aggarwal*, A. Tripathi, P. Mandke, B.T. Singer, V.K. Sidhaye, L.S. King, F.R. D’Alessio, Johns Hopkins University, Baltimore, MD.
POSTER VIEWING - Wine and Cheese Reception
Friday, June 6, 2014
POSTERS – Lung Repair and Remodeling
ENDOPLASMIC RETICULUM STRESS MEDIATES HOUSE DUST MITE-INDUCED AIRWAY EPITHELIAL APOPTOSIS AND FIBROSIS. S.M. Hoffman1, J.E. Tully1, J.D. Nolin1, K.G. Lahue1, D.H. Goldman1, N. Daphtary2, M. Aliyeva2, C.G. Irvin2, A.E. Dixon2, M.E. Poynter2, Vikas Anathy1*, 1Department of Pathology, 2Deparment of Medicine and Vermont Lung Center University of Vermont College of Medicine, Burlington, VT.
MMP EXPRESSION PREDICTS PRIMARY SPONTANEOUS PNEUMOTHORAX. AN IN-VITRO AND IN VIVO STUDY. R. Morse1, G. Langman2, Rachel Elizabeth Norman3*, 1Faculty of Health and Life Sciences, University of the West of England; 2Heart of England NHS Trust, Birmingham; 3Princess Elizabeth Hospital, Guernsey, Channel Islands.
A LARGE LUNG GENE EXPRESSION STUDY IDENTIFYING FIBULIN-5 AS A NOVEL PLAYER IN TISSUE REPAIR IN COPD. C.A. Brandsma1,3, M. van den Berge2,3, D.S. Postma2,3, M.R. Jonker1,3, S. Brouwer1,3, P.D. Paré4,5, D.D. Sin4,5, Y. Bossé6,7, M. Laviolette6, J. Karjalainen8, R.S.N. Fehrmann8, D.C. Nickle9, K. Hao9, A.I.R. Spanjer3,10, L. Franke8, Wim Timens*1,3, 1University of Groningen, Dept Pathology and Medical Biology, 2University of Groningen, Dept Pulmonary Diseases, 3Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands; 4Univ British Columbia, Center for Heart Lung Innovation, St Paul’s Hospital, Vancouver, Canada, 5Univ British Columbia, Respiratory Division, 6Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada, 7Dept Molecular Medicine, Laval University, Québec, Canada; 8University of Groningen, Dept Genetics, Groningen, the Netherlands, 9Merck Research Laboratories, Boston, MA, USA. 10University of Groningen, Dept Molec Pharmacology, Groningen, the Netherlands.
VITAMIN D MODULATES HUMAN LUNG FIRBOBLAST TISSUE REPAIR FUNCTION VIA REGULATING PGE2 SYNTHESIS AND DEGRADATION. Xiangde Liu*, A. Nelson , J. Ikari, F. Makino, H. Basma, J. Obaid, S.I. Rennard, Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.
SEVERE PULMONARY ARTERIAL REMODELING AS A CONSEQUENCE OF REPAIR PROCESSES IN THE INJURED PERIPHERAL AIRSPACES. Gabriele Grunig*, B. Lucas, S.-H. Park, Departments of Environmental Medicine and Medicine (Pulmonary Medicine) New York University Medical Center, New York, NY.
DESIGN OF PROSTAGLANDIN INHIBITION FOR EMPHYSEMA (PIE): A PHASE 2 STUDY TO RESTORE LUNG REPAIR IN EMPHYSEMA. Stephen Rennard1, B. Make2, R. Casaburi3, G. Criner4, B. Celli5, D. Lynch2, T. LeVan1, C. Hersh5, Y. Alnouti1 and K. Schmid1, 1University of Nebraska Medical Center; 2National Jewish Health; 3LA Biomed; 4Temple University; 5Brigham and Women’s Hospital.
TELOMERE SHORTENING AND LUNG TISSUE REMODELING. X. Zhao, C. Chen, Q. Meng, J.-P. Liu, Kexiong Zhang*, Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China.
REPAIR OF AIRWAY EPITHELIUM AFTER CHLORINE-INDUCED LUNG INJURY. Gary W. Hoyle*, S. Musah, J. Chen, D. Humphrey, C.F. Schlueter, Y. Mo, Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY.
POSTERS – Friday, June 6, 2014 – Lung Repair and Remodeling - continued
ENDOGENOUS ENDOSTATIN LIMITS ENDOTHELIAL REPAIR IN LUNG VASCULAR INJURY. Ming-Yuan Jian*, J. Creighton, Department of Anesthesiology and Cell Molecular Biology, the Center for Pulmonary Injury and Repair, University of Alabama, Birmingham, AL.
ANGIOGENESIS OCCURS DURING NORMAL LUNG REPAIR FOLLOWING ACUTE INFLAMMATORY INJURY AND IS DRIVEN BY RECRUITED MACROPHAGES. Zulma X Yunt*, L. VanHuele, M. Mohning, M. Kearns, W.J. Janssen, National Jewish Health, Denver, CO.
TGF-β, MECHANOSTIMULATION, AND MYOFIBROBLASTS: MECHANISMS OF FIBROSIS IN CF LUNG DISEASE. William T. Harris*, N. Ambalavanan, E.J. Sorscher, University of Alabama at Birmingham, Birmingham, AL.
SMALL MOLECULE INHIBITION OF GAS6-MER SIGNALING BY UNC1062 DECREASES CORD BLOOD ENDOTHELIAL COLONY-FORMING CELL GROWTH. Christopher D. Baker*1, B.L. Wisniewski1, C.P.Black1, D. Deryckere1, J. Liu2, S.V. Frye2, S.H. Abman1, X. Wang2, D.K. Graham1, 1Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO; 2 Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Chapel Hill, NC.
TISSUE STEM CELLS PLAY A CRITICAL ROLE IN CIGARETTE SMOKE INDUCED AIRWAY INJURY THAT PRECEDES THE DEVELOPMENT OF SQUAMOUS CELL LUNG CANCER. Moumita Ghosh*, J. Kwon, I. Nakachi, K. Helm, R. Keith, D. Merrick, W. Franklin, Y. Miller, Department of Pediatrics, National Jewish Health and University of Colorado Denver, Aurora, CO.
SEROTONIN SIGNALS VIA ITS TRANSPORTER TO IMPAIR CLEARANCE OF APOPTOTIC CELLS BY MACROPHAGES AND ENHANCE INFLAMMATION: SETTING THE STAGE FOR DYSREGULATED INJURY REPAIR. T. Tanaka‡, E.L. Burnham‡, S. Ahmad§, A. Ahmad§, S.-J. Min¶, S. Suram‡, J. Gaydos‡, R. William Vandivier‡*, ‡From the COPD Center, Division of Pulmonary Sciences and Critical Care Medicine, §Pediatric Airway Research Center, Department of Pediatrics, ¶Division of Health Care Policy and Research, University of Colorado Anschutz Medical Campus, Aurora, CO.
HER2/EGFR BLOCKADE ATTENUATES BLEOMYCIN INDUCED ACUTE LUNG INJURY IN MICE. Andrew Waas1*, R. Mishra2, J. Kern1,2,3, J. Finigan1,2,3, D, Foster2, 1Division Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO; 2Division Oncology, National Jewish Health, Denver, CO; 3Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO.
BIOMECHANICS ANALYSIS AND NOVEL 3-DIMENSIONAL CULTURE MODEL OF AIRWAY-VESSEL REMODELING CAUSED BY CHRONIC INFLAMMATION. R.P. Delaney, K.L. Colvin, M.J. Dufva, S.M. Williams, K.R. Stenmark, Michael E. Yeager*, University of Colorado Denver, Department of Pediatrics-Critical Care; Department of Bioengineering; Cardiovascular Pulmonary Labs, Aurora, CO.
MUC1 MUCIN, AN ANTI-INFLAMMATORY PROTEIN IN THE LUNG, MODULATES THE PHAGOCYTIC ACTIVITY OF MACROPHAGES. K. Kato, R. Uchino, H.Gao, K. Chul Kim*, Center for Inflammation, Translational and Clinical Lung Research, Temple University School of Medicine, Philadelphia, PA.
THE GATA FACTOR ELT-1 REGULATES C. ELEGANS DEVELOPMENTAL TIMING BY PROMOTING EXPRESSION OF THE LET-7 FAMILY MICRORNAS. Max L. Cohen*, K. Morita, S. Kim, M. Han, Howard Hughes Medical Institute and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO.
Program Learning Objectives
A) Provide an international forum for leading clinicians and researchers to exchange ideas relating to lung research in the broad field of lung injury, repair, reconstruction and therapeutic outcomes.
B) Fill knowledge gaps in the understanding of lung injury, repair and reconstruction.
C) Stimulate new perspectives and research in pulmonary medicine in the area of the lung injury, repair and reconstruction, with significant time allowed for discussion joined by leading national and international experts in basic, translational and clinical research.
At the conclusion of this conference the attendees will be able to:
1) Describe the developmental basis for the lung injury, repair and reconstruction.
2) Identify differences in the mechanisms of acute and progressive lung injury and their outcomes.
3) Describe current understanding of the therapeutic and reconstructive approaches to the treatment of acute and progressive lung injury.
4) Identify potential therapeutic targets, novel medications and regenerative medicine approaches that could be applied to returning the injured lung to “normal” thereby improving outcome.
5) Be able to clearly assess and rate shared pathogenic mechanisms that underlie acute and progressive lung injury (e.g. ARDS) and fibrosis (e.g. IPF or other IIPs)
6) Attendees, specifically junior faculty and trainees, will receive feedback on their research in progress (submitted in the form of abstracts, presented as posters and talks) that they can implement to ensure the quality, innovation, and applicability of their work.
Intended Audience: Local/Regional/National/International
Physicians/clinicians (adult and pediatric)/Research Physician-Scientists-Pulmonary Sciences, Critical Care and Sleep Medicine/Primary Care Physicians/General Medicine Physicians/Public Health
Americans with Disability Act statement
Please indicate if you have any need for auxiliary aids or special assistance services:
The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The University of Colorado School of Medicine designates this live activity for a maximum of 13 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.