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5/20/11 THOMAS L. PETTY      
  ASPEN LUNG CONFERENCE      
  54th Annual Meeting      
  "COPD and Lung Cancer: Common Pathogenesis,  
  Shared Clinical Challenges"      
  June 8-11, 2011      
Tuesday, June 7, 2011 -- Evening      
5:00-7:00 PM Evening Registration -- Wine and Cheese Reception   Gant Conference Center
Wednesday, June 8, 2011 -- Morning      
8:00-8:05 AM Introduction/Welcome   Rubin M. Tuder, M.D., Co-Chair
      York E. Miller, M.D., Co-Chair
      Jeffrey A. Kern, M.D., Co-Chair
8:05-8:30 AM Brief History of COPD   Bartolome Celli, M.D.
Moderator: Mark W. Geraci, M.D.      
8:30-9:05 AM STATE OF THE ART      
  “Genetics and Epidemiology of Cigarette   Ann G. Schwartz, Ph.D., M.P.H.
  Smoke-Induced Lung Disease”   Karmanos Cancer Institute
    Wayne State University School of Medicine
9:05-9:30 AM Discussion      
9:30-9:45 AM MULTI-GENE TEST ASSOCIATED WITH COPD RISK. J.C. Willey*, T. Blomquist, E.
  Crawford, J. Hammersley, D. Olson, Y. Yoon, B., Austermiller, N. Lazaridis. University of
  Toledo, Toledo, OH, and Gene Express, Inc., Wilmington, SC.  
9:45-10:00 AM VARIATION IN NF-KB PATHWAY GENES AND RISK OF LUNG CANCER. B.
  Diergaarde*1, Y. Du1, S. Buch2, M. Romkes2, P. Hershberger3, J. Weissfeld1, and J. Siegfried3.
  University of Pittsburgh Cancer Institute and; 1Department of Epidemiology, University of
  Pittsburgh Graduate School of Public Health; 2Center for Clinical Pharmacology, University
  of Pittsburgh School of Medicine; 3Department of Pharmacology and Chemical Biology,
  University of Pittsburgh School of Medicine.      
10:00-10:30 AM ......Coffee Break      
10:30-11:05 AM STATE OF THE ART      
  “Airway Progenitor Cells in COPD and Lung Cancer”   Susan D. Reynolds, Ph.D.
      National Jewish Health
11:05-11:30 AM Discussion      
11:30-11:45 AM LUNG CANCER STEM CELLS: LESSONS LEARNED FROM TISSUE STEM CELLS. M.
  Ghosh*, K. Helm, R. Smith, M. Giordanengo, and S.D. Reynolds. Department of Pediatrics,
  National Jewish Health and University of Colorado, Denver, CO.
11:45-12:00 NTCU INDUCES PRE-MALIGNANT SQUAMOUS DYSPLASIA IN MICE. T.M. Hudish1, L.I.
  Opincariu1, A.B. Mozer1, M.S. Johnson1, T.G. Cleaver2, S.P. Malkoski2, D.T. Merrick1, and
  R.L. Keith1,2*. 1Denver Veterans Affairs Medical Center, Denver, CO; 2University of

Colorado Denver, Department of Medicine, Aurora, CO.

12:00-1:30 PM ......Lunch

Wednesday, June 8, 2011 -- Afternoon  
Moderator: Wilbur A. Franklin, M.D.  
1:30-2:05 PM GILES F. FILLEY LECTURE  
  "EARLY MOLECULAR PATHOGENESIS  
  OF LUNG ADENOCARCINOMA”  
  Ignacio I. Wistuba, M.D.  
  Professor, Departments of Pathology and  
  Thoracic/Head and Neck Medical Oncology  
  University of Texas MD Anderson Cancer Center  
  Houston, Texas  
2:05-2:30 PM Discussion  
2:30-2:45 PM TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE II DELETION INCREASES
  THE MULTIPLICITY AND GROWTH OF K-RAS INDUCED LUNG CANCER. T.G.
  Cleaver1, S.M. Haeger1, K.J. Rodriguez1, J.G. Lighthall5, S.L. Lu2, D. Merrick4, X.J. Wang3,
  S.P. Malkoski1,3*. 1Division of Pulmonary Sciences and Critical Care Medicine, 2Department
  of Otolaryngology, 3Department of Pathology, University of Colorado Denver, Aurora, CO;
  4Department of Pathology, Denver Veterans Affairs Medical Center, Denver, CO;
  5Department of Otolaryngology, Oregon Health & Sciences University, Portland, OR.  
2:45-3:00 PM A SINGLE NUCLEOTIDE POLYMORPHISM IN MICRORNA 146A IS ASSOCIATED WITH
  COPD AND LUNG FUNCTION. T. LeVan1,2*, Z. Weiler1, A. Nelson1, X. Liu1, K.C. Muller3,
  H. Magnussen3, K.F. Rabe3, S. Rennard1. Pulmonary, Critical Care, Sleep and Allergy
  Medicine Division1, Department of Internal Medicine and Department of Epidemiology2,
  University of Nebraska Medical Center, Omaha, NE; Grosshansdorf Hospital, Germany.  
3:00-3:30 PM ......Break  
3:30-4:05 PM THOMAS A. NEFF LECTURE  
  "SYSTEMIC INFLAMMATION AND COPD CORMOBIDITIES”  
  Professor Alvar G.N. Augusti, M.D., Ph.D.  
  Senior Consultant and Director  
  Institut del Tòrax, Hospital Clinic  
  Barcelona, Spain  
4:05-4:25 PM Discussion  
4:25-4:40 PM CIGARETTE SMOKE PROMOTES DENDRITIC CELL ACCUMULATION AND SURVIVAL
  IN COPD. R. Vassallo, P.R. Walters, J. Lamont, T.J. Kottom, E.S. Yi, and A.H. Limper*.
  Thoracic Diseases Research Unit. Pulmonary and Critical Care, Mayo Clinic College of
  Medicine. Rochester, MN.  
4:40-4:55 PM CHRONIC INFLAMMATION IN PATHOGENESIS OF COPD AND LUNG CANCER. R. Birru,
  B. Kahkonon, and Y.P. Di*. Department of Environmental and Occupational Health, University
  of Pittsburgh, Pittsburgh, PA.  
5:00 PM POSTER VIEWING --- SOCIAL HOUR  
Thursday, June 9, 2011 – Morning    
Moderator: Robert Winn, M.D.    
8:00-8:35 AM STATE OF THE ART    
  “Oxidative Stress in the COPD Cancer Continuum” Shyam Biswal, Ph.D., M.S.
      Johns Hopkins Bloomberg
      School of Public Health
8:35-9:00 AM Discussion    
9:00-9:15 AM EXPRESSION OF NRF2-MODULATED GENES IN RESPONSE TO CIGARETTE SMOKE.
  B. Kosmider*, E. Messier, H. Wei Chu, R.J. Mason. National Jewish Health, Denver, CO.
9:15-9:30 AM OXIDATIVE INJURY DUE TO INHALATION OF OZONE CAUSES DOSE-DEPENDANT
  CYTOGENETIC DAMAGE IN PERIPHERAL BLOOD LYMPHOCYTES. M. Arjomandi*, S.
  Venkat, H. Wong, A. Donde, J. Balmes, N. Holland. University of California San Francisco,
  University of California Berkeley, California.    
9:30-10:00 AM ......Coffee Break    
10:00-10:35 AM STATE OF THE ART    
  “Chemoprevention of Lung Cancer”   Robert L. Keith, M.D.
    Denver Veterans Administration Medical Center
      University of Colorado School of Medicine
10:35-11:00 AM Discussion    
11:00-11:15 AM CIGARETTE SMOKE SUPPRESSES PPARγ EXPRESSION AND ACTIVATION IN MURINE
  PULMONARY EPITHELIAL CELLS. S.M. Wells*, J. Weigel and E.B. Klein. Department of
  Environmental, Agricultural & Occupational Health, College of Public Health, University of
  Nebraska Medical Center.    
11:15-11:30 AM RISK FACTORS FOR THE DEVELOPMENT OF LUNG CANCER IN THE COPD GENE
  COHORT. L. Carr1, D. Lynch2, E. Regan1, J. Kern1, J. Hokanson3, C. Wilson1, J. Crapo1, and
  R. Bowler1 for the COPD Gene Investigators*2. 5Department of Medicine1 and Radiology2,
  NJH and Department Epidemiology UCD3, Denver, Colorado.
12:30 PM Picnic at East Maroon Bells Portal    

Friday, June 10, 2011 -- Morning

Moderator: William Vandivier, M.D.

8:00-8:35 AM PARKER B. FRANCIS LECTURESHIP  
  "NOVEL PATHWAYS OF RESPIRATORY INJURY,  
  REPAIR AND NEOPLASIA”      
    Jack A. Elias, M.D.      
  Waldemar Von Zedtwitz Professor of Medicine    
    Professor of Immunobiology      
  Chair, Department of Internal Medicine    
  Yale University School of Medicine      
    New Haven, Connecticut      
8:35-9:00 AM Discussion        
9:00-9:15 AM MECHANISMS OF HOST DEFENSE DURING AIRWAY MUCUS OBSTRUCTION IN Scnn1b
  TRANSGENIC MICE, A MOUSE MODEL OF COPD. A. Livraghi-Butrico, E.A. Duncan, Y.
  Saini, H. Dang, C.M. Doerschuk*, W.K. O’Neal, and R.C. Boucher. Cystic Fibrosis -
  Pulmonary Research and Treatment Center and the Center for Airways Disease, University of
  North Carolina, Chapel Hill, NC.      
9:15-9:30 AM LUNG LAMININ (LM)-332 DEFICIENCY ENHANCES ENGRAFTMENT OF TUMOR CELLS
  INTO THE LUNG BUT RETARDS TUMOR CELL GROWTH. T.L. Adair-Kirk*1, M.J. Meyer1,
  E.N. Smith2, D.R. Piwnica-Worms2, and R.M. Senior1. Departments of Medicine1 and
  Radiology2 at Washington University School of Medicine, St. Louis, MO.  
9:30-10:00 AM ......Coffee Break        
10:00-10:35 AM STATE OF THE ART      
  “Cellular Senescence and Lung Disease: A Potential Link Judith Campisi, Ph.D.
  Between Environment, Aging and Cancer” The Buck Institute for Research on Aging
      Lawrence Berkeley National Laboratory
10:35-11:00 AM Discussion        
11:00-11:15AM TELOMERE LENGTH IS A DETERMINANT OF EMPHYSEMA SUSCEPTIBILITY. J.K.
  Alder1,2, N. Guo1, F. Knougni1, C.J. Anderson1, A.I. Gorgy1, S. Biswal3,4, W. Mitzner3, R.M.
  Tuder5, and M. Armanios1,2*. Departments of Oncology1 and Sidney Kimmel Comprehensive
  Cancer Center2, Johns Hopkins School of Medicine; Department of Environmental Health
  Sciences4, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Division of
  Pulmonary Sciences and Critical Care Medicine5, University of Colorado School of Medicine,
  Aurora, CO.        
11:15-11:3AM ALVEOLAR HYPOXIA PROMOTES LUNG TUMOR GROWTH THROUGH A VEGFR-2
  DEPENDENT MECHANISM. V. Karoor1,4, M. Le3, D. Merrick2,3,4, K.A. Fagan5, E.C.
  Dempsey1,3,4, and Y.E. Miller1,3,4*. 1Department of Medicine, University of Colorado Denver,
  Denver, CO. 2Department of Pathology, University of Colorado Denver, Denver, CO.
  3Department of Veterans Affairs Medical Center, Denver, CO. 4University of Colorado Cancer
  Center, Denver, CO. 5Departments of Medicine and Pharmacology, University of South
  Alabama, Mobile, AL.        
11:30-1:30 PM ......Lunch        

Friday, June 10, 2011 -- Afternoon

Moderator: Russell Bowler, M.D., Ph.D.

1:30-2:05 PM REUBEN M. CHERNIACK LECTURE    
  "EPIGENETICS OF CIGARETTE SMOKE    
  INDUCED LUNG DISEASE”    
  Stephen B. Baylin, M.D.    
  Professor of Oncology    
  Deputy Director, Johns Hopkins Sidney    
  Kimmel Cancer Center    
  The Johns Hopkins University    
  Baltimore, Maryland    
2:05-2:30 PM Discussion    
2:30-2:45 PM VARIABLE DNA METHYLATION IS ASSOCIATED WITH LOW LUNG FUNCTION AND
  COPD AND INCLUDES A SUBSET OF TUMOR SUPPRESSOR GENES AND
  ONCOGENES. W. Qiu1,2, B. Klanderman1,2, D.A. Lomas3, S.I. Rennard4, A. Agusti5, E.K.
  Silverman1,2, D.L. DeMeo1,2*. 1Channing Laboratory, Brigham and Women’s Hospital, USA,
  2Harvard Medical School, USA; 3Cambridge Institute for Medical Research, UK; 4University
  of Nebraska Medical Center, USA; 5Hospital Universitari Son Duerta, ESPAÑA.  
2:45-3:00 PM PROMOTER HYPERMETHYLATION LEADS TO LOSS OF WNT7A IN NSCLC. M.A.
  Tennis*, M. VanScoyk, S. Freeman, R.A. Winn, University of Colorado School of Medicine,
  Denver, CO.    
3:00-3:30 PM ......Break    
3:30-4:05 PM STATE OF THE ART    
  “Endogenous Modifiers of Cigarette Smoke A. McGarry Houghton, M.D.
  Induced Lung Disease” University of Pittsburgh
4:05-4:30 PM Discussion    
4:30-4:45 PM THE EFFECT OF TOLL-LIKE RECEPTOR 4 DEFICIENCY ON EMPHYSEMA IN
  SMOKERS. S.W. Lee1*, J.Y Oh2, 1Department of Internal Medicine, Seoul National
  University Bundang Hospital and 2Department of Internal Medicine, Donkuk University Ilsan
  Hospital, Republic of Korea.    
4:45-5:00 PM SMOKING ALTERED DNA METHYLATION IN ALVEOLAR MACROPHAGES
  CORRELATES WITH GENE EXPRESSION. R. Sears, L.S. Powers, A. Gerke, T.J. Gross, R.A.
  Philibert, and M.M. Monick*. University of Iowa, Carver College of Medicine, Iowa City, IA.
5:00 PM POSTER SESSION—Wine and Cheese Reception    

Saturday, June 11, 2011 -- Morning

Moderator: Richard Martin, M.D.

8:00-8:35 AM ROGER S. MITCHELL LECTURE

“EQUILIBRIA OF HUMANS AND OUR INDIGENOUS

MICROBIOTA AFFECTING INFLAMMATION AND NEOPLASIA”

Martin J. Blaser, M.D.

Frederick H. King Professor of Internal Medicine

Chair, Department of Medicine

Professor of Microbiology

New York University Langone Medical Center

New York New York

8:35-9:00 AM Discussion    
9:00-9:15 AM INTERLEUKIN-15 AND INFLUENZA VIRUS INFECTION IN MOUSE MODEL OF
  CHRONIC OBSTRUCTIVE PULMONARY DISEASE. C.S. Dela Cruz*, M.J. Kang,, W. Liu,
  C.G. Lee, and J.A. Elias, M.D. Pulmonary and Critical Care Medicine, Yale University School
  of Medicine, New Haven CT.    
9:15-9:30 AM ALTERED NK CELL FUNCTION IN COPD: IMPLICATIONS FOR TUMOR
  SURVEILLANCE. M.T. Borchers1* and M. Orozco-Levi2. 1University of Cincinnati Medical
  Center, Cincinnati, OH. 2Group of Research on Injury, Immune Response, and Lung Function,
  Institut Municipal d’Investigació Mèdica (IMIM), Barcelona, Spain.  
9:30-10:00 AM ......Coffee Break    
10:00-10:35 AM STATE OF THE ART    
  “New Approaches to Targeted Therapy” William Pao, M.D., Ph.D.
    Vanderbilt-Ingram Cancer Center
10:35-11:00 AM Discussion    
11:00-11:15AM DISCOVERY OF LUNG CANCER BIOMARKERS BY PROFILING THE PLASMA PROTEOME
  WITH NASCENT MONOCLONAL ANTIBODY LIBRARIES. M. Guergova-Kuras1, I. Kurucz2, W.
  Hempel1, N. Tardieu1, J. Kádas2, C. Malderez-Bloes1, A. Jullien1, Y. Kieffer1, M. Hincapie3, A.
  Guttman4, E. Csánky5, B. Dezso6, B.L. Karger3, and L. Takács*1,2. 1Biosystems International SAS,
  Evry, France. 2Biosystems International K ft., Debrecen, Hungary. 3Barnett Institute and Department
  of Chemistry and Chemical Biology, Northeastern University, Boston Massachusetts. 4Department of
  Pulmonology, Medical and Healthcare Center of University Debrecen, Hungary. 5Department of
  Pulmonology, Semmelweis Hospital and Healthcare Center, Miskolc, Hungary. 6Departments of
  Pathology & Oral Pathology, Medical & Health Science Center & Faculty of Dentistry of University
  Debrecen, Hungary.    
11:15-11:30 AM NICOTINE-INDUCED FIBRONECTIN EXPRESSION MIGHT REPRESENT A COMMON
  MECHANISM BY WHICH TOBACCO PROMOTES LUNG CANCER PROGRESSION AND THE
  DEVELOPMENT OF OBSTRUCTIVE AIRWAYS DISEASE. J. Roman*, Pulmonary, Critical
  Care & Sleep Disorders, University of Louisville and Louisville VAMC.  
11:30-12:30 AM CONFERENCE SUMMARY    
  Bartolome R. Celli, M.D.    
  Professor of Medicine    
  Division of Pulmonary and Critical Care Medicine  
  Harvard University/Brigham Women’s Hospital  
  Boston, Massachusetts    

12:30 PM Discussion and Adjourn

POSTER VIEWING -- SOCIAL HOUR

Wednesday, June 8, 2011

5:00-7:00 PM

POSTERS

TRANSGENIC MICE EXPRESSING HUMAN INTERLEUKIN-32 IN THE LUNGS HAVE PHYSIOLOGIC FEATURES SUGGESTIVE OF EMPHYSEMA. X. Bai, A.R. Ovrutsky, K. Takeda, A. Dakhama, J.M. Hartney, J.L. Matsuda, D. Ordway, E.W. Gelfand, T. Azam, L-Y. Chang, D.A. Goldstrohm, R.P. Bowler, C.A. Dinarello, E.D. Chan*. Denver VAMC, UCD School of Medicine, National Jewish Health, Denver, CO..

LUNG RESPONSES TO AIRBORNE URBAN PARTICULATE MATTER: ROLE OF RELMa (RESISTIN LIKE MOLECULEa). S. Pflanz, C. Hoffman, W.C. Chen; M. Sisco, J. Reibman, T. Gordon, S.H. Park, G. Grunig*.

New York University School of Medicine, New York, NY.

LUNG CANCER INCIDENCE IN THE BODE COHORT: COMPARISON WITH OTHER STUDIES. J.P. de Torres*, J. Marin, C. Casanova, J. Zulueta, C. Cote, B. Celli. Clinica Universidad de Navarra, Hospital Miguel Servet, Hospital Ntra Sra de Candelaria, BayPines VAMC, Brigham and Women’s Hospital, Boston, MA.

NEUTROPHILIC INFLAMMATION IN MICE EXPOSED TO THE COMBINATION OF CIGARETTE SMOKE AND ASBESTOS. G.F. Morris*, J. F. Guenther1,2, Y. Wang, D.E. Sullivan2, and B. Shan1. Program in Lung Biology, Departments of Pathology, 1Medicine, & 2Microbiology, Tulane University School of Medicine, New Orleans, LA.

A PREDICTION MODEL FOR COPD READMISSIONS: CATCHING UP, CATCHING OUR BREATH AND IMPROVING A NATIONAL PROBLEM. B. Amalakuhan*, L. Kiljanek, A. Parvathanen, M. Hester, P. Cheriyath, and D. Fischman. PinnacleHealth Hospitals Network; Harrisburg, PA.

A POTENTIAL PATHOGENIC MECHANISM IN THE DEVELOPMENT OF COPD AND LUNG CANCER: ROLE OF MiR-146a. X. Liu1*, A.J. Nelson1, M.L. Toews2, S.I. Rennard1. 1Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, 2Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE.

SURGICAL CHALLENGE FOR LUNG CANCER PATIENTS WITH COPD. Y. Sekine1*, 2H. Katsura., 1E. Ko. Department of Thoracic Surgery1 and Pulmonary Medicine2. Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, Japan

THE ROLE OF KSRP IN NON-SMALL CELL LUNG CANCER. L.A. Wilson*, M. VanScoyk, M. Tennis, S. Freeman, N. Kelley, R. Winn, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, CO.

THE ROLE OF WNT SIGNALING AS A POTENTIAL THERAPEUTIC IN LUNG CANCER STEM CELLS. M. VanScoyk*, S. Freeman, N. Kelley, R.A. Winn, Veterans Administration Medical Center, Denver, Denver, CO, University of Colorado SOM, Aurora, CO.

CD146 IN THE PATHOGENESIS OF COPD. A. Kratzer*, J. Salys, H.W. Chu, M. Zamora, and L. Taraseviciene- Stewart, University of Colorado Denver, Department of Medicine, Denver, CO.

SOMATOSTATIN RECEPTOR ACTIVATION INHIBITS SMALL CELL LUNG CANCER PROLIFERATION. C. Callison1*, M. Rezzak2, M. Hassanein1,2, Pierre P. Massion1,2,3, Division of Allergy, Pulmonary and Critical Care Medicine1, Vanderbilt University, Vanderbilt-Ingram Comprehensive Cancer Center2 and Veterans Affairs Medical Center3, Nashville, TN.