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2008 Conference


THOMAS L. PETTY
ASPEN LUNG CONFERENCE

2008
Golden Anniversary Meeting

51st Annual Meeting
"Asthma: Insights and Expectations"

June 4-7, 2008

  • Tuesday evening
  • Wednesday morning
  • Wednesday afternoon
  • Thursday morning
  • Friday morning
  • Friday afternoon
  • Saturday morning
  • Wednesday Poster Session
  • Friday Poster Session

Tuesday, June 3, 2008 -- Evening

5:00-7:00 PM Evening Registration -- Wine and Cheese Reception Given Institute

Wednesday, June 4, 2008 -- Morning

8:00-8:15 AM

Introduction/Welcome
Richard J. Martin, Chair

8:15-8:30 AM

Perspective
Thomas L. Petty, M.D.
Moderator:
Peter Henson, Ph.D.

8:30-9:15 AM

STATE OF THE ART
"Airway Inflammation: Lessons from the Bench”
Yvonne Janssen-Heininger, Ph.D.
University of Vermont College of Medicine

9:15-9:30 AM

Discussion

9:30-9:45 AM

INTERLEUKIN-16 STIMULATION RESTS IN RECRUITMENT AND POTENTIAL INDUCTION OF DE NOVO FOXP3+ TREG CELLS IN THE LUNGS.
C. McFadden, L. Cross, D. Green, X. Jin, D. Center, F. Little, W. Cruikshank*, Pulmonary Center, Boston University School of Medicine, Boston, MA.

9:45-10:00 AM

MINDIN SERVES AS AN INTEGRIN LIGAND FOR TRAFFICKING OF EOSINOPHILS.
Z. Li1*, S. Garantziotis1, W. Jia2, E. Potts1, S. Lalani1, Z. Liu3, Y-W. He2, W.M. Foster1, J.W. Hollingsworth1, 1Division of Pulmonary, Allergy and Critical Care Medicine and 2Department of Immunology, Duke University Medical Center, Durham, NC, and 3Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

10:00-10:30 AM

Coffee Break

10:30-11:15 PM

ROGER S. MITCHELL LECTURE
"AIRWAY INFLAMMATION: TRANSLATING THE INFLAMMATORY RESPONSE TO THE PATIENT"
John V. Fahy, M.D.
Professor of Medicine
Pulmonary and Critical Care Division
University of California at San Francisco
San Francisco, California

11:15-11:30 AM

Discussion

11:30-11:45 AM

ASSOCIATION BETWEEN CHEST SYMPTOMS AND LUNG FUNCTION, AND LAB ANIMAL RESEARCH WORK AND THE CD14-1619 GG GENOTYPE.
K. Pacheco*, L. Maier, L. Silveira, K. Goelz, K. Noteward, C. Rose, National Jewish Medical and Research Center, Denver, CO.

11:45-12:00

INFLAMMATORY CYTOKINES PLUS TGF-1 INDUCED EPITHELIAL-MESENCHYMAL TRANSITION IN HUMAN BRONCHIAL EPITHELIAL CELLS.
X. Liu*, Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.

12:00-1:30 PM

Lunch

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Wednesday, June 4, 2008 -- Afternoon

Moderator: Richard Martin, M.D.

1:30-2:15 PM

STATE OF THE ART
"Innate Immunity"
Patricia W. Finn, M.D.
University of California at San Diego

2:15-2:30 PM

Discussion

2:30-2:45 PM

ANIONIC PULMONARY SURFACTANT LIPIDS SUPPRESS RESPIRATORY SYNCYTIAL VIRUS INFECTION: IMPLICATIONS FOR ASTHMA EXACERBATIONS.
M. Nakamura*, H.W. Chu, T. Nakamura, A. Evans, J. Sandoval, E.D. Chan, D.R. Voelker, National Jewish Medical and Research Center, Denver, CO.

2:45-3:00 PM

REGULATION OF AIRWAY EPITHELIAL SHORT PALATE LUNG, AND NASAL EPITHELIUM CLONE1 (SPLUNC1) BY TOLL-LIKE RECEPTOR 2 (TLR2) SIGNALING.</
H.W. Chu*, J. Thaikoottathil, Q. Wu, T. Moss, R. Green, S. LaFasto, N.M. Michels, G. Zhang, J.A. Elias, R.J. Martin, National Jewish Medical and Research Center, Denver, CO and Yale University School of Medicine, New Haven, CT.

3:00-3:30 PM

Break

3:30-4:15 PM

STATE OF THE ART
"Bugs and Asthma: A Different Disease?”
R. Stokes Peebles, M.D.
Vanderbilt University Center for Lung Research

4:15-4:30 PM

Discussion

4:30-4:45 PM

SURFACTANT PROTEIN A (SP-A) FUNCTION IN ASTHMA IS DEFECTIVE AS A MODULATOR OF INFLAMMATION DURING INFECTION.
D. Fertel1*, D.R. Voelker1, T.D. Church1, Y. Wang1, H.W. Chu2, D.R. Voelker2, J.R. Wright1, M. Kraft1, 1Duke University Medical Center, Durham, NC, 2National Jewish Medical and Research Center, Denver, CO

4:45-5:00 PM

PROTECTIVE ROLE OF MAST CELLS AGAINST MYCOPLASMA PNEUMONIAE UNDER ALLERGIC CONDITIONS.
N.M. Michels*, H.W. Chu, S. Oommen, S.C. LaFasto, R.J. Martin, National Jewish Medical and Research Center, Denver,

5:00 PM

POSTER VIEWING --- SOCIAL HOUR

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Thursday, June 5, 2008 -- Morning

Moderator: E. Rand Sutherland, M.D.

8:00-8:45 AM

STATE OF THE ART
"The Beginnings of Asthma”
Fernando D. Martinez, M.D.
University of Arizona

8:45-9:00 AM

Discussion

9:00-9:15 AM

A NOVEL PATHWAY FOR THE CONTROL OF EOSINOPHIL DIFFERENTIATION BY DRUGS, CYTOKINES AND ALLERGEN SENSITIZATION.
P. Xavier-Elsas1*, T. Queto2, C. Jones1, B. de Luca2, D. Masid2, M.C. Santos1, F.Q. Cunha3, B.K. Lam4, Y. Kanaoka4, M.I. Gaspar-Elsas2, Departments 1Immunology, IMPPG-UFRJ, 2Pediatrics, IFF-FIOCRUZ, Rio de Janeiro, and 3Pharmacology, FMRP-USP, São Paulo, Brazil; 4Brigham and Women’s Hospital, Boston, MA.

9:15-9:30 AM

ANTIBIOTIC TREATMENT ENHANCES AIRWAY HYPER-RESPONSIVENESS AND ALLERGIC INFLAMMATION IN A MOUSE MODEL.
K. Saroca1,2, C. Kytasty1,2, A. Chan1,2,, L.M. Alvarez1,2, K.E. Barrett2, T.D. Bigby1,2*, 1VA San Diego Healthcare System, San Diego, CA, and 2University of California, San Diego, La Jolla, CA.

9:30-10:00 AM

Coffee Break

10:00-10:45 AM

STATE OF THE ART
"Pediatric Asthma: A Different Disease?”
Erwin W. Gelfand, M.D.
National Jewish Medical and Research Center

10:45-11:00 AM

Discussion

11:00-11:15 AM

INHALED CORTICOSTEROIDS ALTER PULMONARY FUNCTION AND LUNG GROWTH IN INFANT RHESUS MONKEYS EXPOSED TO HOUSE DUST MITE ALLERGEN AND OZONE.
D.M. Hyde*, L.A. Miller, E.S. Schelegle, M.V. Fanucchi, L.S. Van Winkle, N.K. Tyler, M.V. Avdalovic, M.J. Evans, A. Buckpitt, K.E. Pinkerton, J.P. Joad, L.J. Gershwin, R. Wu, C.G. Plopper, California National Primate Research Center, University of California, Davis, CA.

11:15-11:30 AM

LUNG LINING FLUID GLUTATHIONE ATTENUATES IL-13 INDUCED ASTHMA.
M.H. Lowry1, B.P. McAllister1, J.C. Jean1, L.A.S. Brown2, R.P. Hughey3, W.W. Cruikshank1, S. Amar4, E.C. Lucey1, K. Braun5, P. Johnson5, T.N. Wight5, M. Joyce-Brady1*, 1The Pulmonary Center, Boston University School of Medicine, Boston, MA; 2Department of Pediatrics, Emory University, Atlanta, GA; 3Department of Medicine, University of Pittsburgh, Pittsburgh, PA; 4Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA; and 5The Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, WA.

12:30 PM

Picnic at East Maroon Bells Portal

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Friday, June 6, 2008 -- Morning

Moderator: Mark Geraci, M.D.

8:00-8:45 AM

STATE OF THE ART
"Genetics and Asthma: Where We Are At and Where We Are Going"
Dirkje S. Postma, M.D., Ph.D.
University Medical Center of Groningen

8:45-9:00 AM

Discussion

9:00-9:15 AM

SYSTEMATIC ANALYSES OF GENOTYPE-PHENOTYPE ASSOCIATIONS IN ASTHMA AND ATOPY IN FOUR POPULATION SAMPLES FROM CANADA AND AUSTRALIA.
D. Daley1*, M. Lemire2,3, L. Akhabir1, M. Chan-Yeung4, J.Q. He1, T. McDonald1, A.Sandford1, D. Stefanowicz1, B. Tripp1, D. Zamar1, Y. Bosse5,6, V. Ferretti2, A. Montpetit2, M-C. Tessier2, A. Becker7, A. L. Kozyrskyj7,8, J. Beilby9, P. A. McCaskie10, B. Musk9, N. Warrington10, A. James9, C. Laprise11,12, L. Palmer10, P. D. Paré1, T. J. Hudson2,3.
Affiliations: 1-James Hogg iCAPTURE Center, University of British Columbia (UBC), Vancouver, BC, Canada; 2-McGill University and Génome Québec Innovation Centre, Montreal, Québec, Canada; 3-Ontario Institute for Cancer Research, Toronto, Ontario; 4-Occupational and Environmental Lung Disease Unit, University of British Columbia, Vancouver, BC, Canada, 5-Centre de Recherche, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l’Université Laval, Québec, Canada; 6-Laval University Hospital Research Center (CRCHUL), Québec, Canada; 7-Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; 8-Faculty of Pharmacy and Department of Community Health Sciences, Manitoba Center for Health Policy, Winnipeg, Manitoba Canada;9-Sir Charles Gairdner Hospital, Perth, Western Australia; 10-Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research and School of Population Health, University of Western Australia, Perth, Australia; 11-Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Québec, Canada ; 12-Université de Montréal Community Genomic Medicine Center, Chicoutimi Hospital, Saguenay, Québec, Canada.

9:15-9:30 AM

GENOME-WIDE EXPRESSION PROFILING IN PHENOTYPICALLY DISTINCT GROUPS OF ASTHMATICS IDENTIFIES OVEREXPRESSION OF EPITHELIAL AND MAST CELL GENES IN EXERCISE-INDUCED BRONCHOCONSTRICTION.
T.S. Hallstrand*, M.M. Wurfel, R.P. Beyer, M.L. Aitken, W.R. Henderson, Jr., Departments of Medicine and Environmental and Occupational Health, University of Washington, Seattle, WA.

9:30-10:00 AM

Coffee Break

10:00-10:45 AM

GILES F. FILLEY LECTURE
"THE EPITHELIUM: NOT JUST AN INNOCENT BYSTANDER"
Robert P. Schleimer, Ph.D.
Chief, Division of Allergy-Immunology
Northwestern University
Feinberg School of Medicine
Chicago, Illinois

10:45-11:00 AM

Discussion

11:00-11:15 AM

TIMP-1-NUCLEATES A CRITICAL BRONCHIAL EPITHELIAL RESPONSE NETWORK TO TOBACCO SMOKE IN ASTHMA.
R.J. Freishtat1,2,3*, A.S. Benton2, Z. Wang2,4, E.P. Hoffman2,3, 1Division of Emergency Medicine, Children's National Medical Center, Washington, DC; 2Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC; 3School of Medicine and Health Sciences, The George Washington University, Washington, DC, and 4The Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA.

11:15-11:30 AM

POTENTIATION OF INTERLEUKIN-19 EXPRESSION IN AIRWAY EPITHELIA BY INTERLEUKIN-17A AND INTERLEUKIN-4/-13 IMPORTANT IMPLICATIONS IN ASTHMA.
F. Huang*1, S. Wachi1, P. Thai1, A. Loukoianov1, K.H. Tan1, R.M. Forteza2, R. Wu1, 1Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of California, Davis, 2Division of Pulmonary and Critical Care Medicine, Leonard M. Miller School of Medicine, University of Miami, FL.

11:30-1:30 PM

Lunch

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Friday, June 6, 2008 -- Afternoon

Moderator: Rubin Tuder, M.D.

1:30-2:15 PM

STATE OF THE ART
"Smooth Muscle: The Comeback Kid"
Julian Solway, M.D.
University of Chicago

2:15-2:30 PM

Discussion

2:30-2:45 PM

ENLARGED MUSCLE LAYERS AND INCREASED FIBROSIS IN AIRWAY WALLS DECREASE LYMPHATICS IN FATAL ASTHMATICS: ANOTHER VIEW OF AIRWAY REMODELING.
M. Ebina*, ROMM/IDAC, Tohoku University, Sendai, JAPAN.

2:45-3:00 PM

BETA-AGONIST AND PROSTAGLANDIN E2 (PGE2)-MEDIATED INHIBITION OF AIRWAY SMOOTH MUSCLE (ASM) GROWTH IS PKA-DEPENDENT.
E.C. Riemer*, H. Yan, A.M. Misior, R.M. Pascual, D.A. Deshpande, R.B. Penn, Wake Forest University School of Medicine, Winston-Salem, NC.

3:00-3:30 PM

Break

3:30-4:15 PM

STATE OF THE ART
“Airway Remodeling, Is It Real?”
Qutayba Hamid, M.D., Ph.D.
Meakins-Christie Laboratories, McGill University

4:15-4:30 PM

Discussion

4:30-4:45 PM

MATRIX METALLOPROTEINASE (MMP) INHIBITION BLOCKS INTERLEUKIN-13-INDUCED ELASTIN MESSENGER RNA SUPPRESSION IN HUMAN AIRWAY FIBROBLASTS. D.J. Slade, J.L. Ingram*, T.D. Church, M. Kraft, Duke University Medical Center, Durham, NC.

4:45-5:00 PM

REDOX REGULATION OF THE FAS DEATH PATHWAY BY CASPASE DEPENDENT CLEAVAGE OF GLUTAREDOXIN 1 AND S-GLUTATHIONYLATION OF FAS.
V. Anathy1*, S.W. Aesif1, A.S. Guala1, M. Havermans1, N.L. Reynaert4, Y-S. Ho3, R.C. Budd2, Y.M.W. Janssen-Heininger1, 1Department of Pathology, University of Vermont College of Medicine, Burlington, VT; 2Department of Medicine, University of Vermont College of Medicine, Burlington, VT; 3Institute of Environmental Health Sciences, Wayne State University, Detroit, MI; and 4Department of Respiratory Medicine, Maastricht University, The Netherlands.

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Saturday, June 7, 2008 -- Morning

Moderator: Monica Kraft, M.D.

8:00-8:45 AM

PARKER B. FRANCIS LECTURESHIP
"PHYSIOLOGIC DYSFUNCTION OF THE ASTHMATIC LUNG: WHAT IS GOING ON DOWN THERE ANYWAY?"
Charles G. Irvin, Ph.D.
Director, Vermont Lung Center
University of Vermont College of Medicine
Burlington, Vermont

8:45-9:00 AM

Discussion

9:00-9:15 AM

PATHOPHYSIOLOGICAL CHANGES IN ASTHMA INDUCED BY WEIGHT LOSS.
A.E. Dixon*, R.E. Pratley, L. Spaulding, D.A. Kaminsky, L.A. Whittaker, P.M. Forgione, L.M. Bourassa, D.M. Raymond, D. Wachtel, C.G. Irvin, University of Vermont, Burlington, VT .

9:15-9:30 AM

POLYMORPHISMS IN RESISTIN (RETN) AND RESISTIN LIKE BETA (RETNLB) PREDICT BRONCHIAL HYPER-REACTIVITY IN HUMAN ASTHMA.
R. Johns*, L. Gao, N. Rafaels, A.V. Grant, M. Stockton-Porter, H. Watson, T.H. Beaty, K. Barnes, Johns Hopkins University, Baltimore, MD.

9:30-10:00 AM

Coffee Break

10:00-10:45 AM

THOMAS A. NEFF LECTURE
"THERAPIES REVISITED: WHAT HAVE WE LEARNED?”
Robert F. Lemanske, Jr., M.D.
Department of Medicine and Pediatrics
University of Wisconsin Hospitals and Clinics
Madison, Wisconsin

10:45-11:00 AM

Discussion

11:00-11:15 AM

PREDNISONE-SPARING EFFECT OF MEPOLIZUMAB ON EOSINOPHILIC BRONCHITIS WITH ASTHMA: A RANDOMIZED, PLACEBO-CONTROLLED TRIAL.
P. Nair*, M. Pizzichini, M. Kjarsgaard, M.D. Inman, A. Efthimiadis, E. Pizzichini, F.E. Hargreave, P.M. O’Byrne. Firestone Institute for Respiratory Health, St. Joseph’s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

11:15-11:30 AM

THE OMALIZUMAB-ASSOCIATED DECREASE IN PERIPHERAL BLOOD EOSINOPHILS IN MODERATE-SEVERE IgE-MEDIATED ASTHMA IS SUSTAINED FOLLOWING INHALED STEROID DOSE REDUCTION. M. Massanari*, P. Jimenez, F. Kianifard, R. Maykut, R. Zeldin, Novartis Pharmaceuticals, East Hanover, NJ, USA.

11:30-12:30 PM

CONFERENCE SUMMARY
Homer A. Boushey, M.D.
Professor of Medicine
Chief, Division of Allergy and Immunology
University of California, San Francisco
San Francisco, California, USA

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POSTER VIEWING -- SOCIAL HOUR

Wednesday, June 4, 2008

5:00-7:00 PM - POSTERS

TRAJECTORY OF CHANGE IN ENO, FEV1 & FEV25-75 IN SCHOOL AGE CHILDREN WITH ASTHMA DURING A USUAL AND A DELAYED BEDTIME. G.J. Kieckhefer*, M.J. Lentz, S.Y. Tsai, T. Ward, University of Washington, Seattle, WA.

IL-13 AND PULMONARY SMOOTH MUSCLE BIOLOGY.
E. Daley1,9, C. Emson2,9, C. Guignabert3, J. Louten2, R. de Waal Malefyt2, V.P. Kurup4, C. Hogaboam5, L. Taraseviciene-Stewart6, N.F. Voelkel6**, M. Rabinovitch3, E. Grunig7, G. Grunig8*, 1St. Luke’s Roosevelt Hospital, New York, NY; 2Schering-Plough Biopharma, Palo Alto, CA; 3Department of Pediatrics, Stanford University School of Medicine, CA; 4Allergy Immunology Division, Medical College of Wisconsin, Milwaukee, WI; 5Department of Pathology, University of Michigan, Ann Arbor; 6Division of Pulmonary Medicine, University of Colorado, Denver, CO; 7Department of Medicine, Thoraxclinic at the University Hospital Heidelberg, Germany; 8Department of Microbiology, Columbia University, New York NY; 9Both authors contributed equally.

MANNITOL CHALLENGE: WILL IT REPLACE A METHACHOLINE OR HISTAMINE INHALATION CHALLENGE?
S. Spector*, California Allergy and Asthma Medical Group, Los Angeles, CA, Sandra Anderson* Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

THE EFFICACY OF TNF BLOCKADE IN ALLERGIC ASTHMA MODELS IS DEPENDENT ON THE LEVEL OF ENDOTOXIN IN THE ALLERGIC CHALLENGE.
A.J. Long*, R. McCarthy, C. Goess, C.A. Cuff, Department of Pharmacology, Abbott Bioresearch Center, Worcester, MA.

CHARACTERIZATION OF RESPIRATORY TRACT RESPONSES AGAINST LOW MOLECULAR WEIGHT ALLERGENS.
C.F. Kuper*, J.H.E. Arts, TNO Quality of Life, Department of Toxicology and Applied Pharmacology, AJ Zeist, The Netherlands.

EVALUATION OF DENTAL CARIES ASSOCIATED MICRO-ORGANISMS IN ASTHMATIC CHILDREN.
S. Khalilzadeh1*, J. Salamzade2, F. Salem3, K. Salem4, M. Hakemi Vala5, 1Pediatric Pulmonary Department, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shaheed Beheshti University of Medical Sciences, 2Pharmacology Department, Shaheed Beheshti University, 3FDA, Shaheed Beheshti University, 4Department of Pediatric Dentistry, Gilan Dental School, Rasht, 5Department of Biotechnology, Pasteur Institute of Tehran.

INCREASED MIGRATION OF DENDRITIC CELL INTO AIRWAY EPITHELIA DUE TO INTERLEUKIN-17A INDUCED CCL20 EXPRESSION.
L-Y. Hung*, C-Y. Kao, F. Huang, R. Wu., Division of Pulmonary and Critical Care Medicine, University of California, Davis, CA.

ELEVATED ASYMMETRIC DIMETHYLARGININE ALTERS LUNG FUNCTION AND INDUCES COLLAGEN DEPOSITION IN MICE.
S.M. Wells*, M.C. Buford, C.T. Migliaccio, A. Holian, Center for Environmental Health Sciences, Department of Biomedical and Pharmaceutical Science, University of Montana, Missoula, MT.

ARGINASE EXPRESSION IN AIRWAYS OF MICE EXPOSED TO OVALBUMIN.
J.M. Bratt, L.M. Franzi, A.L. Linderholm, N.J. Kenyon*, Division of Pulmonary and Critical Care Medicine, CCRBM, University of California, Davis, CA.

A MARCKS-RELATED PEPTIDE INHIBITS MUC5AC EXPRESSION IN AIRWAY EPITHELIAL CELLS ISOLATED FROM ASTHMATIC SUBJECTS.
Y. Wang*1, K. Adler2, D. Fertel1, H.W. Chu3, D. Beaver1, M. Crews2, M. Kraft1, 1Duke University Medical Center, Durham, NC, 2North Carolina State University, Raleigh, NC, and 3National Jewish Medical and Research Center, Denver, CO.

DEXAMETHASONE AND IL-13 MODULATE IL-13Ra2 AND IL-13Ra1 EXPRESSION IN AIRWAY FIBROBLASTS IN ASTHMA.
J.L. Ingram*, D.J. Slade, T.D. Church, D.M. Beaver, M. Kraft, Duke Asthma Allergy and Airway Center, Duke University Medical Center, Durham, NC.

GSNO REDUCTASE EXPRESSION IS INCREASED IN THE AIRWAYS OF ASTHMATICS.
J.Y. Chien, Z. Yang, E.N. Potts, T.D. Church. D.M. Beaver, M. Sunday, M. Kraft, L.G. Que*, Duke University Medical Center, Durham, NC.

CD38 PLAYS A DUAL ROLE IN ALLERGEN-INDUCED AIRWAY HYPERRESPONSIVENESS.
F. Gally1*, J.M. Hartney1, K. Takeda2, W.J. Janssen3, A-L. Perraud1, 1Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center; 2Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center; 3Department of Pathology, University of Colorado Health Sciences Center, Division of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center, Denver, CO.

SALIVARY DIAGNOSTICS IN ASTHMA.
P.J. Wexler1, W.L. Siqueira2, E.J. Helmerhorst2, T.M. Blicharz3, R.B. Hayman3, C. Chow3, F.G. Oppenheim2, D.R. Walt3, F.F. Little1*, 1Pulmonary Center, Boston University School of Medicine, Boston, MA; 2Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA; 3Department of Chemistry, Tufts University, Medford, MA.

GENETIC POLYMORPHISM OF THE MUC7 MUCIN GENE IN ASSOCIATION WITH ASTHMA AND ETHNICITY.
A.M. Watson1,3*, W. Ngor1, H. Gordish-Dressman1, R.J. Freishtat1,2,3,5, M.C. Rose1,3,4,5, 1Center for Genetic Medicine Research, Department of 2Emergency Medicine, Children’s National Medical Center (CNMC); 3Immunology Program, Institute of Biomedical Sciences, and 4Departments of Biochemistry and Molecular Biology and of 5Pediatrics, George Washington University, Washington, DC.

MOUSE HOUSE DUST MITE MODEL FOR IDENTIFICATION AND VALIDATION OF NOVEL TARGETS FOR THE TREATMENT OF ASTHMA.
H. Houshyar1*, A. Caron1, J. LaFleur1, J. Derry2, J. Mudget3, Y. Boie1, I-M. Wang2, M. Ruddy4, M. Crackower1, G. Opitek3, D. M. Slipetz1. 1Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada; 2Merck & Co., Inc., Seattle, Washington, , USA; 3Merck & Co., Inc., Rahway, New Jersey, USA; 4Merck & Co., Inc., Boston, Massachusetts, USA

AIRWAY CLOSURE AND ITS RELATION TO NEUTROPHILIC AND EOSINOPHILIC INFLAMMATION IN ACUTE, SEVERE ASTHMA.
D.A. Kaminsky1*, L.K.A. Lundblad1, A.E. Dixon1, R. Olivenstein2, S.E. Lang1, D.M. Raymond1, J.H.T. Bates1, Q. Hamid2, J.G. Martin2, C.G. Irvin1, 1Vermont Lung Center, University of Vermont, and 2Meakins-Christie Laboratories, McGill University, Canada