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Research & Innovation Conference Archive


​Date ​Presenter ​Description ​Video Link
​12/12/2019 ​ Alexis Leal ​Making a cold tumor hot - Immunotherapy in microsatellite stable colorectal cancer Click here​
​12/12/2019 Nicholas Walter
​A new molecular tool to accelerate TB regimen development Click here
​12/5/2019 ​Paul Maclean ​The Colorado NORC Click here
​11/21/2019 ​Kristen Demoruelle ​Sex Differences in Rheumatoid Arthritis-Related Autoimmunity Click here
​11/7/2019 ​Beth Tamurini Changing practice: Clinical pathway integration into hospitalist workflow Click here
11/7/2019 ​Anunta Virapongse Changing practice: Clinical pathway integration into hospitalist workflow ​Click here
​10/10/2019 ​Sarah Jolley ​Identifying neuromyopathy in critically ill patients Click here
​10/10/2019 ​Robert Doebele ​How we finally got to a tumor agnostic treatment paradigm in cancer Click here
​10/3/2019 ​Elizabeth Kudron ​Leveraging genetic data for advances in research & population health Click here​
​09/26/2019 ​Amira Del Pino-Jones ​Assessment of the Diversity and Equity Climate Within the Division of Hospital Medicine Click here​
​09/19/2019 ​Amy McKee ​A role for TNFa in regulating DAMP release from necrotic alveolar macrophages: implications for development of hypersensitivity and granulomatous lung disease Click here
​09/19/2019 ​Andy Levy ​Agreement in Acute MI Definitions: Implications for Value-Based Incentive Programs Click here
​09/12/2019 ​David Schwartz ​IPF: a genetic disease involving the peripheral airways Click here​
​09/12/2019 ​Anosheh Afghahi ​Updates in Breast Cancer Genetics, Screening and Prevention Click here
​05/09/2019 ​Pamela Peterson, MD, MSPH ​Enhancing cardiac rehabilitation adherence through home-based rehabilitation and behavioral nudges Click here
​05/02/2019 ​ Vanessa Sherk, PhD ​All roads lead to bone: Multidisciplinary approaches to understanding fracture risk in obesity Click here
​05/02/2019 ​Jennifer Kemp, PhD ​What's New With Rigor and Reproducibility in NIH Grant Applications? ​Click here
​04/25/2019 ​Kristen Nowak, PhD ​Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults with ADPKD Click here
​04/25/2019 ​Sachin Wani, MD ​Improving Quality in Barrett's Esophagus and Esophageal Adenocarcinoma - Setting Rational Benchmarks Click here
​04/11/2019 ​Breelyn Wilky ​Empowering the immune system in sarcomas: From bedside to bench and back again Click here
​04/04/2019 Matthew Taylor, MD, PhD ​Revealing the Heart Failure Transcriptome Click here
​04/04/2019 ​Jane Reusch, MD ​Exercise in tolerance in Diabetes: Is it a microvascular complication? Click here
​03/14/2019 ​Alexandra McCubbrey, PhD ​Metabolic impact of efferocytosis: a signal for macrophage reprogramming Click here
​03/07/2019 ​Matthew Burchill, PhD ​Liver lymphatic expansion, differentiation and function in the setting of chronic liver disease Click here
​03/07/2019 ​York Miller, MD ​Reversal of Airway Premalignancy: Progress toward Personalized Treatment Click here
​02/28/2019 ​Odette Gore, MD ​A New Approach to Precision Prevention: Multi-Biomarker Assessment of Short-Term Cardiovascular Risk Click here
​02/28/2019 ​Raphael Nemenoff, PhD ​Determinants of Response to Immune Checkpoint Inhibitors in Lung Cancer Click here
​02/21/2019 ​Bradley Haverkos, MD, MPH, MS ​Leveraging immunotherapy to improve treatments for newly diagnosed peripheral T-cell lymphomas Click here
​02/07/2019 ​Joseph Frank, MD ​Opioid Tapering and Patient Engagement: Results of a National VA Survey Click here
​02/06/2019 ​Drs. David Schwartz and Craig Jordan ​Programmatic research in the Department of Medicine and across campus Click here
​01/24/2019 ​Linda A. Barbour, MD, MSPH ​Intrauterine Factors Fueling Transgenerational Obesity—Much More than Sugar to Blame Click here
​01/24/2019 ​Joshua Thurman, MD ​Complement and the Kidney Click here
​01/03/2019 ​Amy Huebschmann, MD ​Improving primary care diabetes management through dissemination and implementation science methods – Moving from Vision to Reality Click here
​01/03/2019 ​Daniel Bessessen, MD ​Treatment of Obesity in Primary Care Click here
​12/13/2018 ​Kathleen Woulfe, PhD ​Age-specific Differences in Myofibril Mechanics in Patients with Dilated Cardiomyopathy Click here​
​12/06/2018 ​Isabel R. Schlaepfer, PhD ​Fat oxidation and Androgen Signaling as a Novel Intersection for Prostate Cancer Therapy Click here
​11/29/2018 ​Beth Tamburini, PhD ​Type 1 interferon and PD-L1 coordinate lymphatic endothelial cell expansion and contraction during an inflammatory immune response   Click here
​11/15/2018 ​Brian Montague, DO, MS, MPH ​Expanding Our Vision of Meaningful Use and Computerized Decision Support: Where are we now and where can we go? Click here
​11/08/2018 ​Subbiah Pugazhenthi, PhD ​Interactions of Metabolic Syndrome with Alzheimer's Disease Click here
​11/08/2018 ​Rena Yadlapati, MD, MHS ​Assessing the Relationship Between Gastro-Esophageal Reflux & Laryngeal Symptoms: Challenges & Opportunities Click here
​11/01/2018 ​Jonathan Gutman, MD ​Why do we do cord blood transplants here - and where are we going? Click here
​10/25/2018 ​Tom Campbell, MD ​As-Needed versus Immediate Etoposide Chemotherapy in Combination with Antiretroviral Therapy for Mild or Moderate AIDS-associated Kaposi Sarcoma in Resource-Limited Settings: Results from the A5264/AMC-067 Randomized Clinical Trial Click here
​10/25/2018 ​Dan Kao, MD, PhD ​Mucosa-derived extracellular adenosine regulates host-microbe interactions in the gut via suppression of a universal bacterial stress response Click here


​Sara Faubel, MD ​Beyond the Ouch Hypothesis: Introducing a New Paradigm to Explain Harm in Acute Kidney Injury Click here
​09/27/2018 ​Traci Lyons, PhD ​Lymphatic development in the postpartum mammary gland drives metastisis of postpartum breast cancers Click here
​09/27/2018 ​Berenice Gitomer, PhD ​Targeting methylation defect in autosomal dominant polycystic kidney disease: Evaluation of therapeutic potential Click here
​09/20/2018 ​CT Lin, MD ​EHR 2.0 Sprint teams to reduce the EHR burden and physician burnout Click here
​09/13/2018 ​Timothy A. McKinsey, PhD ​HDAC Inhibitor Therapy for Diastolic Dysfunction: Targeting Muscle Mechanics and Hidden Fibrosis Click here
​09/13/2018 ​Sean P. Colgan, PhD ​Intimate Conversations Between the Host and the Microbiota within the Mucosa Click here
​09/06/2018 ​David A. Schwartz, MD ​Idiopathic Pulmonary Fibrosis: a genetic disease that involves mucociliary dysfunction in the peripheral airways Click here
​05/17/2018 ​Terry Ng, Fellow ​A multidisciplinary approach to studying an important drug-related adverse event Click here
​05/17/2018 ​Edward Melanson, PhD ​Quantifying brown fat activity using dynamic PET/CT Click here
​05/10/2018 ​Colleen McIlvennan, DNP, MS ​Caregivers of Patients Considering Destination Therapy Left Ventricular Assist Device and a Shared Decision-Making Intervention: The DECIDE-LVAD Trial Click here​
​05/10/2018 ​Sansrita Nepal, MD, MBA ​What do patient's want? Click here
​05/03/2018 ​Lori Walker, PhD ​Cardiac Effects of Cannabis in Post-MI Patients ​Click here
​04/26/2018 ​Jeff Zoucha, MD ​Barriers to Early Hospital Discharge: A Cross-Sectional Study at Five Academic Hospitals Click here
​04/26/2018 ​Kristine A. Kuhn, MD, PhD ​Description: Microbial influences on intestinal barrier integrity and implications for systemic autoimmunity ​Click here
​04/19/2018 ​Hillary Lum, MD, PhD ​A Designing for Dissemination Case Study: Enhancing Advance Care Planning Through the Patient Portal Click here
​04/19/2018 ​Chris Knoepke, PhD, MSW, LCSW ​A Social Perspective on Patient Decision Support Click here
​04/05/2018 ​Katja Kiseljak-Vassiliades, DO ​Development of New Pre-Clinical Models and Testing New Therapeutics in Adrenocortical Carcinoma Click here
​03/22/2018 ​Jose Castillo-Mancilla, MD ​New Insights on Antiretroviral Adherence and Exposure ​Click here
​03/22/2018 ​Kasey Couts, PA-C ​Targeting Gene Fusions Across Melanoma Subtypes Click here
​03/15/2018 ​Michel Chonchol, MD ​Intensive Blood Pressure Control and Kidney Function Decline: Lessons from SPRINT Click here
​03/15/2018 ​Irina Petrache, MD ​Endothelial Cell Injury and Repair in COPD Click here
​03/08/2018 ​Maggie Lam, PhD ​A Data Science Approach to Facilitating Proteomics Translation Click here
​03/08/2018 ​Philip Fung, MD ​Implications of Power Asymmetries in Virtue in Medical Education Click here
​03/01/2018 ​Beth Tamburini, PhD ​Lymphatic Expansion and Differentiation During Chronic Liver Disease Click here
​03/01/2018 ​Michael Rosenberg, MD ​Hope vs. Hype: Clinical Application of Genetic Information Click here
​02/22/2018 Michelle Haas, MD The Latent Tuberculosis Care Continuum in Primary Care Clinics Affiliated with Denver Health Medical Center Click here
​02/22/2018 ​Aik-Choon Tan, PhD Data Driven Drug Repurposing, Repositioning and Development Click here
​02/15/2018 ​Jessica Kendrick, MD ​Sodium Bicarbonate as a Treatment for Vascular Disease in Chronic Kidney Disease Click here
​02/15/2018 ​Meredith Tennis, PhD ​Precision Medicine Approaches to Lung Cancer Chemoprevention Click here
​02/08/2018 ​Paul MacLean, PhD ​A novel approach to studying the relationship between obesity and cancer ​Click here
​02/01/2018 ​Anna Jovanovich, MD ​Exploring Deoxychloric Acid, a Metabolite of Circulating Bile Acids, as a Novel Marker for Vascular Calcification in CKD and a Potential Target for Intervention Click here​
​02/01/2018 ​Lauren Fishbein, MD, PhD ​Genetics of the Mysterious Pheochromocytoma Click here
​01/25/2018 ​Tomer Mark, MD, MSc ​Can We Reduce Cost of Multiple Myeloma Care Without Sacrificing Quality? Click here
​01/25/2018 ​Stephen Keysar, PhD ​Enrichment of Salivary Gland Cancer Stem Cells During Disease Progression
Click here
​01/18/2018 ​Daniel Matlock, MD, MPH ​The Science of Dissemination: Decision Aids as an Example Click here
​12/14/2017 ​Rebecca E. Schweppe, PhD ​Targeting FAK and Src in Thyroid Cancer Click here
​12/14/2017 ​Boris Tabakoff, PhD ​The Road to Personalized Medicine: From Rate to Human and Back Click here
​11/30/2017 ​Gabriela Garcia, MD ​The Critical Role of Adenosine Receptors in Protecting from Kidney Injury Click here
​11/09/2017 ​Matthew Burchill, PhD ​Do Viral Specific T Cells at the Maternal-Fetal Interface Prevent Vertical Click here
​10/19/2017 ​Mamuka Kvaratskhelia, PhD ​Inhibiting HIV-1 Integrase: Taking Aim at a Moving Target. Click here​
​10/12/2017 ​Kathleen M. Gavin, PhD ​The Importance of Adipocyte Lineage when Considering the Impact of Adiposity on Health. Click here​
​09/28/2017 ​Charles Edelstein, MD, PhD ​Polycystic Kidney Disease - a Case of Suppressed Autophagy? Click here​
​09/14/2017 ​Kristine Erlandson, MD ​Can Statins Preserve Physical Function in Older Adults with HIV? Click here​
​09/07/2017 ​David A. Schwartz, MD ​Idiopathic Pulmonary Fibrosis: A Genetic Disease that Involves Mucociliary Dysfunction in the Peripheral Airways.  Click here
​09/07/2017 ​Bryan R. Haugen, MD ​Modeling Advanced Thyroid Cancer: From Pharmacogenomics Discovery to Systems Biology. Click here
​05/18/2017 ​James Colbert, MD ​Aging-related Changes in Gut Microbiome Mediate Septic Kidney Injury Click here
​05/11/2017 ​Nikita Pozdeyev, MD, PhD ​Integrating Heterogeneous Drug Sensitivity Data from Cancer Pharmacogenomic Studies. Click here
​04/13/2017 ​Arthur Gutierrez-Hartmann, MD ​ESE-1/Elf3 Expression is Required for the Malignant State in HER2+ Luminal B Breast Cancer and Correlates with Poor Clinical Outcomes. Click here
​4/06/2017 ​Elena Shagisultanova, MD, PhD ​Rational Combination of Targeted Drugs Puts a Triple Deadlock on Breast Cancer Signaling. ​Click here
​​4/06/2017 ​Susan Calcaterra, MD, MPH ​Opioid Prescribing During Hospitalization and Its Impact on Future Opioid Use. Click here
​03/23/2017 ​Nirmal K. Banda, PhD ​RNAi Therapeutics Coming of Age: Targeting Complement to Treat Rheumatoid Arthritis. Click here
​03/23/2017 ​Eric A. Coleman, MD, MPH ​Evaluating Leadership in Practice Change ​Click here
​03/16/2017 ​Kathleen C. Barnes, PhD ​Personalized Medicine Click here
​03/16/2017 ​Eric Schmidt, MD ​Circulating Glycocalyx Fragments Mediate Septic Neurocognitive Dysfunction Click here
​03/09/2017 ​Michael Ho, MD, PhD ​Data Science to Patient Value (D2V) Click here
​09/09/2017 ​Ivor Douglas, MD ​Rapid Microbiological Diagnostics Click here
​03/02/2017 ​Vinay Kini, MD, MSHP ​Can We Improve Value in Noninvasive Cardiac Testing? Click here​
​02/09/2017 ​Anuj Mehta, MD ​Tracheostomy Utilization and Outcomes in the United States Click here​
​01/05/2017 ​Daniel Pollyea, MD, MS ​Targeting Leukemia Stem Cells in Clinical  Click here​
​12/1/2016 ​Todd Pitts, PhD ​Metabolic Reprogramming to Enhance the Efficacy of mTOR Inhibition in Colorectal Cancer Click here​
​10/13/2016 ​William J. Janssen, MD​ ​​Nature vs. Nurture: Cell Origin Distinguishes the Programming of Alveolar Macrophage Subtypes during Acute Lung Injury Click here​
​10/06/2016 ​Scott Alper, PhD ​mRNA Splicing Genes, Inflammation, and Hematologic Malignancies ​Click here​
​09/22/2016 ​Eric Pietras, PhD​ ​Preventing Pneumococcal Disease in HIV-Infected Persons Click here​
​09/15/2016 ​Sean Colgan, PhD ​Tissue Metabolism and Inflammation in the Mucosa ​Click here​
​09/15/2016 ​Christopher Evans, PhD ​Unexpected Functions of Airway Mucus: Sweet Spots in Lung Injury and Inflammation Click here​
​09/08/2016 ​Amy Huebschmann, MD, MS ​How Can Clinical Practices Pragmatically Increase Physical Activity for Patients with Type 2 Diabetes? A Systematic Review Click here​
​05/26/2016 ​ Berenice Reed-Gitomer, PhD ​Autosomal Dominant Polycystic Kidney Disease, Not Only a Disease of the Kidney: Identification of a Bone Defect in Affected Patients Click here​
​05/26/2016 ​Kerrie Moreau, PhD ​Cardiovascular Consequences of Hypogonadism in Men Click here​
​05/19/2016 ​Larry Allen, MD ​Emotion and Cognitive Biases in Decision Making for Life-Threatening Illness. ​Click here​
​05/05/2016 ​Jose Castillo-Mancilla, MD ​Antiretroviral Adherence Beyond Virologic Suppression Click here​
​05/05/2016 ​Marc-Andre Cornier, MD ​The Effects of Exercise on Appetite Regulation. Click here​
​03/17/2016 ​Evelyn Hutt, MD ​Palliative Care for Homeless Veterans ​Click here​
02/18/2016 ​Danielle Loeb, MD ​Development, Validation and Predictors of Two New Self-Efficacy Scales: Primary Care Physician Self-Efficacy in Managing Mental Illness and Working in a Team-Based Model Click here​
​02/18/2016 ​Eric Schmidt, MD From Preclinical to Practical: Urinary Glycosaminoglycans as Predictors of Septic Shock Outcomes Click here​
​02/04/2016 ​Jennifer Richer, PhD ​Targeting the Androgen Receptor in Breast Cancers Resistant to Anti-estrogen Treatments Click here​
​01/28/2016 ​Adela Cota-Gomez, PhD Does Modulation of Sp1/Sp3 by HIV-1 Tat Contribute to Oxidative Stress in HIV-PAH?
​Click here​
​01/28/2016 ​Christine Vohwinkel, MD, PhD ​Regulation of Alveolar Epithelial Carbohydrate Metabolism during Acute Lung Injury ​Click here​
​01/21/2016 ​Eva Aagaard, MD ​Creating a Climate for Change: Impact of Faculty Development Programs in Zimbabwe Click here​
​10/08/2015 ​Isabel R. Schlaepfer, PhD, MA ​Lipid Catabolism via CPT1A in Prostate Cancer: Novel Avenues for Imaging and Therapy ​Click here​
​09/10/2015 ​Amrut Ambardekar, MD ​Aortic Changes with Continuous-Flow Left Ventricular Assist Device Support and Implications for Cardiac Recovery ​Click here​
​05/07/2015 ​V. Michael Holers, MD​ ​Targeting Mechanisms of Local Complement Activation for Diagnostic and Therapeutic Applications ​Click here​
​04/30/2015 ​David A. Schwartz, MD​ ​Idiopathic Pulmonary Fibrosis: A Mucociliary Disease of the Peripheral Airways? Click here​
​04/30/2015 ​Bryan Haugen, MD ​Exploiting Host Tumor Interactions in Thyroid Cancer Click here​
​04/23/2015 ​Rachael Van Pelt, PhD The Cardioprotective Effect of Leg Fat ​Click here​
​04/02/2015 ​Mark Gritz, PhD ​ACTION and RMADA: Vehicles for AHRQ and CMS Sponsored Research Click here​
​03/05/2015 ​Jose Castillo-Mancilla, MD ​Quantifying Drug Adherence to Antiretroviral Therapy ​Click here​
​02/26/2015 ​Duy Nguyen, MD ​Improving Anti-Arrhythmic Efficacy and Safety through Facilitated Ablation Biophysics Click here​
​02/26/2015 ​Daniel A. Pollyea, MD ​Targeting Leukemic Stem Cells in Clinical Trials: New Rules, New Therapies, New Results Click here​
​02/19/2015 Linda Barbour, MD and E. 'Jed' Friedman, PhD Intrauterine and Postnatal Influences on Offspring Obesity - Mice to Monkeys to Mothers
Click here​
​02/12/2015 ​Elizabeth Kessler, MD ​Physical Function and Metabolic Changes Induced by Prostate Cancer Treatment Click here​
​02/05/2015 ​Kristine Kuhn, MD, PhD ​Connecting the Microbiome to Autoimmunity through Intraepithelial Lymphocytes ​Click here​
​12/11/2014 ​Marileila Garcia, PhD ​Facing Molecular Testing Dilemmas in Solid Tumors Click here​
​12/4/2014 ​Shelley Miyamoto, MD ​Biochemical Differences Between the Failing Pediatric and Adult Myocardium ​Click here​
​11/20/2014 ​Jennifer Stevens-Lapsley, PT, PhD ​Mechanisms of Muscle Dysfunction with Trauma: Using Knee Arthroplasty as a Model Click here​
​11/20/2014 ​Laura Hurley, MD ​Financial Barriers to Adult Vaccine Delivery Click here​
​09/18/2014 ​Ernest Moore ​Trauma Induced Coagulopathy Click here​
​09/11/2014 ​Roger A. Bannister, PhD ​RGK Proteins and Skeletal Muscle Excitability Click here​
​09/04/2014 ​Nia Mitchell, MD ​Studying Take Off Pounds Sensibly (TOPS): Determining the Reach and Effectiveness of a National, Nonprofit Weight Loss Program Click here​
​05/15/2014 ​Danielle Loeb, MD ​A "Real World" Implementation of a Depression Screening and Treatment Protocol in Two Academic Outpatient Internal Medicine Clinics Utilizing the Electronic Medical Record Click here​
​05/01/2014 ​Mark Geraci, MD ​Review of the New CCTSI: Overview, Technology Resources and Grants Programs Click here
​04/24/2014 ​Michael Kahn, MD, PhD and Ken Jones ​Existing and Future Biomedical Informatics Resources to Support Local, Regional, and National Translational Research Click here
​04/24/2014 ​Sarah Faubel, MD ​The Counter-Inflammatory Response after Acute Kidney Injury Click here
​04/17/2014 ​Steven M. Bradley, MD ​Better Patient Health at Lower Cost: Achieving High-Value Healthcare Click here
​04/17/2014 ​Richard J. Johnson, MD ​Insights on the Epidemic of Chronic Kidney Disease in Central America Click here
​03/20/2014 ​Sharilyn Almodovar, PhD ​Presence of CXCR4-utilizing Human Immunodeficiency Virus (HIV) is Associated with Pulmonary Arterial Hypertension Click here
​03/13/2014 ​Elizabeth Connick, MD ​Are B Cell Follicles Immune Privileged Sites in HIV Infection? Evidence from the SIV-Infected Rhesus Macaque Model Click here
​03/13/2014 ​William Sauer, MD ​Innovative Strategies for Improving the Safety and Efficacy of Cardiac Ablation ​Click here
​03/06/2014 ​Stephen Malkoski, MD, PhD ​Targeting Defective DNA Repair in Smad4 Deficient Lung Cancer ​Click here
​02/27/2014 ​Elizabeth M. Harry, MD and Jonathan Manheim ​Accountable Care/Quality ​Click here
​02/27/2014 ​Hugo R. Rosen, MD, FACP Novel Roles for Liver Sinusoidal Endothelial Cells in Hepatits C Immunity Click here
​02/20/2014 ​Ivana Yang, PhD ​Cilium Gene Expression in Idiopathic Pulmonary Fibrosis ​Click here
​02/20/2014 ​Peter A. Watson, PhD ​Research Collaborations Between the Denver VA Medical Center and the University of Colorado Anschutz Medical Campus: A Fresh Perspective Click here
​02/13/2014 ​Anne M. Libby, PhD ​Launching Faculty to Success in Clinical and Outcomes Research: 10th Anniversary of the Clinical Faculty Scholars Program ​Click here
​02/13/2014 ​Christopher Lieu, MD and Todd Pitts, MS ​From Bench to Bedside: Translational Drug Development in Metastatic Colorectal Cancer Click here
​02/06/2014 ​Bryan Haugen, MD ​NFkB Signaling in Advanced Thyroid Cancer: A Potential Therapeutic Target Click here
​01/30/2014 ​Elaine H. Morrato, DrPh, MPH ​Dissemination and Implementation Science: Resources and Opportunities Click here
​01/23/2014 ​William Hiatt, MD ​Pathophysiology of Claudication in Peripheral Artery Disease ​Click here
​01/09/2014 ​Wendy Kohrt, PhD ​The CCTSI Clinical and Translational Research Centers and MicroGrant Program Click here
​12/19/2013 ​Jean S. Kutner, MD, MSPH ​Statin deprescribing: Evidence from the first trial conducted in the Palliative Care Research Cooperative Group (PCRC) Click here​
​12/19/2013 ​Michael Edwards, PhD ​Using Bioinformatics to Understand Lung Tumorigenesis ​Click here
​12/12/2013 ​Kunhua Song, PhD ​Cellular Reprogramming and Heart Repair ​Click here
​12/12/2013 ​Margaret E. Wierman, MD ​Using Genetic and Genomic Approaches to Identify Novel Therapeutic Targets for Pituitary Tumors ​Click here
​12/05/2013 ​Anna Peljto, PhD ​MUC5B Genotype Contributes to Phenotypic Heterogeneity in Idiophatic Pulmonary Fibrosis Click here