Main Research Focus:
The Schedin Lab is focused on developing breast cancer chemopreventive strategies that are targeted to specific windows of breast development. Our approach is to understand the role of mammary extracellular matrix (ECM) proteins in mediating epithelial cell death during key windows of normal mammary gland differentiation, such as adolescent mammary gland development, the estrous cycle, and the pregnancy, lactation, and involution cycle. Major areas of investigation include adolescent mammary development, mammary epithelial cell/stromal interactions, tissue remodeling, mammary carcinogenesis, and chemoprevention using rodent and 3-dimensional culture models and human tissue. Current Research Projects Include: 1) Determining the role of physiologic tissue remodeling in promoting metastasis in pregnancy-associated breast cancer. 2) Identifying the ECM proteomes of the ‘breast-cancer protected’ and ‘at-risk’ mammary gland to identify stromal mediators of tumor cell dormancy and metastasis, and 3) identify dietary interventions targeted to puberty that result in the development of mammary tissue resistant to carcinogenic insult.
O'Brien J, Lyons T, Monks J, Lucia MS, Wilson RS, Hines L, Man YG, Borges V, Schedin P. Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. Am J Pathol. 2010 Mar;176(3):1241-55.
Taraseviciute A, Vincent BT, Schedin P, Jones PL. Quantitative analysis of three-dimensional human mammary epithelial tissue architecture reveals a role for tenascin-C in regulating c-met function. Am J Pathol. 2010 Feb;176(2):827-38.
MacLean PS, Giles ED, Johnson GC, McDaniel SM, Fleming-Elder BK, Gilman KA, Andrianakos AG, Jackman MR, Shroyer KR, Schedin PJ. A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats. Obesity (Silver Spring). 2010 Apr;18(4):696-703.
Lyons TR, Schedin PJ, Borges VF. Pregnancy and breast cancer: when they collide. J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):87-98.
Hansen KC, Kiemele L, Maller O, O'Brien J, Shankar A, Fornetti J, Schedin P. An in-solution ultrasonication-assisted digestion method for improved extracellular matrix proteome coverage. Mol Cell Proteomics. 2009 Jul;8(7):1648-57.
O'Brien J, Schedin P. Macrophages in breast cancer: do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer? J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):145-57.
Schedin P, Borges V. Breaking down barriers: the importance of the stromal microenvironment in acquiring invasiveness in young women's breast cancer. Breast Cancer Res. 2009;11(2):102.
Hattar R, Maller O, McDaniel S, Hansen KC, Hedman KJ, Lyons TR, Lucia S, Wilson RS Jr, Schedin P. Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes. Breast Cancer Res. 2009;11(1):R5.
McDaniel SM, O'Neill C, Metz RP, Tarbutton E, Stacewicz-Sapuntzakis M, Heimendinger J, Wolfe P, Thompson H, Schedin P. Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate. J Nutr. 2007 Jun;137(6):1415-22.
Schedin P, O'Brien J, Rudolph M, Stein T, Borges V. Microenvironment of the involuting mammary gland mediates mammary cancer progression. J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):71-82.
Schedin P. Pregnancy-associated breast cancer and metastasis. Nat Rev Cancer. 2006 Apr;6(4):281-91.
McDaniel SM, Rumer KK, Biroc SL, Metz RP, Singh M, Porter W, Schedin P. Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. Am J Pathol. 2006 Feb;168(2):608-20.