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Paul A. Bunn, Jr, MD

Distinguished Professor, Division of Medical Oncology/University of Colorado, James Dudley Chair in Lung Cancer Research


Bunn Photo  ​Paul A. Bunn, MD              

  

Education
Amherst College - 1967

Cornell University Medical Center, New York, NY – 1971

Bio
In 1984, Dr. Bunn was recruited to the University of Colorado Health
Sciences Center as a Professor of Medicine in Medical Oncology and Head
of the Division of Medical Oncology. In 1986 Dr. Bunn became the
Director of the University of Colorado Comprehensive Cancer Center.
Dr. Bunn has been President of ASCO, IASLC, and AACI, chairman of the
FDA Oncology Drug Advisory Committee, and Executive Director of the
IASLC.

Research
Dr. Bunn’s research interests focus on novel therapies for lung cancer.
He has published more than 300 articles in peer-reviewed journals,
over 122 reviews and editorials, and 90 book chapters on lung cancer.
Dr. Bunn’s studies have set standards for the treatment of lung cancer,
have identified issues of natural history and have identified biomarkers of prognosis and therapy selection. Dr. Bunn
is the principal investigator on numerous national and local therapeutic trials and is also the principal investigator for the SPORE grant in lung cancer that is designed to conduct translational research in lung cancer.


Funding

SPORE In Lung Cancer: NIH/NCI 09/30/1992 to 04/30/2014. $1,513,778 - 25% effort combined
The major goal of the overall project is to establish a Specialized Program in Research Excellence (SPORE) in Lung Cancer to expand our understanding of the biology of lung cancer, to find new methods of diagnosis, prevention and treatment and to serve as a regional, national and international resource for the study of lung cancer.

Publications

  • Helfrich BA, Kim J, Gao D, Chan DC, Zhang Z, Tan AC, Bunn PA Jr.  Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo.  Mol Cancer Ther. 2016 Oct;15(10):2314-2322. Epub 2016 Aug 5.  PMID: 27496133
  • Merrick DT, Gao D, Miller YE, Keith RL, Baron AE, Feser W, Kennedy TC, Blatchford PJ, Braudrick S, Hirsch FR, Heasley L, Bunn PA Jr, Franklin WA.  Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma.  Cancer Prev Res (Phila). 2016 Jan;9(1):96-104.  PMID: 26542061
  • Iyengar P, Kavanagh BD, Wardak Z, Smith I, Ahn C, Gerber DE, Dowell J, Hughes R, Abdulrahman R, Camidge DR, Gaspar LE, Doebele RC, Bunn PA, Choy H, Timmerman R. Phase II Trial of Stereotactic Body Radiation Therapy Combined With Erlotinib for Patients With Limited but Progressive Metastatic Non-Small-Cell Lung Cancer. J Clin Oncol. 2014 Oct 27. pii: JCO.2014.56.7412. PMID: 25349291
  • Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Varella-Garcia M, Franklin WA, Aronson SL, Su PF, Shyr Y, Camidge DR, Sequist LV, Glisson BS, Khuri FR, Garon EB, Pao W, Rudin C, Schiller J, Haura EB, Socinski M, Shirai K, Chen H, Giaccone G, Ladanyi M, Kugler K, Minna JD, Bunn PA. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA. 2014 May 21;311(19):1998-2006. doi: 10.1001/jama.2014.3741. PMID: 24846037
  • Peled N, Barash O, Tisch U, Ionescu R, Broza YY, Ilouze M, Mattei J, Bunn PA Jr, Hirsch FR, Haick H. Volatile fingerprints of cancer specific genetic mutations. Nanomedicine. 2013 Aug;9(6):758-66. doi: 10.1016/j.nano.2013.01.008. Epub 2013 Feb 18. PMID: 23428987
  • Casás-Selves M, Kim J, Zhang Z, Helfrich BA, Gao D, Porter CC, Scarborough HA, Bunn PA Jr, Chan DC, Tan AC, DeGregori J. Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Res. 2012 Aug 15;72(16):4154-64. doi: 10.1158/0008-5472.CAN-11-2848. Epub 2012 Jun 27. PMID: 22738915
  • Witta SE, Jotte RM, Konduri K, Neubauer MA, Spira AI, Ruxer RL, Varella-Garcia M, Bunn PA Jr, Hirsch FR. Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy. J Clin Oncol. 2012 Jun 20;30(18):2248-55. doi: 10.1200/JCO.2011.38.9411. Epub 2012 Apr 16. PMID: 22508830

PubMed articles​ ​