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Eric Murnane Poeschla, MD

Professor and Division Chief



Phone: 303-724-8770

E-mail: eric.poeschla@ucdenver.edu

Mailing Address: University of ColoradoDivision of Infectious Diseases, Mail Code B168,12700 E. 19th Avenue,Aurora, CO 80045

Medical School

Yale Medical School 

Residency

Internal Medicine, University of California at San Francisco 

Fellowship

Infectious Diseases, University of California at San Diego 

Prior Faculty Appointments

University of University of California at San Diego

Mayo Clinic College of Medicine (1999-2014) 

Present Appointment (September 2014 to Present)

Professor of Medicine

Tim Gill Endowed Research Chair and

Head, Division of Infectious Diseases

University of Colorado School of Medicine 

Research Interests 

We investigate viral replication, host innate immunity to viruses, and viral disease pathogenesis. We have previously focused on HIV-1, but have now expanded our work to include other positive strand RNA viruses, such as picornaviruses (Painter et al., 2015), in particular the role of innate immune system recognition of viral dsRNA and other pathogen-associated molecular patterns (PAMPs) by system sensors including RIG-I-associated receptors (RLRs such as MDA5, RIG-I, LGP2). Our basic HIV research continues to concentrate on basic molecular and cell biological aspects of viral replication (host cell dependency factors, innate immunity/restriction factors, integration, encapsidation). We contributed foundational work on the HIV integration cofactor role of LEDGF (e.g., Llano et al. Science, 2006; Ciuffi et al., Nature Medicine, 2005) and we continue to be very interested in host factor participation in the post-entry events that culminate in integration. We have begun work on gene therapy-based HIV cure strategies that employ site-specific gene targeting of HIV dependency factors with TALENs and CRISPR/Cas systems. The primate-nonprimate lentiviral/host comparison, the human-animal interface, and the process of viral emergence across species barriers has been a theme since my basic research career started with construction of the first FIV-based lentiviral vectors (Poeschla et al., Nature Medicine, 1998). We recently developed new germline transgenesis methods in order to enable experimental genetic modification and breeding in an AIDS-susceptible species (Wongsrikeao et al., Nature Methods, 2012). This research has taken us into novel areas of reproductive biology. We provide a demonstrated training environment. We have graduated nine Ph.D.s in virology, multiple ID fellow and post-doctoral fellows have moved on to start their own laboratories, and multiple post-baccalaureate students.​