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Stephanie Dillon, PhD

Instructor
 
 

Phone: 303-724-4602
Email: stephanie.dillon@ucdenver.edu
Address:University of Colorado
Medicine-Infectious Diseases, Mail Stop #B168
Building P15 Research Complex 2, Room 11005
12700 E. 19th Avenue
Aurora, CO 80045

Education:
2000 PhD University of Otago, Dunedin, New Zealand

Postdoctoral Fellowships 

2001  Baylor Institute for Immunology Research, Dallas, Texas

2002-2005 Emory University, Atlanta, Georgia

2005-2007 University of Colorado Denver, Denver, Colorado

 

Dendritic cells are innate immune cells that are crucial in bridging the innate and adaptive immune responses.  Our research is focused on understanding how HIV-1 infection influences dendritic cell function and their interactions with T cells.  Recently, we have begun to investigate the contribution of intestinal dendritic cells to the gastrointestinal pathology observed in patients infected with HIV-1.  

 

 

1) Dillon, S.M., Rogers, L.M, Howe, R., Hostetler, L.A., Buhrman, J., McCarter, M.D. and Wilson, C.C.  (2010). Human Intestinal Lamina Propria CD1c+ Dendritic Cells Display an Activated Phenotype at Steady State and Produce IL-23 in Response to TLR7/8 Stimulation.  J. Immunol.  184: 6612-6621.

2) Howe, R., Dillon, S., Rogers, L., McCarter, M., Kelly, C., Gonzales, R., Madinger, N. and Wilson, C. (2009).  Evidence for Dendritic Cell-Dependent CD4+ T Helper-1 Type Responses to Commensal Bacteria in Normal Human Intestinal Lamina Propria.  Clin. Immunol.  131, 317-332.

3) Mengshol, J.A., Golden-Mason, L., Castelblanco, N., Im, K., Dillon, S.M., Wilson, C.C and Rosen, H.R.  (2009). Impaired Plasmacytoid Dendritic Cell Maturation and Differential Chemotaxis in Chronic HCV:  Associations with Anti-viral Treatment Outcomes.  Gut 58, 964-973.

4) Dillon, S., Robertson, K., Pan, S., MaWhinney, S., Meditz, A., Folkvord, J., Connick, E., McCarter, M., Wilson, CC. (2008).  Plasmacytoid and Myeloid Dendritic Cells With a Partial Activation Phenotype Accumulate in Lymphoid Tissue During Asymptomatic, Chronic Human Immunodeficiency Virus Type 1 Infection.  J Acquir Immune Defic Syndr. 48: 1-12.

5) Dillon, S., Sasagawa, T., Crawford, A., Prestidge, J., Inder, M., Jerram, J., Mercer, A., and Hibma, M.  (2007). Resolution of Cervical Dysplasia is Associated With T Cell Proliferative Responses to Human Papillomavirus Type 16 E2.  J. Gen. Virol. 88, 803-813.

6) D’Souza, M., Pontenot, A.P., Mack, D.G., Lozupone, C., Dillon, S., Meditz, A., Wilson, C.C., Connick, E., Palmer, B.P.  (2007).  Programmed Death 1 Expression on HIV-specific CD4+ T cells is Driven by Viral Replication and Associatd With T cell Dysfunction.  J. Immunol. 179: 1979-1987.

7) Dillon, S., Agrawal, S., Banerjee, K., Letterio, J., Denning, T., Oswald-Richter, K., Kasprowicz, D., Kellar, K, Pare, J., Van Dyke, T., Ziegler, S., Unutmaz, D., and  Pulendran, B. (2006)  Yeast Zymosan, a Stimulus For TLR2 and Dectin-1, Induces Regulatory Antigen-presenting Cells and Immunological Tolerance.  J. Clin. Invest.  116:916-928.

8) Agrawal, A., Dillon, S., Denning, T., and Pulendran, B.  (2006). ERK1-/- Mice Exhibit Th1 Polarization and Increased Susceptibility to Experimental Autoimminue Encephalomyelitis.  J. Immunol. 176, 5788-5796.

9) Pulendran, B., Agrawal, A., Dillon, S., and Agrawal, S.  (2005). Dendritic cells: Targets for Immune Modulation by Microbes and Immunologists.  In Vaccine Adjuvants: Immunological and Clinical Principles Edited by: C. J. Hackett and D. A. Harn, Jr. Humana Press Inc., Totowa, NJ.

10) Pulendran, B., Dillon, S., Joseph, C., Curiel, T., Banchereau, J. and Mohamadzadeh, M.  (2004). Dendritic Cells Generated in the Presence of GM-CSF Plus IL-15 Prime Potent CD8+ Tc1 Responses In Vivo.  Eur. J. Immunol. 34: 66-73.

11) Dillon, S., Agrawal, A., Van Dyke, T., Landreth, G., McCauley, L., Koh, A., Maliszewski, C., Akira, S. and Pulendran, B.  (2004).  A Toll-like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, Via Induction of Extracellular Signal-related Kinase Mitogen-activated Protein Kinase and c-Fos in Dendritic Cells.  J. Immunol. 172, 4733-4743.