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Clinical Trials

​See what human subject trials are accepting applicants


For more information click the study identifier or search the identifier number at clinicaltrials.gov.

 Mastocytosis

ClinicalTrials.gov
Identifier
Study Title Study Coordinator​
NC​T02561988​
A Phase 1 Study of BLU-285 in Patients with Advanced Systemic Mastocytosis (advSM) and Relapsed or Refractory Myeloid Malignancies
Ryan Scannura​, 720-848-8033
12

 Non Hodgkin Lymphoma

​ClinicalTrials.gov
Identifier
Study Title Study Coordinator​
​​NCT02567656 ​​A Phase I/Ib, Dose Escalation Study to Evaluate Safety and Efficacy of RP6530, a Dual PI3K δ/γ Inhibitor, in Patients With Relapsed or Refractory T-cell Lymphoma ​Kelsey Moore, 720-848-8089​​​
NCT02443077 ​​​A randomized, double-blind, phase 3 study of ibrutinib during and following autologous stem cell transplantation versus placebo in patients with replapsed or refractory diffuse large B-cell lymphoma of the activated B-cell subtype ​Tricia Feddick, 720-848-8034
NCT02580552 ​A Phase 1 Dose-ranging Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MRG-106 Following Local Intratumoral and Subcutaneous Injection in Patients With Cutaneous T Cell Lymphoma (CTCL), Mycosis Fungoides (MF) Sub-type ​Bradley Haverkos, 720-848-8698
NCT02448381 ​A Phase 3 Multicenter, Randomized, Double-Blind, Placebo Controlled Study to Determine the Efficacy of Topical SGX301 (Synthetic Hypericin) and Fluorescent Bulb-Light Irradiation for the Treatment of Cutaneous T-Cell Lymphoma ​Bradley Haverkos, 720-848-8698
NCT02568267 ​An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements ​Bradley Haverkos, 720-848-8698
NCT02731742 ​A Phase 1/1b Trial of MK-1966 (mAb against IL-10) in Combination with SD-101 (TLR9 agonist) in Subjects With Advanced Malignancies ​Bradley Haverkos, 720-848-8698
NCT02327078 ​A Phase 1/2 Study of the Safety, Tolerability, and Efficacy of Epacadostat (IDO inhibitor) Administered in Combination With Nivolumab in Select Advanced Cancers (including DLBCL) ​Bradley Haverkos, 720-848-8698
NCT02635672 ​An Open-label, Multicenter Phase I Study to Characterize the Safety, Tolerability, Preliminary Anti-tumor Activity, Pharmacokinetics and Maximum Tolerated Dose of BAY1251152 (CDK9 inhibitor) in Patients With Advanced Hematological Malignancies (including NHL and CMYC+ NHL) ​Bradley Haverkos, 720-848-8698
NCT02702492 ​A Phase 1 Open-Label Study of the Safety, Tolerability and Efficacy of KPT-9274, a Dual Inhibitor of PAK4 and NAMPT, in Patients With Advanced Solid Malignancies or Non-Hodgkin Lymphoma​ ​​Bradley Haverkos, 720-848-8698
NCT02465060 ​Molecular Analysis for Therapy Choice (MATCH) Bradley Haverkos, 720-848-8698​
NCT01943851 A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies. Kelsey Moore, 720-848-8089​​​
NCT02561273​ ​Combination Chemotherapy and Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma. ​Megan
Gager, 720-848-3773​
NCT03119467​
A Phase I/Ib, Study to Evaluate Safety and Efficacy of RP4010, in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Megan Gager, 720-848-3773
NCT02624986​ ​A Study of Idasanutlin in Combination With Obinutuzumab in Relapsed/Refractory (R/R) Follicular Lymphoma (FL) and in Combination With Rituximab in R/R Diffuse Large B-Cell Lymphoma (DLBCL) Participants. ​Manali
Kamdar, 720-848-3389​
NCT02733042 ​COMING SOON: Durvalumab as Monotherapy and in combination therapy in subjects with lymphoma or chronic lymphocytic leukemia (FUSION NHL 001) Manali Kamdar​, 720-848-3389
NCT00002663​ COMING SOON: ​EBV specific adoptive T-cell therapy for EBV-associated lymphoproliferative diseases or malignancies (including HLH) where no other standard therapy exists  ​​Bradley Haverkos, 720-848-8698​​
​​​​​​​​​13

 Acute Lymphoblastic Leukemia (non transplant)

No current trials recruiting​​​​1

 Acute Myeloid Leukemia (non-transplant)

 
ClinicalTrials.gov
Identifier
Study Title Study Coordinator​
​NCT02848248 ​A phase 1 study of SGN-CD123A in patients with relapsed or refractory acute myeloid leukemia (AML). Kayla Fischer, 720-848-0736

​​NCT03013998​

Study of Biomarker-Based Treatment of Acute Myeloid Leukemia​. (The Beat AML Trial)​. Novel study that pairs patients with one of multiple clinical trials running in parallel, depending on the unique biological features of that particular patient. Rachel Freeby, 720-848-0736
NCT01943851 ​

A Phase I/II Open-label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies​

​Kelsey Moore, 720-848-8089​
NCT02577406​ A phase 2, multicenter, open-label, randomized study comparing the efficacy and safety of AG-221 versus conventional care regimens in older subjects with late stage acute myeloid leukemia harboring an isocitrate dehydrogenase 2 mutation.
Rachel Freeby, 720-848-0736​​
NCT02670044 ​A Phase IB/II Multi-Arm Study With Venetoclax in Combination With Cobimetinib and Venetoclax in Combination With Idasanutlin in Patients Aged >/= 60 Years With Relapsed or Refractory Acute Myeloid Leukemia Who Are Not Eligible for Cytotoxic Therapy ​Shirstine Rahkola, 720-848-1776​​
​NCT02632708​ ​A Phase 1, Multicenter, Open-Label, Safety Study of AG-120 or AG-221 in Combination With Induction Therapy and Consolidation Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia With an IDH1 and/or IDH2 Mutation ​Tricia Feddick, 720-848-8034​

​​​​​​​​​​​​​​​​​​​​​10

 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (non transplant)

No current trials recruiting​​

2

 Hodgkin Lymphoma (non transplant)

No current trials recruiting​​3

 Myelodysplastic Syndrome (non transplant)

ClinicalTrials.gov
Identifier
Study Title Study Coordinator​
NCT02508870​ ​A Safety and Pharmacology Study of Atezolizumab Administered Alone or in Combination With Azacitidine in Participants With Myelodysplastic Syndromes.

Ryan Scannura​, 720-848-8033​

NCT02706899​ ​​​A Phase 1/2 Study of Vadastuximab Talirine (SGN-CD33A) in Combination With Azacitidine in Patients With Previously Untreated International Prognostic Scoring System (IPSS) Intermediate-2 or High Risk Myelodysplastic Syndrome (MDS) Megan McClain, 720-848-3773​​​​
​NCT02966782​ ​COMING SOON: A Study Evaluating Venetoclax Alone and in Combination With Azacitidine in Subjects With Higher-Risk Myelodysplastic Syndromes (MDS) After Hypomethylating Agent-Failure. ​Dan Pollyea, 720-848-0414​

​​​4

 Myeloma (non transplant)

ClinicalTrials.gov Identifier Study Title Study Coordinator
​​NCT02755597​ A phase 3, multicenter, randomized, double blind, study of Bortezomib and Dexamethasone in combination with either Venetoclax or placebo in subjects with relapsed or refractory multiple myeloma who are sensitive or naïve to proteasome inhibitors
Megan McClain, 720-848-3773​​​​
NCT01592370​  ​An Investigational Immuno-Therapy Study to Determine the Safety and Effectiveness of Nivolumab and Daratumumab, With or Without Pomalidomide and Dexamethasone, in Patients With Multiple Myeloma. Shirstine Rahkola, 720-848-1776​​​
​​​​​​​5

 OLD-Non Hodgkin Lymphoma: Follicular & other indolent (non transplant)

ClinicalTrials.Gov
Identifier
Study Title Study Coordinator
NCT02257567​ ​A phase IB/II study evaluating the safety, tolerability and anti-tumor activity of polatuzumab vedotin (dcds4501a) in combination with rituximab (r) or obinutuzumab (g) and bendamustine (b) in relapsed or refractory follicular or diffuse large b-cell lymphoma. ​Emily Denoncourt, 720-848-0566
​​​6

 OLD-Non Hodgkin Lymphoma: Mantle Cell (non transplant)

​No current trials recruiting7

 OLD-Non Hodgkin Lymphoma: DLBCL and other aggressive (non transplant)

ClinicalTrials.Gov
Identifier
Study Title Study Coordinator
​NCT02492737​ ​A Phase I, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation. ​Natalie Monson, 720-848-2199​
NCT02257567​ ​A phase IB/II study evaluating the safety, tolerability and anti-tumor activity of polatuzumab vedotin (dcds4501a) in combination with rituximab (r) or obinutuzumab (g) and bendamustine (b) in relapsed or refractory follicular or diffuse large b-cell lymphoma. ​Emily Denoncourt, 720-848-0566
NCT02567656​  ​A Phase I/Ib, Dose Escalation Study to Evaluate Safety and Efficacy of RP6530, a Dual PI3K δ/γ Inhibitor, in Patients With Relapsed or Refractory T-cell Lymphoma ​Kelsey Moore, 720-848-8089​​
​​​​​​8

 Transplant

ClinicalTrials.Gov
Identifier
Study Title Study Coordinator​
​NCT01841333 ​A Phase 2 Study of PF-04449913 for the Treatment of Acute Leukemia Patients with High Risk of Post-Allogeneic Stem Cell Transplantation Relapse ​​Natalie Monson, 720-848-2199​
NCT01690520 ​Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes. ​Hayden Smith​, 720-848-8026​
​​​​​​​9