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J. Andy Mengshol, MD, PhD

Assistant Professor of Medicine



Assistant Professor of Medicine

Education

Undergraduate: U.C. Davis, Biochemistry B.S., 1993
Graduate: Dartmouth Medical School, Biochemistry Ph.D., 2001
Medical School: Dartmouth Medical School M.D., 2003
Internship/Residency: Internal Medicine, University of Colorado School of Medicine, 2003-2005
Fellowship: ABIM Research pathway Gastroenterology/Hepatology University of Colorado School of Medicine, 2005-2009

Board certified in Internal Medicine and Gastroenterology

Faculty Appointments

Assistant Professor of Medicine, University of Colorado School of Medicine
Staff Physician VA Medical Center, Denver CO

Awards

Presidents Undergraduate Fellowship 1992
Howard Hughes Undergraduate Summer Research Fellowship 1992
Elected to Phi Sigma 1993
Graduated with honors, U.C. Davis 1993
Norris Cotton Cancer Center Summer Research Fellowship 1996
Medical Student Achievement Award, American College of Rheumatology 1999, 2001
American Federation for Aging Research, Glenn Scholarship 2000
NIH pre-doctoral fellowship, Immunology Training Grant 2000
NIH post-doctoral fellowship, Autoimmunity and Connective Tissue Biology Training Grant 2001
Ph.D. Class Marshall, Dartmouth Medical School 2001
NIH postdoctoral fellow, Gastroenterology Training Grant 2006-2009
Freedman award 2009  

Research Interests

Unlike hepatic infections such as Hepatitis A that are cleared, acute Hepatitis C virus (HCV) infection progresses to chronic infection in 60-80%. The mechanism leading to chronic infection is incompletely understood but evidence suggests that HCV can impair the immune response. Initial studies from Dr. Rosen's laboratory and others documented defects in the long-term adaptive, antigen specific, T cell response to viral antigens. The immediate, innate immune response is essential for the formation of a good adaptive response, therefore we hypothesize that HCV inhibits the hepatic innate response directly, leading to a poor adaptive response and viral persistence.

My research focuses on how HCV interacts with adaptive immune cells and antigen presenting cells from the liver including Kupffer cells (liver macrophages), T cells and dendritic cells. I collaborate with Drs Rosen, and Colgan within the department of Gastroenterology and Hepatology.

Representative Publications

  1. Golden-Mason, L., Palmer, B., Klarquist, J., Mengshol, J.A., Castelblanco, N. and Rosen, H.R. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction (2007) J Virol, 81, 9249-9258. (click here for pdf)
  1. Mengshol, J. A., Golden-Mason, L., Rosen, H. R., Mechanisms of Disease: HCV-induced liver injury (2007) Nat Clin Pract Gastroeneterol and Hepatol 4 622-634. (click here for pdf)
  1. Mengshol, J. A., Golden-Mason, L., Castelblanco, N., Im, K., Dillon, S., Wilson, C. C., Rosen, H. R. for the Virahep-C Study Group, Impaired Plasmacytoid Dendritic Cell Maturation and Differential Chemotaxis in Chronic HCV: Associations with Antiviral Treatment Outcomes, 2009 Gut 58(7): 964-73.(click here for pdf)
  1. Mengshol, J.A., Golden-Mason, L., Arikawa, T., Smith, M., Niki, T., McWilliams, R., Randall, J., McMahan, R., Rangachari, M., Dobrinskikh, E., Busson, P., Polyak, S.J., Hirashima, M, Rosen, H.R. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in chronic hepatitis C infection 2010 PLoS ONE 5(3): e9504. doi:10.1371/journal.pone.0009504.(click here for pdf)

Additional publications by Dr. Mengshol can be found at http://www.ncbi.nlm.nih.gov/pubmed?term=%22Mengshol_JA%22[Author]