Improving overall health and well-being by prevention, diagnosis, treatment and cure of Diabetes, Obesity, Metabolic disorders and Endocrine disorders.

Lauren Fishbein & Nikita Pozdeyev – VA Merit Award - Genetic Risk for Aggressive Thyroid Cancer in an Understudied Male Predominant Veteran Population

Rebecca Schweppe – Cancer League of CO Grant - The role of subcellular localization of FAK in thyroid cancer

Arwa Elsheikh – Congratulations on the “THRIVE Award” which was also highlighted in ASBMR eNews weekly

Andrew Libby – Promoted to Assistant Professor

Darleen Sandoval - Co-hosting a new podcast for the ADA’s Diabetes Journal - DiabetesBio. Like, rate and subscribe!  https://x.com/ADA_DiabetesPro/status/1755964039065206815?s=20; https://podcasts.apple.com/us/podcast/diabetesbio/id1726209584

Rasouli N, Younes N, Ghosh A, Albu J, Cohen RM, DeFronzo RA, Diaz E, Sayyed Kassem L, Luchsinger JA, McGill JB, Sivitz WI, Tamborlane WV, Utzschneider KM, Kahn SE; GRADE Research Group. Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial. Diabetes Care. 2024 Jan 11:dc231070. doi: 10.2337/dc23-1070. Epub ahead of print. PMID: 38211595. 

Utzschneider KM, Younes N, Butera NM, Balasubramanyam A, Bergenstal RM, Barzilay J, DeSouza C, DeFronzo RA, Elasy T, Krakoff J, Kahn SE, Rasouli N, Valencia WM, Sivitz WI; GRADE Research Group. Impact of Insulin Sensitivity and β-Cell Function Over Time on Glycemic Outcomes in GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study): Differential Treatment Effects of Dual Therapy. Diabetes Care. 2024 Jan 8:dc231059. doi: 10.2337/dc23-1059. Epub ahead of print. PMID: 38190619. 

Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain Res. 2024 Jan 18:148772. doi: 10.1016/j.brainres.2024.148772. Epub ahead of print. PMID: 38244754.

Harrison DJ, Prada F, Nokoff NJ, Iwamoto SJ, Pastor T, Jacobsen RM, Yeung E. Considerations for Gender-Affirming Hormonal and Surgical Care Among Transgender and Gender Diverse Adolescents and Adults With Congenital Heart Disease. J Am Heart Assoc. 2024 Feb 6;13(3):e031004. doi: 10.1161/JAHA.123.031004. Epub 2024 Jan 31. PMID: 38293963.

Brock P, Liyanarachchi S, Nieminen TT, Chan C, Kohlmann W, Stout LA, Yao S, La Greca A, Jensen KE, Kolesar J, Salhia B, Gulhati P, Hicks JK, Ringel MD. CHEK2 founder variants and thyroid cancer risk. Thyroid. 2024 Jan 27. doi: 10.1089/thy.2023.0529. Epub ahead of print. PMID: 38279823.

Hernandez TL, Farabi SS, Fosdick BK, Hirsch N, Dunn EZ, Rolloff K, Corbett JP, Haugen E, Marden T, Higgins J, Friedman JE, Barbour LA. Randomization to a Provided Higher-Complex-Carbohydrate Versus Conventional Diet in Gestational Diabetes Mellitus Results in Similar Newborn Adiposity. Diabetes Care. 2023 Nov 1;46(11):1931-1940. doi: 10.2337/dc23-0617. PMID: 37643311; PMCID: PMC10620537.
**CU Anschutz News highlighted the above-mentioned article - https://news.cuanschutz.edu/nursing/a-diet-game-changer

Nikita Pozdeyev paper selected as JCEM’s featured article of the week - “Pozdeyev N, Dighe M, Barrio M, Raeburn C, Smith H, Fisher M, Chavan S, Rafaels N, Shortt JA, Lin M, Leu MG, Clark T, Marshall C, Haugen BR, Subramanian D, Crooks K, Gignoux C, Cohen T. Thyroid Cancer Polygenic Risk Score Improves Classification of Thyroid Nodules as Benign or Malignant. J Clin Endocrinol Metab. 2024 Jan 18;109(2):402-412. doi: 10.1210/clinem/dgad530. PMID: 37683082.Thyroid Cancer Polygenic Risk Score Improves Classification of Thyroid Nodules as Benign or Malignant.” 

Kim Bruce & Miguel Lanaspa-Garcia – The Ludeman Family Center for Women’s Health Research Grant - "Does GLUT5-mediated Fructose Metabolism drive Alzheimer’s disease risk in Females?“

Low-Wang C, Seggelke S, McDermott M, Reusch J – Diabetes and COVID-19,Chapter 2 - Pathophysiology: How COVID-19 Impacts the Pancreas and Peripheral Insulin Resistance, DOI https://doi.org/10.1007/978-3-031-28536-3

Bolf EL, Beadnell TC, Rose MM, D'Alessandro A, Nemkov T, Hansen KC, Schweppe RE. Dasatinib and Trametinib Promote Anti-Tumor Metabolic Activity. Cells. 2023 May 12;12(10):1374. doi: 10.3390/cells12101374. PMID: 37408209; PMCID: PMC10216321.

Hicks HM, Pozdeyev N, Sams SB, Pugazhenthi U, Bales ES, Hofmann MC, McKenna LR, Schweppe RE. Fibronectin contributes to a BRAF inhibitor-driven invasive phenotype in thyroid cancer through EGR1, which can be blocked by inhibition of ERK1/2. Mol Cancer Res. 2023 May 23:MCR-22-1031. doi: 10.1158/1541-7786.MCR-22-1031. Epub ahead of print. PMID: 37219859. 

Taormina JM, Gilden AH, Iwamoto SJ. Meeting the Body Mass Index Requirement for Gender-affirming Surgery Using Antiobesity Medication. JCEM Case Rep. 2023 Jun 28;1(3):luad067. doi: 10.1210/jcemcr/luad067. PMID: 37388627; PMCID: PMC10301860.

Taormina JM, Iwamoto SJ. Filling a gap in care: addressing obesity in transgender and gender diverse patients. Int J Obes (Lond). 2023 Jul 6. doi: 10.1038/s41366-023-01334-0. Epub ahead of print. PMID: 37414875.

Pinto AJ, Bergouignan A, Dempsey PC, Roschel H, Owen N, Gualano B, Dunstan DW. The Physiology of Sedentary Behavior. Physiol Rev. 2023 Jun 16. doi: 10.1152/physrev.00022.2022. Epub ahead of print. PMID: 37326297.

Whitney Adair promoted to Senior Instructor

Seth Creasy selected as a 2023 Research Scholar

Sarah Mayson elected to the APDEM Council (Association for Program Directors in Endocrinology, Diabetes and Metabolism), term 2023-2025

Micol Rothman – UPL Transgender Program funds renewed

Colleen McKenna (Bergman Lab) – NIH F32 Grant: The Role of IMAT Inflammatory Secretome on Muscle Insulin Resistance

Pribish AM, Iwamoto SJ. Cardiovascular disease and feminizing gender-affirming hormone therapy: Implications for the provision of safe and lifesaving care. Curr Opin Physiol. 2023 Jun;33:100650. doi: 10.1016/j.cophys.2023.100650. Epub 2023 Mar 1. PMID: 36968433 PMCID: PMC10035588.

Chou R, Dana T, Mayson SE, Cibas ES, Durante C, Solórzano CC, Mandel SJ, Orloff LA. Ultrasound Follow-Up of Benign Thyroid Nodules: A Scoping Review. Thyroid. 2023 Apr;33(4):420-427. doi: 10.1089/thy.2022.0692. Epub 2023 Mar 17. PMID: 36800900.

Jane Reusch, MD – 2023 Harold Rifkin Award   

Kim Bruce – Spring 2023 AB Nexus Research Collaboration Grant   

Manuscript accepted for publication – Title: Dasatinib and Trametinib Promote an Anti-Tumor Metabolic Program in Thyroid Cancer Cells Authors: Eric L. Bolf, Thomas C. Beadnell, Madison M. Rose, Angelo D'Alessandro, Travis Nemkov, Kirk C. Hansen, Rebecca E. Schweppe *Journal: Cells   

Manuscript accepted for publication – Title: "Fibronectin contributes to a BRAF inhibitor-driven invasive phenotype in thyroid cancer through EGR1, which can be blocked by inhibition of ERK1/2."Authors: Hannah M. Hicks, Nikita Pozdeyev, Sharon B. Sams, Umarani Pugazhenthi, Elise S. Bales, Marie-Claude Hofmann, Logan R. McKenna, Rebecca E. Schweppe. Journal: Molecular Cancer Research   

Iwamoto SJ, Defreyne J, Kaoutzanis C, Davies RD, Moreau KL, Rothman MS. Gender-affirming hormone therapy, mental health, and surgical considerations for aging transgender and gender diverse adults. Ther Adv Endocrinol Metab. 2023 Apr 19;14:20420188231166494. doi: 10.1177/20420188231166494. PMID: 37113210; PMCID: PMC10126651.

Cecilia Low Wang – Associate Director for the Mentored Scholarly Activity program for medical students.

Dan Bessesen – 2023 Florence Rena Sabin Award

Jim Falko – 2023 National Lipid Association (NLA) Honorary Lifetime Membership Award

Tania Reis – 2023 NIH Director’s Pioneer Award Finalist Interview

Rocio Pereira – COVID deaths and health disparities interview on NPR/CPR

Bryan Bergman & Co PI Karin Zemski Berry – SIRC Grant “Triple Quadrupole Linear Ion Trap for Lipidomic Analysis”.

Pribish, AM (cardiology fellow), Iwamoto, SJ. – "Cardiovascular disease and feminizing gender-affirming hormone therapy: Implications for the provision of safe and lifesaving care."Current Opinion in Physiology. 2023 Jun;33:100650. PMID: 36968433.

Layla Abushamat (Former Fellow, Reusch Lab) – ADA 2022 Annual Research Report Highlight – “Diabetes, Exercise, and Heart Health”

Mike McDermott received the CU SOM Distinguished Physician Award

Beth Tupta received the 2022 Medical Staff Clinician of the Year Award

Mike McDermott was named president-elect of the American Thyroid Association.  

Kimberley Bruce received the 2022 Department of Medicine Rising Star Award.

Bryan Haugen received the 2023 Endocrine Society Laureate Award for Outstanding Scholarly Physician

• An Assessment of Diversity, Inclusion, and Health Equity Training in Endocrinology Fellowship Programs in the United States. Malek R, Shibli - Rahhal A, Correa R, Szmuilowicz ED, Morgan F, Luthra P, Sirisena I, Gianoukakis A, Praw SS, Lieb DC, Haw JS, Mayson SE. Endocr Pract. 2022 Aug 16:S1530-891X(22)00599-7. doi: 10.1016/j.eprac.2022.08.010. Epub ahead of print. PMID: 35985561.
• Dave Saxon - UC Health Today - Innovative Care - Young and fit, she discovered dangerously high cholesterol at the age of 20
• Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes D. Nathan, M.D., J. Lachin, Sc.D., A Balasubramanyam, M.D., H Burch, J. Buse, M.D., N. Butera, Ph.D., R. Cohen, M.D., J. Crandall, M.D., S. Kahn, M.B., Ch.B., H. Krause-Steinrauf, M.S., M. Larkin, R.N., N Rasouli, M.D., M. Tiktin, D.N.P., D. Wexler, M.D., and N. Younes, Ph.D. n engl j med 387;12 nejm.org September 22, 2022
• Bryan Bergman - NIH-R01 - UCDenver - Effects of aging and exercise training on intermuscular adipose tissue (IMAT) in MoTrPAC
• Kimberly Bruce - R01 - National Institute on Aging - Targeting Microglial Lipoprotein Lipase in Alzheimer's disease
• Kelly Fuller (Sandoval Post Doc) - CWHR Seed Grant - Sex Differences Score - Exploring sex differences in hepatic lipid metabolism after bariatric surgery.
• Maigen Bethea (Sandoval Lab) - BIRCWH K12 Grant; promotion to Research Assistant in October

Arely Diaz (Reis Lab) - 2022-2023 MOLB Bolie Award​ ​

Sean Iwamoto received a “Coin of Recognition” by the Secretary of VA for his service to transgender Veterans and working to expand gender-affirming care at the VA.​ ​

Bryan Bergman - MoTrPAC IMAT R01 - received 19th percentile, within 5% of the funding line. ​ ​

Elizabeth Thomas - RO1 score in 11% - “Effects of early vs. late time restricted eating vs. daily caloric restriction on weight loss and metabolic outcomes in adults with obesity”​ ​

Annie Caldwell - LudemanFamily Center for Women’s Health Early-Career Faculty Development Award​ ​

Darcy Kahn (Bergman Post Doc) - Thesis Defense on 6/24/22​ ​ “The role of osteoanabolic agents in the management of patients with osteoporosis”. McClung MR, Rothman MS, Lewiecki EM, Hanley DA, Harris ST, Miller PD, Kendler DL.Postgrad Med. 2022 May 30:1-11. doi: 10.1080/00325481.2022.2069582. Online ahead of print.PMID: 35635798 Review.​ ​ ​

Avery Diaz (Reis Lab) - 2023 MOLB Bolie Award

Sean Iwamoto received a "Coin of Recognition" by the Secretary of VA for his service to transgender Veterans and working to expand gender-affirming care at the VA.

MultiD transgender program team selected to present at the WPATH (World Professional Association for Transgender Health) conference:

• Sean Iwamoto’s pilot study on feminizing hormones and coagulation biomarkers
• Plastic surgery team on gender-affirming breast surgery outcomes
• Mini-symposium for Micol Rothman and team on rural gender-affirming care
  

Endo Society Meeting Highlight - Nikita Pozdeyev's study - "AI for thyroid nodule ultrasound characterization" was highlighted in the media portion of the Endocrine Society meeting

Bryan Bergman - 16%-18% on NIDDK's payline for grant "Effect of weight loss on intermuscular adipose tissue (IMAT) signaling

Bryan Bergman - MoTrPAC IMAT R01 - received 19th percentile, within 5% of the funding line

Elizabeth Thomas - R01 score in 11% - "Effects of early vs. late time restricted eating vs. daily caloric restriction on weight loss and metabolic outcomes in adults with obesity"

Annie Caldwell - Ludeman Family Center for Women's Health Early-Career Faculty Development Award

Darcy Kahn (Bergman Post Doc) - Thesis Defense on 6/24/22

“The role of osteoanabolic agents in the management of patients with osteoporosis”. McClung MR, Rothman MS, Lewiecki EM, Hanley DA, Harris ST, Miller PD, Kendler DL.Postgrad Med. 2022 May 30:1-11. doi: 10.1080/00325481.2022.2069582. Online ahead of print.PMID: 35635798 Review.​ ​