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 Description

 

Dr. Wierman received her MD and residency training at at Baylor College of Medicine. Her fellowship and research training was at Massachusetts General Hospital and the Brigham and Women’s Hospital at Harvard University. She has been a faculty member at the University of Colorado since 1987 and her expertise is in reproductive and neuroendocrinology. Dr. Wierman’s research interests are in the regulation of the genes that control the reproductive axis. She studies the mechanisms by which gonadal sex steroids and peptide hormones regulate the expression of the gonadotropin releasing hormone (GnRH). The major goal of her work is to define the mechanisms by which GnRH neuronal development is controlled in order to gain a deeper understanding of the pubertal process, infertility, and hypogonadism. The other focus of the lab is to understand the mechanisms of pituitary tumorigenesis. Translational studies are identifying new genes that cause or are markers of pituitary tumor. Both cellular and transgenic animal models as well as human studies are ongoing. Collaborative projects with other investigators at UCDHSC include the role of sex hormones in body weight distribution at menopause and sex hormone effects on HIV transmission and progression in women

Selected Publications 

  • Xu M, Shorts-Cary L, Knox AJ, Kleinsmidt-DeMasters B, Lillehei K, Wierman ME. Epidermal growth factor receptor pathway substrate 8 is overexpressed in human pituitary tumors: role in proliferation and survival. Endocrinology. 2009 May;150(5):2064-71. PUBMED

  • Pierce A, Bliesner B, Xu M, Nielsen-Preiss S, Lemke G, Tobet S, Wierman ME. Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Mol Endocrinol. 2008 Nov;22(11):2481-95. PUBMED

  • Rothman MS, Wierman ME. Female hypogonadism: evaluation of the hypothalamic-pituitary-ovarian axis. Pituitary. 2008;11(2):163-9. PUBMED

  • Rothman MS, Wierman ME. The role of gonadotropin releasing hormone in normal and pathologic endocrine processes. Curr Opin Endocrinol Diabetes Obes. 2007 Aug;14(4):306-10. PUBMED

  • Wierman ME, Kohrt WM.Vascular and metabolic effects of sex steroids: new insights into clinical trials. Reprod Sci. 2007 May;14(4):300-14. PUBMED

  • Nielsen-Preiss SM, Allen MP, Xu M, Linseman DA, Pawlowski JE, Bouchard RJ, Varnum BC, Heidenreich KA, Wierman ME. Adhesion Related Kinase Induction of Migration Requires PI3-kinase and Ras Stimulation of Rac Activity in immortalized GnRH neuronal cells. Endocrinology. 2007 PUBMED 

  • Wierman ME. Sex steroid effects at target tissues: mechanisms of action. Adv Physiol Educ. 2007 Mar;31(1):26-33. Review. PUBMED

  • Shorts-Cary L, Xu M, Ertel J, Kleinschmidt-Demasters BK, Lillehei K, Matsuoka I, Nielsen-Preiss S, Wierman ME. Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion. Endocrinology. 2007 Mar;148(3):967-75. PUBMED 

  • Wierman ME, Basson R, Davis SR, Khosla S, Miller KK, Rosner W, Santoro N. Androgen therapy in women: an Endocrine Society Clinical Practice guideline. J Clin Endocrinol Metab. 2006 Oct;91(10):3697-710. PUBMED

Education

Coming Soon!

Reasearch Interests

 

·        GnRH neuron development, survival migration & gene expression

·        Molecular pathogenesis of pituitary tumors

·        Neuroendocrine dysfunction after traumatic brain injury