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 Description

 

Dr. Harvell graduated from Clark Atlanta University with a B.S. and M.S. in Chemistry. She received a Ph.D. in Pathology and Microbiology from the University of Nebraska Medical Center while participating in the Cancer Research Training Program offered through the Eppley Institute for Research in Cancer and Allied Diseases. She joined the faculty of the University of Colorado Denver in 2007 after completing a postdoctoral fellowship in the laboratory of Dr. Kathryn Horwitz. As a postdoctoral fellow, Dr. Harvell developed an experimental in vivo model for studying mechanisms of estrogen and progesterone signaling in human breast cancers. She then translated that experimental work to the analysis of clinical tumors involving patients undergoing hormonal therapies for their breast cancers. Dr. Harvell is currently funded by a K12 award and is BIRCWH Scholar. Presently, she is investigating the role of hormones on tumor aggressiveness in pregnancy-associated breast cancer

Selected Publications 

  • DME Harvell*, JK Richer*, M Singh, N Spoelstra, C Finlayson, VF Borges, AD Elias, and KB Horwitz.  2008. Estrogen Regulated Gene Expression in Response to Neoadjuvant Endocrine Therapy of Breast Cancers: Tamoxifen Agonist Effects Dominate in the Presence of an Aromatase Inhibitor. Breast Cancer Res Treat, Mar 13, [Epub ahead of print] (*Co-First Author) PUBMED
     
  • DME Harvell, N Spoelstra, JL MaManaman, M Singh, C Finlayson, T Phang, S Trapp, L Hunter, WW Dye, VF Borges, AD Elias, KB Horwitz, and JK Richer. 2008. Molecular signatures of response and intrinsic resistance to neoadjuvant endocrine therapy for breast cancer. Breast Cancer Res Treat, Mar 9, [Epub ahead of print] PUBMED
     
  • JC Harrell, W Dye, DME Harvell, M Pinto, P Jedlicka, CA Sartorius and KB Horwitz. 2007. Estrogen insensitivity in a model of estrogen receptor positive breast cancer lymph node metastasis. Cancer Res, 67(21):10582-91. PUBMED
     
  • JC Harrell, W Dye, DME Harvell, CA Sartorius and KB Horwitz. 2008. Contaminating cells alter gene signatures in whole organ versus laser capture microdissected tumors: a comparison of experimental breast cancers and their lymph node metastases. Clin Exp Metastasis, 25(1):81-8. PUBMED
     
  • L Tung, H Abdel-Hafiz, T Shen, DME Harvell, L Nitao, JK Richer, CA Sartorius, GS Takimoto, and KB Horwitz. 2006. Progesterone Receptors (PR)-B and PR-A regulate transcription by different mechanisms:  AF-3 exerts regulatory control over coactivator binding to PR-B, Mol Endocrinol, 20(11):2656-70. PUBMED
     
  • DME Harvell, JK Richer, DC Allred, CA Sartorius, and KB Horwitz. 2006. Estrogen Regulates Different Genes in Human Breast Cancer Xenografts Compared to the Identical Cells in Culture. Endocrinology, 147(2):700-713. PUBMED
  • CA Sartorius, DME Harvell, Shen T and KB Horwitz. 2005. Progestins Initiate a Luminal to Myoepithelial Switch in Estrogen Dependent Human Breast Tumors Without Altering Growth.  Cancer Res, 65(21):9779-88. PUBMED

 

Education

Coming Soon!

Reasearch Interests

 

·        Hormones

·        Breast Cancer