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 Description

 

Major research interest is the Prediction and prevention of type I (insulin-dependent) diabetes mellitus including studies of the immunogenetics of type I diabetes, focusing on the activation and natural history of specific patterns of autoimmunity in genetically susceptible individuals. Genetic characterization of individuals from three groups: 1) identical twins of patients with type I diabetes; 2) a population-based Colorado cohort (identified by cord blood screening of HLA alleles of more than 30,000 newborns); and 3) unique families with multiple generations affected by type I diabetes.

Investigation of autoimmunity in the NOD mouse model of type I diabetes of anti-insulin autoantibodies and anti-insulin islet-infiltrating T cells which have a shared T cell receptor A chain motif.

 

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Selected Publications 

  • Zhang L, Jin N, Nakayama M, O'Brien RL, Eisenbarth GS, Born WK. Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23. J Autoimmun. 2010 PUBMED

  • Gianani R, Campbell-Thompson M, Sarkar SA, Wasserfall C, Pugliese A, Solis JM, Kent SC, Hering BJ, West E, Steck A, Bonner-Weir S, Atkinson MA, Coppieters K, von Herrath M, Eisenbarth GS. Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia. 2010 PUBMED

  • Yu L, Liu Y, Miao D, Wenzlau J, Davidson H, Hutton J, Eisenbarth GS. Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. J Immunol Methods. 2009 PUBMED

  • Triolo TM, Baschal EE, Armstrong TK, Toews CS, Fain PR, Rewers MJ, Yu L, Miao D, Eisenbarth GS, Gottlieb PA, Barker JM.Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes. J Clin Endocrinol Metab. 2009 Nov;94(11):4517-23. PUBMED

  • Kobayashi,M.; Jasinski,J.; Liu,E.; Li,M.; Miao,D.; Zhang,L.; Yu,L.; Nakayama,M.; Eisenbarth,GS. Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc.Natl.Acad.Sci.U.S.A. 105:10090-10094, 2008. PUBMED

  • Nakayama,M.; Beilke,J.N.; Jasinski,J.M.; Kobayashi,M.; Miao,D.; Li,M.; Coulombe,M.G.; Liu,E.; Elliott,J.F.; Gill,R.G.; Eisenbarth,GS. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J.Clin.Invest. 117:1835-1843, 2008.

  • Aly TA, Ide A, Jahromi MM, Barker JM, Fernando MS, Babu SR, Yu L, Miao D, Erlich HA, Fain PR, Barriga KJ, Norris JM, Rewers MJ, Eisenbarth GS.
    Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14074-9. Epub 2006 Sep 11. PUBMED

  • Jasinski JM, Yu L, Nakayama M, Li MM, Lipes MA, Eisenbarth GS, Liu E. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes. 2006 Jul;55(7):1978-84. PUBMED

  • Homann D, Eisenbarth GS. An immunologic homunculus for type 1 diabetes. J Clin Invest. 2006 May;116(5):1212-5. PUBMED 

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