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ClinImmune Labs

    Contact: ClinImmune Labs
    Bioscience Park Center
    12635 E. Montview Blvd, Suite 300
    Aurora, CO 80045-7116

    Histocompatibility: 303-724-1300 
    Stem Cell: 303-724-1564
    Cord Blood: 303-724-1306
    Flow Cytometry: 303-724-7203

    Executive Director Brian Freed, PhD 

    ClinImmune Labs is an academic component of the Division of Allergy & Clinical Immunology, within the Department of Medicine, School of Medicine at the University of Colorado Anschutz Medical Campus. Located in the Bioscience Park Center of the Anschutz Medical Campus in Aurora, Colorado, ClinImmune Labs is a highly efficient academic business that integrates the highest quality laboratory services and products with its scholarly mission to contribute to the science of and education about stem cell therapy. Our company views a very important component of its business as consultative. Our staff provides education and technical advice to the research and medical community on stem cell processing and storage, islets, histocompatibility analysis and sequencing issues.

    As an academic-based biotechnology company, ClinImmune Labs is committed to providing the highest quality service to our clinical customers both in Denver and throughout the world (e.g. Brazil, Colombia, Canada, France, Israel and Australia), to our research faculty at the University of Colorado at Denver and Health Sciences Center and Boulder campuses, stem cell biologists throughout the U.S, and to the biotechnology companies that reside in the Rocky Mountains.

    ClinImmune Labs is accredited by the American Society for Histocompatibility and Immunogenetics (ASHI), the College of American Pathologists (CAP), the Clinical Laboratory Improvement Act (CLIA), the AABB (American Associations of Blood Banks), and the Foundation for Accreditation of Cellular Therapy (FACT).

    For more information about and to discuss possible collaborations with our organization, please contact Jane Oppenheim, Director, Business Development, ClinImmune Labs at, or call her at 303-724-1649.


    Accredited by the American Society for Histocompatibility and Immunogenetics (ASHI), the College of American Pathologists (CAP), and the United Network for Organ Sharing (UNOS), ClinImmune Labs and its expert technical staff are committed to providing the highest quality histocompatibility testing services for clinical research studies as well as clinical transplantation and transfusion programs in Colorado, across the U.S. and abroad.

    Testing available for:

    Epitope analysis as part of population studies

    Genetic HLA Disease Association

    Immunotherapy, including vaccine development

    Clinical Transplantation- solid organ and hematopoietic stem cell

    Platelet Transfusion support


    Clinically Approved Assays:

    • HLA-A, B, Cw, DRB, DQ, DPB1 loci
    • Low to high resolution Class I and Class II testing for HLA-A, B, Cw, DRB1,DRB3/4/5, DQB1, DPB1
    • Low resolution testing for DQA1
    • Serological and molecular testing
    • Cylex´s Immune Function Test, IMMUKNOW®
    • HLA Antibody Detection
      • Panel Reactive Antibody (PRA)
        • Luminex HLA Class I, Class II, and MICA Antibody screen
        • Luminex PRA, including HLA Specificity Analysis
        • Luminex single antigen beads for Class I, Class II, and MICA antibodies
      • Titration/Quantitation studies for pre-transplant immunotherapy protocols
      • Flow crossmatching for transplant compatibility
      • Platelet support panels to assess allo-reactive HLA antibodies and HLA-A,B typing for selection of matched platelets

    Services Provided:

    • Initial consultations provided for test selection, cost effectiveness, sample and turn-around time requirements
    • Customized requisitions and clear, concise reports; electronic data transfer
    • Additional test interpretation consults upon request
    • Donor search strategy support
    • Analysis of HLA allele frequency

The University of Colorado Cord Blood Bank (UCCBB), a major component of ClinImmune Labs, has a twelve year history of collecting, processing, banking and distributing cord blood for human transplantation. UCCBB is a public cord blood bank, which has consented 10,700 women and banked 6,700 cord blood units, of which more than 500 have been transplanted at 100 different transplant centers in the United States and abroad.

UCCBB is a major provider of Hispanic cord blood units to patients in the United States, Mexico, Central and South America. UCCBB is accredited by AABB and provides cord blood to stem cell investigators in Michigan, New York, Tennessee and Colorado.

UCCBB is managed by immunogeneticists and stem cell transplant physicians with decades of experience in this field. In addition, the parent organization, ClinImmune Labs, provides sophisticated HLA high resolution DNA typing, hematopoietic stem cell and pancreatic islet cell processing, flow cytometry and regulatory oversight to the cord blood bank.

The bank benefits both managerially and financially from an organization that integrates histocompatibility, adult stem cell banking, cellular therapeutics and regulatory affairs. The University of Colorado Cord Blood Bank is unique among banks in the United States in that all of the cord blood units are processed in a Class 1000 cGMP processing facility and managed by CordBloodBankManager® software developed under our guidance and constantly updated to meet our needs.

Please Note: New Checkoff Colorado Opportunity to donate to Statewide Umbilical Cord Blood Collection on Line 39 of Form 104!

Colorado taxpayers can now checkoff a box on their 2009 Form 104 Colorado Individual Tax Return to donate to the ADULT STEM CELLS CURE FUND, which provides resources to encourage and enable new mothers across Colorado to donate their babies' umbilical cord blood to a public cord blood bank. These funds will allow our cord blood bank to collect statewide.

More information about public cord blood banking.


    Flow Cytometry and Cell Sorting Facility

    The Clinical Immunology Flow Cytometry/Cell Sorting facility is located on the 10th floor of Research 2 on the Anschutz Medical Campus. The facility was established with the specific goal of providing the large community of peer-funded investigators at the University of Colorado Denver and regional biotechnology companies with access to cell analysis technology. The facility is a joint effort by the Division of Allergy & Clinical Immunology and the Colorado Center for AIDS Research (CFAR).The facility provides instrumentation, personnel, and expertise to assist users in multiparametric flow cytometry and fluorescence-activated cell sorting (FACS) for both research and clinical applications. The Flow Cytometry Facility follows Clinical Laboratory Improvement amendments (CLIA) guidelines and is certified by the College of American Pathologists (CAP).

    Please note our services, equipment and pricing below:

    Academic Rate Non-Academic Industry Rate
    CELL Analysis      
    FACScan (1-3 colors)**
    $40 $60
    FACSCalibar (1-4 colors)**
    $50 $75
    LSR II (1-13 colors)**
    $75 $100
    FACSAria (1-13 colors)
    $99 $125
    Cell Sorting      
    FACSAria (1-13 colors)*
    $125 $150
    Data Analysis      
    FlowJO, Diva, Cell Quest
    Free Free
    Training and Consultation
    Free Free
    * The price for cell sorting (FACSAria) includes technician time.
    * Please add $40/hour to the price of the FACScan, FACSCalibur and LSR II if the samples are run by Flow Lab personnel.

    The facility's technical director, Brent Palmer Ph.D., and staff help design experiments, develop and implement new applications as well as collaborate scientifically with users. The staff provide full service flow cytometry assistance, including sample preparation, staining, and data acquisition and analysis. We currently perform immunophenotyping for a number of clinical trials, including CD4/CD8 immunophenotyping for the Adult Clinical Trials Group (ACTG). Click here to review our Transplantation Engraftment Monitoring service that combines sorting with chimerism testing. Please contact Brent Palmer PhD ( if you have additional questions about our services.

    Information for New Users

    The following is a list of facility usage policies. Click here to download the user agreement form, fill out the information at the bottom of the page and return to facility personnel. Samples cannot be analyzed until this form has been signed and returned and a speed type number is provided. To receive access to the scheduling software, Click here to download the request for access to CLINIM/FLOWSHARED.

    New users will then need to schedule a time for a training session with the flow laboratory personnel. This training will initially take about 1 hour. To schedule training, please contact Dr. Palmer at 303-724-7203 ( After the initial training, new users will need some supervision and assistance which we will provide until the user and facility staff feel confident that the user can operate the instruments on his or her own. Once approved on the machines, researchers will be able to use the flow cytometers 24 hours a day 7 days a week.

    General Information about Flow Cytometry

    Flow cytometry is a multi faceted technique for characterizing and delineating cell populations via size, shape, surface and intracellular protein expression, which yields valuable information on both phenotype and cell expression. Flow cytometry is unique in its ability to rapidly analyze and sort thousands of cells per second while simultaneously providing data on distinctive cell populqations resolved at the single cell level. Flow cytometry can be used as a tool to identify novel cell populations based on the expression of cell surface markers through intracellular staining. It can also be used to examine antigen specific T cells, gene expression, or qualify the proliferative capacity of different cell populations. In addition it is a technique that can be performed using any cell sample suspension, e.g., blood cells, collagen digested or disaggregated tissue (e.g. lung, liver, and spleens cells), stem cells and cultured cells.

    The BD FACSAria is a cell sorter that is capable of rapid, simultaneous purification of phenotypically distinct populations of cells. Up to four different cell populations can be purified simultaneously from the same sample.

    Useful Flow Cytometry Links