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Xueni Chen, MD - Instructor

Division of Allergy and Clinical Immunology



 

12700 E. 19th Avenue, B164, R2
Aurora, CO 80045
Phone:  303-724-7204
Fax:  303-724-7212
Xueni.Chen@ucdenver.edu

 

1983 MD Hunan Medical University, Hunan, China

1987 MS Hunan Medical University, Hunan, China

1997-2001 Visiting Fellow, National Institution of Allergy and Infectious Diseases

Foreign Scientist Grant from Telethon International Medical-Scientific Commission, Italy 1993-1995

NIAID Staff Recognition Award in Recognition and Appreciation of Special Achievement, 2000

NIAID Staff Recognition Award in Recognition and Appreciation of Special Achievement, 2001

Peanut allergy is the most common cause of food related anaphylaxis. So far, eleven peanut proteins ( Ara h 1-11) have been identified as allergens. Ara h 2 and Ara h 6 are the most potent. Our research indicate that the activity of Ara h 2 and Ara h 6 together account for the approximately 90% of the allergenic activity of peanuts.  We plan to define in molecular detail how Ara h 2 and Ara h 6 interact to be responsible for mast cell activation in peanut allergic patients.

Chen X, Scala G, Liu W, Quinto I, Chun T, Justement J, Cohen OJ, VanCott TC, Iwanicki M, Lewis MG, Greenhouse J, Barry T, Venzon D, and Fauci AS.  Protection of Rhesus macaques against disease progression from pathogenic SHIV-89.6D by vaccination with phage-displayed HIV-1 epitopes.  Nature Medicine.  2001; 7:1225-31.

Liu W, Quinto I, Chen X, Palmieri C, Rabin RL, Schwarz OM, Nelson DL and Scala G.  Direct inhibition of Bruton’s tyrosine kinase by IBtk, a Btk binding protein.  Nature Immunology.  2001; 2:939-46.

Chen X, Liu W, Quinto I and Scala G.  Site-directed mutagenesis mediated by a single polymerase chain reaction product.  Methods in Molecular Biology.  2002; 182:67-70.

Quinto I, Puca A, Greenhouse J, Sivera P, Yalley-Ogunro J, Lewis M, Palmieri C, Trimboli F, Byrum R, Adelsberger J, Venzon D, Chen X, and Scala G.  High attenuation and immunogenicity of a simian immunodeficiency virus expressing a proteolysis-resistant inhibitor of NF-kB.  J Bio Chem.  2004; 279:1720.

Johnson KM, Chen X, Boitano A, Swenson L, Opipari AW and Glick GD.  Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423.  Chemistry & Biology.  2005;12:485-96.

Chen X, Hyatt BA, Mucenski ML, Mason RJ and Shannon JM.  Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells.  Pro Natl Acad Sci USA.  2006; 103:11724-29.

Wang J, Edeen K, Manzer R, Wang S, Chen X, Cosgrove GP, Fang X and Mason RJ.  Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro.  Am J Respir Cell Mol Biol.  2007; 36:661-68.

Porterfield HS, Murray KS, Schlichting DG, Chen X, Hansen KC, Duncan MW and Dreskin SC.  Effector activity of peanut allergens: a critical role for Arah2, Arah 6, and their variants.  Clinical et Experimental Allergy.  2009; 39:1099-108.