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Cara L. Mack, MD - Associate Professor

Primary - Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition 

Secondary - Department of Medicine, Division of Allergy and Clinical Immunology

 

13123 East 16th Ave. B290, The Children's Hospital
Aurora, CO 80045
Phone: 303-724-7200 (lab office)
Fax: 720-777-7277
Cara.Mack@ucdenver.edu

 

1982-86 BS (Molecular Biology) University of Wisconsin, Madison, WI

1988-92 MD (Medicine) Loyola University Stritch School of Medicine, Maywood, IL

1992-95 Pediatric Residency, University of Chicago Hospitals, Chicago, IL

1995-96 Chief Residency, University of Chicago Hospitals, Chicago, IL

1998-2001 Fellowship (Pediatric Gastroenterology) Children’s Memorial Hospital, Northwestern University, Chicago, IL

 

Board Certification:

1995 Pediatrics

2005 Pediatric Gastroenterology

2006 Pediatric Transplant Hepatology

Neonatal and childhood liver diseases.

Autoimmune-mediated intestinal and liver disease.

Pediatric liver transplantation.

Pediatric Liver Clinic

 

Clinic Location:

Pediatric Liver Clinic

The Children's Hospital

13123 E. 16th Avenue

Aurora, CO 80045

 

Clinic Days:

Monday and Thursday mornings

 

Appointment Contact:

720-777-6669

For more information please see Dr. Mack's profile at CUDoctors.com.

 

Dr. Cara Mack investigates biliary atresia in humans and utilizes a mouse model to study the hypothesis that the pathogenesis of biliary atresia involves a viral-induced, progressive autoimmune-mediated injury of bile ducts.

 

Research Team:

Rebecca Tucker, PhD

 

 

 

 

Sokol RJ and Mack CL.  Optimizing outcomes and bridging biliary atresia into adulthood.  Hepatology. 2005 Feb; 41 (2):231-3.

Mack CL and Sokol RJ  Unraveling the pathogenesis and etiology of biliary atresia.  Pediatr Res.  2005 May; 57 (5 Pt 2):87R-94R.

Mack CL, Tucker RM, Sokol RJ and Kotzin BL.  Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia.  Clin Immunol.  2005 May; 115(2):2004.

Whitington PF, Malladi P, Melin-Aldana H, Azzam R, Mack CL and Sahai A.  Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia.  Pediatr Res.  2005 Jun; 57(6):837-44.

Mack CL, Tucker RM, Lu B, Sokol RJ, Fontenot AP and Gill R.  Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia.  Hepatology.  2006 Nov; 44(5):1231-1239.

Mack CL.  Serum Cytokines as Biomarkers of Disease and Clues to Pathogenesis.  Hepatology.  2007; 46(1):6-8.

Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ and Fontenot AP.  Oligoclonal Expansions of CD4+ and CD8+ T Cells in the Target Organ of Patients with Biliary Atresia.  Gastroenterology.  2007; 133(1):278-287.

Mack CL.  The Pathogenesis of Biliary Atresia: Evidence for Virus-Induced Autoimmune Disease.  Semin Liver Dis. 2007; 27(3):233-42.

Barnes BH, Tucker RM, Wehrmann F, Mack DG, Ueno Y and Mack CL.  Cholangiocytes as immune modulators in rotavirus-induced murine biliary atresia.  Liver Int.  2008.

Lu BR, Mack CL.  Inflammation and Biliary Tract Injury.  Curr Opin Gastroenter.  2009; 25.