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Brian M. Freed, PhD - Professor

Division of Allergy and Clinical Immunology

Executive Director, ClinImmune Labs


12705 E. Montview Blvd. Ste 250
Aurora, CO 80045
Phone: 303-724-0535
Fax: 303-724-1310


Headlines: $6.3 million grant awarded to CU med school for cord blood.  The Denver Post.

CU Cord Blood Bank wins $6.3M federal grant.  Denver Business Journal.

Cord Blood Bank Looks to Expand Volume, Diversity of Supply. UCH Insider.


1970-71 Colegio Ibitiruna, Governador Valadares, Brazil

1976 BA (Biology) State University of New York at Plattsburgh

1978 MA (Virology) State University of New York at Plattsburgh

1990 MS (Immunology) Albany Medical College, Albany, New York

1990 PhD (Immunology) Albany Medical College, Albany New York

1999 Diplomate, American Board of Histocompatibility and Immunogenetics

2006 AABB Certified Cord Blood Bank Director

2008 FACT Certified Stem Cell Lab Director


Honors, Awards and Activities:

Honorary Professor, Kunming Medical College, Kunming, Yunnan Province, China

Department of Medicine PhD Research and Teaching Award (2007)

Member, FDA Immunologic Devices Panel

Editorial Boards, Journal of Biological Chemistry and Immunotoxicology

HLA genetics in solid organ and stem cell transplantation

Umbilical cord blood banking

Clinical immunology


Clinical Team:


Cheri Anobile
Michael Aubrey, MS
Kristen Blackburn
Abigail Blades
Sarah Bruno
Zavinta Buzeviciute
Linda Cagle
Danielle Crow
Megan Ferguson
Shannon Flannery
Sandra Fradenburg
Esmeralda Gutierrez
Flor Gutierrez
Ashley Harris
Phylicia Hermanson
Randy Huser
Jessica Karasek
Ji-Hae Kim
Laura Kuehn
Jimei Li
Mark Landolt
John Loughridge
Kit Mausbach
Dianne McLaughlin
Christine Miller
Sharon Miller
Cassie Nelson
Lora Offord
Jane Oppenheim
Allison Piluso
Mary Portas
Nivin Qudeimat-Tercero
Christen Racanelli
Tina Roark
Kristen Schultz
Tanya Serran
Katharine Spanjer
Linda Spinelli
David Stephens
Sabine Stockinger
Patrick Supon
Marian Tamondong-Reside
Stephanie Warnell
Gina Wedermyer

Effects of smoking on pulmonary immune responses; HLA epitopes and immune mediated diseases.


Research Team:

Min Zhang, MD

Stringer KA, Freed BM, Dunn JS, Ayers S, Gustafson DL and Flores SC.  Particulate phase cigarette smoke increases MnSOD, NQO1 and Cinc-1 in rat lungs.  Free Rad Biol Med.  2004; 37:1527.

Dunn JS, Freed BM, Gustafson DL and Stringer KA.  Inhibition of human neutrophil reactive oxygen species production and p67phox translocation by cigarette smoke extract.  Atherosclerosis.  2005; 179:261.

Lambert C, McCue J, Portas M, Ouyang Y, Li J, Rosano TG, Lazis A and Freed BM. Acrolein in cigarette smoke inhibits T cell activation.  J Allergy Clin Immunology.  2005; 116:916.

Bill JR, Mack DG, Falta MT, Maier LA, Sullivan AK, Joslin FG, Martin AK, Freed BM, Kotzin BL and Fontenot AP.  Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II β chain.  J Immunology.  2005; 175:7029.

Meyer MA, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW, Bonventre JV, Nemenoff RA and Malkinson AM.  Attenuation of the inflammatory response following butylated hydroxytoluene (BHT) treatment of cytosolic phospholipase A2 (cPLA2) null mice.  Am J Physiol Lung Cell Mol Physiol.  2006; 290:2160.

Gibney EM, Cagle L, Freed B, Warnell SE, Chan L and Wiseman AC.  Detection of donor-specific antibodies using HLA-coated microspheres: another tool for kidney transplant risk stratification.  NephrologyDialysis and Transplantation.  2006; 21:2625.

Frazer-Abel A, McCue J, Lazis S, Portas M, Lambert C and Freed BM.  Cigarette tar phenols impede T cell cycle progression by inhibiting cyclin-dependent kinases.  Mol Immunol.  2007; 44:488.

Lambert C, Li J, Jonscher K, Quintana M, Harvey JA and Freed BM.  Acrolein inhibits cytokine gene expression by alkylating cysteine and arginine residues in the NF-kB1 DNA-binding domain.  J Biol Chem.  2007; 282:19666.

Mack CL, Falta ML, Sullivan AK, Karrer F, Sokol RJ, Freed BM and Fontenot AP.  Oligoclonal expansions of CD4+ and CD8+ T cells in the target organ of patients with biliary atresia.  Gastroenterology.  2007; 133:278.

Freed BM and Lambert C.  Redox regulation of transcription by cigarette smoke.  In Comprehensive Toxicology (in press).  2010.

Marketing a Killer: The Art of Cigarette Advertising. University of Colorado School of Medicine Arts in Medicine Lectures, 2004.

Recent Advances in Cord Blood Transplantation. Northside Hospital, Atlanta, GA 2005

Recent Developments in Cord Blood Transplantation. Annual Meeting of the Association of Medical

Laboratory Immunologists, Denver, 2005.

Cord Blood Banking-A US Perspective. Brazilian National Cancer Institute, Rio de Janeiro, Brazil, 2005.

Administration of Cord Blood Banks for a National Network. Annual Meeting of American Association of Blood Banks (AABB), Seattle, 2005.

HLA and Autoimmunity. The Children’s Hospital, Denver, CO, 2005.

Cord Blood Transplantation. Southern California Branch American Society Microbiology, 2006.

Regulation of Inflammatory Gene Expression by Cigarette Smoke Aldehydes.  Philip Morris International, Cologne, Germany, 2008.

Induction of Proinflammatory and Immunosuppressive Immune Responses by Cigarette Smoke Aldehydes. Society of Toxicology Annual Meeting, Baltimore, Maryland, 2009.

International Standards for Cord Blood Banking. Mediconex Annual Meeting, Cairo, Egypt, 2009.

The Business of Cord Blood Banking: Legal, Regulatory and Financial Barriers to Success.  Mediconex Annual Meeting, Cairo, Egypt, 2009.

Current Status of Cord Blood Transplantation.  Mediconex Annual Meeting, Cairo, Egypt, 2009.       

The Future of Stem Cell Therapy.  Mediconex Annual Meeting, Cairo, Egypt, 2009.

Smoking and Immunity.  University of Rochester School of Medicine 2010.