My laboratory is interested in understanding several aspects of signal transduction and gene expression in adult and pediatric human heart failure. One of our main interests is analyzing the role of microRNAs in regulating gene expression. microRNAs are small RNAs that can regulate expression of several genes. They do so by interacting with mRNAs, which results in their degradation or translation repression.
We are also interested in understanding the role of proteins involved in regulating signaling pathways in heart failure. Altered levels or activities of these proteins can have an important impact on cardiomyocyte function. We use molecular and biochemistry techniques to study the role of these proteins and microRNAs in cardiomyocyte function.
Specifically, we study:
Activation of signal transduction pathways in response to stimulation of the beta-adrenergic receptor pathway, with a special focus on the role of CaMKII in the pathology of heart failure.
The YY1 transcription factor and its role in preventing pathologic hypertrophy through interaction with HDAC5.
Regulation of microRNA levels and function in human and animal models of heart failure and their role in cardiac disease.
Our main goal is to identify potential new therapeutic agents for the treatment of heart failure.