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Buttrick & Walkers Lab

Buttrick & Walkers lab group is on the cell biology and physiology of acquired cardiac hypertrophy and failure. To approach this broad area, we have analyzed molecular adaptations that lead to biochemical alterations in the sarcomere, with a particular focus on kinase dependent signaling. We have also developed functional assays (isolated sarcomere and myofilament preparations) to evaluate the functional significance of these alterations. Historically, we have relied heavily on transgenic mouse models of disease but more recently we have employed human tissue specimens to confirm findings generated using murine models.

Division of Cardiology
University of Colorado, Denver
12631 E. 17th AVe, Rm 7121
Aurora, CO 80045
Office: 303-724-2089
Fax: 303-724-2094