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Colleen Glyde Julian, PhD

Department of Medicine, Mail Stop 8611
Aurora, Colorado 80045
2007    PhD, Health and Behavioral Sciences, University of Colorado Denver
2001    MS, Kinesiology & Applied Physiology, University of Colorado Boulder  
1997    BS, Environmental, Population and Organismic Biology, University of Colorado Boulder
Research Interests:
My research aims to understand the functional role of epigenetic and genomic mechanisms for hypoxia-induced fetal growth restriction (IUGR). By integrating genomic and functional (i.e., physiologic and transcriptional) studies, the long-term goal of this work is to identify potential targets for the development of novel therapies for IUGR, and to design more effective methods to detect individuals at risk for hypoxia-related pregnancy complications. Additional research interests include: human adaptation to chronic hypoxia; maternal adaptation to pregnancy; determinants of pregnancy outcome at high altitude; and the influence of environmental epigenetic modifiers during intrauterine life for adult-onset disease.
Awards and Honors:
2014-Present  CCTSI, Child Maternal Health Pilot Award
2013-Present  Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Scholar
2012-Present  Center for Global Health, University of Colorado; Affiliated Faculty Member
2011-Present  Editorial Board, Extreme Physiology and Medicine
2007    Outstanding Junior Trainee Research Award, 15th International Hypoxia Symposium, Canada
2007    Outstanding Graduate Research Award, Research & Creative Activities Symposium, University of Colorado
2006    United Nations Population Fund (UNFPA) Internship, Ulaanbaatar, Mongolia
2006    Students for Global Health Officer, University of Colorado
2005    Finalist, Junior Trainee Research Award, 14th International Hypoxia Symposium, Canada
2004    SCIOS Young Investigator Travel Award, 15th World Congress of the ISSHP, Portugal
1. Subudhi A, Bucher J, Bourdillon N, Davis C, Elliott J, Eutermoster M, Evero O, Fan JL, Jameson-Van Houten S, Julian CG, Kark J, Kark S, Kayser B, Kern JP, Kim SE, Lathan C, Laurie SS, Lovering AT, Paterson R, Polaner D, Ryan BJ, Spira J, Tsao JW, Wachsmuth NB, Roach RC. AltitudeOmics: The Integrative Physiology of the Onset and Retention of Acclimatization to Hypoxia in Humans. PLOS One (In Press) 2014.
2. Julian CG, Yang IV, Browne VA, Vargas E, Rodriguez C, Pedersen BS, Moore LG, and DA Schwartz. Inhibition of peroxisome proliferator-activated receptor gamma (PPARγ): a potential link between chronic maternal hypoxia and impaired fetal growth. FASEB J. 2013 Dec 4. [PMID: 24307415]
3. Subudhi AW, Fan JL, Evero O, Bourdillon N, Kayser B, Julian CG, Lovering AT, Panerai RB, and RC Roach. AltitudeOmics: Cerebral autoregulation during ascent, acclimatization, and re-exposure to high altitude and its relation with acute mountain sickness. J Appl Physiol (1985). 2013 Dec 26. [PMID: 24371013]
4. Julian CG, Subudhi AW, Hill RC, Wilson MJ, Dimmen AC, Hansen KC, and RC Roach. Exploratory proteomic analysis of acute mountain sickness and hypobaric hypoxia in humans [J Appl Physiol (1985). 2013 Nov 21. [PMID: 24265281]
5. Subudhi AW, Fan J, Evero O, Bourdillon N, Kayser B, Julian CG, Lovering AT, Panerai RB, and RC Roach. AltitudeOmics: Effect of ascent, acclimatization, and re-exposure to 5,260m on cerebral autoregulation. Exp Physiol. 2013 Nov 15. [PMID: 24243839]
6. Schwartz J, Cioffi-Ragan D, Wilson MJ, Julian CG, Beatty B, Moore LG, Galan HL Little effect of gestation at 3100 m on fetal fat accretion or the fetal circulation. Am J Hum Biol. 2013 Jul;25(4):544-9. PMID: 23754523
7. Soria R, Julian CG Vargas E, Moore LG and DA Giussani. Graduated effects of high altitude hypoxia and highland ancestry on birth size. Pediatr Res. 2013 Sep 2. [PMID: 23999073]
8. Julian CG, Vargas E, Gonzales M, Dávila RD, Ladenburger A, Reardon L, Schoo C, Powers RW, Teofilo Lee-Chiong, LG Moore. Sleep-disordered breathing in preclinical chronic mountain sickness (excessive erythrocytosis). Respir Physiol Neurobiol. 2013 Apr 1;186(2):188-96. [PMID: 23380170]
9. Bigham, AW, Wilson MJ, Julian CG, Kiyamu M, Vargas E, Leon-Velarde F, Rivera-Chira M, Rodriquez C, Browne VA, Parra E, Brutsaert TD, Moore LG, Shriver MD. Andean and Tibetan patterns of adaptation to high altitude. Am J Hum Biol. 2013 Jan 24. [PMID: 23348729]
10. Davila RD*, Julian CG*, Browne VA, Toledo-Jaldin L, Rodriguez A, Vargas E and Moore LG. Role of cytokines in altitude-associated increase in preeclampsia Pregnancy Hypertens. 2012 Jan;2(1):65-70.
11. Julian CG, Vargas E, Browne VA, Wilson MJ, Bigham AW, Rodriguez C, McCord JM and Moore LG.  Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA, J Mat Neo Med, 2012.
12. Julian CG, Subudhi AW, Wilson MJ, Dimmen AC, Pecha T, Roach RC. Acute mountain sickness, inflammation, and permeability: new insights from a blood biomarker study. J Appl Physiol. 2011 Aug;111(2):392-9.
13. Moore LG, Charles S, Julian CG. Humans at high altitude: hypoxia and fetal growth [special Issue on “Energetics and oxygen transport mechanisms during embryonic development”]. Respir Physiol Neurobiol. 2011 Aug;178 (1):181-90.
14. Wilson MJ, Julian CG, Roach RC. Genomic analysis of high altitude adaptation: Innovations and implications. Curr Sports Med Rep. 2011 Mar-Apr;10(2):59-612011.
15. Subudhi AW, Dimmen AC, Julian CG, Wilson MJ, Panerai RB, Roach RC. Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia. J Appl Physiol, 2011 May;110(5):1219-25.
16. Browne VA, Toledo-Jaldin L, Davila RD, Lopez LP, Yamashiro H, Cioffi-Ragan D, Julian CG, Wilson MJ, Bigham AW, Shriver MD, Honigman B, Vargas E, Roach RC, Moore LG. High end-arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude. Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1221-9.
17. Julian CG, Hageman J, Wilson MJ, Vargas E, Moore LG. No effect of lifelong high-altitude residence on raising uteroplacental O2 delivery during pregnancy or protecting against lower birth weight; Am J Hum Biol, 2011, Jul-Aug;23(4):509-16.
18. Julian, C. High altitude and pregnancy. Invited review for Clinics in Chest Medicine Pulmonary Disease and Pregnancy, Guest Editor: G. Bourjeily; March 2011 (Vol 32, Issue 1).
19. Davila RD, Julian CG, Wilson MJ, Browne VA, Rodriguez C, Bigham AW, Shriver MD, Vargas E, Moore LG. Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude? Reprod Sci. 2011, Jan;18(1):79-87. 2012 Jan;2(1):65-70.
20. Bigham AW, Bauchet, M, Pinto D, Mao X, Akey J, Mei R, Scherer S, Julian CG, Wilson M, Herráez López D, Brutsaert T, Parra E, Moore L, Shriver M. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet, 2010 Sep 9;6(9).
21. Davila RD, Julian CG, Wilson MJ, Browne VA, Rodriguez C, Bigham AW, Shriver MD, Vargas E, Moore LG. Do Anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by Andean ancestry?  Reprod Sci. 2010 Sep;17(9):861-70.
22. Bigham AW, Mao X, Mei R, Brutsaert T, Wilson MJ, Julian CG, Parra EJ, Akey JM, Moore LG and MD Shriver. Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Hum Genomics, 2009. Dec; 4 (2):79-90.
23. Julian CG, Wilson MJ and LG Moore. Evolutionary adaptation to high altitude: a view from in utero. Am J Hum Biol. 2009 Sep-Oct;21(5):614-22.
24. Julian CG, Vargas E, Browne V, Tellez W, Rodriguez A, Wilson MJ, Rodriguez C, Yamashiro H, Shriver M, Lopez M, Moore LG. Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth Am J Physiol Regul Integr Comp Physiol. 2009;296(5)R1564-75.  
25. Julian CG, Galan HL, Wilson MJ, Desilva W, Cioffi-Ragan D, Schwartz J, Moore LG.  Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude. Am J Physiol Regul Integr Comp Physiol. 2008;295(3)R906-15.
26. Wilson MJ, Lopez M, Vargas M, Julian C, Tellez W, Rodriguez A, Bigham A, Armaza JF, Niermeyer S, Shriver M, Vargas E, Moore LG.  Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents. Am J Physiol Regul Integr Comp Physiol. 2007;293(3):R1313-24.
27. Vargas M, Vargas E, Julian CG, Armaza JF, Rodriguez A, Tellez W, Niermeyer S, Wilson M, Parra E, Shriver M, Moore LG.  Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude. Am J Physiol Regul Integr Comp Physiol. 2007;293(3):R1303-12.
28. Julian CG, Vargas E, Armaza JF, Niermeyer S, Moore LG. High-altitude ancestry protects against hypoxia-associated reductions in fetal growth. Arch Dis Child Fetal Neonatal Ed. 2007;92(5):F372-7.
29. Julian CG, Gore CJ, Wilber RL, Daniels JT, Fredericson M, Stray-Gundersen J, Hahn AG, Parisotto R, Levine BD. Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners. J Appl Physiol. 2004;96:1800-1807.
Book Chapter
Julian CG, 2005 Boosting economy through lower-body strength. In K. Beck (Ed.), Run Strong (Ch. 6) Champaign, Illinois, Human Kinetics.