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Welcome to the Integrated Department of Immunology at the University of Colorado - School of Medicine and National Jewish Health.

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B Cell Development and Function



Susan Boackle, MD - Role of complement receptor 2 in B cell tolerance.

John Cambier, PhD - Aging associated defects in B cell development and function. Molecular basis of B cell anergy. Molecular basis and physiologic function of MHC class II signaling. BCR and FcgRIIB cross talk in regulation of B cell function.

Leonard Dragone, MD/PhD - The role of Src-like adaptor (SLAP) In B-cell development, receptor editing and the pathogenesis of SLE.

James Hagman, PhD -Epigenetic and transcriptional regulation of early B cell development in the bone marrow. Control of DNA methylation and gene activation in B cells. Generation of gene-targeted and conditional knock-out mice.

V. Michael Holers, MD - Role of Complement in B cell activation and autoimmunity.

Roberta Pelanda, PhD - Autoreactive and non-autoreactive B cell development and selection. Molecular basis of B cell survival. Mechanisms of autoantibody production.

Yosef Refaeli, PhD - Alteration of normal B-cell development and function by dysregulated oncogenes.

Raul Torres, PhD - Signals guiding B cell development and function. Chemokine response and adhesion of developing B lineage cells. Chemokine response and adhesion of mature B cells during a humoral immune response.

Linda van Dyk, PhD - B cell signaling and differentiation in viral infection.

Lawrence Wysocki, PhD - Somatic hypermutation in autoimmunity.  Regulatory anergic B cells.